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Protein

60S ribosomal protein L26

Gene

rpl-26

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: GO_Central
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-CEL-1799339 SRP-dependent cotranslational protein targeting to membrane
R-CEL-72689 Formation of a pool of free 40S subunits
R-CEL-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-CEL-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-CEL-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L26
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rpl-26
ORF Names:F28C6.7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
F28C6.7a ; CE03278 ; WBGene00004440 ; rpl-26
F28C6.7b ; CE20731 ; WBGene00004440 ; rpl-26
F28C6.7c ; CE32883 ; WBGene00004440 ; rpl-26

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001307951 – 14260S ribosomal protein L26Add BLAST142

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q19869

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q19869

PeptideAtlas

More...
PeptideAtlasi
Q19869

PRoteomics IDEntifications database

More...
PRIDEi
Q19869

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q19869

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004440 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
39707, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.F28C6.7a.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q19869

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q19869

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3401 Eukaryota
COG0198 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014165

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000216571

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q19869

KEGG Orthology (KO)

More...
KOi
K02898

Identification of Orthologs from Complete Genome Data

More...
OMAi
VRIMRGD

Database of Orthologous Groups

More...
OrthoDBi
1488916at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q19869

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.30, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01326_A Ribosomal_L24_A, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005824 KOW
IPR014722 Rib_L2_dom2
IPR005825 Ribosomal_L24/26_CS
IPR005756 Ribosomal_L26/L24P_euk/arc
IPR008991 Translation_prot_SH3-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11143 PTHR11143, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00467 KOW, 1 hit
PF16906 Ribosomal_L26, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00739 KOW, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50104 SSF50104, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01080 rplX_A_E, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01108 RIBOSOMAL_L24, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: Q19869-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVNPFVSSD SGKSRKAHFN APSHERRRIM SAPLTKELRT KHGIRAIPIR
60 70 80 90 100
TDDEVVVMRG RHKGNTGRVL RCYRKKFVIH IDKITREKAN GSTVHIGIHP
110 120 130 140
SKVAITKLKL DKDRRALVER KAAGRSRVTG ILKGKHTDET VN
Note: No experimental confirmation available.
Length:142
Mass (Da):16,075
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB496362F0BFEC354
GO
Isoform b (identifier: Q19869-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-142: AITKLKLDKDRRALVERKAAGRSRVTGILKGKHTDETVN → RFV

Note: No experimental confirmation available.
Show »
Length:106
Mass (Da):12,149
Checksum:iBFC2D533D71991EA
GO
Isoform c (identifier: Q19869-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-142: AITKLKLDKDRRALVERKAAGRSRVTGILKGKHTDETVN → RSLSPS

Note: No experimental confirmation available.
Show »
Length:109
Mass (Da):12,374
Checksum:i6255499A3EA533D7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_020728104 – 142AITKL…DETVN → RFV in isoform b. CuratedAdd BLAST39
Alternative sequenceiVSP_020727104 – 142AITKL…DETVN → RSLSPS in isoform c. CuratedAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z68315 Genomic DNA Translation: CAA92674.1
Z68315 Genomic DNA Translation: CAA92678.1
Z68315 Genomic DNA Translation: CAD59149.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T21486
T21490

NCBI Reference Sequences

More...
RefSeqi
NP_495823.1, NM_063422.4 [Q19869-1]
NP_495824.1, NM_063423.6 [Q19869-2]
NP_871965.1, NM_182165.5 [Q19869-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Cel.18248

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F28C6.7a; F28C6.7a; WBGene00004440 [Q19869-1]
F28C6.7b; F28C6.7b; WBGene00004440 [Q19869-2]
F28C6.7c; F28C6.7c; WBGene00004440 [Q19869-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174379

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F28C6.7

UCSC genome browser

More...
UCSCi
F28C6.7a.1 c. elegans [Q19869-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68315 Genomic DNA Translation: CAA92674.1
Z68315 Genomic DNA Translation: CAA92678.1
Z68315 Genomic DNA Translation: CAD59149.1
PIRiT21486
T21490
RefSeqiNP_495823.1, NM_063422.4 [Q19869-1]
NP_495824.1, NM_063423.6 [Q19869-2]
NP_871965.1, NM_182165.5 [Q19869-3]
UniGeneiCel.18248

3D structure databases

ProteinModelPortaliQ19869
SMRiQ19869
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi39707, 1 interactor
STRINGi6239.F28C6.7a.2

PTM databases

iPTMnetiQ19869

Proteomic databases

EPDiQ19869
PaxDbiQ19869
PeptideAtlasiQ19869
PRIDEiQ19869

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF28C6.7a; F28C6.7a; WBGene00004440 [Q19869-1]
F28C6.7b; F28C6.7b; WBGene00004440 [Q19869-2]
F28C6.7c; F28C6.7c; WBGene00004440 [Q19869-3]
GeneIDi174379
KEGGicel:CELE_F28C6.7
UCSCiF28C6.7a.1 c. elegans [Q19869-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174379
WormBaseiF28C6.7a ; CE03278 ; WBGene00004440 ; rpl-26
F28C6.7b ; CE20731 ; WBGene00004440 ; rpl-26
F28C6.7c ; CE32883 ; WBGene00004440 ; rpl-26

Phylogenomic databases

eggNOGiKOG3401 Eukaryota
COG0198 LUCA
GeneTreeiENSGT00390000014165
HOGENOMiHOG000216571
InParanoidiQ19869
KOiK02898
OMAiVRIMRGD
OrthoDBi1488916at2759
PhylomeDBiQ19869

Enzyme and pathway databases

ReactomeiR-CEL-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-CEL-1799339 SRP-dependent cotranslational protein targeting to membrane
R-CEL-72689 Formation of a pool of free 40S subunits
R-CEL-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-CEL-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-CEL-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q19869

Gene expression databases

BgeeiWBGene00004440 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di2.30.30.30, 1 hit
HAMAPiMF_01326_A Ribosomal_L24_A, 1 hit
InterProiView protein in InterPro
IPR005824 KOW
IPR014722 Rib_L2_dom2
IPR005825 Ribosomal_L24/26_CS
IPR005756 Ribosomal_L26/L24P_euk/arc
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11143 PTHR11143, 1 hit
PfamiView protein in Pfam
PF00467 KOW, 1 hit
PF16906 Ribosomal_L26, 1 hit
SMARTiView protein in SMART
SM00739 KOW, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
TIGRFAMsiTIGR01080 rplX_A_E, 1 hit
PROSITEiView protein in PROSITE
PS01108 RIBOSOMAL_L24, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL26_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19869
Secondary accession number(s): Q8I121, Q9U3H7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 16, 2019
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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