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Entry version 130 (18 Sep 2019)
Sequence version 5 (01 Jun 2003)
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Protein

Protein phosphatase 1 regulatory subunit 37 homolog

Gene

F28C1.3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 37 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:F28C1.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
F28C1.3a ; CE31919 ; WBGene00009201
F28C1.3b ; CE31920 ; WBGene00009201

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003209431 – 944Protein phosphatase 1 regulatory subunit 37 homologAdd BLAST944

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q19857

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00009201 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q19857 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati203 – 224LRR 1Add BLAST22
Repeati232 – 255LRR 2Add BLAST24
Repeati262 – 282LRR 3Add BLAST21
Repeati290 – 311LRR 4Add BLAST22
Repeati318 – 338LRR 5Add BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi551 – 730Ser-richAdd BLAST180
Compositional biasi932 – 935Poly-Arg4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PPP1R37 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1908 Eukaryota
ENOG410XSTR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157454

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113378

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q19857

KEGG Orthology (KO)

More...
KOi
K17576

Identification of Orthologs from Complete Genome Data

More...
OMAi
NVTGASM

Database of Orthologous Groups

More...
OrthoDBi
294047at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q19857

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516 LRR_6, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform a (identifier: Q19857-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSMKFLTGLQ DLLGLYETGT AASSPASPIP PTSPAMFAVP PQQQSHSAAT
60 70 80 90 100
SVRKKTCQDA NSSGEDPNGR IRQCSHARTV SFPADMDLIT GYHEAPSSLF
110 120 130 140 150
HSYHDSQRVI DSSEILTAYR EACQRRQCAP SAAVEKQIGY FHKSPDTRQE
160 170 180 190 200
LLSLKGERVS HAQMEALEEI FKRVQFNTID FEYTFLDDDC AISLGEMIEF
210 220 230 240 250
YDSCVRLNLS FNKQIDMRGW TTIFRSIRHA VSLQMLNLRY TNLNDRSIPA
260 270 280 290 300
LCKMARAQPS ASLTCLHLEN TQMSGKNLLV LICALKNNTG LRELYLGDNG
310 320 330 340 350
LQPTDGSHIY QLITSNSSLQ LLDLRNNSIG DSGVRHICDG LRHREAVEKS
360 370 380 390 400
SLSAMVLWNN NVTGASMDSL AEALIENTKI ETLNIGNNNL GVEGIARLKP
410 420 430 440 450
ALASNSHLHR LGLQNTGINC EGAIILAECI ADNIALLRVD IRDNPIALAG
460 470 480 490 500
LLALHSAMKM NTSITLLNID ASCVKLSSEK VREYQDEFER YFREIQTYCD
510 520 530 540 550
RNKDDVLKRL TVTFDDEEGD SGVEKKDGNE CEGEDNKDRQ DTPAETENGV
560 570 580 590 600
SSNESKLENE EVGVSKPESN NNEKSPLMAS SSTSKLSRKE RHQRFVRSSS
610 620 630 640 650
LTCTETVHDI HDRLREMSGS THSLDAAIAA AASNSTMQNL LTVSYGSNPG
660 670 680 690 700
PLDSSSNSES MKTIKKSFTV TAASSSSLPL AEWGSLPALP QASPSSTPVV
710 720 730 740 750
RKLRRFSVSP SSSVFDVATT SSAASSTASS PIPENSIALP VRPSTLAIGI
760 770 780 790 800
PIIGSVPAGP SSAPLILVED HKDGPITSNQ ISDTERRISE EIERQKKDEQ
810 820 830 840 850
EIEKSCRSVI RDLLNYVEYE EKSQVERKAS LLLRNTFSRP NPEELLRNLR
860 870 880 890 900
LSEATGSTTP RTPLTPSRYV QVFNINSFLK LYFIKACILR VLEIAEELEG
910 920 930 940
ESDEQICQSV IRCLVRDVLQ AEKNELRSTL DRRRRHNSVR NSPV
Length:944
Mass (Da):104,236
Last modified:June 1, 2003 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E29F9E54A3E4FF6
GO
Isoform b (identifier: Q19857-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     481-485: Missing.

Show »
Length:939
Mass (Da):103,560
Checksum:i1A7FEB42DB84BABA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H2L2C5H2L2C5_CAEEL
Protein phosphatase 1 regulatory su...
CELE_F28C1.3, F28C1.3
922Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H2L2C6H2L2C6_CAEEL
Protein phosphatase 1 regulatory su...
CELE_F28C1.3, F28C1.3
917Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_031756481 – 485Missing in isoform b. Curated5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z75539, Z75552 Genomic DNA Translation: CAD54134.1
Z75539, Z75552 Genomic DNA Translation: CAA99846.3

Protein sequence database of the Protein Information Resource

More...
PIRi
C89243
T21471

NCBI Reference Sequences

More...
RefSeqi
NP_506126.2, NM_073725.4 [Q19857-1]
NP_872197.1, NM_182397.3 [Q19857-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F28C1.3a.1; F28C1.3a.1; WBGene00009201 [Q19857-1]
F28C1.3b.1; F28C1.3b.1; WBGene00009201 [Q19857-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
179708

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F28C1.3

UCSC genome browser

More...
UCSCi
F28C1.3a c. elegans [Q19857-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75539, Z75552 Genomic DNA Translation: CAD54134.1
Z75539, Z75552 Genomic DNA Translation: CAA99846.3
PIRiC89243
T21471
RefSeqiNP_506126.2, NM_073725.4 [Q19857-1]
NP_872197.1, NM_182397.3 [Q19857-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiQ19857

Genome annotation databases

EnsemblMetazoaiF28C1.3a.1; F28C1.3a.1; WBGene00009201 [Q19857-1]
F28C1.3b.1; F28C1.3b.1; WBGene00009201 [Q19857-2]
GeneIDi179708
KEGGicel:CELE_F28C1.3
UCSCiF28C1.3a c. elegans [Q19857-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
179708
WormBaseiF28C1.3a ; CE31919 ; WBGene00009201
F28C1.3b ; CE31920 ; WBGene00009201

Phylogenomic databases

eggNOGiKOG1908 Eukaryota
ENOG410XSTR LUCA
GeneTreeiENSGT00940000157454
HOGENOMiHOG000113378
InParanoidiQ19857
KOiK17576
OMAiNVTGASM
OrthoDBi294047at2759
PhylomeDBiQ19857

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q19857

Gene expression databases

BgeeiWBGene00009201 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)
ExpressionAtlasiQ19857 baseline and differential

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13516 LRR_6, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPR37_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19857
Secondary accession number(s): Q23160, Q8I0R8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: September 18, 2019
This is version 130 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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