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Entry version 161 (02 Jun 2021)
Sequence version 3 (20 Jan 2009)
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Protein

A disintegrin and metalloproteinase with thrombospondin motifs gon-1

Gene

gon-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Secreted metalloprotease required for distal tip cell (DTC) migration along the body wall basement membranes, a key step that promotes gonad morphogenesis (PubMed:10588887, PubMed:10376599, PubMed:15556862).

Probably acts by remodeling the basement membrane during cell migration (PubMed:10376599).

Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons, probably by controlling collagen IV emb-9 degradation, a component of the synapse basement membrane (PubMed:25080592, PubMed:25232106).

Also involved in the organization of adult muscle morphology (PubMed:25232106).

Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos (PubMed:22419820, PubMed:26218657).

Required for the secretion of insulin-like peptide ins-7, daf-28 and ins-18 and TGF beta-like protein daf-7 (PubMed:26218657).

In peripheral tissues, negatively regulates insulin-mediated daf-16 translocation and thereby negatively regulates lifespan and dauer formation (PubMed:26218657).

7 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi424Zinc; catalyticPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei425PROSITE-ProRule annotation1
Metal bindingi428Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi434Zinc; catalyticPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metalloendopeptidase activity Source: GO_Central
  • metallopeptidase activity Source: WormBase
  • zinc ion binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Metalloprotease, Protease
Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-5173214, O-glycosylation of TSR domain-containing proteins

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M12.135

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs gon-1Curated (EC:3.4.24.-By similarity)
Short name:
ADAMTS gon-1Curated
Alternative name(s):
Abnormal gonad development protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gon-1Imported
ORF Names:F25H8.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
F25H8.3a ; CE42668 ; WBGene00001650 ; gon-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Basement membrane, Endoplasmic reticulum, Extracellular matrix, Golgi apparatus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown in distal tip cells results in deformation of ER structure and inhibition of protein secretion which are rescued upon GON-domain expression.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi425E → A: Loss of function; abolishes DTCs migration or gonad arm extension. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000044096029 – 273By similarityAdd BLAST245
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000250561274 – 2150A disintegrin and metalloproteinase with thrombospondin motifs gon-1Add BLAST1877

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi402 ↔ 488PROSITE-ProRule annotation
Disulfide bondi440 ↔ 470PROSITE-ProRule annotation
Disulfide bondi600 ↔ 637PROSITE-ProRule annotation
Disulfide bondi604 ↔ 642PROSITE-ProRule annotation
Disulfide bondi615 ↔ 627PROSITE-ProRule annotation
Glycosylationi842N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1139N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1370N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1432N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi1528N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1590N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1606N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1654N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1679 ↔ 1718PROSITE-ProRule annotation
Disulfide bondi1690 ↔ 1730PROSITE-ProRule annotation
Disulfide bondi1690 ↔ 1694PROSITE-ProRule annotation
Disulfide bondi1694 ↔ 1735PROSITE-ProRule annotation
Disulfide bondi1705 ↔ 1718PROSITE-ProRule annotation
Disulfide bondi1730 ↔ 1735PROSITE-ProRule annotation
Glycosylationi1828N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1855N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1942N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1960N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1997N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q19791

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q19791

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q19791

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the gonadal distal tip cells (DTCs) (PubMed:10376599). Expressed in muscles, including body wall, vulval and anal depressor muscles (PubMed:10376599, PubMed:25232106, PubMed:26218657). Expressed in motor neurons and in ASI and ASJ neurons (PubMed:26218657).3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in some cells at the embryonic stage (260-280 min after the first cleavage) (PubMed:26218657). In hermaphrodites, expression is first detected in gonads in L2 larvae and is limited to the distal tip cells (DTCs), then continues in DTCs throughout L4 larval stage and becomes faint or absent in adults (PubMed:10376599). Also expressed in muscle cells throughout development (PubMed:10376599). At the larval stages, expressed in some head neurons, intestine and excretory cells (PubMed:26218657).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001650, Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q19791, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.F25H8.3b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini280 – 493Peptidase M12BPROSITE-ProRule annotationAdd BLAST214
Domaini503 – 587DisintegrinAdd BLAST85
Domaini588 – 643TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini943 – 1003TSP type-1 2PROSITE-ProRule annotationAdd BLAST61
Domaini1004 – 1057TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini1060 – 1115TSP type-1 4PROSITE-ProRule annotationAdd BLAST56
Domaini1116 – 1165TSP type-1 5PROSITE-ProRule annotationAdd BLAST50
Domaini1168 – 1227TSP type-1 6PROSITE-ProRule annotationAdd BLAST60
Domaini1228 – 1277TSP type-1 7PROSITE-ProRule annotationAdd BLAST50
Domaini1280 – 1339TSP type-1 8PROSITE-ProRule annotationAdd BLAST60
Domaini1352 – 1409TSP type-1 9PROSITE-ProRule annotationAdd BLAST58
Domaini1410 – 1469TSP type-1 10PROSITE-ProRule annotationAdd BLAST60
Domaini1474 – 1524TSP type-1 11PROSITE-ProRule annotationAdd BLAST51
Domaini1527 – 1585TSP type-1 12PROSITE-ProRule annotationAdd BLAST59
Domaini1621 – 1675TSP type-1 13PROSITE-ProRule annotationAdd BLAST55
Domaini1678 – 1736TSP type-1 14PROSITE-ProRule annotationAdd BLAST59
Domaini1737 – 1793TSP type-1 15PROSITE-ProRule annotationAdd BLAST57
Domaini1794 – 1866TSP type-1 16PROSITE-ProRule annotationAdd BLAST73
Domaini1867 – 1924TSP type-1 17PROSITE-ProRule annotationAdd BLAST58
Domaini1924 – 2123GONPROSITE-ProRule annotationAdd BLAST200

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1590 – 1614DisorderedSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The GON domain mediates protease-independent function in ER to Golgi transport.2 Publications

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3538, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167121

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000660_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q19791

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q19791

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 16 hits
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041645, ADAM_CR_2
IPR010294, ADAM_spacer1
IPR013273, ADAMTS/ADAMTS-like
IPR024079, MetalloPept_cat_dom_sf
IPR012314, Pept_M12B_GON-ADAMTSs
IPR001590, Peptidase_M12B
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF05986, ADAM_spacer1, 1 hit
PF08685, GON, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01857, ADAMTSFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209, TSP1, 18 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895, SSF82895, 16 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS51046, GON, 1 hit
PS50092, TSP1, 15 hits
PS00142, ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q19791-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSIGGSFHL LQPVVAALIL LVVCLVYALQ SGSGTISEFS SDVLFSRAKY
60 70 80 90 100
SGVPVHHSRW RQDAGIHVID SHHIVRRDSY GRRGKRDVTS TDRRRRLQGV
110 120 130 140 150
ARDCGHACHL RLRSDDAVYI VHLHRWNQIP DSHNKSVPHF SNSNFAPMVL
160 170 180 190 200
YLDSEEEVRG GMSRTDPDCI YRAHVKGVHQ HSIVNLCDSE DGLYGMLALP
210 220 230 240 250
SGIHTVEPII SGNGTEHDGA SRHRQHLVRK FDPMHFKSFD HLNSTSVNET
260 270 280 290 300
ETTVATWQDQ WEDVIERKAR SRRAANSWDH YVEVLVVADT KMYEYHGRSL
310 320 330 340 350
EDYVLTLFST VASIYRHQSL RASINVVVVK LIVLKTENAG PRITQNAQQT
360 370 380 390 400
LQDFCRWQQY YNDPDDSSVQ HHDVAILLTR KDICRSQGKC DTLGLAELGT
410 420 430 440 450
MCDMQKSCAI IEDNGLSAAF TIAHELGHVF SIPHDDERKC STYMPVNKNN
460 470 480 490 500
FHIMAPTLEY NTHPWSWSPC SAGMLERFLE NNRGQTQCLF DQPVERRYYE
510 520 530 540 550
DVFVRDEPGK KYDAHQQCKF VFGPASELCP YMPTCRRLWC ATFYGSQMGC
560 570 580 590 600
RTQHMPWADG TPCDESRSMF CHHGACVRLA PESLTKIDGQ WGDWRSWGEC
610 620 630 640 650
SRTCGGGVQK GLRDCDSPKP RNGGKYCVGQ RERYRSCNTQ ECPWDTQPYR
660 670 680 690 700
EVQCSEFNNK DIGIQGVAST NTHWVPKYAN VAPNERCKLY CRLSGSAAFY
710 720 730 740 750
LLRDKVVDGT PCDRNGDDIC VAGACMPAGC DHQLHSTLRR DKCGVCGGDD
760 770 780 790 800
SSCKVVKGTF NEQGTFGYNE VMKIPAGSAN IDIRQKGYNN MKEDDNYLSL
810 820 830 840 850
RAANGEFLLN GHFQVSLARQ QIAFQDTVLE YSGSDAIIER INGTGPIRSD
860 870 880 890 900
IYVHVLSVGS HPPDISYEYM TAAVPNAVIR PISSALYLWR VTDTWTECDR
910 920 930 940 950
ACRGQQSQKL MCLDMSTHRQ SHDRNCQNVL KPKQATRMCN IDCSTRWITE
960 970 980 990 1000
DVSSCSAKCG SGQKRQRVSC VKMEGDRQTP ASEHLCDRNS KPSDIASCYI
1010 1020 1030 1040 1050
DCSGRKWNYG EWTSCSETCG SNGKMHRKSY CVDDSNRRVD ESLCGREQKE
1060 1070 1080 1090 1100
ATERECNRIP CPRWVYGHWS ECSRSCDGGV KMRHAQCLDA ADRETHTSRC
1110 1120 1130 1140 1150
GPAQTQEHCN EHACTWWQFG VWSDCSAKCG DGVQYRDANC TDRHRSVLPE
1160 1170 1180 1190 1200
HRCLKMEKII TKPCHRESCP KYKLGEWSQC SVSCEDGWSS RRVSCVSGNG
1210 1220 1230 1240 1250
TEVDMSLCGT ASDRPASHQT CNLGTCPFWR NTDWSACSVS CGIGHRERTT
1260 1270 1280 1290 1300
ECIYREQSVD ASFCGDTKMP ETSQTCHLLP CTSWKPSHWS PCSVTCGSGI
1310 1320 1330 1340 1350
QTRSVSCTRG SEGTIVDEYF CDRNTRPRLK KTCEKDTCDG PRVLQKLQAD
1360 1370 1380 1390 1400
VPPIRWATGP WTACSATCGN GTQRRLLKCR DHVRDLPDEY CNHLDKEVST
1410 1420 1430 1440 1450
RNCRLRDCSY WKMAEWEECP ATCGTHVQQS RNVTCVSAED GGRTILKDVD
1460 1470 1480 1490 1500
CDVQKRPTSA RNCRLEPCPK GEEHIGSWII GDWSKCSASC GGGWRRRSVS
1510 1520 1530 1540 1550
CTSSSCDETR KPKMFDKCNE ELCPPLTNNS WQISPWTHCS VSCGGGVQRR
1560 1570 1580 1590 1600
KIWCEDVLSG RKQDDIECSE IKPREQRDCE MPPCRSHYHN KTSSASMTSL
1610 1620 1630 1640 1650
SSSNSNTTSS ASASSLPILP PVVSWQTSAW SACSAKCGRG TKRRVVECVN
1660 1670 1680 1690 1700
PSLNVTVAST ECDQTKKPVE EVRCRTKHCP RWKTTTWSSC SVTCGRGIRR
1710 1720 1730 1740 1750
REVQCYRGRK NLVSDSECNP KTKLNSVANC FPVACPAYRW NVTPWSKCKD
1760 1770 1780 1790 1800
ECARGQKQTR RVHCISTSGK RAAPRMCELA RAPTSIRECD TSNCPYEWVP
1810 1820 1830 1840 1850
GDWQTCSKSC GEGVQTREVR CRRKINFNST IPIIFMLEDE PAVPKEKCEL
1860 1870 1880 1890 1900
FPKPNESQTC ELNPCDSEFK WSFGPWGECS KNCGQGIRRR RVKCVANDGR
1910 1920 1930 1940 1950
RVERVKCTTK KPRRTQYCFE RNCLPSTCQE LKSQNVKAKD GNYTILLDGF
1960 1970 1980 1990 2000
TIEIYCHRMN STIPKAYLNV NPRTNFAEVY GKKLIYPHTC PFNGDRNDSC
2010 2020 2030 2040 2050
HCSEDGDASA GLTRFNKVRI DLLNRKFHLA DYTFAKREYG VHVPYGTAGD
2060 2070 2080 2090 2100
CYSMKDCPQG IFSIDLKSAG LKLVDDLNWE DQGHRTSSRI DRFYNNAKVI
2110 2120 2130 2140 2150
GHCGGFCGKC SPERYKGLIF EVNTKLLNHV KNGGHIDDEL DDDGFSGDMD
Length:2,150
Mass (Da):242,582
Last modified:January 20, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB18051C284C29116
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H2L2A7H2L2A7_CAEEL
A disintegrin and metalloproteinase...
gon-1 CELE_F25H8.3, F25H8.3
2,165Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z69360, Z69361 Genomic DNA Translation: CAA93287.2

Protein sequence database of the Protein Information Resource

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PIRi
T21371

NCBI Reference Sequences

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RefSeqi
NP_001255447.1, NM_001268518.1

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
F25H8.3a.1; F25H8.3a.1; WBGene00001650

UCSC genome browser

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UCSCi
F25H8.3, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69360, Z69361 Genomic DNA Translation: CAA93287.2
PIRiT21371
RefSeqiNP_001255447.1, NM_001268518.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.F25H8.3b

Protein family/group databases

MEROPSiM12.135

PTM databases

iPTMnetiQ19791

Proteomic databases

EPDiQ19791
PaxDbiQ19791

Genome annotation databases

EnsemblMetazoaiF25H8.3a.1; F25H8.3a.1; WBGene00001650
UCSCiF25H8.3, c. elegans

Organism-specific databases

WormBaseiF25H8.3a ; CE42668 ; WBGene00001650 ; gon-1

Phylogenomic databases

eggNOGiKOG3538, Eukaryota
GeneTreeiENSGT00940000167121
HOGENOMiCLU_000660_0_1_1
InParanoidiQ19791
PhylomeDBiQ19791

Enzyme and pathway databases

ReactomeiR-CEL-5173214, O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q19791

Gene expression databases

BgeeiWBGene00001650, Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues
ExpressionAtlasiQ19791, baseline and differential

Family and domain databases

Gene3Di2.20.100.10, 16 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR041645, ADAM_CR_2
IPR010294, ADAM_spacer1
IPR013273, ADAMTS/ADAMTS-like
IPR024079, MetalloPept_cat_dom_sf
IPR012314, Pept_M12B_GON-ADAMTSs
IPR001590, Peptidase_M12B
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF05986, ADAM_spacer1, 1 hit
PF08685, GON, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 1 hit
PRINTSiPR01857, ADAMTSFAMILY
SMARTiView protein in SMART
SM00209, TSP1, 18 hits
SUPFAMiSSF82895, SSF82895, 16 hits
PROSITEiView protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS51046, GON, 1 hit
PS50092, TSP1, 15 hits
PS00142, ZINC_PROTEASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGON1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19791
Secondary accession number(s): Q27524
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: January 20, 2009
Last modified: June 2, 2021
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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