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Entry version 122 (18 Sep 2019)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Uncharacterized protein

Gene

CELE_F23H12.5

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-399954 Sema3A PAK dependent Axon repulsion
R-CEL-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-CEL-399956 CRMPs in Sema3A signaling
R-CEL-416550 Sema4D mediated inhibition of cell attachment and migration
R-CEL-416572 Sema4D induced cell migration and growth-cone collapse
R-CEL-416700 Other semaphorin interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CELE_F23H12.5Imported, F23H12.5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
F23H12.5 ; CE05708 ; WBGene00009094

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500418720220 – 802Sequence analysisAdd BLAST783

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q19764

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q19764

PeptideAtlas

More...
PeptideAtlasi
Q19764

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00009094 Expressed in 4 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-27050N

Protein interaction database and analysis system

More...
IntActi
Q19764, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F23H12.5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q19764

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni125 – 152DisorderedSequence analysisAdd BLAST28
Regioni169 – 253DisorderedSequence analysisAdd BLAST85
Regioni284 – 366DisorderedSequence analysisAdd BLAST83
Regioni542 – 566DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi125 – 151PolarSequence analysisAdd BLAST27
Compositional biasi200 – 253PolarSequence analysisAdd BLAST54
Compositional biasi298 – 318PolarSequence analysisAdd BLAST21
Compositional biasi351 – 366PolarSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410K9K1 Eukaryota
ENOG4110J7N LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000022440

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q19764

Identification of Orthologs from Complete Genome Data

More...
OMAi
WMINDME

Database of Orthologous Groups

More...
OrthoDBi
862202at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027231 Semaphorin
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11036 PTHR11036, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00090 TSP_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209 TSP1, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895 SSF82895, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50092 TSP1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q19764-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRMKLLFLFL MSLMAFTTSQ YEPLSVISSS WSMWSPWSFC SNNLMIRVRA
60 70 80 90 100
CSTVRGYKCL GHNKEFQSCN SPPKRNSLDY EDPETADREM AMKQLYQDYE
110 120 130 140 150
PEIPDEAKYA QTRGNRNFHM ISQTTAMPPA PRAPTSSPTV SASTSDHFSV
160 170 180 190 200
MNRGGTGVGM MTDEEEEYFD ETVKMSPQSP KPTYPSVPST FEFEKYPKST
210 220 230 240 250
EEPTSTPSTS TSTTTTTTTS TTTTTTEAPT TTTTIKTTTE SIEPIPQTVT
260 270 280 290 300
PNSPKIVDHE AFVEPEDVNF RGKYTLEEPL PEVSVPTFAA PPGTQTPDFE
310 320 330 340 350
LETESTETPS TPSSFPIDMD PEDSTDGSTH SVGSYSIGKE PMWGEEPVPL
360 370 380 390 400
ASNTQAPSRN MPTFAISPST RRLGEVRRAP STVNTHIEMP MSMLPFVPTA
410 420 430 440 450
AEEPQTTSFE VETTTEIPQP SYLQNPRIAL VTSQQNFQHF PKLMNEQRAS
460 470 480 490 500
PGPYFRTVPS PSEYDEPTTT KKPKIVTVEI TNKPLKKKRR NRRLKKLNRL
510 520 530 540 550
GKIRTMAVLP TEYTIPATKP MKPMPTPAKY EIQEENFIAP KATEPSASEP
560 570 580 590 600
QPTRASEKDR QVYEENRELE SRIAALRNKV EMNRKILATM KIPEGVETPV
610 620 630 640 650
VTTTQKPLKA SEDLMLGGDT ARALSWMIND MERMVDDKTK TEVSDQLPVE
660 670 680 690 700
KIEEEPIGFR IGDFESDETT TTVSPFPFPI PENGFALIRS KRDASTQFKN
710 720 730 740 750
GKKVIWSPWS EWTKCQCGKQ SRKRKCLKYL GGSKYAYDDQ KFIPIDQSTN
760 770 780 790 800
DIEFGEPAEF PEELEEPAPM DSQEYENLNR VKRSLKCPSP QIEVQSCSSS

VC
Length:802
Mass (Da):90,137
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A9CA26F60A62EE5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAA98943.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T21315

NCBI Reference Sequences

More...
RefSeqi
NP_506096.1, NM_073695.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F23H12.5.1; F23H12.5.1; WBGene00009094

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
179695

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F23H12.5

UCSC genome browser

More...
UCSCi
F23H12.5 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAA98943.1
PIRiT21315
RefSeqiNP_506096.1, NM_073695.4

3D structure databases

SMRiQ19764
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-27050N
IntActiQ19764, 2 interactors
STRINGi6239.F23H12.5

Proteomic databases

EPDiQ19764
PaxDbiQ19764
PeptideAtlasiQ19764

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF23H12.5.1; F23H12.5.1; WBGene00009094
GeneIDi179695
KEGGicel:CELE_F23H12.5
UCSCiF23H12.5 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
179695
WormBaseiF23H12.5 ; CE05708 ; WBGene00009094

Phylogenomic databases

eggNOGiENOG410K9K1 Eukaryota
ENOG4110J7N LUCA
HOGENOMiHOG000022440
InParanoidiQ19764
OMAiWMINDME
OrthoDBi862202at2759

Enzyme and pathway databases

ReactomeiR-CEL-399954 Sema3A PAK dependent Axon repulsion
R-CEL-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-CEL-399956 CRMPs in Sema3A signaling
R-CEL-416550 Sema4D mediated inhibition of cell attachment and migration
R-CEL-416572 Sema4D induced cell migration and growth-cone collapse
R-CEL-416700 Other semaphorin interactions

Gene expression databases

BgeeiWBGene00009094 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR027231 Semaphorin
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF00090 TSP_1, 2 hits
SMARTiView protein in SMART
SM00209 TSP1, 2 hits
SUPFAMiSSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS50092 TSP1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ19764_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19764
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 18, 2019
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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