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Entry version 120 (26 Feb 2020)
Sequence version 2 (01 Dec 2000)
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Protein

Innexin-3

Gene

inx-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Structural component of the gap junctions.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • embryonic morphogenesis Source: WormBase
  • ion transport Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.25.1.1 the gap junction-forming innexin (innexin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Innexin-3
Alternative name(s):
Protein opu-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:inx-3
Synonyms:opu-3
ORF Names:F22F4.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
F22F4.2 ; CE33055 ; WBGene00002125 ; inx-3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 53HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei104 – 124HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei193 – 213HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei278 – 298HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002085061 – 420Innexin-3Add BLAST420

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q19746

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q19746

PeptideAtlas

More...
PeptideAtlasi
Q19746

PRoteomics IDEntifications database

More...
PRIDEi
Q19746

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00002125 Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q19746, 1 interactor

Molecular INTeraction database

More...
MINTi
Q19746

STRING: functional protein association networks

More...
STRINGi
6239.F22F4.2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGA4 Eukaryota
ENOG410XT2D LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_035763_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q19746

KEGG Orthology (KO)

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KOi
K22037

Identification of Orthologs from Complete Genome Data

More...
OMAi
MANMFNE

Database of Orthologous Groups

More...
OrthoDBi
738314at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q19746

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000990 Innexin

The PANTHER Classification System

More...
PANTHERi
PTHR11893 PTHR11893, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00876 Innexin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01262 INNEXIN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51013 PANNEXIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q19746-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGVPFIDRW LSETFKPKTF DDAVDRLSYV TTATLLAFFS IMVSCKQYVG
60 70 80 90 100
SAIQCWMPME FKGGWEQYAE DYCFIQNTFF IPERSEIPGD VEDRQKAEIG
110 120 130 140 150
YYQWVPIVLA IQAFMFYLPS WIWSSLYKQC GLDFPSVISE AEALRSQDSE
160 170 180 190 200
TRTKGVNKLV DFIGDILDTR SKNEYGRFYC YRFGKGLGSM TSMLYICIKL
210 220 230 240 250
MYLANVFVQF IILNKFLGNE TFLWGFHTFA DLYAGREWQD SGVFPRVTLC
260 270 280 290 300
DFSVRKLANV HRYTVQCVLM INMFNEKIYL FIWFWFVFVL ITTFINTLCT
310 320 330 340 350
IYRLSFDSSR HNYIRSLLSG PVNNFKDEKA MIASFANNGL KQDGVLLMRF
360 370 380 390 400
IDDHAGAMVT KEICEELFKK HGENLQHNRD FHHGHSTKST SPGLEEGHHE
410 420
HLYTPEKMKL MAPDYPIKHA
Length:420
Mass (Da):48,917
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B8B6E65924966B1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U59211 mRNA Translation: AAB09670.1
FO080452 Genomic DNA Translation: CCD63822.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T16141

NCBI Reference Sequences

More...
RefSeqi
NP_509002.2, NM_076601.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F22F4.2.1; F22F4.2.1; WBGene00002125

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
180866

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F22F4.2

UCSC genome browser

More...
UCSCi
F22F4.2 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59211 mRNA Translation: AAB09670.1
FO080452 Genomic DNA Translation: CCD63822.1
PIRiT16141
RefSeqiNP_509002.2, NM_076601.6

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ19746, 1 interactor
MINTiQ19746
STRINGi6239.F22F4.2

Protein family/group databases

TCDBi1.A.25.1.1 the gap junction-forming innexin (innexin) family

Proteomic databases

EPDiQ19746
PaxDbiQ19746
PeptideAtlasiQ19746
PRIDEiQ19746

Genome annotation databases

EnsemblMetazoaiF22F4.2.1; F22F4.2.1; WBGene00002125
GeneIDi180866
KEGGicel:CELE_F22F4.2
UCSCiF22F4.2 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
180866
WormBaseiF22F4.2 ; CE33055 ; WBGene00002125 ; inx-3

Phylogenomic databases

eggNOGiENOG410IGA4 Eukaryota
ENOG410XT2D LUCA
HOGENOMiCLU_035763_0_1_1
InParanoidiQ19746
KOiK22037
OMAiMANMFNE
OrthoDBi738314at2759
PhylomeDBiQ19746

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q19746

Gene expression databases

BgeeiWBGene00002125 Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR000990 Innexin
PANTHERiPTHR11893 PTHR11893, 1 hit
PfamiView protein in Pfam
PF00876 Innexin, 1 hit
PRINTSiPR01262 INNEXIN
PROSITEiView protein in PROSITE
PS51013 PANNEXIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINX3_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19746
Secondary accession number(s): Q17393
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: February 26, 2020
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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