UniProtKB - Q19746 (INX3_CAEEL)
Protein
Innexin-3
Gene
inx-3
Organism
Caenorhabditis elegans
Status
Functioni
Structural component of the gap junctions.1 Publication
GO - Molecular functioni
- gap junction channel activity Source: UniProtKB
- gap junction hemi-channel activity Source: UniProtKB
GO - Biological processi
- embryonic morphogenesis Source: WormBase
- ion transport Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel |
Biological process | Ion transport, Transport |
Protein family/group databases
TCDBi | 1.A.25.1.1, the gap junction-forming innexin (innexin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Innexin-3Alternative name(s): Protein opu-3 |
Gene namesi | Name:inx-3 Synonyms:opu-3 ORF Names:F22F4.2 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F22F4.2 ; CE33055 ; WBGene00002125 ; inx-3 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein PROSITE-ProRule annotation
Other locations
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: WormBase
- gap junction Source: WormBase
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 33 – 53 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 104 – 124 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 193 – 213 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 278 – 298 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Gap junction, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208506 | 1 – 420 | Innexin-3Add BLAST | 420 |
Proteomic databases
EPDi | Q19746 |
PaxDbi | Q19746 |
PeptideAtlasi | Q19746 |
Expressioni
Gene expression databases
Bgeei | WBGene00002125, Expressed in multi-cellular organism and 5 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | Q19746, 1 interactor |
MINTi | Q19746 |
STRINGi | 6239.F22F4.2 |
Family & Domainsi
Sequence similaritiesi
Belongs to the pannexin family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3883, Eukaryota |
HOGENOMi | CLU_035763_0_1_1 |
InParanoidi | Q19746 |
OMAi | MANMFNE |
OrthoDBi | 738314at2759 |
PhylomeDBi | Q19746 |
Family and domain databases
InterProi | View protein in InterPro IPR000990, Innexin |
PANTHERi | PTHR11893, PTHR11893, 1 hit |
Pfami | View protein in Pfam PF00876, Innexin, 1 hit |
PRINTSi | PR01262, INNEXIN |
PROSITEi | View protein in PROSITE PS51013, PANNEXIN, 1 hit |
i Sequence
Sequence statusi: Complete.
Q19746-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGVPFIDRW LSETFKPKTF DDAVDRLSYV TTATLLAFFS IMVSCKQYVG
60 70 80 90 100
SAIQCWMPME FKGGWEQYAE DYCFIQNTFF IPERSEIPGD VEDRQKAEIG
110 120 130 140 150
YYQWVPIVLA IQAFMFYLPS WIWSSLYKQC GLDFPSVISE AEALRSQDSE
160 170 180 190 200
TRTKGVNKLV DFIGDILDTR SKNEYGRFYC YRFGKGLGSM TSMLYICIKL
210 220 230 240 250
MYLANVFVQF IILNKFLGNE TFLWGFHTFA DLYAGREWQD SGVFPRVTLC
260 270 280 290 300
DFSVRKLANV HRYTVQCVLM INMFNEKIYL FIWFWFVFVL ITTFINTLCT
310 320 330 340 350
IYRLSFDSSR HNYIRSLLSG PVNNFKDEKA MIASFANNGL KQDGVLLMRF
360 370 380 390 400
IDDHAGAMVT KEICEELFKK HGENLQHNRD FHHGHSTKST SPGLEEGHHE
410 420
HLYTPEKMKL MAPDYPIKHA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U59211 mRNA Translation: AAB09670.1 FO080452 Genomic DNA Translation: CCD63822.1 |
PIRi | T16141 |
RefSeqi | NP_509002.2, NM_076601.6 |
Genome annotation databases
EnsemblMetazoai | F22F4.2.1; F22F4.2.1; WBGene00002125 |
GeneIDi | 180866 |
KEGGi | cel:CELE_F22F4.2 |
UCSCi | F22F4.2, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U59211 mRNA Translation: AAB09670.1 FO080452 Genomic DNA Translation: CCD63822.1 |
PIRi | T16141 |
RefSeqi | NP_509002.2, NM_076601.6 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q19746, 1 interactor |
MINTi | Q19746 |
STRINGi | 6239.F22F4.2 |
Protein family/group databases
TCDBi | 1.A.25.1.1, the gap junction-forming innexin (innexin) family |
Proteomic databases
EPDi | Q19746 |
PaxDbi | Q19746 |
PeptideAtlasi | Q19746 |
Genome annotation databases
EnsemblMetazoai | F22F4.2.1; F22F4.2.1; WBGene00002125 |
GeneIDi | 180866 |
KEGGi | cel:CELE_F22F4.2 |
UCSCi | F22F4.2, c. elegans |
Organism-specific databases
CTDi | 180866 |
WormBasei | F22F4.2 ; CE33055 ; WBGene00002125 ; inx-3 |
Phylogenomic databases
eggNOGi | KOG3883, Eukaryota |
HOGENOMi | CLU_035763_0_1_1 |
InParanoidi | Q19746 |
OMAi | MANMFNE |
OrthoDBi | 738314at2759 |
PhylomeDBi | Q19746 |
Miscellaneous databases
PROi | PR:Q19746 |
Gene expression databases
Bgeei | WBGene00002125, Expressed in multi-cellular organism and 5 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000990, Innexin |
PANTHERi | PTHR11893, PTHR11893, 1 hit |
Pfami | View protein in Pfam PF00876, Innexin, 1 hit |
PRINTSi | PR01262, INNEXIN |
PROSITEi | View protein in PROSITE PS51013, PANNEXIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | INX3_CAEEL | |
Accessioni | Q19746Primary (citable) accession number: Q19746 Secondary accession number(s): Q17393 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | December 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families