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Entry version 57 (12 Aug 2020)
Sequence version 1 (11 Jul 2006)
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Protein

Probable DNA-directed RNA polymerase II subunit RPB1 homolog

Gene

IIV3-090L

Organism
Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi57Zinc 1By similarity1
Metal bindingi60Zinc 1By similarity1
Metal bindingi67Zinc 1By similarity1
Metal bindingi70Zinc 1By similarity1
Metal bindingi97Zinc 2By similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi132Zinc 2By similarity1
Metal bindingi493Magnesium; catalyticBy similarity1
Metal bindingi495Magnesium; catalyticBy similarity1
Metal bindingi497Magnesium; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription
LigandMagnesium, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable DNA-directed RNA polymerase II subunit RPB1 homolog (EC:2.7.7.6)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:IIV3-090L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiInvertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri345201 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesVaridnaviriaBamfordviraeNucleocytoviricotaMegaviricetesPimascoviralesIridoviridaeBetairidovirinaeChloriridovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiAedes vexans (Inland floodwater mosquito) (Culex vexans) [TaxID: 7163]
Culex territans [TaxID: 42431]
Culiseta annulata [TaxID: 332058]
Ochlerotatus sollicitans (eastern saltmarsh mosquito) [TaxID: 310513]
Ochlerotatus taeniorhynchus (Black salt marsh mosquito) (Aedes taeniorhynchus) [TaxID: 329105]
Psorophora ferox [TaxID: 7183]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001358 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003774941 – 1377Probable DNA-directed RNA polymerase II subunit RPB1 homologAdd BLAST1377

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q196X0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.Curated

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K03006

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.132.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000722, RNA_pol_asu
IPR006592, RNA_pol_N
IPR007080, RNA_pol_Rpb1_1
IPR007066, RNA_pol_Rpb1_3
IPR007083, RNA_pol_Rpb1_4
IPR007081, RNA_pol_Rpb1_5
IPR038120, Rpb1_funnel_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04997, RNA_pol_Rpb1_1, 1 hit
PF00623, RNA_pol_Rpb1_2, 2 hits
PF04983, RNA_pol_Rpb1_3, 1 hit
PF05000, RNA_pol_Rpb1_4, 1 hit
PF04998, RNA_pol_Rpb1_5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00663, RPOLA_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q196X0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTFQPEIADI AKISFGVLSP EEILKMSCCK VTSVKVSDKG ENIYSKFMGT
60 70 80 90 100
IENGENCKTC DRDVWECPGH FGHFHLEVPV VNPIFINDAC NILRCICFNC
110 120 130 140 150
YKFIVSVDHL KLENLVRRFQ DILLYVKNIK HCYNCESEKL PLSVVNEIIV
160 170 180 190 200
DEDKNPLDTR KLLRVLENVD DETVRFLGFN PTMSHPKNFI FTVFPILPPC
210 220 230 240 250
CRPYVMSEEN CCDDDLTYQL IEIIKNNQYL GDEFLKKAEL KRKKSLLQSS
260 270 280 290 300
LPPTTDIKQK HLTNLWFRIS TYFNNSKKKA KHAATAKPIT GLKERIAGKE
310 320 330 340 350
GQIRHNLLGK RCDQSGRTVV GPDPTLRLNE LCVPKEMAEI LTIPVHVTPF
360 370 380 390 400
NRDALTQLVN SNKANFLIKA ANPKRSINLK NVINYRGTLL YFGDIIERDG
410 420 430 440 450
TRITITDTKF VLQPGDTIIR NGKALKEIRY PERKQIELEV GDVIKRQLMD
460 470 480 490 500
GDYVLLNRQP TLHKASMMAF KVVIKPVKTL KINLAITKPF NCDFDGDEMN
510 520 530 540 550
IHVPQSYEAI AELKELSCAS KCIMSVQNGK PNVAIVQDSL IGLWFLSRDQ
560 570 580 590 600
WFCQTLKRSQ FFNLLLTIDK AQNFLTRMDQ ICHVLKSKFP SKGNWEGSGL
610 620 630 640 650
DGDGRVSPKV GRMVFNGRGL LSFLFPYDFD YCGGDGLSIE SGVFLEGTLE
660 670 680 690 700
KNVVNTLIKY IYKDYGETVV ADFVDNIQFL TNHYLVDRGF TINASDCLKN
710 720 730 740 750
ESIAPEIVSL TRATFSKATT VRDVTINPFI QEQKTLAILN SCTDQCMKLS
760 770 780 790 800
KECLSSDNNF CVTTESGSKG SIFNICQITS LLGQQTIDGK RVYGLLHPQD
810 820 830 840 850
NEFQDRGFIA NSFVEGLSPR EFLHHAMAGR KGVIDTALLT SVSGYGQRQG
860 870 880 890 900
VKLNEDIKIY PDYTVRDVNG RLYQYIFGEA GYDPSQTIVV DGHQTICNVY
910 920 930 940 950
RLVNRLNRSY DSSALRPLTE DEIEWMVDFI QPRREYEYIP PDVEQRICSI
960 970 980 990 1000
RRDPIVGQLR RIQTVDALVP ILKSHLEKCF YQTLMSPGEC VGIIGAQSMG
1010 1020 1030 1040 1050
EFSTQATLNT FHVAGSTTTG AVTNCLTRFQ EINNATKNPK NITCKVYFTK
1060 1070 1080 1090 1100
GNGTIEEIRR RGKDVKHIVF RDVVEKWTVE PATAEWWYAT FKQLYAAPIA
1110 1120 1130 1140 1150
ESGTVTKRVR FHLKRDIVFA YRISPQEIKQ SLESKFDVSC IFSPFDEGLI
1160 1170 1180 1190 1200
LDVFGKIEPH KLEAFVALML PTYISGLEGI KAISYHKCDE LKIWYIQTSG
1210 1220 1230 1240 1250
GTLSDFYTLD DIDVEHTTTN NIWDIYHTLG IEAAREFRIK ELVEIIGTGV
1260 1270 1280 1290 1300
DLSHIKLRAD RLTFTGTIQS LTRYTMRGEK PFSKVGFEEI MENFYKTARD
1310 1320 1330 1340 1350
AEVDDLTGVS ASIMCGKRAK VGTSMFDIKL NLDAILCPPS TSPLLTTEDG
1360 1370
TTSATTPIAA TTPEQEDDEA FVDYDYT
Length:1,377
Mass (Da):155,906
Last modified:July 11, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D48D10DAA84FF8B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ643392 Genomic DNA Translation: ABF82120.1

NCBI Reference Sequences

More...
RefSeqi
YP_654662.1, NC_008187.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4156234

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:4156234

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ643392 Genomic DNA Translation: ABF82120.1
RefSeqiYP_654662.1, NC_008187.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ196X0

Genome annotation databases

GeneIDi4156234
KEGGivg:4156234

Phylogenomic databases

KOiK03006

Family and domain databases

Gene3Di1.10.132.30, 1 hit
InterProiView protein in InterPro
IPR000722, RNA_pol_asu
IPR006592, RNA_pol_N
IPR007080, RNA_pol_Rpb1_1
IPR007066, RNA_pol_Rpb1_3
IPR007083, RNA_pol_Rpb1_4
IPR007081, RNA_pol_Rpb1_5
IPR038120, Rpb1_funnel_sf
PfamiView protein in Pfam
PF04997, RNA_pol_Rpb1_1, 1 hit
PF00623, RNA_pol_Rpb1_2, 2 hits
PF04983, RNA_pol_Rpb1_3, 1 hit
PF05000, RNA_pol_Rpb1_4, 1 hit
PF04998, RNA_pol_Rpb1_5, 1 hit
SMARTiView protein in SMART
SM00663, RPOLA_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPB1_IIV3
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q196X0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: July 11, 2006
Last modified: August 12, 2020
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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