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Entry version 149 (29 Sep 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Glutamine--fructose-6-phosphate transaminase (isomerizing)

Gene

gfat-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-446210, Synthesis of UDP-N-acetyl-glucosamine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate transaminase (isomerizing)ARBA annotation (EC:2.6.1.16ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gfat-2Imported
ORF Names:CELE_F22B3.4Imported, F22B3.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
F22B3.4 ; CE03255 ; WBGene00009035 ; gfat-2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q19699

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q19699

PeptideAtlas

More...
PeptideAtlasi
Q19699

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00009035, Expressed in germ line (C elegans) and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q19699, 1 interactor

STRING: functional protein association networks

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STRINGi
6239.F22B3.4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q19699

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 315Glutamine amidotransferase type-2InterPro annotationAdd BLAST314
Domaini387 – 526SISInterPro annotationAdd BLAST140
Domaini558 – 700SISInterPro annotationAdd BLAST143

Keywords - Domaini

Glutamine amidotransferaseARBA annotation, RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1268, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000173234

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012520_5_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q19699

Identification of Orthologs from Complete Genome Data

More...
OMAi
TSYYSGC

Database of Orthologous Groups

More...
OrthoDBi
262871at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q19699

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05008, SIS_GlmS_GlmD_1, 1 hit
cd05009, SIS_GlmS_GlmD_2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017932, GATase_2_dom
IPR035466, GlmS/AgaS_SIS
IPR035490, GlmS/FrlB_SIS
IPR029055, Ntn_hydrolases_N
IPR001347, SIS_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01380, SIS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56235, SSF56235, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51278, GATASE_TYPE_2, 1 hit
PS51464, SIS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q19699-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGIFAYLNF LAPKKRSEIV DILVQGLQRM EYRGYDSAGI AIDGSNDIEN
60 70 80 90 100
PHSKIALLRK RGKVSVLNDY IKENNEKLNM DMEYNIHCGI AHTRWATHGS
110 120 130 140 150
PRDVNSHPHR SNDNNEFLVV HNGIITNYRE IKEYLEKKGH KFESETDTEV
160 170 180 190 200
IAKLTQHVHD RYPDFSFRQL VETVIQQLEG AFALAFKSSR FPGQLVASRR
210 220 230 240 250
GSPLLVGIKS NSTLHTSHFP VSYSKGRCFM SNNATHLREE TSFVETPNNI
260 270 280 290 300
LDLSIAVRNP SGSAKLPDNN STTRPFDSTD FEVEYFIASD AAAIIEHTKQ
310 320 330 340 350
VLFLEDDDVA FVEDGSLTIH RISRHADSGE QKREVQLLEL EIQEIMKGSY
360 370 380 390 400
KTFMQKEIFE QPESVVNTMR GRVLPSGQVV LGGLKEYLPA IKRCRRLIMV
410 420 430 440 450
ACGTSYHSAI ACRQVLEELS ELPVVVELAS DFLDRETPIF RNDVCLFISQ
460 470 480 490 500
SGETADTLMA LRYCKPRGAL TIGVTNTVGS SIGRESHCGI HINAGPEIGV
510 520 530 540 550
ASTKAYTSQI VSLLLFALTI SEDRISKMKR RAEIIDALNN LPILIRDVLD
560 570 580 590 600
LDDQVLKIAE QIYKDKSLLI MGRGLNFATC LEGALKIKEL SYMHCEGIMS
610 620 630 640 650
GELKHGPLAM VDEFLSICMV VCNDHVYKKS LNALQQVVAR KGAPIIIADS
660 670 680 690 700
SVPESDLAGM KHVLRVPRTV DCVQNILTVI PLQLLSYHIA ELNGANVDRP
710
RNLAKSVTVE
Length:710
Mass (Da):79,296
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6BC1E5F181717608
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA92735.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T21230

NCBI Reference Sequences

More...
RefSeqi
NP_502156.1, NM_069755.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F22B3.4.1; F22B3.4.1; WBGene00009035
F22B3.4.2; F22B3.4.2; WBGene00009035

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
178067

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F22B3.4

UCSC genome browser

More...
UCSCi
F22B3.4, c. elegans

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA92735.1
PIRiT21230
RefSeqiNP_502156.1, NM_069755.5

3D structure databases

SMRiQ19699
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ19699, 1 interactor
STRINGi6239.F22B3.4

Proteomic databases

EPDiQ19699
PaxDbiQ19699
PeptideAtlasiQ19699

Genome annotation databases

EnsemblMetazoaiF22B3.4.1; F22B3.4.1; WBGene00009035
F22B3.4.2; F22B3.4.2; WBGene00009035
GeneIDi178067
KEGGicel:CELE_F22B3.4
UCSCiF22B3.4, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178067
WormBaseiF22B3.4 ; CE03255 ; WBGene00009035 ; gfat-2

Phylogenomic databases

eggNOGiKOG1268, Eukaryota
GeneTreeiENSGT00940000173234
HOGENOMiCLU_012520_5_2_1
InParanoidiQ19699
OMAiTSYYSGC
OrthoDBi262871at2759
PhylomeDBiQ19699

Enzyme and pathway databases

ReactomeiR-CEL-446210, Synthesis of UDP-N-acetyl-glucosamine

Gene expression databases

BgeeiWBGene00009035, Expressed in germ line (C elegans) and 5 other tissues

Family and domain databases

CDDicd05008, SIS_GlmS_GlmD_1, 1 hit
cd05009, SIS_GlmS_GlmD_2, 1 hit
InterProiView protein in InterPro
IPR017932, GATase_2_dom
IPR035466, GlmS/AgaS_SIS
IPR035490, GlmS/FrlB_SIS
IPR029055, Ntn_hydrolases_N
IPR001347, SIS_dom
PfamiView protein in Pfam
PF01380, SIS, 2 hits
SUPFAMiSSF56235, SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS51278, GATASE_TYPE_2, 1 hit
PS51464, SIS, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ19699_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19699
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 29, 2021
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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