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Protein

Phosphoacetylglucosamine mutase

Gene

CELE_F21D5.1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.UniRule annotation

Catalytic activityi

N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: UDP-N-acetyl-alpha-D-glucosamine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glucosamine 6-phosphate N-acetyltransferase (gna-1)
  2. Phosphoacetylglucosamine mutase (CELE_F21D5.1)
This subpathway is part of the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I), the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Phosphoserine intermediateUniRule annotation1
Metal bindingi73Magnesium; via phosphate groupUniRule annotation1
Metal bindingi286MagnesiumUniRule annotation1
Metal bindingi288MagnesiumUniRule annotation1
Metal bindingi290MagnesiumUniRule annotation1
Binding sitei521SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-446210 Synthesis of UDP-N-acetyl-glucosamine
UniPathwayiUPA00113; UER00530

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoacetylglucosamine mutaseUniRule annotation (EC:5.4.2.3UniRule annotation)
Short name:
PAGMUniRule annotation
Alternative name(s):
Acetylglucosamine phosphomutaseUniRule annotation
N-acetylglucosamine-phosphate mutaseUniRule annotation
Gene namesi
ORF Names:CELE_F21D5.1Imported, F21D5.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF21D5.1 ; CE03244 ; WBGene00009006

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

EPDiQ19680
PaxDbiQ19680
PeptideAtlasiQ19680

Expressioni

Gene expression databases

BgeeiWBGene00009006

Interactioni

Protein-protein interaction databases

STRINGi6239.F21D5.1.1

Structurei

3D structure databases

ProteinModelPortaliQ19680
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 96PGM_PMM_IInterPro annotationAdd BLAST42
Domaini120 – 179PGM_PMM_IInterPro annotationAdd BLAST60
Domaini312 – 397PGM_PMM_IIIInterPro annotationAdd BLAST86
Domaini493 – 534PGM_PMM_IVInterPro annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni390 – 392Substrate bindingUniRule annotation3
Regioni512 – 516Substrate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the phosphohexose mutase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2537 Eukaryota
COG1109 LUCA
GeneTreeiENSGT00390000000509
HOGENOMiHOG000210027
InParanoidiQ19680
KOiK01836
OMAiLHYMVCC
OrthoDBiEOG091G065D
PhylomeDBiQ19680

Family and domain databases

CDDicd03086 PGM3, 1 hit
InterProiView protein in InterPro
IPR005844 A-D-PHexomutase_a/b/a-I
IPR016055 A-D-PHexomutase_a/b/a-I/II/III
IPR005846 A-D-PHexomutase_a/b/a-III
IPR005843 A-D-PHexomutase_C
IPR036900 A-D-PHexomutase_C_sf
IPR016066 A-D-PHexomutase_CS
IPR016657 PAGM
PfamiView protein in Pfam
PF02878 PGM_PMM_I, 2 hits
PF02880 PGM_PMM_III, 1 hit
PF00408 PGM_PMM_IV, 1 hit
PIRSFiPIRSF016408 PAGM, 1 hit
SUPFAMiSSF53738 SSF53738, 3 hits
SSF55957 SSF55957, 1 hit
PROSITEiView protein in PROSITE
PS00710 PGM_PMM, 1 hit

Sequencei

Sequence statusi: Complete.

Q19680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLTVPVEYS RAGNTTHSGN VHAIQDDEKF SYGTAGFRFK SEKLPFIVFR
60 70 80 90 100
CAYVASLRAR QLNSAIGVMI TASHNPSCDN GVKLVDPSGD MLNEQWEIYA
110 120 130 140 150
TEVVNATDAE LPAAVRALEK QISVGKTQLS RVVCGMDTRC SGPCLMNAAR
160 170 180 190 200
AGAALFNVQF DDIGVVSTPM LHYAVKAFNE PKFAEPTHDG YYSAIADSFK
210 220 230 240 250
KLYEITEEPK DSRYQPKVIV DCANGVGAPR FRNLLERIPS SLLEVEFRNE
260 270 280 290 300
SEELNQGCGA DFVKISQKLP ANFSPTAAEP KCASFDGDAD RLMYFRAKAS
310 320 330 340 350
ENSESNDAEL FDGDKIAVLI VTYIREQLKD YENSTPMERL RLGIVQTAYA
360 370 380 390 400
NGSSTRYIRE KLGIEPIIVP TGVKHLHEAA SEFDIGIYFE ANGHGTVVFS
410 420 430 440 450
EIFDRIIRRT PTESLPLRRL ALFSRVINET VGDAFADLLA VEAVLRHYGW
460 470 480 490 500
SMDDWAEKLY RDVPNVQIKV PVIDRSIFKT TNAEQTLVKP VGIQKMIDTD
510 520 530 540 550
VAKYNNSRAF IRPSGTENIV RVYAEADTVE NTLQLGKSLE QVVLNLCNSN
Length:550
Mass (Da):61,078
Last modified:November 1, 1996 - v1
Checksum:iB22219FBF5070BCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA91032.1
PIRiT21194
RefSeqiNP_501500.1, NM_069099.5
UniGeneiCel.17541

Genome annotation databases

EnsemblMetazoaiF21D5.1; F21D5.1; WBGene00009006
GeneIDi177678
KEGGicel:CELE_F21D5.1
UCSCiF21D5.1.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiQ19680_CAEEL
AccessioniPrimary (citable) accession number: Q19680
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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