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Entry version 136 (08 May 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Cohesin subunit scc-3

Gene

scc-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication (PubMed:14499625, PubMed:12808038, PubMed:14560015, PubMed:12827206). The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the scc-1 subunit of the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). Has a role in stabilization of homologous chromosome associations during meiotic synapsis (PubMed:12827206). Involved in early meitoic double-stranded break (DSB) processing, and recruitment of the 9-1-1 cell cycle checkpoint complex to damage sites (PubMed:21856158).By similarity5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: WormBase
  • chromatin binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-2468052 Establishment of Sister Chromatid Cohesion
R-CEL-2470946 Cohesin Loading onto Chromatin
R-CEL-2500257 Resolution of Sister Chromatid Cohesion
R-CEL-3108214 SUMOylation of DNA damage response and repair proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cohesin subunit scc-3By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:scc-3Imported
ORF Names:F18E2.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
F18E2.3 ; CE05664 ; WBGene00004738 ; scc-3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knock-down is embryonic lethal (PubMed:14560015, PubMed:12827206). RNAi-mediated knock-down from early in larval development results in a sterile uncoordinated phenotype and adults go on to display a protruding vulva, which is characteristic of defective cell division, and defects in embryonic cells and in mitotic and meiotic gonadal cells (PubMed:14499625, PubMed:14560015). Worms have abnormal and small uteri and an endomitotic oocyte phenotype (PubMed:14560015). There is aberrant chromosome segregation in mitosis and defective homologous alignment of chromosomes and chromosome cohesion in meiosis (PubMed:14499625, PubMed:12808038, PubMed:14560015).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004328451 – 1096Cohesin subunit scc-3CuratedAdd BLAST1096

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q19555

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q19555

PeptideAtlas

More...
PeptideAtlasi
Q19555

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in gonadal cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004738 Expressed in 5 organ(s), highest expression level in germ line (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the cohesin complex, composed of the smc-1 and smc-3 heterodimer attached via their hinge domain, scc-1 which links them, and scc-3 (PubMed:12827206).

Interacts with scc-1, smc-1 and tim-1 (PubMed:12827206).

1 Publication

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-967 Nuclear mitotic cohesin complex

Database of interacting proteins

More...
DIPi
DIP-26563N

Protein interaction database and analysis system

More...
IntActi
Q19555, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F18E2.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q19555

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini320 – 405SCDPROSITE-ProRule annotationAdd BLAST86

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili261 – 312Sequence analysisAdd BLAST52

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SCC3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2011 Eukaryota
COG5537 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182972

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000018649

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q19555

KEGG Orthology (KO)

More...
KOi
K06671

Identification of Orthologs from Complete Genome Data

More...
OMAi
ICDLLII

Database of Orthologous Groups

More...
OrthoDBi
167826at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q19555

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR039662 Cohesin_Scc3/SA
IPR020839 SCD
IPR013721 STAG

The PANTHER Classification System

More...
PANTHERi
PTHR11199 PTHR11199, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08514 STAG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51425 SCD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q19555-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSETPTDQSP QRMSTRNQAR VNYTDMAAGN NSVEKEPVFR SPTASTRGRK
60 70 80 90 100
KRAANVDVAD LSASFGNLNN FSTPPKRGRP RGGGLGSARG GRAPMVRRTT
110 120 130 140 150
TEESAEVDDR ELVAAVKSGK KITEAVDRWI GRYNEKFLVA IAEMHQFFFA
160 170 180 190 200
ICGCKGIVTP QMSATLTYKD IICRMTEDFE EDSADYPLVH GGSLKKVRAN
210 220 230 240 250
LHNFIHTLII RTKASMLFDS NLMDGFVQLL TGMADSQVRA FRHTATFCAM
260 270 280 290 300
KITSALVDVT IELTQSKEKT SKQIEAEKAK LKNNSAGNEK YEALVAQRTQ
310 320 330 340 350
TEERAEEIRQ IIGYLFRSVF VHRYRDVVPD IRCICIQELG HWMDVYPEHF
360 370 380 390 400
VEDSYLKYIG WSMFDKVGDV RQRCIRALIP LFEKTLILDK LELFVNKFKD
410 420 430 440 450
RLVSMLLDKD LETSIETVHL MRVLYTVFPT LLTIKDVVPI YELIYASNRP
460 470 480 490 500
LAVAAGMFLN TKVFRSAEKP GKAPTAANIP LVKDLTTFFI EGDLHQHATY
510 520 530 540 550
LVDALFESNP IVKDWATMGE LLINDQYQLD SNFETKLIEI LTCSVVQSAT
560 570 580 590 600
GEPPVGRHIV KKGAPSAKES RDLVEDRQRL TETLIPLIPR LITKFSSDNE
610 620 630 640 650
KIINLVNIPL HFQLETYLSA RMQTHLMELM EGLDSLIEKH LDEELLKAVA
660 670 680 690 700
ELYYHLTTNS SISALVEGHK MKLLDGVAAF IRKSMQQFDD DQMGEEEEAL
710 720 730 740 750
FVSYIKRMAA FAGFMDLRHW DLWDILLKVV SNYTREDTQR DVRERSMQML
760 770 780 790 800
FMQLCFDSMN IKKEGETPKA DQVRKLKKRR DQLIRIVTET LNEEACGVEQ
810 820 830 840 850
AYLVICDLMI LFGSQLAEES KALEPLIWRP DAMVLGNLKI FLDVNVFDVS
860 870 880 890 900
NLDDMDQQEK IEVMHKMRQH VAQYAKLIIH GAMPVAEASH LIKRYQSHFQ
910 920 930 940 950
DFGDIFKNLL SKCREISFVE TGVMICETLK TLYSQLDEDQ GTDPLSESFN
960 970 980 990 1000
SIRDLAKRLG PAFGVDYAKN RFAISSLHKK AIDFAFEEYD KENHQMPKNI
1010 1020 1030 1040 1050
FFLEIAIEFS GKLLAQDKMA VVRYLNKIYT NRVGTSTVVW EPYRLYLGSL
1060 1070 1080 1090
SDRNDDDNMS VRSGMTVTSN ATMRSTASST RGRGRGRGRS RIADDF
Length:1,096
Mass (Da):124,775
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC12008760DECD4A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z75537 Genomic DNA Translation: CAA99836.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T21091

NCBI Reference Sequences

More...
RefSeqi
NP_506193.1, NM_073792.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F18E2.3; F18E2.3; WBGene00004738

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
179749

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F18E2.3

UCSC genome browser

More...
UCSCi
F18E2.3 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75537 Genomic DNA Translation: CAA99836.1
PIRiT21091
RefSeqiNP_506193.1, NM_073792.3

3D structure databases

SMRiQ19555
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-967 Nuclear mitotic cohesin complex
DIPiDIP-26563N
IntActiQ19555, 2 interactors
STRINGi6239.F18E2.3

Proteomic databases

EPDiQ19555
PaxDbiQ19555
PeptideAtlasiQ19555

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF18E2.3; F18E2.3; WBGene00004738
GeneIDi179749
KEGGicel:CELE_F18E2.3
UCSCiF18E2.3 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
179749
WormBaseiF18E2.3 ; CE05664 ; WBGene00004738 ; scc-3

Phylogenomic databases

eggNOGiKOG2011 Eukaryota
COG5537 LUCA
GeneTreeiENSGT00950000182972
HOGENOMiHOG000018649
InParanoidiQ19555
KOiK06671
OMAiICDLLII
OrthoDBi167826at2759
PhylomeDBiQ19555

Enzyme and pathway databases

ReactomeiR-CEL-2468052 Establishment of Sister Chromatid Cohesion
R-CEL-2470946 Cohesin Loading onto Chromatin
R-CEL-2500257 Resolution of Sister Chromatid Cohesion
R-CEL-3108214 SUMOylation of DNA damage response and repair proteins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q19555

Gene expression databases

BgeeiWBGene00004738 Expressed in 5 organ(s), highest expression level in germ line (C elegans)

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR039662 Cohesin_Scc3/SA
IPR020839 SCD
IPR013721 STAG
PANTHERiPTHR11199 PTHR11199, 1 hit
PfamiView protein in Pfam
PF08514 STAG, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51425 SCD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCC3_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19555
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2015
Last sequence update: November 1, 1996
Last modified: May 8, 2019
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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