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Entry version 155 (12 Aug 2020)
Sequence version 2 (01 Mar 2003)
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Protein

Cytoplasmic dynein 2 heavy chain 1

Gene

che-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a motor for intraflagellar retrograde transport in chemosensory neurons (PubMed:10545497, PubMed:28479320). Functions in cilia biogenesis (PubMed:10545497, PubMed:27515926).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi115 – 122ATPSequence analysis8
Nucleotide bindingi1637 – 1644ATPSequence analysis8
Nucleotide bindingi1921 – 1928ATPSequence analysis8
Nucleotide bindingi2226 – 2233ATPSequence analysis8
Nucleotide bindingi2565 – 2572ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Motor protein
Biological processCilium biogenesis/degradation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-5620924, Intraflagellar transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoplasmic dynein 2 heavy chain 1
Alternative name(s):
Abnormal chemotaxis protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:che-3Imported
ORF Names:F18C12.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
F18C12.1 ; CE32386 ; WBGene00000485 ; che-3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Shorter phasmid cilia with an irregular morphology.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi295R → C: Shorter cilium, and severely reduced speed and reduced frequency of intraflagellar retrograde transport of mutant protein. 1 Publication1
Mutagenesisi1384R → C: Reduced frequency of intraflagellar retrograde transport of mutant protein. 1 Publication1
Mutagenesisi1693R → C: Shorter cilium, and reduced speed and frequency of intraflagellar retrograde transport of mutant protein. 1 Publication1
Mutagenesisi2935K → Q: Reduced binding to microtubules. Severely truncated cilium. Accumulates in truncated cilium and does not undergo intraflagellar retrograde transport. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003187481 – 4171Cytoplasmic dynein 2 heavy chain 1Add BLAST4171

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q19542

PeptideAtlas

More...
PeptideAtlasi
Q19542

PRoteomics IDEntifications database

More...
PRIDEi
Q19542

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000485, Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The cytoplasmic dynein complex 2 is probably composed by a heavy chain che-3 homodimer and a number of light intermediate chains.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
38027, 5 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F18C12.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q19542

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1598StemBy similarityAdd BLAST1598
Regioni1599 – 1823AAA 1By similarityAdd BLAST225
Regioni1883 – 2100AAA 2By similarityAdd BLAST218
Regioni2184 – 2432AAA 3By similarityAdd BLAST249
Regioni2527 – 2767AAA 4By similarityAdd BLAST241
Regioni2776 – 3064StalkBy similarityAdd BLAST289
Regioni3140 – 3367AAA 5By similarityAdd BLAST228
Regioni3575 – 3784AAA 6By similarityAdd BLAST210

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili164 – 203Sequence analysisAdd BLAST40
Coiled coili629 – 693Sequence analysisAdd BLAST65
Coiled coili829 – 861Sequence analysisAdd BLAST33
Coiled coili927 – 1048Sequence analysisAdd BLAST122
Coiled coili1354 – 1383Sequence analysisAdd BLAST30
Coiled coili2790 – 2877Sequence analysisAdd BLAST88
Coiled coili2999 – 3059Sequence analysisAdd BLAST61
Coiled coili3308 – 3336Sequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154620

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000038_7_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q19542

KEGG Orthology (KO)

More...
KOi
K10414

Identification of Orthologs from Complete Genome Data

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OMAi
TSWIICD

Database of Orthologous Groups

More...
OrthoDBi
26380at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q19542

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR026983, DHC_fam
IPR026815, DYNC2H1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013594, Dynein_heavy_dom-1
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR10676, PTHR10676, 1 hit
PTHR10676:SF352, PTHR10676:SF352, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q19542-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSDSKDQRK TYFLRVASYL LGLNIVEEKL KSTEPLEIFL DSNTNLLVFS
60 70 80 90 100
RSEQKLELSN KMKSSAPSAN VFRVVFYKTQ SVPLNNDNFK SVVNVISANG
110 120 130 140 150
TLNHVFLKSV QNVFGKELTE GNNMQLIAAV NELEESLLAT VEMSGGGSLH
160 170 180 190 200
DEIRSWKGQT GKPANDYNEA FKQLQLLVET MEERSIDELS ELVECFEDTC
210 220 230 240 250
DELWNCGTPY PQNRMKMLIE YGASYLCETI TFKIDDSAIW RNDKVADQLR
260 270 280 290 300
SAIDVCDQML IIVRLLTAQT WKRNVEHTWE GDAMEMKFLN GFKDRLDEIL
310 320 330 340 350
SLKSLGGQLE ELLEERGVRE ETEKTIETAM RGMAPLAYNP FTEPNWKSRL
360 370 380 390 400
LVSERSIEGT IDRTLPILKQ RLAPANGDSQ SIVLSLEKLK SFLCRSNIKE
410 420 430 440 450
KLQHEREMFL NRLVSMLSQK NQEFNEKSLQ VDAKNFQFLT EVAARIVWIR
460 470 480 490 500
QQTSQMESIR SLSKMMLNNI SNYSAFASKL DEFIEKLQYA EKECFDDWCR
510 520 530 540 550
ETVGLIDNKN ETINLETTGK IMYLEASNRE LNVNYSDRLL RLLKEVRQLI
560 570 580 590 600
SLGFNIPSKI MSCANNGEKY YRFGVILKQI AHFYNTIDQQ MIPSQQSLML
610 620 630 640 650
EEAIAFEKLV IPRKDASNSA SKVTWNDPKQ LEEFIVQLQS AEQKLSNRNR
660 670 680 690 700
RLRNVHMELI EMVEKLMDLN IVKQNNEWKE IILKIRSKMK EEEIVHGAVK
710 720 730 740 750
NNMKPWLIHW DFQLYKALLI QYEWGIESIQ SQLSTISVSL VFADQKIQLR
760 770 780 790 800
PTIEEIRSKY YKELCRFLRI PDKFRGVQED ENSTKFYAQM IERSMHLLPT
810 820 830 840 850
VYEKAEQLMM KVETCDAIFV DWLVISQVDL EELIEENLKT AADWESQFKI
860 870 880 890 900
LKGKAREAER LPHELKFECI LVSTAGVKSA IEDAIQRLYD ALSWTLRHSI
910 920 930 940 950
STTSQSISTF LSQAIEVLNT VPQSIDEIAE ANAKHVIFAE NNRRLKEEWK
960 970 980 990 1000
VMEEQLTLLR SVAGTGMEQI DNLEQTWDRF ELMLDGHQSM IKDQVEVLKS
1010 1020 1030 1040 1050
NVETSVKGMK DEAEKLKARW EQFKPRNDAL QGDREEMLKA IQFIKEKRVQ
1060 1070 1080 1090 1100
WQQLSDGREK IEKECGQFGL EPPKMDIIDE IDEDIKQFED NWLIYEMFNN
1110 1120 1130 1140 1150
ELDTMSQEEW IVFRSKTYLF DEFLQKWMEK LKGTGSQTHM SVRLMKDVEH
1160 1170 1180 1190 1200
FKEVSSALKF CRGDVLSADH WHEMFRFLGL PRGTTIEKLK FADLLSVSKN
1210 1220 1230 1240 1250
IIENTDQLKQ LNSRAQGEVA IRDAIQELTL WAAQTEFTLA DYKHSNGQNL
1260 1270 1280 1290 1300
KIIKEWKESI NSLKDSQALL QSLKSSPYYS QFTDKTAVWE TRLADLDVFL
1310 1320 1330 1340 1350
AQMNEIQRKW IYLEPIFGRG ALPSEASRFS RVDSEYRAIL NDVSKDARLV
1360 1370 1380 1390 1400
SLCSRQSLKK SLEQIVDQLN RCQKALNQFL EQKRTAFPRF YFIGDDDLLE
1410 1420 1430 1440 1450
ILGQSTNPQV IQTHMKKLFQ GINRVQFSST GETIISMVSS EGETVPLSKA
1460 1470 1480 1490 1500
VRIVPQVESW LQELSDEMRR TLKDLTAQAV ADAQPSLAKY PSQVLCLAEE
1510 1520 1530 1540 1550
VKFSASIENN LNGSSDLNSF KSQLLEKLKA YTNMKVDDKV SDLKLKSLIL
1560 1570 1580 1590 1600
DLIHHIDVVD QLLTNQAKSI NSWTWQRQLR FYLVNGGIVL RQVSSEFEYT
1610 1620 1630 1640 1650
YEYQGNYAKL VHTPLTDKCY LTLTQAMYMG LGGNPYGPAG TGKTESVKAL
1660 1670 1680 1690 1700
AALMGRQVLV FNCDEGIDVT SMGRIFTGIV ECGAWGCFDE FNRLDSTVLS
1710 1720 1730 1740 1750
AVSMQIQTIQ GAIKSRAGSC TFGGKNVQVN PNSAIFVTLN PAGKGYGGRQ
1760 1770 1780 1790 1800
KMPDNLKQLF RAVVMGKPDN ELISSTILYS EGFVDATALA RKIVSVFQLS
1810 1820 1830 1840 1850
RQMLSKQQHY DWGLRALKVV LGGCGALRRT QTNKNETDLV VQALLLNTLS
1860 1870 1880 1890 1900
KLTFSDSERF NSLIDDIFSN VTKEMTKFEE LVEPLGVAAQ EMGIKLGDKQ
1910 1920 1930 1940 1950
MEKVFQLYEQ MRQRIGVVVV GAAGSGKSTI WKILQRSLIL TKKPLKVTQF
1960 1970 1980 1990 2000
NPKAVNRSKL LGNMDMDTRE WSDGIITMAA REVTKDTSVH HWIVCDGDID
2010 2020 2030 2040 2050
PEWVEALNSV LDDNRLLTMP SGERIQFGSN VNFLFETDSL QFASPATVSR
2060 2070 2080 2090 2100
MGMIYISEED VTPKDIVASW LVKTTEDLHA DMPSWIEEHF WRCLKWVRSH
2110 2120 2130 2140 2150
KISGITSFAI LKNGLTHLKA SKTKTQFLVL LFNGFLPTVT PENRQEFAKG
2160 2170 2180 2190 2200
VVFQGMSVPD PKNICYDERI DGIMSYTDDV SQNVTKEEVE REDLRPFVQT
2210 2220 2230 2240 2250
ADTQRYSDII GSWLQSGNRE SFLITGTTGC GKQQLLKHCF QNDPESQLAS
2260 2270 2280 2290 2300
LYCSAQSSSS HLLQLIQQNC VQASNPTGRV WRPKDRPNMI LFLKGINLPA
2310 2320 2330 2340 2350
PDKYGTNELL ALLQQLLTYQ GFFDHNLEWV SIENIQFVGS MNPIGDGAAV
2360 2370 2380 2390 2400
SISNRLFSLL RCVSLNTTDS SQLTSIYRTY LTPILEEVGE RNSEIIANRM
2410 2420 2430 2440 2450
VDIYNKVQSN FRPTDSVVFL FSPRDLTNWV VSLLRHELDQ GKLEAVICFE
2460 2470 2480 2490 2500
ARRIFADRLP TENDKLKFEE ILRNVIPISQ ANETVIFKEK VYVTTGTVVP
2510 2520 2530 2540 2550
GESNTGLPLT PINMSDFNQL LAKSINRFAF EIANFNCPLT SQLAFFCACI
2560 2570 2580 2590 2600
DRVLTGPGGH LFLPGRPGFG RRDSVRLVAH MHNIQVFSPP VTANFSAKQF
2610 2620 2630 2640 2650
DNELKNAITQ AVTNNEHVVL ILEDHQLRKN IFLQAINSLL ASGNVPGLFT
2660 2670 2680 2690 2700
QQELDGLVAL VSEAANQASF TGALQQFLAH RIRSLVHVVL ILEVEANDFK
2710 2720 2730 2740 2750
INITENPAIL KHCNVIFADR FDRNSLVEIP KIQMESQGIT TTDAILTGFN
2760 2770 2780 2790 2800
DVLVNLPEHL SIQPIKYRQF VENFFQLLGY KRLTLSVRLE RLKGGVSKLN
2810 2820 2830 2840 2850
EARDEVAKMQ KKAGKKSKLL AEKQAEADEA LKAITESMSG AEDQKLSMEQ
2860 2870 2880 2890 2900
LKAATEKENV RIEEQKAKID EQLKEVQPLI DEARRAVGSI KSESLSEIRS
2910 2920 2930 2940 2950
LRAPPEAVRD ILQAVLLFMG ILDTSWEAMR KFLSKSGVKD DIMNFDANRI
2960 2970 2980 2990 3000
TNEIHKKVTA LVKQKSNSFE EANAKRASAA AAPLAAWVKA NLEYSKILEK
3010 3020 3030 3040 3050
IAPLEGEKNK LVKNLKKAEK QMENLSKGLQ SVDEVVGELK RKFEVLMKEA
3060 3070 3080 3090 3100
TQIKVDLDRE QDTIRIAGTL VESLSGEFER WKIQIETFGE EQSKMELCSL
3110 3120 3130 3140 3150
ITSAFITYLG GCSEKDRKSL LKSMCKMFNM PPTFKPLSFA SLETEQLNWK
3160 3170 3180 3190 3200
TKGLPADQLS LENGSILFTS CHAPLIIDRS GQVSLFLSKF LEKSETFKAA
3210 3220 3230 3240 3250
QPDLMTQIEL AIRFGKTIII DDIVEFDSAL IPILRKDLSS QGPRQVISFG
3260 3270 3280 3290 3300
GKSIDFNPDF KIYFCTRDEK VDIRPNSYVQ LNIVNFTTTI SALSAQLLDV
3310 3320 3330 3340 3350
AIHLEKPELE ERSSSLLRDA ELKKLELEGL EQLLLQQLAS SQGNLLENTA
3360 3370 3380 3390 3400
LLDSLNKSKE SAEIITKSIV ESEQLHKELT TQKDIYVPLS LFTSSLFFSF
3410 3420 3430 3440 3450
SNLQFHNPMY NYSVNTIMHL FGKTIKSCED KSSTRVETLA RQMQLTVFYH
3460 3470 3480 3490 3500
ISRGIFRQDR LMFAVAFINA TMPKMFQPKE WELFTGVLVD ESTDLSALRV
3510 3520 3530 3540 3550
QWISPDRLQS LARIRTHLPS LFNNFQIQDD ATWNEFSKTL QCENAFPKNV
3560 3570 3580 3590 3600
ELKMTHFQKV LFIQAVKPER LYNCLMDFVL KTLNIPSINP PAFELKHIFQ
3610 3620 3630 3640 3650
ESESTEPILF ILADGADPSQ ELSEFASSMN VPYHSISMGQ GQEIAAYEAI
3660 3670 3680 3690 3700
RESASKGEWL CLNNLHLMLQ AVPSIFKHLS LTTPHENFRL WLTTEGDARF
3710 3720 3730 3740 3750
PSMMLQQSLK ITFEPPPGVR NNLLRTYTQI DRSTKNVITC QSIFVLAWLH
3760 3770 3780 3790 3800
ALLQERRTFI PQGWTKFYEF GASDVRVAKS FVEQLTANKA DWEFVRGILK
3810 3820 3830 3840 3850
FVIYGGRIEN DFDFKVLDSY LNVLFCDEKI NGRAGSQLVK GIDLLATTNV
3860 3870 3880 3890 3900
QEYIGHISKS VPSVDEPYLF GLPENIKYSW QIVEADRTIS SIRTLALGDT
3910 3920 3930 3940 3950
KNALSDQSDK ISQIVSLWKK LCQSDDLPKR ELPTAIRSAD PISEVLCLET
3960 3970 3980 3990 4000
INALSLIKQL HRSIGHVAKS MKTPSLASPA VQKTIQSLVF QQTPDEWDSM
4010 4020 4030 4040 4050
WAGPSDPADY LNVVVKKTRG TLQLFESSKS SSLLSSPIDF SDLFYPNIFL
4060 4070 4080 4090 4100
NALRQTTSRQ IKIPLDQLIL SSAWTPSQLP AKQCVQVQGL LLQGATFDSF
4110 4120 4130 4140 4150
LRETTVSSAA YSQAPIVFLA WTSESSSTIT GEQIQVPVYS SSERSDLICS
4160 4170
VNMPCRGADQ WNIAAVALFL R
Length:4,171
Mass (Da):473,818
Last modified:March 1, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD45B5ADE572D06BC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z75536 Genomic DNA Translation: CAA99830.2

Protein sequence database of the Protein Information Resource

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PIRi
T21085

NCBI Reference Sequences

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RefSeqi
NP_492221.2, NM_059820.2

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
F18C12.1.1; F18C12.1.1; WBGene00000485

Database of genes from NCBI RefSeq genomes

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GeneIDi
172593

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_F18C12.1

UCSC genome browser

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UCSCi
F18C12.1, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75536 Genomic DNA Translation: CAA99830.2
PIRiT21085
RefSeqiNP_492221.2, NM_059820.2

3D structure databases

SMRiQ19542
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi38027, 5 interactors
STRINGi6239.F18C12.1

Proteomic databases

PaxDbiQ19542
PeptideAtlasiQ19542
PRIDEiQ19542

Genome annotation databases

EnsemblMetazoaiF18C12.1.1; F18C12.1.1; WBGene00000485
GeneIDi172593
KEGGicel:CELE_F18C12.1
UCSCiF18C12.1, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
172593
WormBaseiF18C12.1 ; CE32386 ; WBGene00000485 ; che-3

Phylogenomic databases

eggNOGiKOG3595, Eukaryota
GeneTreeiENSGT00940000154620
HOGENOMiCLU_000038_7_2_1
InParanoidiQ19542
KOiK10414
OMAiTSWIICD
OrthoDBi26380at2759
PhylomeDBiQ19542

Enzyme and pathway databases

ReactomeiR-CEL-5620924, Intraflagellar transport

Miscellaneous databases

Protein Ontology

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PROi
PR:Q19542

Gene expression databases

BgeeiWBGene00000485, Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

Gene3Di1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR026983, DHC_fam
IPR026815, DYNC2H1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013594, Dynein_heavy_dom-1
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase
PANTHERiPTHR10676, PTHR10676, 1 hit
PTHR10676:SF352, PTHR10676:SF352, 1 hit
PfamiView protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit
SUPFAMiSSF52540, SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYHC2_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19542
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: August 12, 2020
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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