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Entry version 137 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Tubulin-specific chaperone D

Gene

tbcd-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tubulin-folding protein; involved in the first step of the tubulin folding pathway (By similarity). Plays a role in microtubule polymerization (PubMed:16054029).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tubulin-specific chaperone DBy similarity
Alternative name(s):
Tubulin folding cofactor D homologImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tbcd-1Imported
ORF Names:F16D3.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
F16D3.4 ; CE09437 ; WBGene00008887 ; tbcd-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown results in reduced microtubule growth rate.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004362501 – 1232Tubulin-specific chaperone DCuratedAdd BLAST1232

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q19493

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q19493

PeptideAtlas

More...
PeptideAtlasi
Q19493

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00008887, Expressed in germ line (C elegans) and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.F16D3.4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TBCD family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1943, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017103

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003043_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q19493

Identification of Orthologs from Complete Genome Data

More...
OMAi
EPHEAWH

Database of Orthologous Groups

More...
OrthoDBi
79003at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q19493

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR033162, TBCD
IPR022577, Tubulin_specific_chaperoneD_C

The PANTHER Classification System

More...
PANTHERi
PTHR12658, PTHR12658, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12612, TFCD_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q19493-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKTKYPTLV RISRFLFTDL VSMKIRFQRA WLRNVFADKT TRLTRKCSSS
60 70 80 90 100
MLHLREFLQF LGFLLKYLSM DEDAPVDESN EGIIGCLPSA VNIHHIEEIK
110 120 130 140 150
ELVDQLPIIF KLENECDETA AEVNYLRYSR LLHLYQEQPR LLDKWIPEIV
160 170 180 190 200
ANLVDLVTLI GIDVSKPRAM TPLSRESLKY LSDLCIVRGS KTIVRLLPHQ
210 220 230 240 250
VHLLDPLLQT LEYYETSQLS DHNQRNVLLM WLWIVVKNPF DLRRFDPTGD
260 270 280 290 300
PDNVITRIMN VALHYMKWDW NSSQASAALV IAHCLSRTDG IPKVLSFLSR
310 320 330 340 350
LLDSIKTHHE NKKLLLADLI LLLAILKHVD RRVLTGHIGT IHEQLSFLYP
360 370 380 390 400
IDEKKGGLIC KCLVKVVQRI GLIALKPRTC SWSYNRGKRL LEGMLDDNEE
410 420 430 440 450
YSDEPSFSNK VNSNQSCNNE IDKENQWNDG DELENSEIVE FALMHVLEAL
460 470 480 490 500
SHSDTAVRWS AAKGVGRITV RLPNFDLATQ VVGSIISSHF GEVAEYSSWH
510 520 530 540 550
SHGACLALAE LAHRGVLLPS LLEDIVPALE LSLVFEDVMG RHQNGNQVRD
560 570 580 590 600
AACYAVWALS RTYEPSMMAP YLQRLASALL CGALFDRQVN LRRAASAALQ
610 620 630 640 650
EMVGRQKNVS HGIPLIQSVD YFAVTNRQKC YEHLCVPVAE YSTYSAIILR
660 670 680 690 700
HLITKKVVHW DEKIREQAAI SLEKISEIRL ENVSDDYYME ILDDFLKASC
710 720 730 740 750
ETRISPFLRH GYLLASGHLI KGLTSRGMDF SSKQTEIAWI PHILWPFCDM
760 770 780 790 800
TTQPGALIRR TLCKFIQLVS ASKKVLLLEK DKSEWLDVLL QLITDPREII
810 820 830 840 850
RSLAKTAVGE FVMTYLMNDE ELIQKVKTRV IAAMTKCSDE SERIGMGMIC
860 870 880 890 900
ESLNSEAVDY EMFESLCNTI LTPTSSDAKW ALARQQTVFA LNRISVNSST
910 920 930 940 950
ETFNRIGQKC FETLYKAMTD YTTSANGDIG RFVREASMRA MSTILVDAKT
960 970 980 990 1000
EPPFLDEHVI KSAKYMVQQS AERISRTREC ACACLKSLVK CEITGRCLPH
1010 1020 1030 1040 1050
IDLLMNIYSE PMDFISDRTV FQLKPLLDLG SEYYEQLILG IVVSAGGLAE
1060 1070 1080 1090 1100
GTQKTAKQLL LDHQREICEN KPRFDHFLST CADLFQRARK VNRIGNSFMQ
1110 1120 1130 1140 1150
ILPQIFGNLG IYEQCPETSE SIIEMVDTMK TIAVRSSMMS RQRLSIDSLG
1160 1170 1180 1190 1200
ELLNCGKKST VYRSALTMIL DTLNSQQPVL RKSAAERLYE HLCCAEESDD
1210 1220 1230
EVLEVLATTN WQDENDNVLK QAVAGISEKL IF
Length:1,232
Mass (Da):140,014
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E6DD1FF44530C50
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB01496.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T21018

NCBI Reference Sequences

More...
RefSeqi
NP_492270.1, NM_059869.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F16D3.4.1; F16D3.4.1; WBGene00008887

UCSC genome browser

More...
UCSCi
F16D3.4, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB01496.1
PIRiT21018
RefSeqiNP_492270.1, NM_059869.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.F16D3.4

Proteomic databases

EPDiQ19493
PaxDbiQ19493
PeptideAtlasiQ19493

Genome annotation databases

EnsemblMetazoaiF16D3.4.1; F16D3.4.1; WBGene00008887
UCSCiF16D3.4, c. elegans

Organism-specific databases

WormBaseiF16D3.4 ; CE09437 ; WBGene00008887 ; tbcd-1

Phylogenomic databases

eggNOGiKOG1943, Eukaryota
GeneTreeiENSGT00390000017103
HOGENOMiCLU_003043_0_0_1
InParanoidiQ19493
OMAiEPHEAWH
OrthoDBi79003at2759
PhylomeDBiQ19493

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q19493

Gene expression databases

BgeeiWBGene00008887, Expressed in germ line (C elegans) and 5 other tissues

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR033162, TBCD
IPR022577, Tubulin_specific_chaperoneD_C
PANTHERiPTHR12658, PTHR12658, 1 hit
PfamiView protein in Pfam
PF12612, TFCD_C, 1 hit
SUPFAMiSSF48371, SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBCD_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19493
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 11, 2016
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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