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Entry version 148 (16 Oct 2019)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Yeast SEC homolog

Gene

sec-24.1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transportSAAS annotation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-204005 COPII-mediated vesicle transport
R-CEL-5694530 Cargo concentration in the ER
R-CEL-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Yeast SEC homologImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sec-24.1Imported
ORF Names:CELE_F12F6.6Imported, F12F6.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
F12F6.6 ; CE05594 ; WBGene00004755 ; sec-24.1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q19371

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q19371

PeptideAtlas

More...
PeptideAtlasi
Q19371

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004755 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q19371, 3 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F12F6.6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q19371

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini454 – 492zf-Sec23_Sec24InterPro annotationAdd BLAST39
Domaini531 – 773Sec23_trunkInterPro annotationAdd BLAST243
Domaini778 – 861Sec23_BSInterPro annotationAdd BLAST84
Domaini872 – 973Sec23_helicalInterPro annotationAdd BLAST102
Domaini996 – 1063Gelsolin-likeInterPro annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 353DisorderedSequence analysisAdd BLAST353

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 28PolarSequence analysisAdd BLAST16
Compositional biasi29 – 50Pro-richSequence analysisAdd BLAST22
Compositional biasi51 – 86PolarSequence analysisAdd BLAST36
Compositional biasi100 – 135PolarSequence analysisAdd BLAST36
Compositional biasi179 – 203PolarSequence analysisAdd BLAST25
Compositional biasi219 – 253Pro-richSequence analysisAdd BLAST35
Compositional biasi259 – 328Pro-richSequence analysisAdd BLAST70

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1984 Eukaryota
COG5028 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182924

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000196365

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q19371

KEGG Orthology (KO)

More...
KOi
K14007

Identification of Orthologs from Complete Genome Data

More...
OMAi
DTPPEYF

Database of Orthologous Groups

More...
OrthoDBi
330236at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q19371

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01479 Sec24-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.20.10, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR006900 Sec23/24_helical_dom
IPR036175 Sec23/24_helical_dom_sf
IPR006896 Sec23/24_trunk_dom
IPR012990 Sec23_24_beta_S
IPR041742 Sec24-like_trunk_dom
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00626 Gelsolin, 1 hit
PF08033 Sec23_BS, 1 hit
PF04815 Sec23_helical, 1 hit
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 1 hit
SSF81811 SSF81811, 1 hit
SSF82754 SSF82754, 1 hit
SSF82919 SSF82919, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q19371-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYQPPPNGQ MPGYPQQQFN QQPQFQSNGF PPPAAPQKPA QVPGGFPPPH
60 70 80 90 100
QQPNGQYQNG GLNGNSSHLA QSVNNMSIGA RSTPSAQPPN PYQPAGYPGA
110 120 130 140 150
PPQQLQQVQR QQTPQQFAAV PQSVQAPSAT PAGPLQAMQQ APAPTPGIPQ
160 170 180 190 200
MNQGAHLPPQ PHQIHQPTPL RPQIPGFPQA GGSPSSFQAG APTSQNVQGY
210 220 230 240 250
PGGPSSAPSA YPGAPQVPQA PNSFIPPGTG GFPPGQPTAG SFPPGPQVPG
260 270 280 290 300
SYPSGPADIP QGPGMPRAFP PGASAPVAPG MPGAFPPGQG GPGMPGSFPP
310 320 330 340 350
GAPGPGGPGM PGSFAPGAPG PGGPGGYPSG GPGMPGMQGG YPGGPPQQRQ
360 370 380 390 400
QRLDPNMMPS AVQVIDDDSS TRSGIFPTGY PNAELPPLVS TNSFAQDQGN
410 420 430 440 450
CNPKFMRSTL YTAPQTNDIL KASQIPLAVV ISPFASLTEY EKEPPVVDLG
460 470 480 490 500
PQGPIRCQRC KAYICPFMEF QDGGRSFRCP FCHARTSVED AYFAHLDHTG
510 520 530 540 550
RRTDIEMRPE LCLGAYDLVA TKQYCKNGIA PKEPAFIFMI DVSYNAISNG
560 570 580 590 600
MLPILCQNLE KVLRNLPRES GQLESSMRIG LATFDQAVHF FDISSASPKM
610 620 630 640 650
LVMSDVQEPF VPMVDGLLLP YNEALPGLRA ALAEIPKLFS QSKTTETILQ
660 670 680 690 700
PVVQAGLDAL KCADRAGKVI LFSTVLPTYD APGKLKSKND RSLLGTDKEK
710 720 730 740 750
NALVPQEDSY TKLGEQCVKS GVTVDLFLFP NAFIDVATIG QLSAVTGGSI
760 770 780 790 800
FKFQYFSADK DGVRMLNELE RHVSKKIAFD CMARVRTSTG IRPITFTGSF
810 820 830 840 850
YMENSTDLEL ATLDESKAFI TEIKHDDSLK DPASFIQTAV LYTSMTGQRR
860 870 880 890 900
LRILNLCLPV TADYNQVYRL ADPEALTAFM LKQAVQLNRD KGSSEMRESL
910 920 930 940 950
SSRCAQFLAT YREKCSEGAP LGQLILPESL KLMPLYVNSI LKNDAISGGS
960 970 980 990 1000
EMTVDDKVWQ MELIRGLRTE NVMPLIYPRV MPISDLQIND TEEMKDLPKP
1010 1020 1030 1040 1050
VRASSEFLEN SKAYIIDNGV ILFVWVGSAC PQTWVQDVFG VGATNQIDTE
1060 1070 1080 1090 1100
SGTIPEKDNG HSRALRRAIQ LLPRGIRERK TFVVVEKSGL EPWMKKFLVE
1110 1120
DKAGPANMSY VDYLVDIHRK IRDLIS
Length:1,126
Mass (Da):121,123
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67C1FADF3D3F3EB3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA97788.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T20801

NCBI Reference Sequences

More...
RefSeqi
NP_502178.1, NM_069777.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F12F6.6.1; F12F6.6.1; WBGene00004755

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
178078

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F12F6.6

UCSC genome browser

More...
UCSCi
F12F6.6 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA97788.1
PIRiT20801
RefSeqiNP_502178.1, NM_069777.3

3D structure databases

SMRiQ19371
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ19371, 3 interactors
STRINGi6239.F12F6.6

Proteomic databases

EPDiQ19371
PaxDbiQ19371
PeptideAtlasiQ19371

Genome annotation databases

EnsemblMetazoaiF12F6.6.1; F12F6.6.1; WBGene00004755
GeneIDi178078
KEGGicel:CELE_F12F6.6
UCSCiF12F6.6 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178078
WormBaseiF12F6.6 ; CE05594 ; WBGene00004755 ; sec-24.1

Phylogenomic databases

eggNOGiKOG1984 Eukaryota
COG5028 LUCA
GeneTreeiENSGT00950000182924
HOGENOMiHOG000196365
InParanoidiQ19371
KOiK14007
OMAiDTPPEYF
OrthoDBi330236at2759
PhylomeDBiQ19371

Enzyme and pathway databases

ReactomeiR-CEL-204005 COPII-mediated vesicle transport
R-CEL-5694530 Cargo concentration in the ER
R-CEL-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Gene expression databases

BgeeiWBGene00004755 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Family and domain databases

CDDicd01479 Sec24-like, 1 hit
Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR006900 Sec23/24_helical_dom
IPR036175 Sec23/24_helical_dom_sf
IPR006896 Sec23/24_trunk_dom
IPR012990 Sec23_24_beta_S
IPR041742 Sec24-like_trunk_dom
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF08033 Sec23_BS, 1 hit
PF04815 Sec23_helical, 1 hit
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF81811 SSF81811, 1 hit
SSF82754 SSF82754, 1 hit
SSF82919 SSF82919, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ19371_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19371
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 16, 2019
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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