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Entry version 124 (18 Sep 2019)
Sequence version 2 (01 Nov 1998)
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Protein

Monensin-resistant homolog 2

Gene

mon-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be required for traffic between late Golgi and early endosomes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Monensin-resistant homolog 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mon-2
ORF Names:F11A10.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
F11A10.4a ; CE17656 ; WBGene00008685 ; mon-2
F11A10.4b ; CE46488 ; WBGene00008685 ; mon-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002979061 – 1646Monensin-resistant homolog 2Add BLAST1646

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q19338

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q19338

PeptideAtlas

More...
PeptideAtlasi
Q19338

PRoteomics IDEntifications database

More...
PRIDEi
Q19338

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00008685 Expressed in 5 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.F11A10.4b

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MON2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1848 Eukaryota
ENOG410XQA8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000174858

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113631

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q19338

Identification of Orthologs from Complete Genome Data

More...
OMAi
NICYESD

Database of Orthologous Groups

More...
OrthoDBi
411011at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q19338

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR026829 Mon2-like
IPR032817 Mon2_C
IPR032691 Sec7_N

The PANTHER Classification System

More...
PANTHERi
PTHR10663:SF333 PTHR10663:SF333, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16213 DCB, 1 hit
PF16206 Mon2_C, 1 hit
PF12783 Sec7_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: Q19338-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSINAVDSKK LVEALLGDLR LLSQEAKKKQ NHVKEAAESG VVRIRNISTA
60 70 80 90 100
SVGDTVLITN LRAACTELLH PLVLSCETRH TRLVQIALQG IQRLVQHRIL
110 120 130 140 150
SQNGATIVTN ELWSLVEAEC EELRVLQTVP PLVSSELIVT GNTLAKCIVM
160 170 180 190 200
CFRLHFAKDP IVINAASAAV RQLVSTVFER VIQEDGIFST ELTVVNPSGG
210 220 230 240 250
RPSPRAAPPT LRPCAADAYM LFKDLCLLIN GEAPIWLVGI QETTRTLGLE
260 270 280 290 300
LLESLLKGFP SVFIRHTEFG DLLKDDVCPL IIRLFSPNVK AMHISSQHPS
310 320 330 340 350
SRTSNASFNN YPPTISHERQ SFPISMRLVR IVTLIVQFYQ TILHTECEIF
360 370 380 390 400
ISTLLKFVDG DRKGWQRPLA LESLHRIVSS TDLVKWMTES FDCRPNSTHV
410 420 430 440 450
LEQVAIGLST VVQQCLVCTT FSSDQENEID RSQEDGGPGF LSKGLWVPYV
460 470 480 490 500
EHLTSKKTIL LDSLDRMDAV AIPEGYVLSR CCVALCDMTQ AVYAAIDKLC
510 520 530 540 550
LVDENSEAGS SETKLEIAKV AYANSQPSIL AAIGSLLAAS TDEIVSDQLL
560 570 580 590 600
CCLSTLISAG CRVGADADLH RSVYVLAIMS LPSPSYLNQF AGIAPPSPAN
610 620 630 640 650
KRDAPVSEQV FDLEAWPSTT QVTASGPPCP CPVVSTELWN KQVLLTSKNL
660 670 680 690 700
QAARTFIASI TTHIKELNNL WYLCMATCEH LSWLLAMRPT QVGQFERETR
710 720 730 740 750
DDHSNVPTVV TNAALSDIAM LSSLMDKVAP AIAALPDKSF LSVIDALIRL
760 770 780 790 800
SDESLAVAAT GRESSLFPLA VLYKVCSLSL MRLQVFWQKA ANHFIKVCNH
810 820 830 840 850
TSVSMRDWAA VALTSLAKHA VKSKTSMDAK SQQEMIISSL LALCSIPHIQ
860 870 880 890 900
VRRRQLDCVM SLMQTDGAFL LSTSWPNVIQ IISAIIDSDT ECELSLVRQG
910 920 930 940 950
YLGLRLVSSD FLQSIPFDCI SGLVEAISRY SKQNTDQNIS LSALTLLWTI
960 970 980 990 1000
SDFIYRKMES VGNDASEAVW MVLYTCLSES CVDSRFAVRK SACQTLLQTV
1010 1020 1030 1040 1050
TAHGHALRSA AWHSVIWQIM IPLLDKVRSQ TRCASTEKSN GELIMHHSRD
1060 1070 1080 1090 1100
TEQKQWTETC IHTISAISKI FNSQRKSLLA LNDFGAVWEA FLGYLDWAAC
1110 1120 1130 1140 1150
YENAELSLSA IRSYQEVLLG KISSQTLNVN SHEKSNGSDS TIDAITPELP
1160 1170 1180 1190 1200
QAQWVESWKV WLRISRGLAR QGCAAMANSV NADSKSISST PRMNSSSSSL
1210 1220 1230 1240 1250
ASLAPGIYVP GPSHLTAILH VFPPLFDKVA KSITVDDLKY ESLPAVLESM
1260 1270 1280 1290 1300
MNVPIPSEQA PFVLPSATTH LTPTQEALLE AVKIVFVECT LSGTSLRAAI
1310 1320 1330 1340 1350
PDQIRLLLKF ASMATQRISP NKVAPGGQKS YRDYALTTIV PFSEYSLRIA
1360 1370 1380 1390 1400
IEFFTSTSQN PEVANSLIAI DIIKFLGEPL YMKYTCISAS TWKLAATSLM
1410 1420 1430 1440 1450
SVLRTSIPYA RQNPEVFRGL WSAICDTMER WLFTPNKSTR LAADERKRDE
1460 1470 1480 1490 1500
LMECQAIEII RSEMLAYASR LPQEDVQRLI ALLHRGSISQ IDSTDVLDSH
1510 1520 1530 1540 1550
TQRNELAKAC FDALLMSSDG AHTNTEEDEG RGILGNVAVT SLLQRCTQVM
1560 1570 1580 1590 1600
SDFCKDWSAA GDLRLPRSRI LEIISALQAV DSLIARLARD PKMTELYSHL
1610 1620 1630 1640
VSLFPSVVDV MPCCHADPQL EHQLIKTIKS YQTLFLLQNI PQATVE
Note: No experimental confirmation available.
Length:1,646
Mass (Da):181,546
Last modified:November 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B13B919952F895A
GO
Isoform b (identifier: Q19338-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1497-1497: L → LAS

Note: No experimental confirmation available.
Show »
Length:1,648
Mass (Da):181,704
Checksum:i0783B742AF5FEABB
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0439411497L → LAS in isoform b. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z68297, Z68507 Genomic DNA Translation: CAA92597.1
Z68297, Z68507 Genomic DNA Translation: CCD31054.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T20740

NCBI Reference Sequences

More...
RefSeqi
NP_001255622.1, NM_001268693.1 [Q19338-1]
NP_001255623.1, NM_001268694.1 [Q19338-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F11A10.4a.1; F11A10.4a.1; WBGene00008685 [Q19338-1]
F11A10.4b.1; F11A10.4b.1; WBGene00008685 [Q19338-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
178153

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F11A10.4

UCSC genome browser

More...
UCSCi
F11A10.4 c. elegans [Q19338-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68297, Z68507 Genomic DNA Translation: CAA92597.1
Z68297, Z68507 Genomic DNA Translation: CCD31054.1
PIRiT20740
RefSeqiNP_001255622.1, NM_001268693.1 [Q19338-1]
NP_001255623.1, NM_001268694.1 [Q19338-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.F11A10.4b

Proteomic databases

EPDiQ19338
PaxDbiQ19338
PeptideAtlasiQ19338
PRIDEiQ19338

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF11A10.4a.1; F11A10.4a.1; WBGene00008685 [Q19338-1]
F11A10.4b.1; F11A10.4b.1; WBGene00008685 [Q19338-2]
GeneIDi178153
KEGGicel:CELE_F11A10.4
UCSCiF11A10.4 c. elegans [Q19338-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178153
WormBaseiF11A10.4a ; CE17656 ; WBGene00008685 ; mon-2
F11A10.4b ; CE46488 ; WBGene00008685 ; mon-2

Phylogenomic databases

eggNOGiKOG1848 Eukaryota
ENOG410XQA8 LUCA
GeneTreeiENSGT00940000174858
HOGENOMiHOG000113631
InParanoidiQ19338
OMAiNICYESD
OrthoDBi411011at2759
PhylomeDBiQ19338

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q19338

Gene expression databases

BgeeiWBGene00008685 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR026829 Mon2-like
IPR032817 Mon2_C
IPR032691 Sec7_N
PANTHERiPTHR10663:SF333 PTHR10663:SF333, 1 hit
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF16206 Mon2_C, 1 hit
PF12783 Sec7_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMON2_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19338
Secondary accession number(s): G5EBK9, Q21561
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: November 1, 1998
Last modified: September 18, 2019
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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