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Entry version 130 (08 May 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Sister chromatid cohesion protein 1

Gene

scc-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle (PubMed:12827206, PubMed:12808038). The cohesin complex is required for the cohesion of sister chromatids after DNA replication (PubMed:12827206, PubMed:12808038). The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At metaphase-anaphase transition, this protein is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • damaged DNA binding Source: WormBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-2468052 Establishment of Sister Chromatid Cohesion
R-CEL-2470946 Cohesin Loading onto Chromatin
R-CEL-2500257 Resolution of Sister Chromatid Cohesion
R-CEL-3108214 SUMOylation of DNA damage response and repair proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sister chromatid cohesion protein 1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:scc-1Imported
Synonyms:coh-2Imported, rad-21.1Imported
ORF Names:F10G7.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
F10G7.4 ; CE02628 ; WBGene00004737 ; scc-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Postembryonic RNAi-mediated knock-down results in either larval arrest, or adult sterility with a protruding vulva phenotype (PubMed:12808038, PubMed:12827206). Worms have defective chromosome segregation (PubMed:12808038).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004328431 – 645Sister chromatid cohesion protein 1CuratedAdd BLAST645

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q19325

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q19325

PeptideAtlas

More...
PeptideAtlasi
Q19325

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at high levels in actively dividing cells, during all stages of development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004737 Expressed in 5 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the cohesin complex, composed of the smc-1 and smc-3 heterodimer attached via their hinge domain, scc-1 which links them, and scc-3. Interacts with smc-1, smc-3, scc-3 and tim-1.1 Publication

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-967 Nuclear mitotic cohesin complex

Database of interacting proteins

More...
DIPi
DIP-24317N

Protein interaction database and analysis system

More...
IntActi
Q19325, 11 interactors

Molecular INTeraction database

More...
MINTi
Q19325

STRING: functional protein association networks

More...
STRINGi
6239.F10G7.4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q19325

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi461 – 465Poly-AspSequence analysis5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the rad21 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1213 Eukaryota
ENOG410XRB4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154655

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000017446

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q19325

KEGG Orthology (KO)

More...
KOi
K06670

Identification of Orthologs from Complete Genome Data

More...
OMAi
WKKKGGV

Database of Orthologous Groups

More...
OrthoDBi
1253899at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q19325

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.580, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039781 Rad21/Rec8-like
IPR006909 Rad21/Rec8_C_eu
IPR006910 Rad21_Rec8_N
IPR023093 ScpA-like_C
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12585 PTHR12585, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04824 Rad21_Rec8, 1 hit
PF04825 Rad21_Rec8_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q19325-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFYAQFVLAK KGPLAKVWLA AHWEKKLTKA QIFETDVPQA IEEVIRPKVK
60 70 80 90 100
MALRTVGHLL LGIVRIYSKK TRYLLADTNE AYQKMKINFR NGFSFEVDIP
110 120 130 140 150
ENAEIEEDFS NFIDKYNITV PEFHDADYNE QLIMANVSRR EDITMKETVN
160 170 180 190 200
FNVEFNIDAD FDGFGDEGES WQLDHLYGSV EPLSLRPTPQ PESLMEVERD
210 220 230 240 250
RDVAANGTEI SRIDADSVIF SEGPTRPNLI FDNQEGGNFM PEMNLKVENQ
260 270 280 290 300
TLENDGGVGP ADMFSSMIHP VREHAVADVQ NDDGMDFDYQ PFEPENVEPS
310 320 330 340 350
RPQSPESFAL EPLDVEHMEG RKKRQRKARK LIVDAETMIS NDAFREQQED
360 370 380 390 400
FSDTMRVVEM APPTRKMFNL CVSGDLQHLS REPGCKMFNR ELLQRYRRCL
410 420 430 440 450
VTREFDLNYT MQELSDSSSF TPSMEAQAEP WEDLNLNEDI QEDIQAQGPA
460 470 480 490 500
VDEFFNDVRM DDDDDRQPAQ EMDFGDNFDF PQEVEHQECA PIPIQSGFAG
510 520 530 540 550
ENKENEDAED WSDPFGSSNS SRRGQLEAYG FGNTSTYKED DGKWAKRAKH
560 570 580 590 600
ILKKVSADIE TSGQADFSSV TATAKNRKQA AEQFYSLLTL AKSQAISVDQ
610 620 630 640
SEPYGEIVIR PGANFKEACP LSSPKPMGLG NTMENSTMRT PMRPV
Length:645
Mass (Da):73,409
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFB2DAB771B8943B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO081114 Genomic DNA Translation: CCD69206.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G88130

NCBI Reference Sequences

More...
RefSeqi
NP_494836.1, NM_062435.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F10G7.4; F10G7.4; WBGene00004737

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
173808

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F10G7.4

UCSC genome browser

More...
UCSCi
F10G7.4 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081114 Genomic DNA Translation: CCD69206.1
PIRiG88130
RefSeqiNP_494836.1, NM_062435.4

3D structure databases

SMRiQ19325
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-967 Nuclear mitotic cohesin complex
DIPiDIP-24317N
IntActiQ19325, 11 interactors
MINTiQ19325
STRINGi6239.F10G7.4

Proteomic databases

EPDiQ19325
PaxDbiQ19325
PeptideAtlasiQ19325

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF10G7.4; F10G7.4; WBGene00004737
GeneIDi173808
KEGGicel:CELE_F10G7.4
UCSCiF10G7.4 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
173808
WormBaseiF10G7.4 ; CE02628 ; WBGene00004737 ; scc-1

Phylogenomic databases

eggNOGiKOG1213 Eukaryota
ENOG410XRB4 LUCA
GeneTreeiENSGT00940000154655
HOGENOMiHOG000017446
InParanoidiQ19325
KOiK06670
OMAiWKKKGGV
OrthoDBi1253899at2759
PhylomeDBiQ19325

Enzyme and pathway databases

ReactomeiR-CEL-2468052 Establishment of Sister Chromatid Cohesion
R-CEL-2470946 Cohesin Loading onto Chromatin
R-CEL-2500257 Resolution of Sister Chromatid Cohesion
R-CEL-3108214 SUMOylation of DNA damage response and repair proteins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q19325

Gene expression databases

BgeeiWBGene00004737 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di1.10.10.580, 1 hit
InterProiView protein in InterPro
IPR039781 Rad21/Rec8-like
IPR006909 Rad21/Rec8_C_eu
IPR006910 Rad21_Rec8_N
IPR023093 ScpA-like_C
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12585 PTHR12585, 2 hits
PfamiView protein in Pfam
PF04824 Rad21_Rec8, 1 hit
PF04825 Rad21_Rec8_N, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCC1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19325
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2015
Last sequence update: November 1, 1996
Last modified: May 8, 2019
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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