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Entry version 149 (16 Oct 2019)
Sequence version 2 (01 Oct 2001)
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Protein

Cell division cycle protein 23 homolog

Gene

mat-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11861581, PubMed:15238519). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (PubMed:11861581). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells (PubMed:11134076, PubMed:11861581, PubMed:15238519). Required for embryonic anterior-posterior axis formation (PubMed:11832245). Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion (PubMed:15556870). Involved in regulating GABA neurotransmitter release at neuromuscular junctions in GABA motor neurons (PubMed:24321454).6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.Curated
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell cycle, Cell division, Meiosis, Mitosis, Neurotransmitter transport, Transport, Ubl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-CEL-179409 APC-Cdc20 mediated degradation of Nek2A
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell division cycle protein 23 homolog1 Publication
Alternative name(s):
Anaphase-promoting complex subunit 8By similarity
Short name:
APC8By similarity
Metaphase-to-anaphase transition defect protein 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mat-3Imported
Synonyms:apc-8Imported, cdc-23Imported, pod-4Imported, vex-2Imported
ORF Names:F10C5.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
F10C5.1 ; CE26888 ; WBGene00003134 ; mat-3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Developmental defects in the gonad, germline, male tail and hermaphrodite vulva (PubMed:15238519). Increased number of germ cells arrested at the metaphase stage of mitosis during the larval stage L4; by adulthood, there are no nuclei in the distal part of the gonad and as a result, no sperm or oocytes are formed (PubMed:15238519). RNAi-mediated knockdown results in defective metaphase to anaphase transition (Mat phenotype) and embryos that arrest at the one-cell stage that display defects in the formation of the anterior-posterior axis (PubMed:11861581, PubMed:11832245).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi70E → K in or192; results in sterility. 1 Publication1
Mutagenesisi161E → K in ax68; results in sterility. 1 Publication1
Mutagenesisi237E → K in ax82; results in sterility. 1 Publication1
Mutagenesisi339A → L in ax77; results in sterility. 1 Publication1
Mutagenesisi401E → K in ax79 and ax136; results in sterility. 1 Publication1
Mutagenesisi433L → F in av26; weak suppressor of mat-3 mutations. 1 Publication1
Mutagenesisi451A → V in ax70; results in sterility. 1 Publication1
Mutagenesisi502S → F in or172, or180 and or187; maternal-effect embryonic lethal. 1 Publication1
Mutagenesisi502S → F in or180; embryonic lethal. 2 Publications1
Mutagenesisi528A → T in ax148; maternal-effect embryonic lethal. 1 Publication1
Mutagenesisi532G → D in ax71; results in sterility. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004353301 – 673Cell division cycle protein 23 homologCuratedAdd BLAST673

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q19294

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q19294

PeptideAtlas

More...
PeptideAtlasi
Q19294

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003134 Expressed in 5 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The APC/C complex is probably composed of at least 12 subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1, mat-2, mat-3, such-1 and gfi-3.

Curated

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3382 Anaphase Promoting Complex/Cyclosome

Database of interacting proteins

More...
DIPi
DIP-24631N

Protein interaction database and analysis system

More...
IntActi
Q19294, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F10C5.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati86 – 120TPR 1Sequence analysisAdd BLAST35
Repeati159 – 195TPR 2Sequence analysisAdd BLAST37
Repeati232 – 267TPR 3Sequence analysisAdd BLAST36
Repeati332 – 365TPR 4Sequence analysisAdd BLAST34
Repeati400 – 433TPR 5Sequence analysisAdd BLAST34
Repeati434 – 467TPR 6Sequence analysisAdd BLAST34
Repeati469 – 501TPR 7Sequence analysisAdd BLAST33
Repeati502 – 535TPR 8Sequence analysisAdd BLAST34
Repeati539 – 572TPR 9Sequence analysisAdd BLAST34
Repeati577 – 610TPR 10Sequence analysisAdd BLAST34

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the APC8/CDC23 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1155 Eukaryota
ENOG410XPS3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182950

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000019767

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q19294

KEGG Orthology (KO)

More...
KOi
K03355

Identification of Orthologs from Complete Genome Data

More...
OMAi
CFLDAEM

Database of Orthologous Groups

More...
OrthoDBi
761109at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q19294

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13181 TPR_8, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 5 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q19294-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVSFSTPVQ NSTASRLALI QQAAARSGAL PPAGQYRGSK LSPFDVSQMS
60 70 80 90 100
GVSISMVERA KINGPEFVEE LEWLRQQTTS RCFLDAEMWT NEILAHLPDK
110 120 130 140 150
WCAPNTLNLY NQVSELVLDN TRSPMASPAS NSLYAPGEDQ MPTVKRNHTS
160 170 180 190 200
RFAQSLIKNK EFRRAAFFLE KTMNGNKLDH FLHFRCLFLA YYQEHLENDA
210 220 230 240 250
EGIERKTSFA EERSPFSLLY QRMEDKKLRE NEDVWFEYLM GLLEVELGLK
260 270 280 290 300
DLAEKSFRNV VIREPRIWPA WEALSRLIAD IEDADKFVTS AEVKSLWMGD
310 320 330 340 350
WFMTLVLQRF HQHSMAIQKA EQLVTRGMTG LPMIITKIAA CSNARHDHDQ
360 370 380 390 400
AISNFEDVRK ADPYRLGDLH LLSDSLYIRN DQKKLSTLAI EVYKVHKFRW
410 420 430 440 450
ETCCIVANYH AIRRDSEHAI KFFQRALRLN PGLAALWVLI GHEFMEMKNN
460 470 480 490 500
AAACVSYRRA IEIDPADHRG WYGLGQMYDI MKMPAYALFY YQEAQKCKPH
510 520 530 540 550
DSRLLVALGD IYSKLNRIED AEKCFTGAYL FGDVEGNALW SLAKLHERYS
560 570 580 590 600
DDNKAAQAFE VFLVVYELVT SAEEKIIYAI AFLANHFFKI EDFDKASEYA
610 620 630 640 650
TKCLAFETLC QEGNRLFREI AKIQARESRL PVEEAPGPSN ASAAGGQEAM
660 670
DTEEAPQEGG EEEMSEGEDD FSF
Length:673
Mass (Da):76,993
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD76FAA6D4892E5FA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO081107 Genomic DNA Translation: CCD69151.1

NCBI Reference Sequences

More...
RefSeqi
NP_497203.1, NM_064802.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F10C5.1.1; F10C5.1.1; WBGene00003134

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175205

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F10C5.1

UCSC genome browser

More...
UCSCi
F10C5.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081107 Genomic DNA Translation: CCD69151.1
RefSeqiNP_497203.1, NM_064802.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

ComplexPortaliCPX-3382 Anaphase Promoting Complex/Cyclosome
DIPiDIP-24631N
IntActiQ19294, 2 interactors
STRINGi6239.F10C5.1

Proteomic databases

EPDiQ19294
PaxDbiQ19294
PeptideAtlasiQ19294

Genome annotation databases

EnsemblMetazoaiF10C5.1.1; F10C5.1.1; WBGene00003134
GeneIDi175205
KEGGicel:CELE_F10C5.1
UCSCiF10C5.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175205
WormBaseiF10C5.1 ; CE26888 ; WBGene00003134 ; mat-3

Phylogenomic databases

eggNOGiKOG1155 Eukaryota
ENOG410XPS3 LUCA
GeneTreeiENSGT00950000182950
HOGENOMiHOG000019767
InParanoidiQ19294
KOiK03355
OMAiCFLDAEM
OrthoDBi761109at2759
PhylomeDBiQ19294

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-CEL-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-CEL-179409 APC-Cdc20 mediated degradation of Nek2A
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q19294

Gene expression databases

BgeeiWBGene00003134 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13181 TPR_8, 2 hits
SMARTiView protein in SMART
SM00028 TPR, 7 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 5 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDC23_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19294
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2016
Last sequence update: October 1, 2001
Last modified: October 16, 2019
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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