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Protein

von Hippel-Lindau tumor suppressor homolog

Gene

vhl-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the response to variation in environmental oxygen levels by targeting the hypoxia-inducible transcription factor hif-1 for proteasomal degradation when oxygen levels are normal (around 20%) (PubMed:11595184). By regulating hif-1 expression, plays a role in iron homeostasis, aging, heat acclimation and progeny size (PubMed:12686697, PubMed:19372390, PubMed:22396654). Mediates resistance to enteropathogenic E.coli (PubMed:16091039). Mediates susceptibility to B.thuringiensis pore-forming toxins (PubMed:20011506). Not involved in P.aeruginosa susceptibility (PubMed:20865124).7 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • protein ubiquitination Source: UniProtKB-UniPathway
  • response to hypoxia Source: WormBase

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
von Hippel-Lindau tumor suppressor homologImported
Gene namesi
Name:vhl-1Imported
ORF Names:F08G12.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF08G12.4 ; CE03169 ; WBGene00006922 ; vhl-1

Subcellular locationi

Pathology & Biotechi

Disruption phenotypei

Increased mortality induced by B.thuringiensis pore-forming toxins Cry21A and Cry21B (PubMed:20011506). Increased mortality and sensitivity to paralysis induced by enteropathogenic E.coli infection (PubMed:16091039). Increased mortality upon heat stress (PubMed:12686697). RNAi-mediated knockdown causes an enhanced resistance to polyglutamine or amyloid-beta-mediated paralysis and an increase in adult life span.4 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004333681 – 174von Hippel-Lindau tumor suppressor homologCuratedAdd BLAST174

Proteomic databases

EPDiQ19213
PaxDbiQ19213

Expressioni

Gene expression databases

BgeeiWBGene00006922 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Interactioni

Subunit structurei

Interacts with hif-1 (hydroxylated on 'Pro-621'); the interaction induces hif-1 degradation (PubMed:11595184). May be a component of the cullin E3 ubiquitin ligase complex (By similarity).By similarity1 Publication

Protein-protein interaction databases

IntActiQ19213, 4 interactors
MINTiQ19213
STRINGi6239.F08G12.4

Structurei

3D structure databases

ProteinModelPortaliQ19213
SMRiQ19213
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VHL family.Curated

Phylogenomic databases

eggNOGiKOG4710 Eukaryota
ENOG4111PRU LUCA
HOGENOMiHOG000021082
InParanoidiQ19213
KOiK03871
OMAiNHPWVAR
OrthoDBiEOG091G0NHA
PhylomeDBiQ19213

Family and domain databases

CDDicd05468 pVHL, 1 hit
Gene3Di2.60.40.780, 1 hit
InterProiView protein in InterPro
IPR002714 VHL
IPR024053 VHL_beta_dom
IPR037140 VHL_beta_dom_sf
IPR036208 VHL_sf
IPR022772 VHL_tumour_suppress_b/a_dom
PANTHERiPTHR15160:SF1 PTHR15160:SF1, 1 hit
PfamiView protein in Pfam
PF01847 VHL, 1 hit
SUPFAMiSSF49468 SSF49468, 1 hit

Sequencei

Sequence statusi: Complete.

Q19213-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDGSMDDDG RLFPDLGSST HDNREIRVRF LNRCAYPVDV FWLNPSKQPT
60 70 80 90 100
KYGTLAQKKY LDIKTFKDHP WVARRSFDGC KVLVNEKEVF WPEPAPRMNL
110 120 130 140 150
IVRNHCVITM KVQSLREIAG RSFLRHNPTE VPNKIKGLPR ELQFEVKHFL
160 170
DRKQEYSEIV CRSIPPPGPQ RPQQ
Length:174
Mass (Da):20,345
Last modified:November 1, 1996 - v1
Checksum:iA082698EF932EAC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z66561 Genomic DNA Translation: CAA91456.1
PIRiT20589
RefSeqiNP_509889.1, NM_077488.3
UniGeneiCel.11039

Genome annotation databases

EnsemblMetazoaiF08G12.4; F08G12.4; WBGene00006922
GeneIDi181321
KEGGicel:CELE_F08G12.4
UCSCiF08G12.4 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z66561 Genomic DNA Translation: CAA91456.1
PIRiT20589
RefSeqiNP_509889.1, NM_077488.3
UniGeneiCel.11039

3D structure databases

ProteinModelPortaliQ19213
SMRiQ19213
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ19213, 4 interactors
MINTiQ19213
STRINGi6239.F08G12.4

Proteomic databases

EPDiQ19213
PaxDbiQ19213

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF08G12.4; F08G12.4; WBGene00006922
GeneIDi181321
KEGGicel:CELE_F08G12.4
UCSCiF08G12.4 c. elegans

Organism-specific databases

CTDi181321
WormBaseiF08G12.4 ; CE03169 ; WBGene00006922 ; vhl-1

Phylogenomic databases

eggNOGiKOG4710 Eukaryota
ENOG4111PRU LUCA
HOGENOMiHOG000021082
InParanoidiQ19213
KOiK03871
OMAiNHPWVAR
OrthoDBiEOG091G0NHA
PhylomeDBiQ19213

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

PROiPR:Q19213

Gene expression databases

BgeeiWBGene00006922 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

CDDicd05468 pVHL, 1 hit
Gene3Di2.60.40.780, 1 hit
InterProiView protein in InterPro
IPR002714 VHL
IPR024053 VHL_beta_dom
IPR037140 VHL_beta_dom_sf
IPR036208 VHL_sf
IPR022772 VHL_tumour_suppress_b/a_dom
PANTHERiPTHR15160:SF1 PTHR15160:SF1, 1 hit
PfamiView protein in Pfam
PF01847 VHL, 1 hit
SUPFAMiSSF49468 SSF49468, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVHL_CAEEL
AccessioniPrimary (citable) accession number: Q19213
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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