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Entry version 162 (17 Jun 2020)
Sequence version 5 (06 Feb 2013)
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Protein

A disintegrin and metalloproteinase with thrombospondin motifs adt-2

Gene

adt-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates body size probably independently of the TGF beta-like dbl-1 pathway. However, may regulate some dbl-1-mediated transcription. Plays a role in cuticle collagen fibril organization. Required for embryonic development.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi361Zinc; catalyticPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei362PROSITE-ProRule annotation1
Metal bindingi365Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi371Zinc; catalyticPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M12.A47

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs adt-2Curated (EC:3.4.24.-By similarity)
Short name:
ADAMTS adt-2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:adt-2Imported
Synonyms:sma-21Imported
ORF Names:F08C6.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
F08C6.1a ; CE48012 ; WBGene00000083 ; adt-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown causes a reduction in adult body length and width and a reduction in adult lifespan. The cuticle displays several defects including disruption of the lateral cuticle overlying the seam cells, abnormal constriction of the annuli, discontinuous alae and mislocalization of collagen col-19 positive fibrils. Prevents the up-regulation of a transcriptional reporter of the TGF beta-like dbl-1 pathway, RAD-SMAD.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi364G → S in wk156; reduced seam cell size, lifespan and reduced adult body length with increased body width. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000044090118 – 163Sequence analysisAdd BLAST146
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_5010117116164 – 1020A disintegrin and metalloproteinase with thrombospondin motifs adt-2Sequence analysisAdd BLAST857

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi54N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi70N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi376 ↔ 396PROSITE-ProRule annotation
Disulfide bondi714 ↔ 745PROSITE-ProRule annotation
Disulfide bondi718 ↔ 750PROSITE-ProRule annotation
Disulfide bondi729 ↔ 735PROSITE-ProRule annotation
Disulfide bondi769 ↔ 805PROSITE-ProRule annotation
Disulfide bondi773 ↔ 810PROSITE-ProRule annotation
Disulfide bondi784 ↔ 795PROSITE-ProRule annotation
Disulfide bondi825 ↔ 855PROSITE-ProRule annotation
Disulfide bondi829 ↔ 860PROSITE-ProRule annotation
Disulfide bondi840 ↔ 845PROSITE-ProRule annotation
Disulfide bondi875 ↔ 905PROSITE-ProRule annotation
Disulfide bondi879 ↔ 910PROSITE-ProRule annotation
Disulfide bondi890 ↔ 895PROSITE-ProRule annotation
Disulfide bondi927 ↔ 957PROSITE-ProRule annotation
Disulfide bondi931 ↔ 962PROSITE-ProRule annotation
Disulfide bondi942 ↔ 947PROSITE-ProRule annotation
Disulfide bondi978 ↔ 1009PROSITE-ProRule annotation
Disulfide bondi982 ↔ 1014PROSITE-ProRule annotation
Disulfide bondi993 ↔ 999PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q19204

PeptideAtlas

More...
PeptideAtlasi
Q19204

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression starts at the L1 larval stage in glial cells associated with amphid, phasmid, labial and posterior deirid sensory neurons and continues throughout adulthood. Expressed in vulva at the L4 larval stage and in adults.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000083 Expressed in multi-cellular organism and 3 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q19204 differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q19204, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F08C6.1a.2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini211 – 407Peptidase M12BPROSITE-ProRule annotationAdd BLAST197
Domaini431 – 529DisintegrinBy similarityAdd BLAST99
Domaini702 – 751TSP type-1 1PROSITE-ProRule annotationAdd BLAST50
Domaini757 – 811TSP type-1 2PROSITE-ProRule annotationAdd BLAST55
Domaini813 – 861TSP type-1 3PROSITE-ProRule annotationAdd BLAST49
Domaini863 – 911TSP type-1 4PROSITE-ProRule annotationAdd BLAST49
Domaini915 – 963TSP type-1 5PROSITE-ProRule annotationAdd BLAST49
Domaini966 – 1015TSP type-1 6PROSITE-ProRule annotationAdd BLAST50

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi174 – 181Cysteine switchBy similarity8

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.By similarity

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INCT Eukaryota
ENOG410Y8M9 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_296160_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q19204

Identification of Orthologs from Complete Genome Data

More...
OMAi
RVDKCGV

Database of Orthologous Groups

More...
OrthoDBi
211122at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 7 hits
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041645 ADAM_CR_2
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17771 ADAM_CR_2, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209 TSP1, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895 SSF82895, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50092 TSP1, 6 hits
PS00142 ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q19204-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLPLLISGL LFRNADAFLP FFNEDDLKYT FGVDTHAEVP NHEEIDPVPY
60 70 80 90 100
YHQNGSLHKL EFMAFNKKYN LSLEPTLAKL LSSGVTVVKK NEKKGGSLDF
110 120 130 140 150
GSTLDSCHYH HYGEKVYAAI SNCDGRIKGT VIDDGEIIVV HPFPDHHAHR
160 170 180 190 200
SKRATENGAH VVYKRETLAG EPKDFCGLDN VVTEESLVED ESAIFEDVFV
210 220 230 240 250
TGQRLTQQSD LIVELAVFVD ENLWRHFSSK HGGMADRKLQ DYTLTLLNNI
260 270 280 290 300
QIMYYQPTAS PPLTFRVIRY EVLTRQPSAL AGYLHNHGNA QMYLDRFCRY
310 320 330 340 350
QRNLAVRDWD HAIMLTGYDI HRGAGSRSIS GIARLDGMCD PWNTCTLAEG
360 370 380 390 400
LDFTSAFIGT HELGHSVGMR HDEPYCQSKH IMSSSLGPGK VTWSTCSLRD
410 420 430 440 450
YHQFLQRLDG RGKNCLRVSN MPNKLEISSN VKPGQIYDAN LQCELMHGNG
460 470 480 490 500
YQQVTPRQDS YDGICYMMWC GQSSFGRIIT SHPALEGTFC GPSKWCQLGR
510 520 530 540 550
CVPWTGTNEI QPTVQHVAPV VTTLPSRIDG SWSGWGATIC SQCTCNGILG
560 570 580 590 600
SVGLAIARRT CSAPYPANGG SDCVGSTSRA VLCSRQCGRA SKSVDEYISD
610 620 630 640 650
KCMEQKRLKN DRELTGKGSQ LNRFPQRACK VFCDVQQHYG SQRNYRFFGD
660 670 680 690 700
NLPDGTSCGY DRYCLDGECL ALNCNNNALI SRDQSCPTDT CPITDQSSSV
710 720 730 740 750
YRGQWGTWSL WTSCTATCGG GYRKRNRACS ITGQCEGNED ETEVCSSESC
760 770 780 790 800
PSVLRVGNEW STWTEWNHCS VSCGRGSQAR YRKCLSPHRT LAFDCPEKNI
810 820 830 840 850
EVRSCDNGPC NAIGVWGTWG GWSTCSTSCG PGTLVRQRTC NREPCDGSAH
860 870 880 890 900
ERRSCNVATC QNDGIWSLWN EWSDCSRVCG KGLRSRSRSC FGSGCMGASS
910 920 930 940 950
EQQFCNEQAC ASSSANDWGT WSGWSQCSVS CGAGVKRRTR TCRTGNCPGN
960 970 980 990 1000
YKESAICNDR DCENKNAAWG GWGYWSSCSE TCGDGVRKRV RKCYGSGNCD
1010 1020
GQQYEKQYCN LRVCDFRRKF
Length:1,020
Mass (Da):113,527
Last modified:February 6, 2013 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i232095EE5B98FAC7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z291Q7Z291_CAEEL
Peptidase M12B domain-containing pr...
adt-2 CELE_F08C6.1, F08C6.1
975Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7Z292Q7Z292_CAEEL
A disintegrin and metalloproteinase...
adt-2 CELE_F08C6.1, F08C6.1
125Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB072347 mRNA Translation: BAC41253.1
BX284606 Genomic DNA Translation: CCD67341.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T15976

NCBI Reference Sequences

More...
RefSeqi
NP_001024532.2, NM_001029361.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F08C6.1a.1; F08C6.1a.1; WBGene00000083
F08C6.1a.2; F08C6.1a.2; WBGene00000083

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
181022

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F08C6.1

UCSC genome browser

More...
UCSCi
F08C6.1a.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072347 mRNA Translation: BAC41253.1
BX284606 Genomic DNA Translation: CCD67341.2
PIRiT15976
RefSeqiNP_001024532.2, NM_001029361.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ19204, 2 interactors
STRINGi6239.F08C6.1a.2

Protein family/group databases

MEROPSiM12.A47

Proteomic databases

PaxDbiQ19204
PeptideAtlasiQ19204

Genome annotation databases

EnsemblMetazoaiF08C6.1a.1; F08C6.1a.1; WBGene00000083
F08C6.1a.2; F08C6.1a.2; WBGene00000083
GeneIDi181022
KEGGicel:CELE_F08C6.1
UCSCiF08C6.1a.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181022
WormBaseiF08C6.1a ; CE48012 ; WBGene00000083 ; adt-2

Phylogenomic databases

eggNOGiENOG410INCT Eukaryota
ENOG410Y8M9 LUCA
HOGENOMiCLU_296160_0_0_1
InParanoidiQ19204
OMAiRVDKCGV
OrthoDBi211122at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q19204

Gene expression databases

BgeeiWBGene00000083 Expressed in multi-cellular organism and 3 other tissues
ExpressionAtlasiQ19204 differential

Family and domain databases

Gene3Di2.20.100.10, 7 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR041645 ADAM_CR_2
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF17771 ADAM_CR_2, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 6 hits
SMARTiView protein in SMART
SM00209 TSP1, 6 hits
SUPFAMiSSF82895 SSF82895, 6 hits
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50092 TSP1, 6 hits
PS00142 ZINC_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADT2_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19204
Secondary accession number(s): Q8IU50
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2017
Last sequence update: February 6, 2013
Last modified: June 17, 2020
This is version 162 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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