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Protein

60S ribosomal protein L11-2

Gene

rpl-11.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.By similarity

Miscellaneous

There's a functional difference between the two L11-encoding proteins in C.elegans. rpl-11.1 plays a role in the germline whereas rpl-11.2 has a somatic function.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-CEL-1799339 SRP-dependent cotranslational protein targeting to membrane
R-CEL-72689 Formation of a pool of free 40S subunits
R-CEL-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-CEL-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-CEL-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L11-2Curated
Gene namesi
Name:rpl-11.2Imported
ORF Names:F07D10.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF07D10.1 ; CE07033 ; WBGene00004423 ; rpl-11.2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown results in a growth defect.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004369031 – 19660S ribosomal protein L11-2CuratedAdd BLAST196

Proteomic databases

EPDiQ19162
PaxDbiQ19162
PeptideAtlasiQ19162

Expressioni

Gene expression databases

BgeeiWBGene00004423

Interactioni

Subunit structurei

Component of the large ribosomal subunit.By similarity

Protein-protein interaction databases

DIPiDIP-26065N
IntActiQ19162, 3 interactors
STRINGi6239.F07D10.1.2

Structurei

3D structure databases

ProteinModelPortaliQ19162
SMRiQ19162
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal ribosomal protein uL5 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0397 Eukaryota
COG0094 LUCA
GeneTreeiENSGT00910000144211
HOGENOMiHOG000231312
InParanoidiQ19162
KOiK02868
OMAiEDTMAWF
OrthoDBiEOG091G0LSV
PhylomeDBiQ19162

Family and domain databases

Gene3Di3.30.1440.10, 1 hit
InterProiView protein in InterPro
IPR002132 Ribosomal_L5
IPR031309 Ribosomal_L5_C
IPR020929 Ribosomal_L5_CS
IPR022803 Ribosomal_L5_dom_sf
IPR031310 Ribosomal_L5_N
PANTHERiPTHR11994 PTHR11994, 1 hit
PfamiView protein in Pfam
PF00281 Ribosomal_L5, 1 hit
PF00673 Ribosomal_L5_C, 1 hit
PIRSFiPIRSF002161 Ribosomal_L5, 1 hit
SUPFAMiSSF55282 SSF55282, 1 hit
PROSITEiView protein in PROSITE
PS00358 RIBOSOMAL_L5, 1 hit

Sequencei

Sequence statusi: Complete.

Q19162-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDIEKQTEI REKKARNVMR ELKIQKLCLN ICVGESGDRL TRAAKVLEQL
60 70 80 90 100
TGQTPVFSKA RYTVRTFGIR RNEKIAVHCT VRGPKAEEIL EKGLKVKEYE
110 120 130 140 150
LYKENFSDTG NFGFGVQEHI DLGIKYDPSI GIYGMDFYVV LDRAGRRIAK
160 170 180 190
RRRAPGRVGP SHRVEREESI KWFQQKYDGI ILPPKPKVKR TFHRRR
Length:196
Mass (Da):22,776
Last modified:November 1, 1996 - v1
Checksum:iA5B397B6254FBD92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CCD61193.1
PIRiT29860
RefSeqiNP_508413.1, NM_076012.5
UniGeneiCel.38559

Genome annotation databases

EnsemblMetazoaiF07D10.1; F07D10.1; WBGene00004423
GeneIDi180535
KEGGicel:CELE_F07D10.1
UCSCiF07D10.1.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiRL112_CAEEL
AccessioniPrimary (citable) accession number: Q19162
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 6, 2016
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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