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Entry version 135 (17 Jun 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Aspartyl aminopeptidase

Gene

dnpp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Plays a role in membrane trafficking and is specifically involved in the recycling and degradation of endocytic cargo.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.1 Publication EC:3.4.11.21

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=13.58 mM for H-Asp-NHMec (at pH 7.5)1 Publication
  2. KM=8.854 mM for H-Glu-NHMec (at pH 7.5)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi92Zinc 1By similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei166SubstrateBy similarity1
    Metal bindingi263Zinc 1By similarity1
    Metal bindingi263Zinc 2By similarity1
    Binding sitei299SubstrateBy similarity1
    Metal bindingi300Zinc 2By similarity1
    Metal bindingi343Zinc 1By similarity1
    Binding sitei343SubstrateBy similarity1
    Binding sitei346SubstrateBy similarity1
    Binding sitei371SubstrateBy similarity1
    Binding sitei378SubstrateBy similarity1
    Metal bindingi437Zinc 2By similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
    LigandMetal-binding, Zinc

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    M18.002

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Aspartyl aminopeptidaseImported (EC:3.4.11.211 Publication)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:dnpp-1Imported
    ORF Names:F01F1.9Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

    Organism-specific databases

    WormBase

    More...
    WormBasei
    F01F1.9b ; CE01235 ; WBGene00017163 ; dnpp-1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Animals are viable. Suppresses the abnormal formation of intestinal vacuoles phenotype in mutants lacking the phospholipid-transporting ATPase tat-1 or its chaperone chat-1.1 Publication

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi92H → F in M3; results in loss of enzymatic activity; when associated with F-166 and F-437. 1 Publication1
    Mutagenesisi166H → F in M3; results in loss of enzymatic activity; when associated with F-92 and F-437. 1 Publication1
    Mutagenesisi331E → L in qx49; loss of enzymatic activity. 1 Publication1
    Mutagenesisi437H → F in M3; results in loss of enzymatic activity; when associated with F-92 and F-166. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001734531 – 470Aspartyl aminopeptidaseCuratedAdd BLAST470

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q19087

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q19087

    PeptideAtlas

    More...
    PeptideAtlasi
    Q19087

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q19087

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in various cell types and tissues including the pharynx, neurons, body wall muscle, intestine and vulva.1 Publication

    <p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

    Expressed from the embryonic stage to adulthood.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    WBGene00017163 Expressed in multi-cellular organism and 4 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q19087 differential

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Tetrahedron-shaped homododecamer built from six homodimers.

    By similarity

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Q19087
    With#Exp.IntAct
    itself3EBI-367822,EBI-367822

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    41044, 35 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q19087, 2 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    6239.F01F1.9

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q19087

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase M18 family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2596 Eukaryota
    COG1362 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_019532_2_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q19087

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GHAVHPN

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q19087

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.30.250.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001948 Peptidase_M18
    IPR023358 Peptidase_M18_dom2

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR28570 PTHR28570, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02127 Peptidase_M18, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00932 AMINO1PTASE

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    Q19087-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAAALKPSAP EIRKAAQEFI NYLNKAVTPF HATQEVKDRL LQAGFTELPE
    60 70 80 90 100
    SGHWDIQPTS KYFVTKNRSA ILAFAVGGSY KPGSGFSIVV GHTDSPCLRV
    110 120 130 140 150
    KPISHQKSDK FLQVGVSTYG GGIWRTWFDR DLSVAGLVIV KNGEKLQHKL
    160 170 180 190 200
    IDVKKPVLFI PNLAIHLETD RTTFKPNTET ELRPILETFA AAGINAPQKP
    210 220 230 240 250
    ESTGFADPRN ITNNHHPQFL GLIAKEAGCQ PEDIVDLDLY LYDTNKAAIV
    260 270 280 290 300
    GMEDEFISGA RLDNQVGTYT AISGLLESLT GESFKNDPQI RIAACFDNEE
    310 320 330 340 350
    VGSDSAMGAS SSFTEFVLRR LSAGGSTTAF EEAIGKSMLI SADQAHATHP
    360 370 380 390 400
    NYSAKHEENH RPAFHGGVVV KVNVNQRYAT TSTTHAALKQ VAFEAQVPLQ
    410 420 430 440 450
    VVVVRNDSPC GSTVGPILAT KLGLQTVDVG CPQLAMHSIR EFADTSSIYQ
    460 470
    ATTLYSTFYE RLSTVLSNMQ
    Length:470
    Mass (Da):51,157
    Last modified:November 1, 1996 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i839830EE2F60F13F
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A2K5ATU7A0A2K5ATU7_CAEEL
    Aspartyl aminopeptidase
    dnpp-1 CELE_F01F1.9, F01F1.9
    507Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    BX284603 Genomic DNA Translation: CCD65992.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T15946

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_498265.1, NM_065864.5

    Genome annotation databases

    Ensembl metazoan genome annotation project

    More...
    EnsemblMetazoai
    F01F1.9b.1; F01F1.9b.1; WBGene00017163

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    175822

    UCSC genome browser

    More...
    UCSCi
    F01F1.9 c. elegans

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BX284603 Genomic DNA Translation: CCD65992.1
    PIRiT15946
    RefSeqiNP_498265.1, NM_065864.5

    3D structure databases

    SMRiQ19087
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi41044, 35 interactors
    IntActiQ19087, 2 interactors
    STRINGi6239.F01F1.9

    Protein family/group databases

    MEROPSiM18.002

    Proteomic databases

    EPDiQ19087
    PaxDbiQ19087
    PeptideAtlasiQ19087
    PRIDEiQ19087

    Genome annotation databases

    EnsemblMetazoaiF01F1.9b.1; F01F1.9b.1; WBGene00017163
    GeneIDi175822
    UCSCiF01F1.9 c. elegans

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    175822
    WormBaseiF01F1.9b ; CE01235 ; WBGene00017163 ; dnpp-1

    Phylogenomic databases

    eggNOGiKOG2596 Eukaryota
    COG1362 LUCA
    HOGENOMiCLU_019532_2_0_1
    InParanoidiQ19087
    OMAiGHAVHPN
    PhylomeDBiQ19087

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:Q19087

    Gene expression databases

    BgeeiWBGene00017163 Expressed in multi-cellular organism and 4 other tissues
    ExpressionAtlasiQ19087 differential

    Family and domain databases

    Gene3Di2.30.250.10, 1 hit
    InterProiView protein in InterPro
    IPR001948 Peptidase_M18
    IPR023358 Peptidase_M18_dom2
    PANTHERiPTHR28570 PTHR28570, 1 hit
    PfamiView protein in Pfam
    PF02127 Peptidase_M18, 1 hit
    PRINTSiPR00932 AMINO1PTASE

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNPEP_CAEEL
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19087
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2001
    Last sequence update: November 1, 1996
    Last modified: June 17, 2020
    This is version 135 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    3. Peptidase families
      Classification of peptidase families and list of entries
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