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UniProtKB - Q19013 (GLS2_CAEEL)
Protein
Putative glutaminase 2
Gene
glna-2
Organism
Caenorhabditis elegans
Status
Functioni
Catalytic activityi
- EC:3.5.1.2
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 213 | SubstrateBy similarity | 1 | |
Binding sitei | 262 | SubstrateBy similarity | 1 | |
Binding sitei | 308 | SubstrateBy similarity | 1 | |
Binding sitei | 315 | SubstrateBy similarity | 1 | |
Binding sitei | 342 | SubstrateBy similarity | 1 | |
Binding sitei | 394 | SubstrateBy similarity | 1 | |
Binding sitei | 412 | Substrate; via amide nitrogenBy similarity | 1 |
GO - Molecular functioni
- glutaminase activity Source: GO_Central
GO - Biological processi
- glutamate biosynthetic process Source: GO_Central
- glutamine catabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
Reactomei | R-CEL-210500, Glutamate Neurotransmitter Release Cycle R-CEL-5628897, TP53 Regulates Metabolic Genes R-CEL-8964539, Glutamate and glutamine metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Putative glutaminase 2 (EC:3.5.1.2)Short name: GLS Alternative name(s): L-glutamine amidohydrolase |
Gene namesi | Name:glna-2 ORF Names:DH11.1 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | DH11.1a ; CE28902 ; WBGene00008435 ; glna-2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000110584 | 1 – 605 | Putative glutaminase 2Add BLAST | 605 |
Proteomic databases
EPDi | Q19013 |
PaxDbi | Q19013 |
PeptideAtlasi | Q19013 |
PRIDEi | Q19013 |
Expressioni
Gene expression databases
Bgeei | WBGene00008435, Expressed in material anatomical entity and 3 other tissues |
ExpressionAtlasi | Q19013, baseline and differential |
Interactioni
Protein-protein interaction databases
BioGRIDi | 39614, 1 interactor |
DIPi | DIP-59881N |
IntActi | Q19013, 1 interactor |
STRINGi | 6239.DH11.1.2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 480 – 509 | ANK 1Add BLAST | 30 | |
Repeati | 513 – 543 | ANK 2Add BLAST | 31 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 569 – 605 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 569 – 585 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the glutaminase family.Curated
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0506, Eukaryota |
GeneTreei | ENSGT00390000010463 |
HOGENOMi | CLU_016439_1_0_1 |
InParanoidi | Q19013 |
OMAi | MAGNEFM |
OrthoDBi | 349094at2759 |
PhylomeDBi | Q19013 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 3.40.710.10, 1 hit |
HAMAPi | MF_00313, Glutaminase, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR012338, Beta-lactam/transpept-like IPR015868, Glutaminase IPR041541, Glutaminase_EF-hand |
PANTHERi | PTHR12544, PTHR12544, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF17959, EF-hand_14, 1 hit PF04960, Glutaminase, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF56601, SSF56601, 1 hit |
TIGRFAMsi | TIGR03814, Gln_ase, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q19013-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSKPTTQKS VMYRIPSERT LESLHEMIGS RMSKMSLKNT LRGISNPYER
60 70 80 90 100
DENEGSEDMI FELFKIPNKN EASIGKLLTV LRQLGLRDDD PRLVPMMEKI
110 120 130 140 150
KDFEKIAEEK CSEATEQKHW KLTKEQFKEC IAPSIDIVSR ALQTDMVIPN
160 170 180 190 200
WVTFVDQIRT LFNECKEIRE GQVATYIPQL ARQSPNLWAV SLCTVDGQRA
210 220 230 240 250
SFGDVKHPFC VQSVSKAFNY AIVASDLGAD VVHSYVGQEP SGRLFNEICL
260 270 280 290 300
DSTNKPHNPM VNSGAIVITS LIKSKTNMAD RFDFVLNQYR KIAGNEFIGF
310 320 330 340 350
NNATFLSERA TADRNYALSY FMKENRCFPK ETESLTDALD FYFQLCSVEV
360 370 380 390 400
TCESLAVMAS TLANGGVCPI TNETCVDPNP CRDVLSLMYS CGMYDASGQF
410 420 430 440 450
SFNVGLPAKS GVSGAMIVVV PNVMGICLFS PPLDSLGNSC RGVAFCKKLV
460 470 480 490 500
STFNFHNYDC LVHNSNIKSD PRRRDIRERD RLIPVFHVAR AGDLPTMRRL
510 520 530 540 550
YMQGEDLNTS DHDDRTVLHI AATEGYETMI KFLVNVAKVD VDKKDRWGRT
560 570 580 590 600
PLDEAKFFKH DHVSRFLEKA MKRPEQHRKD SVSSLDTDDE IDDDGFPEKP
SFTID
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0S4XRA9 | A0A0S4XRA9_CAEEL | Glutaminase | glna-2 CELE_DH11.1, DH11.1 | 190 | Annotation score: | ||
A0A0S4XRH7 | A0A0S4XRH7_CAEEL | Glutaminase | glna-2 CELE_DH11.1, DH11.1 | 346 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49126 Genomic DNA Translation: CAA88938.2 |
PIRi | T20384 |
RefSeqi | NP_495675.1, NM_063274.3 |
Genome annotation databases
EnsemblMetazoai | DH11.1a.1; DH11.1a.1; WBGene00008435 DH11.1a.2; DH11.1a.2; WBGene00008435 |
GeneIDi | 174282 |
KEGGi | cel:CELE_DH11.1 |
UCSCi | DH11.1.1, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49126 Genomic DNA Translation: CAA88938.2 |
PIRi | T20384 |
RefSeqi | NP_495675.1, NM_063274.3 |
3D structure databases
AlphaFoldDBi | Q19013 |
SMRi | Q19013 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 39614, 1 interactor |
DIPi | DIP-59881N |
IntActi | Q19013, 1 interactor |
STRINGi | 6239.DH11.1.2 |
Proteomic databases
EPDi | Q19013 |
PaxDbi | Q19013 |
PeptideAtlasi | Q19013 |
PRIDEi | Q19013 |
Genome annotation databases
EnsemblMetazoai | DH11.1a.1; DH11.1a.1; WBGene00008435 DH11.1a.2; DH11.1a.2; WBGene00008435 |
GeneIDi | 174282 |
KEGGi | cel:CELE_DH11.1 |
UCSCi | DH11.1.1, c. elegans |
Organism-specific databases
CTDi | 174282 |
WormBasei | DH11.1a ; CE28902 ; WBGene00008435 ; glna-2 |
Phylogenomic databases
eggNOGi | KOG0506, Eukaryota |
GeneTreei | ENSGT00390000010463 |
HOGENOMi | CLU_016439_1_0_1 |
InParanoidi | Q19013 |
OMAi | MAGNEFM |
OrthoDBi | 349094at2759 |
PhylomeDBi | Q19013 |
Enzyme and pathway databases
Reactomei | R-CEL-210500, Glutamate Neurotransmitter Release Cycle R-CEL-5628897, TP53 Regulates Metabolic Genes R-CEL-8964539, Glutamate and glutamine metabolism |
Miscellaneous databases
PROi | PR:Q19013 |
Gene expression databases
Bgeei | WBGene00008435, Expressed in material anatomical entity and 3 other tissues |
ExpressionAtlasi | Q19013, baseline and differential |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 3.40.710.10, 1 hit |
HAMAPi | MF_00313, Glutaminase, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR012338, Beta-lactam/transpept-like IPR015868, Glutaminase IPR041541, Glutaminase_EF-hand |
PANTHERi | PTHR12544, PTHR12544, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF17959, EF-hand_14, 1 hit PF04960, Glutaminase, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF56601, SSF56601, 1 hit |
TIGRFAMsi | TIGR03814, Gln_ase, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GLS2_CAEEL | |
Accessioni | Q19013Primary (citable) accession number: Q19013 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | December 19, 2001 | |
Last modified: | May 25, 2022 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families