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Entry version 147 (02 Dec 2020)
Sequence version 2 (19 Dec 2001)
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Protein

Putative glutaminase 2

Gene

glna-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei213SubstrateBy similarity1
Binding sitei262SubstrateBy similarity1
Binding sitei308SubstrateBy similarity1
Binding sitei315SubstrateBy similarity1
Binding sitei342SubstrateBy similarity1
Binding sitei394SubstrateBy similarity1
Binding sitei412Substrate; via amide nitrogenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • glutaminase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-210500, Glutamate Neurotransmitter Release Cycle
R-CEL-5628897, TP53 Regulates Metabolic Genes
R-CEL-8964539, Glutamate and glutamine metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative glutaminase 2 (EC:3.5.1.2)
Short name:
GLS
Alternative name(s):
L-glutamine amidohydrolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:glna-2
ORF Names:DH11.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
DH11.1a ; CE28902 ; WBGene00008435 ; glna-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001105841 – 605Putative glutaminase 2Add BLAST605

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q19013

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q19013

PeptideAtlas

More...
PeptideAtlasi
Q19013

PRoteomics IDEntifications database

More...
PRIDEi
Q19013

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00008435, Expressed in material anatomical entity and 3 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q19013, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-59881N

Protein interaction database and analysis system

More...
IntActi
Q19013, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.DH11.1.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q19013

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati480 – 509ANK 1Add BLAST30
Repeati513 – 543ANK 2Add BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glutaminase family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0506, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010463

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016439_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q19013

Identification of Orthologs from Complete Genome Data

More...
OMAi
MAGNEFM

Database of Orthologous Groups

More...
OrthoDBi
349094at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q19013

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
3.40.710.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00313, Glutaminase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR012338, Beta-lactam/transpept-like
IPR015868, Glutaminase
IPR041541, Glutaminase_EF-hand

The PANTHER Classification System

More...
PANTHERi
PTHR12544, PTHR12544, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF17959, EF-hand_14, 1 hit
PF04960, Glutaminase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF56601, SSF56601, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03814, Gln_ase, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q19013-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSKPTTQKS VMYRIPSERT LESLHEMIGS RMSKMSLKNT LRGISNPYER
60 70 80 90 100
DENEGSEDMI FELFKIPNKN EASIGKLLTV LRQLGLRDDD PRLVPMMEKI
110 120 130 140 150
KDFEKIAEEK CSEATEQKHW KLTKEQFKEC IAPSIDIVSR ALQTDMVIPN
160 170 180 190 200
WVTFVDQIRT LFNECKEIRE GQVATYIPQL ARQSPNLWAV SLCTVDGQRA
210 220 230 240 250
SFGDVKHPFC VQSVSKAFNY AIVASDLGAD VVHSYVGQEP SGRLFNEICL
260 270 280 290 300
DSTNKPHNPM VNSGAIVITS LIKSKTNMAD RFDFVLNQYR KIAGNEFIGF
310 320 330 340 350
NNATFLSERA TADRNYALSY FMKENRCFPK ETESLTDALD FYFQLCSVEV
360 370 380 390 400
TCESLAVMAS TLANGGVCPI TNETCVDPNP CRDVLSLMYS CGMYDASGQF
410 420 430 440 450
SFNVGLPAKS GVSGAMIVVV PNVMGICLFS PPLDSLGNSC RGVAFCKKLV
460 470 480 490 500
STFNFHNYDC LVHNSNIKSD PRRRDIRERD RLIPVFHVAR AGDLPTMRRL
510 520 530 540 550
YMQGEDLNTS DHDDRTVLHI AATEGYETMI KFLVNVAKVD VDKKDRWGRT
560 570 580 590 600
PLDEAKFFKH DHVSRFLEKA MKRPEQHRKD SVSSLDTDDE IDDDGFPEKP

SFTID
Length:605
Mass (Da):68,336
Last modified:December 19, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFBD8149DA535279
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0S4XRA9A0A0S4XRA9_CAEEL
Glutaminase
glna-2 CELE_DH11.1, DH11.1
190Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0S4XRH7A0A0S4XRH7_CAEEL
Glutaminase
glna-2 CELE_DH11.1, DH11.1
346Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z49126 Genomic DNA Translation: CAA88938.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T20384

NCBI Reference Sequences

More...
RefSeqi
NP_495675.1, NM_063274.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
DH11.1a.1; DH11.1a.1; WBGene00008435
DH11.1a.2; DH11.1a.2; WBGene00008435

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174282

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_DH11.1

UCSC genome browser

More...
UCSCi
DH11.1.1, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49126 Genomic DNA Translation: CAA88938.2
PIRiT20384
RefSeqiNP_495675.1, NM_063274.3

3D structure databases

SMRiQ19013
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-59881N
IntActiQ19013, 1 interactor
STRINGi6239.DH11.1.2

Proteomic databases

EPDiQ19013
PaxDbiQ19013
PeptideAtlasiQ19013
PRIDEiQ19013

Genome annotation databases

EnsemblMetazoaiDH11.1a.1; DH11.1a.1; WBGene00008435
DH11.1a.2; DH11.1a.2; WBGene00008435
GeneIDi174282
KEGGicel:CELE_DH11.1
UCSCiDH11.1.1, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174282
WormBaseiDH11.1a ; CE28902 ; WBGene00008435 ; glna-2

Phylogenomic databases

eggNOGiKOG0506, Eukaryota
GeneTreeiENSGT00390000010463
HOGENOMiCLU_016439_1_0_1
InParanoidiQ19013
OMAiMAGNEFM
OrthoDBi349094at2759
PhylomeDBiQ19013

Enzyme and pathway databases

ReactomeiR-CEL-210500, Glutamate Neurotransmitter Release Cycle
R-CEL-5628897, TP53 Regulates Metabolic Genes
R-CEL-8964539, Glutamate and glutamine metabolism

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q19013

Gene expression databases

BgeeiWBGene00008435, Expressed in material anatomical entity and 3 other tissues
ExpressionAtlasiQ19013, baseline and differential

Family and domain databases

Gene3Di1.25.40.20, 1 hit
3.40.710.10, 1 hit
HAMAPiMF_00313, Glutaminase, 1 hit
InterProiView protein in InterPro
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR012338, Beta-lactam/transpept-like
IPR015868, Glutaminase
IPR041541, Glutaminase_EF-hand
PANTHERiPTHR12544, PTHR12544, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF17959, EF-hand_14, 1 hit
PF04960, Glutaminase, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF56601, SSF56601, 1 hit
TIGRFAMsiTIGR03814, Gln_ase, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLS2_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19013
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 19, 2001
Last modified: December 2, 2020
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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