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UniProtKB - Q19000 (BODG_CAEEL)
Protein
Probable gamma-butyrobetaine dioxygenase
Gene
gbh-1
Organism
Caenorhabditis elegans
Status
Functioni
Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
By similarityCatalytic activityi
- EC:1.14.11.1
Cofactori
Protein has several cofactor binding sites:- Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity
- L-ascorbateBy similarity
: carnitine biosynthesis Pathwayi
This protein is involved in the pathway carnitine biosynthesis, which is part of Amine and polyamine biosynthesis.View all proteins of this organism that are known to be involved in the pathway carnitine biosynthesis and in Amine and polyamine biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 222 | Iron; catalyticBy similarity | 1 | |
Metal bindingi | 224 | Iron; catalyticBy similarity | 1 | |
Metal bindingi | 376 | Iron; catalyticBy similarity | 1 |
GO - Molecular functioni
- gamma-butyrobetaine dioxygenase activity Source: UniProtKB-EC
- iron ion binding Source: InterPro
GO - Biological processi
- carnitine biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Dioxygenase, Oxidoreductase |
Biological process | Carnitine biosynthesis |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
Reactomei | R-CEL-71262, Carnitine synthesis |
UniPathwayi | UPA00118 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable gamma-butyrobetaine dioxygenase (EC:1.14.11.1)Alternative name(s): Gamma-butyrobetaine hydroxylase Short name: Gamma-BBH Gamma-butyrobetaine,2-oxoglutarate dioxygenase |
Gene namesi | Name:gbh-1 ORF Names:D2089.5 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | D2089.5 ; CE00940 ; WBGene00001522 ; gbh-1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000207088 | 1 – 421 | Probable gamma-butyrobetaine dioxygenaseAdd BLAST | 421 |
Proteomic databases
EPDi | Q19000 |
PaxDbi | Q19000 |
PeptideAtlasi | Q19000 |
PRIDEi | Q19000 |
Expressioni
Gene expression databases
Bgeei | WBGene00001522, Expressed in multi-cellular organism and 5 other tissues |
Family & Domainsi
Sequence similaritiesi
Belongs to the gamma-BBH/TMLD family.Curated
Phylogenomic databases
eggNOGi | KOG3888, Eukaryota |
GeneTreei | ENSGT00530000063582 |
HOGENOMi | CLU_021859_2_0_1 |
InParanoidi | Q19000 |
OMAi | SVNILHC |
OrthoDBi | 868657at2759 |
PhylomeDBi | Q19000 |
Family and domain databases
Gene3Di | 3.30.2020.30, 1 hit 3.60.130.10, 1 hit |
InterProi | View protein in InterPro IPR012775, GBBH IPR038492, GBBH-like_N_sf IPR042098, TauD-like_sf IPR003819, TauD/TfdA-like |
Pfami | View protein in Pfam PF02668, TauD, 1 hit |
TIGRFAMsi | TIGR02409, carnitine_bodg, 1 hit |
i Sequence
Sequence statusi: Complete.
Q19000-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSALLIRNI RNASKLASVA GPNSDRIVNV KWSDGKTGVF PLIWLRDTSP
60 70 80 90 100
DPSTYTISPA MTARKLTMLE FDVEQNARKL WIDEDANCLK IEWESGVLSE
110 120 130 140 150
FPSEWLKIRN PSDQEARRRR RKVYLFPEQT WGKAEIEGKL KKFSHEEFMK
160 170 180 190 200
NEQVVHDFLQ AVCIDGIAVL KGAPQGVRGA VEAIGDRIGM IKRTHFGLVF
210 220 230 240 250
EVSLKADASN MAYASNGGLP FHTDFPSLSH PPQLQMLHML QSAEEGGHSL
260 270 280 290 300
FVDGFHVAEQ LRVEKPEIFK ILTTQSMEYI EEGYDVHEIN GKTIRFDYDM
310 320 330 340 350
CARHKVIRLN DDGKVNKIQF GNAMRSWFYD CEPSKVQDVY RAMKTFTEYC
360 370 380 390 400
YQPRNMLKFR LEDGDTVLWA NQRLLHTRDG FRNAPEKART LTGCYFDWDI
410 420
VKSRVRFLRD KLSLEQNQPS A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z36948 Genomic DNA Translation: CAA85412.1 |
PIRi | T20380 |
RefSeqi | NP_496305.1, NM_063904.6 |
Genome annotation databases
EnsemblMetazoai | D2089.5.1; D2089.5.1; WBGene00001522 |
GeneIDi | 174648 |
KEGGi | cel:CELE_D2089.5 |
UCSCi | D2089.5, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z36948 Genomic DNA Translation: CAA85412.1 |
PIRi | T20380 |
RefSeqi | NP_496305.1, NM_063904.6 |
3D structure databases
AlphaFoldDBi | Q19000 |
SMRi | Q19000 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 6239.D2089.5 |
Proteomic databases
EPDi | Q19000 |
PaxDbi | Q19000 |
PeptideAtlasi | Q19000 |
PRIDEi | Q19000 |
Genome annotation databases
EnsemblMetazoai | D2089.5.1; D2089.5.1; WBGene00001522 |
GeneIDi | 174648 |
KEGGi | cel:CELE_D2089.5 |
UCSCi | D2089.5, c. elegans |
Organism-specific databases
CTDi | 174648 |
WormBasei | D2089.5 ; CE00940 ; WBGene00001522 ; gbh-1 |
Phylogenomic databases
eggNOGi | KOG3888, Eukaryota |
GeneTreei | ENSGT00530000063582 |
HOGENOMi | CLU_021859_2_0_1 |
InParanoidi | Q19000 |
OMAi | SVNILHC |
OrthoDBi | 868657at2759 |
PhylomeDBi | Q19000 |
Enzyme and pathway databases
UniPathwayi | UPA00118 |
Reactomei | R-CEL-71262, Carnitine synthesis |
Miscellaneous databases
PROi | PR:Q19000 |
Gene expression databases
Bgeei | WBGene00001522, Expressed in multi-cellular organism and 5 other tissues |
Family and domain databases
Gene3Di | 3.30.2020.30, 1 hit 3.60.130.10, 1 hit |
InterProi | View protein in InterPro IPR012775, GBBH IPR038492, GBBH-like_N_sf IPR042098, TauD-like_sf IPR003819, TauD/TfdA-like |
Pfami | View protein in Pfam PF02668, TauD, 1 hit |
TIGRFAMsi | TIGR02409, carnitine_bodg, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BODG_CAEEL | |
Accessioni | Q19000Primary (citable) accession number: Q19000 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families