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UniProtKB - Q18PE1 (DOK7_HUMAN)

Protein

Protein Dok-7

Gene

DOK7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.1 Publication

GO - Molecular functioni

  • lipid binding Source: UniProtKB-KW
  • protein kinase binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

LigandLipid-binding

Enzyme and pathway databases

SignaLinkiQ18PE1
SIGNORiQ18PE1

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Dok-7
Alternative name(s):
Downstream of tyrosine kinase 7
Gene namesi
Name:DOK7
Synonyms:C4orf25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000175920.15
HGNCiHGNC:26594 DOK7
MIMi610285 gene
neXtProtiNX_Q18PE1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Myasthenic syndrome, congenital, 10 (CMS10)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS10 is an autosomal recessive, post-synaptic form characterized by a typical 'limb girdle' pattern of muscle weakness with small, simplified neuromuscular junctions but normal acetylcholine receptor and acetylcholinesterase function.
See also OMIM:254300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0687503E → K in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs763233743Ensembl.1
Natural variantiVAR_06875131P → T in CMS10; results in a significant reduction of AChR clusters. 1 Publication1
Natural variantiVAR_06875233A → V in CMS10; results in reduced stimulation of MUSK autophosphorylation. 2 Publications1
Natural variantiVAR_06875477T → M in CMS10; results in a decrease of branched, c-shaped and perforated AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs940346413Ensembl.1
Natural variantiVAR_068756109G → C in CMS10; results in a significant reduction of AChR clusters. 1 Publication1
Natural variantiVAR_068757116V → M in CMS10. 1 Publication1
Natural variantiVAR_068758132H → Q in CMS10. 1 Publication1
Natural variantiVAR_068759139V → L in CMS10; results in a significant reduction of AChR clusters. 1 Publication1
Natural variantiVAR_068760146P → L in CMS10. 1 PublicationCorresponds to variant dbSNP:rs770987150EnsemblClinVar.1
Natural variantiVAR_068761157L → R in CMS10. 1 Publication1
Natural variantiVAR_031246158R → Q in CMS10; reduced stimulation of MUSK autophosphorylation when associated with A-174; results in a significant reduction of AChR clusters. 2 PublicationsCorresponds to variant dbSNP:rs6811423EnsemblClinVar.1
Natural variantiVAR_068762161G → R in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs758131044EnsemblClinVar.1
Natural variantiVAR_068763166G → R in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs781227659Ensembl.1
Natural variantiVAR_068764171G → D in CMS10; results in a significant reduction of AChR clusters. 1 Publication1
Natural variantiVAR_068765171G → R in CMS10. 1 Publication1
Natural variantiVAR_068766172G → R in CMS10. 1 PublicationCorresponds to variant dbSNP:rs768892432EnsemblClinVar.1
Natural variantiVAR_027544180G → A in CMS10; results in a significant reduction of AChR clusters. 2 PublicationsCorresponds to variant dbSNP:rs118203994EnsemblClinVar.1
Natural variantiVAR_068767180G → V in CMS10. 1 Publication1
Natural variantiVAR_068773469P → H in CMS10. 1 PublicationCorresponds to variant dbSNP:rs147185207EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi30S → W: Reduced stimulation of MUSK autophosphorylation. 1 Publication1
Mutagenesisi32V → A: Reduced stimulation of MUSK autophosphorylation. 1 Publication1
Mutagenesisi174R → A: Reduced stimulation of MUSK autophosphorylation; when associated with Q-158. 1 Publication1

Keywords - Diseasei

Congenital myasthenic syndrome, Disease mutation

Organism-specific databases

DisGeNETi285489
GeneReviewsiDOK7
MalaCardsiDOK7
MIMi254300 phenotype
OpenTargetsiENSG00000175920
Orphaneti994 Fetal akinesia deformation sequence
98913 Postsynaptic congenital myasthenic syndromes
PharmGKBiPA162384035

Polymorphism and mutation databases

BioMutaiDOK7
DMDMi115311705

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002503711 – 504Protein Dok-7Add BLAST504

Proteomic databases

PaxDbiQ18PE1
PeptideAtlasiQ18PE1
PRIDEiQ18PE1
ProteomicsDBi61176
61177 [Q18PE1-2]
61178 [Q18PE1-3]

PTM databases

iPTMnetiQ18PE1
PhosphoSitePlusiQ18PE1

Expressioni

Tissue specificityi

Preferentially expressed in skeletal muscle and heart. Present in thigh muscle, diaphragm and heart but not in the liver or spleen (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000175920 Expressed in 123 organ(s), highest expression level in heart left ventricle
CleanExiHS_DOK7
ExpressionAtlasiQ18PE1 baseline and differential
GenevisibleiQ18PE1 HS

Organism-specific databases

HPAiHPA059449
HPA062780

Interactioni

Subunit structurei

Homodimer (By similarity). Forms a heterotetramer composed of 2 DOK7 and 2 MUSK molecules which facilitates MUSK trans-autophosphorylation on tyrosine residue and activation (By similarity). Interacts (via IRS-type PTB domain) with MUSK (via cytoplasmic part); requires MUSK phosphorylation.By similarity1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi130124, 6 interactors
IntActiQ18PE1, 5 interactors
STRINGi9606.ENSP00000344432

Structurei

3D structure databases

ProteinModelPortaliQ18PE1
SMRiQ18PE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 109PHPROSITE-ProRule annotationAdd BLAST106
Domaini105 – 210IRS-type PTBPROSITE-ProRule annotationAdd BLAST106

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi262 – 359Ser-richAdd BLAST98

Domaini

The PH domain mediated binding to phospholipids with phosphoinositol headgroups. Affinity is highest for phosphatidyl 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate (By similarity).By similarity

Phylogenomic databases

eggNOGiENOG410IHI2 Eukaryota
ENOG4111MP1 LUCA
GeneTreeiENSGT00390000015386
HOGENOMiHOG000230953
HOVERGENiHBG080009
InParanoidiQ18PE1
OMAiEYQVPSS
OrthoDBiEOG091G064P
PhylomeDBiQ18PE1
TreeFamiTF332288

Family and domain databases

CDDicd14677 PH_DOK7, 1 hit
cd13165 PTB_DOK7, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR037746 Dok-7
IPR037747 Dok-7_PH
IPR037748 Dok-7_PTB
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR21636 PTHR21636, 1 hit
PfamiView protein in Pfam
PF02174 IRS, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q18PE1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTEAALVEGQ VKLRDGKKWK SRWLVLRKPS PVADCLLMLV YKDKSERIKG 
        60         70         80         90        100
LRERSSLTLE DICGLEPGLP YEGLVHTLAI VCLSQAIMLG FDSHEAMCAW 
       110        120        130        140        150
DARIRYALGE VHRFHVTVAP GTKLESGPAT LHLCNDVLVL ARDIPPAVTG 
       160        170        180        190        200
QWKLSDLRRY GAVPSGFIFE GGTRCGYWAG VFFLSSAEGE QISFLFDCIV 
       210        220        230        240        250
RGISPTKGPF GLRPVLPDPS PPGPSTVEER VAQEALETLQ LEKRLSLLSH 
       260        270        280        290        300
AGRPGSGGDD RSLSSSSSEA SHLDVSASSR LTAWPEQSSS SASTSQEGPR 
       310        320        330        340        350
PAAAQAAGEA MVGASRPPPK PLRPRQLQEV GRQSSSDSGI ATGSHSSYSS 
       360        370        380        390        400
SLSSYAGSSL DVWRATDELG SLLSLPAAGA PEPSLCTCLP GTVEYQVPTS 
       410        420        430        440        450
LRAHYDTPRS LCLAPRDHSP PSQGSPGNSA ARDSGGQTSA GCPSGWLGTR 
       460        470        480        490        500
RRGLVMEAPQ GSEATLPGPA PGEPWEAGGP HAGPPPAFFS ACPVCGGLKV 

NPPP
Length:504
Mass (Da):53,097
Last modified:July 25, 2006 - v1
Checksum:i54750E0B0BC33317
GO
Isoform 2 (identifier: Q18PE1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.
     139-178: VLARDIPPAV...FEGGTRCGYW → MMSSSWPGTS...ADSSLKAGPG

Note: No experimental confirmation available.
Show »
Length:366
Mass (Da):37,161
Checksum:i8CFC71602C970AC3
GO
Isoform 4 (identifier: Q18PE1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-255: CGYWAGVFFL...SLLSHAGRPG → GWRLLPVLGR...TCGQAGQWRG
     256-504: Missing.

Note: No experimental confirmation available.
Show »
Length:255
Mass (Da):27,514
Checksum:i098963FABA4A7185
GO
Isoform 3 (identifier: Q18PE1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     500-504: VNPPP → GAAASAPGPA...ELEQRKAAPQ

Note: No experimental confirmation available.
Show »
Length:608
Mass (Da):63,938
Checksum:i384FFACAA0AD8359
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PRA3A0A1W2PRA3_HUMAN
Protein Dok-7
DOK7
194Annotation score:
A0A2R8Y701A0A2R8Y701_HUMAN
Protein Dok-7
DOK7
464Annotation score:

Sequence cautioni

The sequence BAC11367 differs from that shown. Contains a poly-A tail in the 5'region.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0687503E → K in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs763233743Ensembl.1
Natural variantiVAR_06875131P → T in CMS10; results in a significant reduction of AChR clusters. 1 Publication1
Natural variantiVAR_06875233A → V in CMS10; results in reduced stimulation of MUSK autophosphorylation. 2 Publications1
Natural variantiVAR_06875345S → L Does not affect AChR clusters number or complexity. 2 PublicationsCorresponds to variant dbSNP:rs62272670EnsemblClinVar.1
Natural variantiVAR_06875477T → M in CMS10; results in a decrease of branched, c-shaped and perforated AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs940346413Ensembl.1
Natural variantiVAR_06875599A → V1 PublicationCorresponds to variant dbSNP:rs138010842EnsemblClinVar.1
Natural variantiVAR_068756109G → C in CMS10; results in a significant reduction of AChR clusters. 1 Publication1
Natural variantiVAR_068757116V → M in CMS10. 1 Publication1
Natural variantiVAR_068758132H → Q in CMS10. 1 Publication1
Natural variantiVAR_068759139V → L in CMS10; results in a significant reduction of AChR clusters. 1 Publication1
Natural variantiVAR_068760146P → L in CMS10. 1 PublicationCorresponds to variant dbSNP:rs770987150EnsemblClinVar.1
Natural variantiVAR_068761157L → R in CMS10. 1 Publication1
Natural variantiVAR_031246158R → Q in CMS10; reduced stimulation of MUSK autophosphorylation when associated with A-174; results in a significant reduction of AChR clusters. 2 PublicationsCorresponds to variant dbSNP:rs6811423EnsemblClinVar.1
Natural variantiVAR_068762161G → R in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs758131044EnsemblClinVar.1
Natural variantiVAR_068763166G → R in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs781227659Ensembl.1
Natural variantiVAR_068764171G → D in CMS10; results in a significant reduction of AChR clusters. 1 Publication1
Natural variantiVAR_068765171G → R in CMS10. 1 Publication1
Natural variantiVAR_068766172G → R in CMS10. 1 PublicationCorresponds to variant dbSNP:rs768892432EnsemblClinVar.1
Natural variantiVAR_027544180G → A in CMS10; results in a significant reduction of AChR clusters. 2 PublicationsCorresponds to variant dbSNP:rs118203994EnsemblClinVar.1
Natural variantiVAR_068767180G → V in CMS10. 1 Publication1
Natural variantiVAR_027545197D → N1 PublicationCorresponds to variant dbSNP:rs16844422EnsemblClinVar.1
Natural variantiVAR_027546261R → H1 PublicationCorresponds to variant dbSNP:rs16844460EnsemblClinVar.1
Natural variantiVAR_068768272H → Q1 PublicationCorresponds to variant dbSNP:rs115614731Ensembl.1
Natural variantiVAR_027547296Q → R2 PublicationsCorresponds to variant dbSNP:rs6811423EnsemblClinVar.1
Natural variantiVAR_068769323R → C1 PublicationCorresponds to variant dbSNP:rs150728781EnsemblClinVar.1
Natural variantiVAR_050508379G → R. Corresponds to variant dbSNP:rs6831659Ensembl.1
Natural variantiVAR_068770382E → K1 PublicationCorresponds to variant dbSNP:rs560463670EnsemblClinVar.1
Natural variantiVAR_068771402R → Q1 PublicationCorresponds to variant dbSNP:rs370039804Ensembl.1
Natural variantiVAR_027548415P → S1 PublicationCorresponds to variant dbSNP:rs16844464EnsemblClinVar.1
Natural variantiVAR_027549427G → D. Corresponds to variant dbSNP:rs2020433Ensembl.1
Natural variantiVAR_068772440A → T1 PublicationCorresponds to variant dbSNP:rs753026831Ensembl.1
Natural variantiVAR_027550451R → W1 PublicationCorresponds to variant dbSNP:rs16844470EnsemblClinVar.1
Natural variantiVAR_027551461G → D3 PublicationsCorresponds to variant dbSNP:rs9684786EnsemblClinVar.1
Natural variantiVAR_068773469P → H in CMS10. 1 PublicationCorresponds to variant dbSNP:rs147185207EnsemblClinVar.1
Natural variantiVAR_068774503P → T1 PublicationCorresponds to variant dbSNP:rs184556570EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0206331 – 138Missing in isoform 2. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_020634139 – 178VLARD…RCGYW → MMSSSWPGTSPRLSRGSGSC LTSGATGPCQADSSLKAGPG in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_047252175 – 255CGYWA…AGRPG → GWRLLPVLGRGGADQLPVRL HRPRHLPHQGPLWAAAGSTR PKSPGTLDCGGACGPGSPGN PTAGEAAEPPLTCGQAGQWR G in isoform 4. CuratedAdd BLAST81
Alternative sequenceiVSP_047253256 – 504Missing in isoform 4. CuratedAdd BLAST249
Alternative sequenceiVSP_020635500 – 504VNPPP → GAAASAPGPATAHSGSPGPV AVDSPGPERPRGESPTYVNI PVSPSSRKQLHYMGLELQEA SEGVRGAGASLYAQIDIMAT ETAHRVGVRHARAREEQLSE LEQRKAAPQ in isoform 3. Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB220918 mRNA Translation: BAE96739.1
AK075037 mRNA Translation: BAC11367.1 Sequence problems.
AK091037 mRNA Translation: BAC03572.1
AL590235 Genomic DNA No translation available.
BC043568 mRNA Translation: AAH43568.1
BC062369 mRNA Translation: AAH62369.1
BC131544 mRNA Translation: AAI31545.1
BC141852 mRNA Translation: AAI41853.1
CCDSiCCDS3370.2 [Q18PE1-1]
CCDS54717.1 [Q18PE1-4]
RefSeqiNP_001158145.1, NM_001164673.1 [Q18PE1-4]
NP_001243825.1, NM_001256896.1
NP_001288000.1, NM_001301071.1 [Q18PE1-3]
NP_775931.3, NM_173660.4 [Q18PE1-1]
UniGeneiHs.122110
Hs.701584

Genome annotation databases

EnsembliENST00000340083; ENSP00000344432; ENSG00000175920 [Q18PE1-1]
ENST00000507039; ENSP00000423614; ENSG00000175920 [Q18PE1-4]
GeneIDi285489
KEGGihsa:285489
UCSCiuc003ghd.4 human [Q18PE1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

The Leiden Muscular Dystrophy pages, Docking protein 7 (DOK7)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB220918 mRNA Translation: BAE96739.1
AK075037 mRNA Translation: BAC11367.1 Sequence problems.
AK091037 mRNA Translation: BAC03572.1
AL590235 Genomic DNA No translation available.
BC043568 mRNA Translation: AAH43568.1
BC062369 mRNA Translation: AAH62369.1
BC131544 mRNA Translation: AAI31545.1
BC141852 mRNA Translation: AAI41853.1
CCDSiCCDS3370.2 [Q18PE1-1]
CCDS54717.1 [Q18PE1-4]
RefSeqiNP_001158145.1, NM_001164673.1 [Q18PE1-4]
NP_001243825.1, NM_001256896.1
NP_001288000.1, NM_001301071.1 [Q18PE1-3]
NP_775931.3, NM_173660.4 [Q18PE1-1]
UniGeneiHs.122110
Hs.701584

3D structure databases

ProteinModelPortaliQ18PE1
SMRiQ18PE1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130124, 6 interactors
IntActiQ18PE1, 5 interactors
STRINGi9606.ENSP00000344432

PTM databases

iPTMnetiQ18PE1
PhosphoSitePlusiQ18PE1

Polymorphism and mutation databases

BioMutaiDOK7
DMDMi115311705

Proteomic databases

PaxDbiQ18PE1
PeptideAtlasiQ18PE1
PRIDEiQ18PE1
ProteomicsDBi61176
61177 [Q18PE1-2]
61178 [Q18PE1-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340083; ENSP00000344432; ENSG00000175920 [Q18PE1-1]
ENST00000507039; ENSP00000423614; ENSG00000175920 [Q18PE1-4]
GeneIDi285489
KEGGihsa:285489
UCSCiuc003ghd.4 human [Q18PE1-1]

Organism-specific databases

CTDi285489
DisGeNETi285489
EuPathDBiHostDB:ENSG00000175920.15
GeneCardsiDOK7
GeneReviewsiDOK7
HGNCiHGNC:26594 DOK7
HPAiHPA059449
HPA062780
MalaCardsiDOK7
MIMi254300 phenotype
610285 gene
neXtProtiNX_Q18PE1
OpenTargetsiENSG00000175920
Orphaneti994 Fetal akinesia deformation sequence
98913 Postsynaptic congenital myasthenic syndromes
PharmGKBiPA162384035
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHI2 Eukaryota
ENOG4111MP1 LUCA
GeneTreeiENSGT00390000015386
HOGENOMiHOG000230953
HOVERGENiHBG080009
InParanoidiQ18PE1
OMAiEYQVPSS
OrthoDBiEOG091G064P
PhylomeDBiQ18PE1
TreeFamiTF332288

Enzyme and pathway databases

SignaLinkiQ18PE1
SIGNORiQ18PE1

Miscellaneous databases

ChiTaRSiDOK7 human
GenomeRNAii285489
PROiPR:Q18PE1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175920 Expressed in 123 organ(s), highest expression level in heart left ventricle
CleanExiHS_DOK7
ExpressionAtlasiQ18PE1 baseline and differential
GenevisibleiQ18PE1 HS

Family and domain databases

CDDicd14677 PH_DOK7, 1 hit
cd13165 PTB_DOK7, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR037746 Dok-7
IPR037747 Dok-7_PH
IPR037748 Dok-7_PTB
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR21636 PTHR21636, 1 hit
PfamiView protein in Pfam
PF02174 IRS, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDOK7_HUMAN
AccessioniPrimary (citable) accession number: Q18PE1
Secondary accession number(s): A2A499
, A2RRD4, E9PB56, Q6P6A6, Q86XG5, Q8N2J3, Q8NBC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 25, 2006
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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