UniProtKB - Q18PE1 (DOK7_HUMAN)
Protein Dok-7
DOK7
Functioni
GO - Molecular functioni
- lipid binding Source: UniProtKB-KW
- protein kinase binding Source: UniProtKB
GO - Biological processi
- neuromuscular junction development Source: GO_Central
- positive regulation of protein tyrosine kinase activity Source: UniProtKB
Keywordsi
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q18PE1 |
SignaLinki | Q18PE1 |
SIGNORi | Q18PE1 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Dok-7Alternative name(s): Downstream of tyrosine kinase 7 |
Gene namesi | Name:DOK7 Synonyms:C4orf25 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26594, DOK7 |
MIMi | 610285, gene |
neXtProti | NX_Q18PE1 |
VEuPathDBi | HostDB:ENSG00000175920.15 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity
Other locations
- synapse By similarity
Note: Accumulates at neuromuscular junctions.By similarity
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- synapse Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, SynapsePathology & Biotechi
Involvement in diseasei
Myasthenic syndrome, congenital, 10 (CMS10)5 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068750 | 3 | E → K in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs763233743Ensembl. | 1 | |
Natural variantiVAR_068751 | 31 | P → T in CMS10; results in a significant reduction of AChR clusters. 1 Publication | 1 | |
Natural variantiVAR_068752 | 33 | A → V in CMS10; results in reduced stimulation of MUSK autophosphorylation. 2 Publications | 1 | |
Natural variantiVAR_068754 | 77 | T → M in CMS10; results in a decrease of branched, c-shaped and perforated AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs940346413Ensembl. | 1 | |
Natural variantiVAR_068756 | 109 | G → C in CMS10; results in a significant reduction of AChR clusters. 1 Publication | 1 | |
Natural variantiVAR_068757 | 116 | V → M in CMS10. 1 PublicationCorresponds to variant dbSNP:rs1429428597Ensembl. | 1 | |
Natural variantiVAR_068758 | 132 | H → Q in CMS10. 1 Publication | 1 | |
Natural variantiVAR_068759 | 139 | V → L in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs571769859Ensembl. | 1 | |
Natural variantiVAR_068760 | 146 | P → L in CMS10. 1 PublicationCorresponds to variant dbSNP:rs770987150EnsemblClinVar. | 1 | |
Natural variantiVAR_068761 | 157 | L → R in CMS10. 1 Publication | 1 | |
Natural variantiVAR_031246 | 158 | R → Q in CMS10; reduced stimulation of MUSK autophosphorylation when associated with A-174; results in a significant reduction of AChR clusters. 2 PublicationsCorresponds to variant dbSNP:rs754633490Ensembl. | 1 | |
Natural variantiVAR_068762 | 161 | G → R in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs758131044EnsemblClinVar. | 1 | |
Natural variantiVAR_068763 | 166 | G → R in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs781227659Ensembl. | 1 | |
Natural variantiVAR_068764 | 171 | G → D in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs1286619522Ensembl. | 1 | |
Natural variantiVAR_068765 | 171 | G → R in CMS10. 1 Publication | 1 | |
Natural variantiVAR_068766 | 172 | G → R in CMS10. 1 PublicationCorresponds to variant dbSNP:rs768892432EnsemblClinVar. | 1 | |
Natural variantiVAR_027544 | 180 | G → A in CMS10; results in a significant reduction of AChR clusters. 2 PublicationsCorresponds to variant dbSNP:rs118203994EnsemblClinVar. | 1 | |
Natural variantiVAR_068767 | 180 | G → V in CMS10. 1 Publication | 1 | |
Natural variantiVAR_068773 | 469 | P → H in CMS10. 1 PublicationCorresponds to variant dbSNP:rs147185207EnsemblClinVar. | 1 |
Fetal akinesia deformation sequence 3 (FADS3)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 30 | S → W: Reduced stimulation of MUSK autophosphorylation. 1 Publication | 1 | |
Mutagenesisi | 32 | V → A: Reduced stimulation of MUSK autophosphorylation. 1 Publication | 1 | |
Mutagenesisi | 174 | R → A: Reduced stimulation of MUSK autophosphorylation; when associated with Q-158. 1 Publication | 1 |
Keywords - Diseasei
Congenital myasthenic syndrome, Disease variantOrganism-specific databases
DisGeNETi | 285489 |
GeneReviewsi | DOK7 |
MalaCardsi | DOK7 |
MIMi | 254300, phenotype 618389, phenotype |
OpenTargetsi | ENSG00000175920 |
Orphaneti | 994, Fetal akinesia deformation sequence 98913, Postsynaptic congenital myasthenic syndromes |
PharmGKBi | PA162384035 |
Miscellaneous databases
Pharosi | Q18PE1, Tbio |
Genetic variation databases
BioMutai | DOK7 |
DMDMi | 115311705 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000250371 | 1 – 504 | Protein Dok-7Add BLAST | 504 |
Proteomic databases
jPOSTi | Q18PE1 |
MassIVEi | Q18PE1 |
PaxDbi | Q18PE1 |
PeptideAtlasi | Q18PE1 |
PRIDEi | Q18PE1 |
ProteomicsDBi | 19148 61176 [Q18PE1-1] 61177 [Q18PE1-2] 61178 [Q18PE1-3] |
PTM databases
iPTMneti | Q18PE1 |
PhosphoSitePlusi | Q18PE1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000175920, Expressed in heart left ventricle and 143 other tissues |
ExpressionAtlasi | Q18PE1, baseline and differential |
Genevisiblei | Q18PE1, HS |
Organism-specific databases
HPAi | ENSG00000175920, Tissue enhanced (heart muscle, skeletal muscle) |
Interactioni
Subunit structurei
Homodimer (By similarity).
Forms a heterotetramer composed of 2 DOK7 and 2 MUSK molecules which facilitates MUSK trans-autophosphorylation on tyrosine residue and activation (By similarity).
Interacts (via IRS-type PTB domain) with MUSK (via cytoplasmic part); requires MUSK phosphorylation.
By similarity1 PublicationBinary interactionsi
Q18PE1
With | #Exp. | IntAct |
---|---|---|
EFEMP2 [O95967] | 3 | EBI-3046647,EBI-743414 |
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 130124, 8 interactors |
IntActi | Q18PE1, 5 interactors |
STRINGi | 9606.ENSP00000344432 |
Miscellaneous databases
RNActi | Q18PE1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 109 | PHPROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 105 – 210 | IRS-type PTBPROSITE-ProRule annotationAdd BLAST | 106 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 262 – 359 | Ser-richAdd BLAST | 98 |
Domaini
Phylogenomic databases
eggNOGi | ENOG502QQBI, Eukaryota |
GeneTreei | ENSGT00390000015386 |
HOGENOMi | CLU_095366_0_0_1 |
InParanoidi | Q18PE1 |
OMAi | TIWPEQS |
OrthoDBi | 317220at2759 |
PhylomeDBi | Q18PE1 |
TreeFami | TF332288 |
Family and domain databases
CDDi | cd14677, PH_DOK7, 1 hit cd13165, PTB_DOK7, 1 hit |
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR037746, Dok-7 IPR037747, Dok-7_PH IPR037748, Dok-7_PTB IPR002404, IRS_PTB IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR21636, PTHR21636, 1 hit |
Pfami | View protein in Pfam PF02174, IRS, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
PROSITEi | View protein in PROSITE PS51064, IRS_PTB, 1 hit PS50003, PH_DOMAIN, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTEAALVEGQ VKLRDGKKWK SRWLVLRKPS PVADCLLMLV YKDKSERIKG
60 70 80 90 100
LRERSSLTLE DICGLEPGLP YEGLVHTLAI VCLSQAIMLG FDSHEAMCAW
110 120 130 140 150
DARIRYALGE VHRFHVTVAP GTKLESGPAT LHLCNDVLVL ARDIPPAVTG
160 170 180 190 200
QWKLSDLRRY GAVPSGFIFE GGTRCGYWAG VFFLSSAEGE QISFLFDCIV
210 220 230 240 250
RGISPTKGPF GLRPVLPDPS PPGPSTVEER VAQEALETLQ LEKRLSLLSH
260 270 280 290 300
AGRPGSGGDD RSLSSSSSEA SHLDVSASSR LTAWPEQSSS SASTSQEGPR
310 320 330 340 350
PAAAQAAGEA MVGASRPPPK PLRPRQLQEV GRQSSSDSGI ATGSHSSYSS
360 370 380 390 400
SLSSYAGSSL DVWRATDELG SLLSLPAAGA PEPSLCTCLP GTVEYQVPTS
410 420 430 440 450
LRAHYDTPRS LCLAPRDHSP PSQGSPGNSA ARDSGGQTSA GCPSGWLGTR
460 470 480 490 500
RRGLVMEAPQ GSEATLPGPA PGEPWEAGGP HAGPPPAFFS ACPVCGGLKV
NPPP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2PRA3 | A0A1W2PRA3_HUMAN | Protein Dok-7 | DOK7 | 194 | Annotation score: | ||
A0A2R8Y701 | A0A2R8Y701_HUMAN | Protein Dok-7 | DOK7 | 464 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068750 | 3 | E → K in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs763233743Ensembl. | 1 | |
Natural variantiVAR_068751 | 31 | P → T in CMS10; results in a significant reduction of AChR clusters. 1 Publication | 1 | |
Natural variantiVAR_068752 | 33 | A → V in CMS10; results in reduced stimulation of MUSK autophosphorylation. 2 Publications | 1 | |
Natural variantiVAR_068753 | 45 | S → L Does not affect AChR clusters number or complexity. 2 PublicationsCorresponds to variant dbSNP:rs62272670EnsemblClinVar. | 1 | |
Natural variantiVAR_068754 | 77 | T → M in CMS10; results in a decrease of branched, c-shaped and perforated AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs940346413Ensembl. | 1 | |
Natural variantiVAR_068755 | 99 | A → V1 PublicationCorresponds to variant dbSNP:rs138010842EnsemblClinVar. | 1 | |
Natural variantiVAR_068756 | 109 | G → C in CMS10; results in a significant reduction of AChR clusters. 1 Publication | 1 | |
Natural variantiVAR_068757 | 116 | V → M in CMS10. 1 PublicationCorresponds to variant dbSNP:rs1429428597Ensembl. | 1 | |
Natural variantiVAR_068758 | 132 | H → Q in CMS10. 1 Publication | 1 | |
Natural variantiVAR_068759 | 139 | V → L in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs571769859Ensembl. | 1 | |
Natural variantiVAR_068760 | 146 | P → L in CMS10. 1 PublicationCorresponds to variant dbSNP:rs770987150EnsemblClinVar. | 1 | |
Natural variantiVAR_068761 | 157 | L → R in CMS10. 1 Publication | 1 | |
Natural variantiVAR_031246 | 158 | R → Q in CMS10; reduced stimulation of MUSK autophosphorylation when associated with A-174; results in a significant reduction of AChR clusters. 2 PublicationsCorresponds to variant dbSNP:rs754633490Ensembl. | 1 | |
Natural variantiVAR_068762 | 161 | G → R in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs758131044EnsemblClinVar. | 1 | |
Natural variantiVAR_068763 | 166 | G → R in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs781227659Ensembl. | 1 | |
Natural variantiVAR_068764 | 171 | G → D in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant dbSNP:rs1286619522Ensembl. | 1 | |
Natural variantiVAR_068765 | 171 | G → R in CMS10. 1 Publication | 1 | |
Natural variantiVAR_068766 | 172 | G → R in CMS10. 1 PublicationCorresponds to variant dbSNP:rs768892432EnsemblClinVar. | 1 | |
Natural variantiVAR_027544 | 180 | G → A in CMS10; results in a significant reduction of AChR clusters. 2 PublicationsCorresponds to variant dbSNP:rs118203994EnsemblClinVar. | 1 | |
Natural variantiVAR_068767 | 180 | G → V in CMS10. 1 Publication | 1 | |
Natural variantiVAR_027545 | 197 | D → N1 PublicationCorresponds to variant dbSNP:rs16844422EnsemblClinVar. | 1 | |
Natural variantiVAR_027546 | 261 | R → H1 PublicationCorresponds to variant dbSNP:rs16844460EnsemblClinVar. | 1 | |
Natural variantiVAR_068768 | 272 | H → Q1 PublicationCorresponds to variant dbSNP:rs115614731Ensembl. | 1 | |
Natural variantiVAR_027547 | 296 | Q → R2 PublicationsCorresponds to variant dbSNP:rs6811423EnsemblClinVar. | 1 | |
Natural variantiVAR_068769 | 323 | R → C1 PublicationCorresponds to variant dbSNP:rs150728781EnsemblClinVar. | 1 | |
Natural variantiVAR_050508 | 379 | G → R. Corresponds to variant dbSNP:rs6831659Ensembl. | 1 | |
Natural variantiVAR_068770 | 382 | E → K1 PublicationCorresponds to variant dbSNP:rs560463670EnsemblClinVar. | 1 | |
Natural variantiVAR_068771 | 402 | R → Q1 PublicationCorresponds to variant dbSNP:rs370039804EnsemblClinVar. | 1 | |
Natural variantiVAR_027548 | 415 | P → S1 PublicationCorresponds to variant dbSNP:rs16844464EnsemblClinVar. | 1 | |
Natural variantiVAR_027549 | 427 | G → D. Corresponds to variant dbSNP:rs2020433Ensembl. | 1 | |
Natural variantiVAR_068772 | 440 | A → T1 PublicationCorresponds to variant dbSNP:rs753026831Ensembl. | 1 | |
Natural variantiVAR_027550 | 451 | R → W1 PublicationCorresponds to variant dbSNP:rs16844470EnsemblClinVar. | 1 | |
Natural variantiVAR_027551 | 461 | G → D3 PublicationsCorresponds to variant dbSNP:rs9684786EnsemblClinVar. | 1 | |
Natural variantiVAR_068773 | 469 | P → H in CMS10. 1 PublicationCorresponds to variant dbSNP:rs147185207EnsemblClinVar. | 1 | |
Natural variantiVAR_068774 | 503 | P → T1 PublicationCorresponds to variant dbSNP:rs184556570EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020633 | 1 – 138 | Missing in isoform 2. 1 PublicationAdd BLAST | 138 | |
Alternative sequenceiVSP_020634 | 139 – 178 | VLARD…RCGYW → MMSSSWPGTSPRLSRGSGSC LTSGATGPCQADSSLKAGPG in isoform 2. 1 PublicationAdd BLAST | 40 | |
Alternative sequenceiVSP_047252 | 175 – 255 | CGYWA…AGRPG → GWRLLPVLGRGGADQLPVRL HRPRHLPHQGPLWAAAGSTR PKSPGTLDCGGACGPGSPGN PTAGEAAEPPLTCGQAGQWR G in isoform 4. CuratedAdd BLAST | 81 | |
Alternative sequenceiVSP_047253 | 256 – 504 | Missing in isoform 4. CuratedAdd BLAST | 249 | |
Alternative sequenceiVSP_020635 | 500 – 504 | VNPPP → GAAASAPGPATAHSGSPGPV AVDSPGPERPRGESPTYVNI PVSPSSRKQLHYMGLELQEA SEGVRGAGASLYAQIDIMAT ETAHRVGVRHARAREEQLSE LEQRKAAPQ in isoform 3. Curated | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB220918 mRNA Translation: BAE96739.1 AK075037 mRNA Translation: BAC11367.1 Sequence problems. AK091037 mRNA Translation: BAC03572.1 AL590235 Genomic DNA No translation available. BC043568 mRNA Translation: AAH43568.1 BC062369 mRNA Translation: AAH62369.1 BC131544 mRNA Translation: AAI31545.1 BC141852 mRNA Translation: AAI41853.1 |
CCDSi | CCDS3370.2 [Q18PE1-1] CCDS54717.1 [Q18PE1-4] |
RefSeqi | NP_001158145.1, NM_001164673.1 [Q18PE1-4] NP_001243825.1, NM_001256896.1 NP_001288000.1, NM_001301071.1 [Q18PE1-3] NP_775931.3, NM_173660.4 [Q18PE1-1] |
Genome annotation databases
Ensembli | ENST00000340083; ENSP00000344432; ENSG00000175920 [Q18PE1-1] ENST00000507039; ENSP00000423614; ENSG00000175920 [Q18PE1-4] |
GeneIDi | 285489 |
KEGGi | hsa:285489 |
UCSCi | uc003ghd.4, human [Q18PE1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
The Leiden Muscular Dystrophy pages, Docking protein 7 (DOK7) Leiden Open Variation Database (LOVD) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB220918 mRNA Translation: BAE96739.1 AK075037 mRNA Translation: BAC11367.1 Sequence problems. AK091037 mRNA Translation: BAC03572.1 AL590235 Genomic DNA No translation available. BC043568 mRNA Translation: AAH43568.1 BC062369 mRNA Translation: AAH62369.1 BC131544 mRNA Translation: AAI31545.1 BC141852 mRNA Translation: AAI41853.1 |
CCDSi | CCDS3370.2 [Q18PE1-1] CCDS54717.1 [Q18PE1-4] |
RefSeqi | NP_001158145.1, NM_001164673.1 [Q18PE1-4] NP_001243825.1, NM_001256896.1 NP_001288000.1, NM_001301071.1 [Q18PE1-3] NP_775931.3, NM_173660.4 [Q18PE1-1] |
3D structure databases
SMRi | Q18PE1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130124, 8 interactors |
IntActi | Q18PE1, 5 interactors |
STRINGi | 9606.ENSP00000344432 |
PTM databases
iPTMneti | Q18PE1 |
PhosphoSitePlusi | Q18PE1 |
Genetic variation databases
BioMutai | DOK7 |
DMDMi | 115311705 |
Proteomic databases
jPOSTi | Q18PE1 |
MassIVEi | Q18PE1 |
PaxDbi | Q18PE1 |
PeptideAtlasi | Q18PE1 |
PRIDEi | Q18PE1 |
ProteomicsDBi | 19148 61176 [Q18PE1-1] 61177 [Q18PE1-2] 61178 [Q18PE1-3] |
Protocols and materials databases
Antibodypediai | 55035, 418 antibodies |
Genome annotation databases
Ensembli | ENST00000340083; ENSP00000344432; ENSG00000175920 [Q18PE1-1] ENST00000507039; ENSP00000423614; ENSG00000175920 [Q18PE1-4] |
GeneIDi | 285489 |
KEGGi | hsa:285489 |
UCSCi | uc003ghd.4, human [Q18PE1-1] |
Organism-specific databases
CTDi | 285489 |
DisGeNETi | 285489 |
GeneCardsi | DOK7 |
GeneReviewsi | DOK7 |
HGNCi | HGNC:26594, DOK7 |
HPAi | ENSG00000175920, Tissue enhanced (heart muscle, skeletal muscle) |
MalaCardsi | DOK7 |
MIMi | 254300, phenotype 610285, gene 618389, phenotype |
neXtProti | NX_Q18PE1 |
OpenTargetsi | ENSG00000175920 |
Orphaneti | 994, Fetal akinesia deformation sequence 98913, Postsynaptic congenital myasthenic syndromes |
PharmGKBi | PA162384035 |
VEuPathDBi | HostDB:ENSG00000175920.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQBI, Eukaryota |
GeneTreei | ENSGT00390000015386 |
HOGENOMi | CLU_095366_0_0_1 |
InParanoidi | Q18PE1 |
OMAi | TIWPEQS |
OrthoDBi | 317220at2759 |
PhylomeDBi | Q18PE1 |
TreeFami | TF332288 |
Enzyme and pathway databases
PathwayCommonsi | Q18PE1 |
SignaLinki | Q18PE1 |
SIGNORi | Q18PE1 |
Miscellaneous databases
BioGRID-ORCSi | 285489, 3 hits in 982 CRISPR screens |
ChiTaRSi | DOK7, human |
GenomeRNAii | 285489 |
Pharosi | Q18PE1, Tbio |
PROi | PR:Q18PE1 |
RNActi | Q18PE1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175920, Expressed in heart left ventricle and 143 other tissues |
ExpressionAtlasi | Q18PE1, baseline and differential |
Genevisiblei | Q18PE1, HS |
Family and domain databases
CDDi | cd14677, PH_DOK7, 1 hit cd13165, PTB_DOK7, 1 hit |
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR037746, Dok-7 IPR037747, Dok-7_PH IPR037748, Dok-7_PTB IPR002404, IRS_PTB IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR21636, PTHR21636, 1 hit |
Pfami | View protein in Pfam PF02174, IRS, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
PROSITEi | View protein in PROSITE PS51064, IRS_PTB, 1 hit PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DOK7_HUMAN | |
Accessioni | Q18PE1Primary (citable) accession number: Q18PE1 Secondary accession number(s): A2A499 Q8NBC1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2006 |
Last sequence update: | July 25, 2006 | |
Last modified: | April 7, 2021 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot