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Protein

Thymidine kinase

Gene

tdk

Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei122Proton acceptorUniRule annotation1
Metal bindingi178ZincUniRule annotation1
Metal bindingi181ZincUniRule annotation1
Metal bindingi216ZincUniRule annotation1
Metal bindingi219ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPUniRule annotation8
Nucleotide bindingi121 – 124ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processDNA synthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciHWAL362976:G1G1J-827-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:HQ_1795A
OrganismiHaloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Taxonomic identifieri362976 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHaloquadratum
Proteomesi
  • UP000001975 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000181561 – 225Thymidine kinaseAdd BLAST225

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi362976.HQ1795A

Structurei

3D structure databases

ProteinModelPortaliQ18J88
SMRiQ18J88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04798 Archaea
COG1435 LUCA
HOGENOMiHOG000076390
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG093Z0AT6

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 2 hits
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

Q18J88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAITNSGWI EVVTGSMFSG KTEELLRRLR RAEIAGQSIA VFKPAVDDRY
60 70 80 90 100
GETTVGSHVG RQWEAAVVPN EGEDIWNIKH ELSKKKQNHR TTTQCRSGDG
110 120 130 140 150
TNNPGGVIPS NDDSVDVVAI DEANFFSTEL VSVCESLAND GYRVVVSGTD
160 170 180 190 200
QTYRGEPFEP LPQLMAVAEY VDKLQAICTQ CGEPATRNQR LVDDSPAHID
210 220
DPTIVVGADE TYEARCRNCH ILRHE
Length:225
Mass (Da):24,833
Last modified:July 25, 2006 - v1
Checksum:i9564E79B078512D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180088 Genomic DNA Translation: CAJ51923.1
RefSeqiWP_011571070.1, NC_008212.1

Genome annotation databases

EnsemblBacteriaiCAJ51923; CAJ51923; HQ_1795A
GeneIDi4194746
KEGGihwa:HQ_1795A

Similar proteinsi

Entry informationi

Entry nameiKITH_HALWD
AccessioniPrimary (citable) accession number: Q18J88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: February 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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