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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei601For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Enzyme and pathway databases

BioCyciHWAL362976:G1G1J-2066-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotationImported
Ordered Locus Names:HQ_2990AImported
OrganismiHaloquadratum walsbyi (strain DSM 16790 / HBSQ001)Imported
Taxonomic identifieri362976 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupHalobacteriaHaloferacalesHaloferacaceaeHaloquadratum
Proteomesi
  • UP000001975 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi362976.HQ2990A

Structurei

3D structure databases

ProteinModelPortaliQ18G12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 220Glutamine amidotransferase type-2InterPro annotationAdd BLAST219
Domaini282 – 423SISInterPro annotationAdd BLAST142
Domaini455 – 596SISInterPro annotationAdd BLAST142

Phylogenomic databases

eggNOGiarCOG00057 Archaea
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiTSYYSGC
OrthoDBiPOG093Z014P

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q18G12-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGIIGCVNP DGGTREVLMN GLANLDYRGY DSAGIAVADG GIEVAKREGE
60 70 80 90 100
IDRLQKQVTA RSDTLDGPAG IGHTRWSTHG PPTDANAHPH TDETGDVAVV
110 120 130 140 150
HNGIIENYQS IRDELEADGV EFVSETDTEV VPHLISKFRD DGADPQTAFR
160 170 180 190 200
RAVERITGSY ALAVVFENHD TIFATRDGSP LVIGVDENAA FLASDVPAFL
210 220 230 240 250
EYTRDVIYLE DGQFATLRSS GVEVTESDGT SVNPSVTTVE WSADQTAKSG
260 270 280 290 300
YNHFMAKEIH EQPASLRQCL RGRVNELSGS VSVEELSDID SPESVQLVAC
310 320 330 340 350
GTSYHAALYV ARLFRAHGVP AQAHLASEYV TAPAPFDSDS LLIGITQSGE
360 370 380 390 400
TADTLSALRE AQRRGASTLA VTNVVGSTAA RECDHVVYIR AGPEIGVAAT
410 420 430 440 450
KTFSSQLATG NLLVEKLCAS GTKRTSESTR ELIPALRDLP NQLQSVIDNS
460 470 480 490 500
TAKSVVEEYL DYDAYFFIGR GLHRPVALEG ALKFKEITYE HAEGFAAGEL
510 520 530 540 550
KHGPLALVTQ RTPIFAVVTG DGERAQKTIS NIKEVQARDA PVVAVTDGQS
560 570 580 590 600
EVRRYANHTL EIPQTHPRIA PVLANTQLQL VAYHMADRMN RSIDKPRNLA

KSVTVE
Length:606
Mass (Da):65,363
Last modified:July 25, 2006 - v1
Checksum:i2ACC55EC329AD0EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180088 Genomic DNA Translation: CAJ53092.1
RefSeqiWP_011572199.1, NC_008212.1

Genome annotation databases

EnsemblBacteriaiCAJ53092; CAJ53092; HQ_2990A
GeneIDi4194033
KEGGihwa:HQ_2990A

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180088 Genomic DNA Translation: CAJ53092.1
RefSeqiWP_011572199.1, NC_008212.1

3D structure databases

ProteinModelPortaliQ18G12
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi362976.HQ2990A

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ53092; CAJ53092; HQ_2990A
GeneIDi4194033
KEGGihwa:HQ_2990A

Phylogenomic databases

eggNOGiarCOG00057 Archaea
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiTSYYSGC
OrthoDBiPOG093Z014P

Enzyme and pathway databases

BioCyciHWAL362976:G1G1J-2066-MONOMER

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ18G12_HALWD
AccessioniPrimary (citable) accession number: Q18G12
Entry historyiIntegrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 7, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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