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Protein

IMP cyclohydrolase

Gene

purO

Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.UniRule annotation

Catalytic activityi

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. IMP cyclohydrolase (purO)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPurine biosynthesis

Enzyme and pathway databases

BioCyciHWAL362976:G1G1J-8-MONOMER
UniPathwayiUPA00074; UER00135

Names & Taxonomyi

Protein namesi
Recommended name:
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purOUniRule annotation
Ordered Locus Names:HQ_1006A
OrganismiHaloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Taxonomic identifieri362976 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHaloquadratum
Proteomesi
  • UP000001975 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003491591 – 195IMP cyclohydrolaseAdd BLAST195

Interactioni

Protein-protein interaction databases

STRINGi362976.HQ1006A

Structurei

3D structure databases

ProteinModelPortaliQ18DI6
SMRiQ18DI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal IMP cyclohydrolase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04727 Archaea
COG3363 LUCA
HOGENOMiHOG000015497
KOiK11176
OMAiSHVDPIA
OrthoDBiPOG093Z0CY5

Family and domain databases

Gene3Di3.60.20.20, 1 hit
HAMAPiMF_00705 IMP_cyclohydrol, 1 hit
InterProiView protein in InterPro
IPR010191 IMP_cyclohydrolase
IPR020600 IMP_cyclohydrolase-like
IPR036795 IMP_cyclohydrolase-like_sf
PfamiView protein in Pfam
PF07826 IMP_cyclohyd, 1 hit
PIRSFiPIRSF004866 IMP_cclhdr_arch, 1 hit
SUPFAMiSSF75569 SSF75569, 1 hit
TIGRFAMsiTIGR01922 purO_arch, 1 hit

Sequencei

Sequence statusi: Complete.

Q18DI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLGRFIIIG ETTAVYRVSS RSYPNRQIIS RDNMLTVVPT SEAAQTNNPY
60 70 80 90 100
VSYNCMRQGG EKIVIGNGSH VDPIAEKIDR GYPARDALAE ALLALDYEKD
110 120 130 140 150
DYNTPRIAGI VGSSSYVGII RQDAVIIRSI SEPTLVSTYE NDAPTTAQLS
160 170 180 190
LKGDIEEIAQ KAYELEYEHP VCAAAVTHQG QGESGDIVAQ IYNGK
Length:195
Mass (Da):21,320
Last modified:July 25, 2006 - v1
Checksum:i8DA09F3562DC1FE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180088 Genomic DNA Translation: CAJ51136.1
RefSeqiWP_011570303.1, NC_008212.1

Genome annotation databases

EnsemblBacteriaiCAJ51136; CAJ51136; HQ_1006A
GeneIDi4194534
KEGGihwa:HQ_1006A

Similar proteinsi

Entry informationi

Entry nameiPURO_HALWD
AccessioniPrimary (citable) accession number: Q18DI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 25, 2006
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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