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Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.UniRule annotation

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC), Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-1687-MONOMER
UniPathwayiUPA00031; UER00006

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferaseUniRule annotation (EC:2.4.2.17UniRule annotation)
Short name:
ATP-PRTUniRule annotation
Short name:
ATP-PRTaseUniRule annotation
Gene namesi
Name:hisGUniRule annotation
Ordered Locus Names:CD630_15480
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003195171 – 208ATP phosphoribosyltransferaseAdd BLAST208

Interactioni

Subunit structurei

Heteromultimer composed of HisG and HisZ subunits.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD1548

Structurei

3D structure databases

ProteinModelPortaliQ18C67
SMRiQ18C67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Lacks the C-terminal regulatory region which is replaced by HisZ.

Sequence similaritiesi

Belongs to the ATP phosphoribosyltransferase family. Short subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E21 Bacteria
COG0040 LUCA
HOGENOMiHOG000223248
KOiK00765
OMAiYVMMDYD

Family and domain databases

CDDicd13595 PBP2_HisGs, 1 hit
HAMAPiMF_01018 HisG_Short, 1 hit
InterProiView protein in InterPro
IPR013820 ATP_PRibTrfase_cat
IPR018198 ATP_PRibTrfase_CS
IPR001348 ATP_PRibTrfase_HisG
IPR024893 ATP_PRibTrfase_HisG_short
PANTHERiPTHR21403 PTHR21403, 1 hit
PfamiView protein in Pfam
PF01634 HisG, 1 hit
TIGRFAMsiTIGR00070 hisG, 1 hit
PROSITEiView protein in PROSITE
PS01316 ATP_P_PHORIBOSYLTR, 1 hit

Sequencei

Sequence statusi: Complete.

Q18C67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYLTIALAK GRIEGESFKK FKKMGLGDSI DTDTRKLIFK DEENKIIYIH
60 70 80 90 100
VKPSDVVTYV EKGVADLGIA GKDTILENET DVYEIYDLGF GKCKFAVAGL
110 120 130 140 150
KGDSIYREDE YLKVATKYPN IAKKYFKEKG QKIEIIKLNG SVELAPIVGL
160 170 180 190 200
SDVIVDIVET GNTLKANGLE ILEDICNISA RIISNRASYR FKYEQIQNII

RLFEELDN
Length:208
Mass (Da):23,491
Last modified:July 25, 2006 - v1
Checksum:i4413645B24C96129
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ68413.1
RefSeqiWP_003436683.1, NZ_CP010905.2
YP_001088049.1, NC_009089.1

Genome annotation databases

EnsemblBacteriaiCAJ68413; CAJ68413; CD630_15480
GeneIDi31353145
4916284
KEGGicdf:CD630_15480
pdc:CDIF630_01717
PATRICifig|272563.120.peg.1622

Similar proteinsi

Entry informationi

Entry nameiHIS1_PEPD6
AccessioniPrimary (citable) accession number: Q18C67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 25, 2006
Last modified: November 22, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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