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Entry version 139 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Eukaryotic translation initiation factor 3 subunit F

Gene

eif-3.F

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-CEL-72649, Translation initiation complex formation
R-CEL-72689, Formation of a pool of free 40S subunits
R-CEL-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-CEL-72702, Ribosomal scanning and start codon recognition

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit FUniRule annotation
Short name:
eIF3fUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 5UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:eif-3.FUniRule annotation
ORF Names:D2013.7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
D2013.7 ; CE00932 ; WBGene00001229 ; eif-3.F

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Extended lifespan in adults.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003642921 – 294Eukaryotic translation initiation factor 3 subunit FAdd BLAST294

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q18967

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q18967

PeptideAtlas

More...
PeptideAtlasi
Q18967

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001229, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.

UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
39802, 20 interactors

Database of interacting proteins

More...
DIPi
DIP-25689N

Protein interaction database and analysis system

More...
IntActi
Q18967, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.D2013.7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q18967

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 155MPNPROSITE-ProRule annotationAdd BLAST149

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eIF-3 subunit F family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2975, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183073

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027018_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q18967

KEGG Orthology (KO)

More...
KOi
K03249

Identification of Orthologs from Complete Genome Data

More...
OMAi
AVDMEYH

Database of Orthologous Groups

More...
OrthoDBi
1038775at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q18967

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08064, MPN_eIF3f, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_03005, eIF3f, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027531, eIF3f
IPR000555, JAMM/MPN+_dom
IPR037518, MPN
IPR024969, Rpn11/EIF3F_C

The PANTHER Classification System

More...
PANTHERi
PTHR10540:SF6, PTHR10540:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01398, JAB, 1 hit
PF13012, MitMem_reg, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00232, JAB_MPN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50249, MPN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q18967-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASNLTVNVH PGVYMNVVDT HMRRTKSSAK NTGQEKCMGT LMGYYEKGSI
60 70 80 90 100
QVTNCFAIPF NESNDDLEID DQFNQQMISA LKKTSPNEQP VGWFLTTSDI
110 120 130 140 150
TSSCLIYHDY YVRVITEASA RRESPPIVVL TIDTTFSGDM SKRMPVRAYL
160 170 180 190 200
RSKAGIPGAA GPHCAIFNPL RVELAAFPGE LVAMQLIEKA LDSRRREATL
210 220 230 240 250
ESGLEQLETS TAQMIEWLER MLHYVEDVNK NGEKPGDAQI GRQLMDIVTA
260 270 280 290
SSNNMQPEKL DTLVKNTLRD YVMVSYLAKL TQTQLQVHER LVSA
Length:294
Mass (Da):32,932
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8F2B2ED09AB33AF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z47808 Genomic DNA Translation: CAA87773.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T20338

NCBI Reference Sequences

More...
RefSeqi
NP_495988.1, NM_063587.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
D2013.7.1; D2013.7.1; WBGene00001229

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174478

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_D2013.7

UCSC genome browser

More...
UCSCi
D2013.7, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47808 Genomic DNA Translation: CAA87773.1
PIRiT20338
RefSeqiNP_495988.1, NM_063587.6

3D structure databases

SMRiQ18967
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi39802, 20 interactors
DIPiDIP-25689N
IntActiQ18967, 1 interactor
STRINGi6239.D2013.7

Proteomic databases

EPDiQ18967
PaxDbiQ18967
PeptideAtlasiQ18967

Genome annotation databases

EnsemblMetazoaiD2013.7.1; D2013.7.1; WBGene00001229
GeneIDi174478
KEGGicel:CELE_D2013.7
UCSCiD2013.7, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174478
WormBaseiD2013.7 ; CE00932 ; WBGene00001229 ; eif-3.F

Phylogenomic databases

eggNOGiKOG2975, Eukaryota
GeneTreeiENSGT00950000183073
HOGENOMiCLU_027018_0_1_1
InParanoidiQ18967
KOiK03249
OMAiAVDMEYH
OrthoDBi1038775at2759
PhylomeDBiQ18967

Enzyme and pathway databases

ReactomeiR-CEL-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-CEL-72649, Translation initiation complex formation
R-CEL-72689, Formation of a pool of free 40S subunits
R-CEL-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-CEL-72702, Ribosomal scanning and start codon recognition

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q18967

Gene expression databases

BgeeiWBGene00001229, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

CDDicd08064, MPN_eIF3f, 1 hit
HAMAPiMF_03005, eIF3f, 1 hit
InterProiView protein in InterPro
IPR027531, eIF3f
IPR000555, JAMM/MPN+_dom
IPR037518, MPN
IPR024969, Rpn11/EIF3F_C
PANTHERiPTHR10540:SF6, PTHR10540:SF6, 1 hit
PfamiView protein in Pfam
PF01398, JAB, 1 hit
PF13012, MitMem_reg, 1 hit
SMARTiView protein in SMART
SM00232, JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249, MPN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEIF3F_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q18967
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
  3. Translation initiation factors
    List of translation initiation factor entries
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