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Entry version 99 (05 Jun 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Ectopic P granules protein 5

Gene

epg-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in autophagy (PubMed:20550938, PubMed:24374177). Has a role in the degradation of protein aggregates within autophagosomes (PubMed:20550938). Essential for starvation-induced autotrophy and omegasome development (PubMed:20550938).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ectopic P granules protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:epg-5
ORF Names:C56C10.12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
C56C10.12 ; CE02566 ; WBGene00016968 ; epg-5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Increased number and reduced size of P granules (PubMed:20550938). Omegasomes fail to accumulate (PubMed:20550938). RNAi-mediated knockdown results in increased lgg-2-positive autophagosomes following fertilization and at later embryonic stages (PubMed:24374177).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003062611 – 1599Ectopic P granules protein 5Add BLAST1599

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q18892

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q18892

PeptideAtlas

More...
PeptideAtlasi
Q18892

PRoteomics IDEntifications database

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PRIDEi
Q18892

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q18892

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in pharyngeal and body wall muscles and intestine cells.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Ubiquitously expressed during embryogenesis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00016968 Expressed in 4 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C56C10.12

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q18892

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EPG5 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3622 Eukaryota
ENOG410XUQ7 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000007354

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q18892

Identification of Orthologs from Complete Genome Data

More...
OMAi
FECRLTE

Database of Orthologous Groups

More...
OrthoDBi
42984at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q18892

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029651 EPG-5

The PANTHER Classification System

More...
PANTHERi
PTHR31139:SF4 PTHR31139:SF4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q18892-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAELVRPKKP KHRERAQSDY TPPIPDRPAI VNGLRLPAAP SHTIEDLPER
60 70 80 90 100
SASPEPEDQD ISLTEDSLKR EEASEPLKDV RSSPVRPAPP PPRVSQEREA
110 120 130 140 150
PPIPPRSMIF PRSTSMVAES RKESTTAVAP KRSVAVASYP AVPELAELPS
160 170 180 190 200
YTDALQHPQV YPSINGGLQH SHSATAIPEK TRFSAPVERE RVREGEAPPM
210 220 230 240 250
YPSIKTYERN EHGLMTEENL VTFYHNPLYE HAEMFVDQFI KTEEVPTQSG
260 270 280 290 300
SLFPLLARLR TVCDLMTVSE VKGKENTEEL QKCLRECWVQ QSLSVDAKGK
310 320 330 340 350
CGDNNDGTGR ASYFSFELQQ AVLDQMKKLL STNRSNLMDH SVCEETSFRS
360 370 380 390 400
IALQIQWQVI IINNNFMAEN GLSTNCPPSL IASVPMTPGR VALRTALSDI
410 420 430 440 450
FYHLRYPRLS KRFIDTLVGW IKELTCVLNM RQSCDDGIFL LCHLLRLPSP
460 470 480 490 500
IDQWASPFVQ TFIQSQSAPK LKLDYCVALL THLLNPIKAR ESFLRHVAQS
510 520 530 540 550
EKEESTWEIL ADDDDGEANE FSFVTINESD LTAFLDQFPI SELYSIAYLA
560 570 580 590 600
FTSYSDKGSQ FTAMIAFQLL LMKILDNGLT SYSQPGYKMF CKQIGISLKH
610 620 630 640 650
SVRELCSNWR LIRDQVRPGE EHHLQKEVDR VVLLALNYLI HQDTLGLFQF
660 670 680 690 700
VVSLPYAVVS EECRSRCEYA LRSNKKMSIH EIYDTPICEV RARISSQGIS
710 720 730 740 750
KRIGALGAQD SEFLVNSLAS IGSYSNSDVS QLLKELIDVC FCDEDTRDDL
760 770 780 790 800
YKCGGEAIGQ ILIKRPETLH QLLTIIDRNL QHMDSYAINV LSSSRLFECR
810 820 830 840 850
LTEPMISIIG KWLINNPPEH GANRLARRVL SGLHWGLAVD GHNLWIDVDV
860 870 880 890 900
HTIAADTVVK AHSVHCSRSN SMISKSINKI SKLASKVGDA ESLFQQFCWD
910 920 930 940 950
LLVKLKLPTI PSSLVQNDLT AHYVRIVQNC EDDVVVYLEK GVPLLSDLVT
960 970 980 990 1000
SGSSVASVVL LSRLIAQHYQ NVNLMAADKN FMTTFERLLH IDQLPYAVQW
1010 1020 1030 1040 1050
LSGPSSTPTP IVKLICSAIS YYSAKLPPRD YLRAWITLLC AARTGWNEDA
1060 1070 1080 1090 1100
VTYQIVGTIA RIAFVNDTHK LYEITGIIFQ AYQQQLAAEK NQSKGIMSMF
1110 1120 1130 1140 1150
SSDNTVSPLI PDSMLSISPF ASYVMLRVEQ KSFNTFYGHF FETLTKKDKY
1160 1170 1180 1190 1200
TLDNAVKKAS SKCSITVPVE RLAIFRWAKL VTVCNDHQLL PILLQQLSGS
1210 1220 1230 1240 1250
AYRLRKANNL NLCYARRLID DPQMQDVMAA CRKAIEESTI ETKGLSKAVV
1260 1270 1280 1290 1300
GWLFTKHEVT RTGFDFSVFD LDYLLQLILA GDKNMWLDFV NMPYFNSEEF
1310 1320 1330 1340 1350
SERKLYSVTC QLSPKNRESP LPPEIGSPRS RSSAKPFPVL PVHSGLPQAP
1360 1370 1380 1390 1400
LIDPSILFQQ HTVLQLASPF INTIKQLSKQ FAQSGDRMSM DDDSYCKQIK
1410 1420 1430 1440 1450
ALYQPTQQTI PVEIRCSYCS KPKACTMSIK PNVLNSEIDL QMTQNRTKRF
1460 1470 1480 1490 1500
EFWNELYASI VDKAAVATAS IEHLSVLVAK MTSALHPGTR NNVQLTGHSL
1510 1520 1530 1540 1550
FYLITSSVGE NELLFSVASD SFCNSLRSLG EEYVKFRPEE QMDVMQLALD
1560 1570 1580 1590
GFVLSEPLVE VFTPEVLNSD DLCTAYRKLS DAVRMPERSK MALQLLGKQ
Length:1,599
Mass (Da):179,994
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC4E8E7429339091
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO080968 Genomic DNA Translation: CCD68183.1

Protein sequence database of the Protein Information Resource

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PIRi
T15854

NCBI Reference Sequences

More...
RefSeqi
NP_495343.1, NM_062942.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C56C10.12; C56C10.12; WBGene00016968

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C56C10.12

UCSC genome browser

More...
UCSCi
C56C10.12 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080968 Genomic DNA Translation: CCD68183.1
PIRiT15854
RefSeqiNP_495343.1, NM_062942.3

3D structure databases

SMRiQ18892
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C56C10.12

PTM databases

iPTMnetiQ18892

Proteomic databases

EPDiQ18892
PaxDbiQ18892
PeptideAtlasiQ18892
PRIDEiQ18892

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC56C10.12; C56C10.12; WBGene00016968
KEGGicel:CELE_C56C10.12
UCSCiC56C10.12 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3565794
WormBaseiC56C10.12 ; CE02566 ; WBGene00016968 ; epg-5

Phylogenomic databases

eggNOGiKOG3622 Eukaryota
ENOG410XUQ7 LUCA
GeneTreeiENSGT00390000007354
InParanoidiQ18892
OMAiFECRLTE
OrthoDBi42984at2759
PhylomeDBiQ18892

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q18892

Gene expression databases

BgeeiWBGene00016968 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR029651 EPG-5
PANTHERiPTHR31139:SF4 PTHR31139:SF4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEPG5_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q18892
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 1, 1996
Last modified: June 5, 2019
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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