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Entry version 129 (08 May 2019)
Sequence version 3 (01 Jun 2002)
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Protein

Vacuolar protein sorting-associated protein 33B

Gene

vps-33.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes (PubMed:25273556). Believed to act as a component of the putative CORVET endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (PubMed:25273556). The CORVET complex is proposed to function as a rab-5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25273556). Most likely within the CORVET complex, it is involved in the fusion of endocytic compartments (PubMed:25273556). Required for sperm development and function (PubMed:19109425, PubMed:27558849).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 33BCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vps-33.2Imported
ORF Names:C56C10.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
C56C10.1 ; CE30636 ; WBGene00016960 ; vps-33.2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Hermaphrodites exhibit sperm-specific sterility and only lay unfertilized eggs (PubMed:27558849). In contrast to wild-type animals, mutant males produce no or few spermatids in their gonads, but instead their gonads accumulate terminally arrested spermatocytes that do not bud and contain four haploid nuclei (PubMed:27558849). In some instances, the spermatocytes have small buds that do not form spermatids (PubMed:27558849). Oocytes and unfertilized eggs contain some larger endocytic structures tethered to yolk granules (PubMed:27558849). RNAi-mediated knockdown results in defective yolk uptake in oocytes with the appearance of endocytic structures containing yolk tethered to large membranous organelles which could be lysosomes (PubMed:25273556). RNAi-mediated knockdown results in defective endosome maturation with the accumulation of small vesicles near the gut lumen which is possibly indicative of increased endosomal fusion activity, and defective trafficking of proteins such as lmp-1 to lysosomal compartments (PubMed:25273556). RNAi-mediated knockdown in a sand-1 mutant background results in defective endosome fusion with the formation of larger, irregularly-shaped rab-5 positive endosomes in oocytes and intestinal cells, and larger yolk-containing granules than in the sand-1 single mutant (PubMed:25273556). Double RNAi-mediated knockdown together with vsp-33.1 results in defective protein trafficking to lysosomal compartments, and an irregular distribution of vesicles of various sizes throughout the gut cells (PubMed:25273556). Double RNAi-mediated knockdown together with vsp-33.1 in a sand-1 mutant background rescues the large endosome phenotype and the defective protein trafficking to lysosomal compartments in the sand-1 single mutant, but results in lethality (PubMed:25273556).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004412751 – 617Vacuolar protein sorting-associated protein 33BCuratedAdd BLAST617

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q18891

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q18891

PeptideAtlas

More...
PeptideAtlasi
Q18891

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed in somatic tissues including the pharynx, intestine, spermatheca, and in coelomocytes (PubMed:27558849). Expressed in the lining of the gut lumen (PubMed:25273556).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00016960 Expressed in 5 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probable core component of the class C core vacuole/endosome tethering (CORVET) complex. The common core is composed of the class C Vps proteins vps-11, vps-16 and vps-18, and which further associates with vps-8 and vps-33.2 (PubMed:25273556). Interacts with spe-39 (PubMed:19109425).1 Publication1 Publication

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1137 CORVET complex

Database of interacting proteins

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DIPi
DIP-25718N

Protein interaction database and analysis system

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IntActi
Q18891, 2 interactors

STRING: functional protein association networks

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STRINGi
6239.C56C10.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q18891

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1302 Eukaryota
COG5158 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156813

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000017450

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q18891

Identification of Orthologs from Complete Genome Data

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OMAi
KVMLNSQ

Database of Orthologous Groups

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OrthoDBi
406738at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q18891

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1910, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027482 Sec-1-like_dom2
IPR001619 Sec1-like
IPR036045 Sec1-like_sf
IPR027121 VPS33

The PANTHER Classification System

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PANTHERi
PTHR11679 PTHR11679, 1 hit
PTHR11679:SF1 PTHR11679:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00995 Sec1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56815 SSF56815, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q18891-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPGTAELEI DETLHLLRMV MQREFIHYLE TLPGTKELFI DKCLLRPLDM
60 70 80 90 100
IATSSDMKRH GVKRIMHFDL QKSPQVWNIE IDQRVFFLRP NVENARKIVE
110 120 130 140 150
YVEESSENRS ICVIWCNRQL EECDLAFESS GVIGHITQLS LNMCLLPLES
160 170 180 190 200
DLFSLQHVES AQPDLFSVAN MFVALQNLYG VIPTVYGLGS ESKNLWNLVH
210 220 230 240 250
ALCSSNELRA RPDQPISHLF LFDRQLDPVP VLLTGASYEG LLHEFFTIDC
260 270 280 290 300
GKLAFPVDLR KQVQTGPLDF DWIEINPEED KEAHQQNRGD TVKLDNCEDI
310 320 330 340 350
FASIRNKHVT AALEFLHSKA KSIQKSIEKS SMIDDVADYR NFVEKDLRAL
360 370 380 390 400
KKDHKHCELH INACEMMMNK VKMEDYRTMF KLEHEMLLGT VTHEEYFDFV
410 420 430 440 450
FERVPMRSCR DVVLSMMSLA SLKLDGVPDD TYNEFVEMYL QKYGYEHMFE
460 470 480 490 500
LQNLRNSRVI YARRHIAHDR TISERARTWE TLARKFRIVK GNEPMDMSNP
510 520 530 540 550
SDMSYVFGAR ISPLLCKIVE DTIDHGWNQA EYERIIGKDK VLVEENTYIA
560 570 580 590 600
ADRRPDNRTR KAIMVFVNGG ITYWEVAALR LLAIQKNFRI LICTTHVIKK
610
REYLEVRAKD ASSVFGS
Length:617
Mass (Da):71,592
Last modified:June 1, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43F189C051F363D8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD68172.1

Protein sequence database of the Protein Information Resource

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PIRi
T15853

NCBI Reference Sequences

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RefSeqi
NP_495342.2, NM_062941.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C56C10.1; C56C10.1; WBGene00016960

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174095

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C56C10.1

UCSC genome browser

More...
UCSCi
C56C10.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD68172.1
PIRiT15853
RefSeqiNP_495342.2, NM_062941.5

3D structure databases

SMRiQ18891
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-1137 CORVET complex
DIPiDIP-25718N
IntActiQ18891, 2 interactors
STRINGi6239.C56C10.1

Proteomic databases

EPDiQ18891
PaxDbiQ18891
PeptideAtlasiQ18891

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC56C10.1; C56C10.1; WBGene00016960
GeneIDi174095
KEGGicel:CELE_C56C10.1
UCSCiC56C10.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174095
WormBaseiC56C10.1 ; CE30636 ; WBGene00016960 ; vps-33.2

Phylogenomic databases

eggNOGiKOG1302 Eukaryota
COG5158 LUCA
GeneTreeiENSGT00940000156813
HOGENOMiHOG000017450
InParanoidiQ18891
OMAiKVMLNSQ
OrthoDBi406738at2759
PhylomeDBiQ18891

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q18891

Gene expression databases

BgeeiWBGene00016960 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di3.40.50.1910, 1 hit
InterProiView protein in InterPro
IPR027482 Sec-1-like_dom2
IPR001619 Sec1-like
IPR036045 Sec1-like_sf
IPR027121 VPS33
PANTHERiPTHR11679 PTHR11679, 1 hit
PTHR11679:SF1 PTHR11679:SF1, 1 hit
PfamiView protein in Pfam
PF00995 Sec1, 1 hit
SUPFAMiSSF56815 SSF56815, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVP33B_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q18891
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2017
Last sequence update: June 1, 2002
Last modified: May 8, 2019
This is version 129 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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