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Entry version 161 (08 May 2019)
Sequence version 2 (01 May 1999)
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Protein

Replication factor C subunit 1

Gene

rfc-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-UniRule
  • DNA binding Source: GO_Central
  • DNA clamp loader activity Source: UniProtKB-UniRule

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-110312 Translesion synthesis by REV1
R-CEL-110314 Recognition of DNA damage by PCNA-containing replication complex
R-CEL-110320 Translesion Synthesis by POLH
R-CEL-174411 Polymerase switching on the C-strand of the telomere
R-CEL-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-CEL-5655862 Translesion synthesis by POLK
R-CEL-5656121 Translesion synthesis by POLI
R-CEL-5656169 Termination of translesion DNA synthesis
R-CEL-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-CEL-5696400 Dual Incision in GG-NER
R-CEL-6782135 Dual incision in TC-NER
R-CEL-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-CEL-69091 Polymerase switching

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replication factor C subunit 1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rfc-1Imported
ORF Names:C54G10.2Imported, CELE_C54G10.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
C54G10.2a ; CE20613 ; WBGene00004337 ; rfc-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q18841

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q18841

PeptideAtlas

More...
PeptideAtlasi
Q18841

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004337 Expressed in 5 organ(s), highest expression level in adult organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q18841, 3 interactors

Molecular INTeraction database

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MINTi
Q18841

STRING: functional protein association networks

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STRINGi
6239.C54G10.2a

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini339 – 477AAAInterPro annotationAdd BLAST139

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the activator 1 large subunit family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPR7 Eukaryota
ENOG410XP0K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111066

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000017534

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q18841

KEGG Orthology (KO)

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KOi
K10754

Identification of Orthologs from Complete Genome Data

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OMAi
QQMFFVD

Database of Orthologous Groups

More...
OrthoDBi
555101at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q18841

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR008921 DNA_pol3_clamp-load_cplx_C
IPR013725 DNA_replication_fac_RFC1_C
IPR027417 P-loop_NTPase
IPR012178 RFC1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00004 AAA, 1 hit
PF08519 RFC1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036578 RFC1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48019 SSF48019, 1 hit
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q18841-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTKRKIVVS SDSDDDMPFT QEKQKKAATP AKKRTKPVVL TDDDEEEENA
60 70 80 90 100
PQKKTAPKRS RKQEKEESDI TSDEDELVRG TDEKKKRKGG KKELPVGQKT
110 120 130 140 150
LDYMFKPSSS SSKRDDPKKK VEKTLVNPAD FFKNSPAPSA SKLPKVAPKT
160 170 180 190 200
VEKPKTPAKK PVEISPSTKE NTKTKKVSDD EFVDSDDSFD TFTPITVKKK
210 220 230 240 250
TPEKRKETPK KKELPSVKKE FPKKQSIPVK KEKETPQKKA LSVKKDPPKV
260 270 280 290 300
TSESSSSSQV STSSVVFQPK PSGPPPALSW VDKYKPKRMG ELVGQNGDKS
310 320 330 340 350
PINKLLEWIK DWAKHNLGEG AKIKKPKPAP WMSSQDGTSF KAALLSGSPG
360 370 380 390 400
VGKTTCAYMA CQQLGLQLVE MNASDVRSKK HLEAKIGELS GSHQIEQFFG
410 420 430 440 450
AKKCAPQDNQ KVHHILIMDE VDGMSGNEDR AGISELIQII KESKIPIICI
460 470 480 490 500
CNDRQHPKIR TLANYCYDLR FPKPRVETIR SRMMTICSQE KMKIGKEELD
510 520 530 540 550
EIIELSGHDV RQTIYNLQMR SKGVGAKINQ KDMAVDAFSA ARRLLDSRTT
560 570 580 590 600
LMEKQEMFFT DYGIMPLFVQ DNYLNMKNEK HSPIQAIRGI RKAADFISLG
610 620 630 640 650
DLIDRQIRGG GSWKLLNEQS MISAALPAIA TGGHLKAMIQ FPSWLGKNST
660 670 680 690 700
AGKRKRLLQQ LVQHTHLKVS AGTHSFATDY APMLRQKITK PLLEHEADGI
710 720 730 740 750
PDVISTMTEY DLIKDDTEAL TEIVAWPGKI DPASKILSKV KASLTRTLNK
760 770 780 790 800
TGRMLPYSMD SVSKGKKRGV NSIGIEMDEE GNLVEKFEDE DGESDNEDNE
810 820 830
EKTTDVVIKV RTGGGAGASK SARGGRGGGR ARGGRGSKK
Length:839
Mass (Da):93,128
Last modified:May 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA38AC691F6FFB00
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAA99812.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T20230

NCBI Reference Sequences

More...
RefSeqi
NP_001256606.1, NM_001269677.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C54G10.2a; C54G10.2a; WBGene00004337

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
179967

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C54G10.2

UCSC genome browser

More...
UCSCi
C54G10.2 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAA99812.1
PIRiT20230
RefSeqiNP_001256606.1, NM_001269677.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ18841, 3 interactors
MINTiQ18841
STRINGi6239.C54G10.2a

Proteomic databases

EPDiQ18841
PaxDbiQ18841
PeptideAtlasiQ18841

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC54G10.2a; C54G10.2a; WBGene00004337
GeneIDi179967
KEGGicel:CELE_C54G10.2
UCSCiC54G10.2 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
179967
WormBaseiC54G10.2a ; CE20613 ; WBGene00004337 ; rfc-1

Phylogenomic databases

eggNOGiENOG410IPR7 Eukaryota
ENOG410XP0K LUCA
GeneTreeiENSGT00730000111066
HOGENOMiHOG000017534
InParanoidiQ18841
KOiK10754
OMAiQQMFFVD
OrthoDBi555101at2759
PhylomeDBiQ18841

Enzyme and pathway databases

ReactomeiR-CEL-110312 Translesion synthesis by REV1
R-CEL-110314 Recognition of DNA damage by PCNA-containing replication complex
R-CEL-110320 Translesion Synthesis by POLH
R-CEL-174411 Polymerase switching on the C-strand of the telomere
R-CEL-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-CEL-5655862 Translesion synthesis by POLK
R-CEL-5656121 Translesion synthesis by POLI
R-CEL-5656169 Termination of translesion DNA synthesis
R-CEL-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-CEL-5696400 Dual Incision in GG-NER
R-CEL-6782135 Dual incision in TC-NER
R-CEL-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-CEL-69091 Polymerase switching

Gene expression databases

BgeeiWBGene00004337 Expressed in 5 organ(s), highest expression level in adult organism

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR008921 DNA_pol3_clamp-load_cplx_C
IPR013725 DNA_replication_fac_RFC1_C
IPR027417 P-loop_NTPase
IPR012178 RFC1
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF08519 RFC1, 1 hit
PIRSFiPIRSF036578 RFC1, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF48019 SSF48019, 1 hit
SSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ18841_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q18841
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: May 1, 1999
Last modified: May 8, 2019
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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