Beta-catenin/armadillo-related protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• alpha-catenin binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cadherin binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• nuclear hormone receptor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein phosphatase binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II-specific DNA-binding transcription factor binding Source: WormBase <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.5

    "Distinct beta-catenins mediate adhesion and signalling functions in C. elegans."
    Korswagen H.C., Herman M.A., Clevers H.C.
    Nature 406:527-532(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH POP-1.
• transcription coactivator activity Source: WormBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.6

    "The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo."
    Natarajan L., Witwer N.E., Eisenmann D.M.
    Genetics 159:159-172(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH APR-1 AND POP-1.
• transcription factor binding Source: WormBaseInferred from physical interactionⁱ
  • Ref.6

    "The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo."
    Natarajan L., Witwer N.E., Eisenmann D.M.
    Genetics 159:159-172(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH APR-1 AND POP-1.
  • "A beta-catenin identified by functional rather than sequence criteria and its role in Wnt/MAPK signaling."
    Kidd A.R., Miskowski J.A., Siegfried K.R., Sawa H., Kimble J.
    Cell 121:761-772(2005) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• canonical Wnt signaling pathway Source: WormBase <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • Ref.5

    "Distinct beta-catenins mediate adhesion and signalling functions in C. elegans."
    Korswagen H.C., Herman M.A., Clevers H.C.
    Nature 406:527-532(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH POP-1.
• cell adhesion Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.1

    "The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development."
    Eisenmann D.M., Maloof J.N., Simske J.S., Kenyon C., Kim S.K.
    Development 125:3667-3680(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
• cell fate specification Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.1

    "The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development."
    Eisenmann D.M., Maloof J.N., Simske J.S., Kenyon C., Kim S.K.
    Development 125:3667-3680(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
• cellular response to oxidative stress Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • Ref.11

    "Functional interaction between beta-catenin and FOXO in oxidative stress signaling."
    Essers M.A.G., de Vries-Smits L.M.M., Barker N., Polderman P.E., Burgering B.M.T., Korswagen H.C.
    Science 308:1181-1184(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH DAF-16.
• dauer larval development Source: ParkinsonsUK-UCLInferred from genetic interactionⁱ
  • Ref.11

    "Functional interaction between beta-catenin and FOXO in oxidative stress signaling."
    Essers M.A.G., de Vries-Smits L.M.M., Barker N., Polderman P.E., Burgering B.M.T., Korswagen H.C.
    Science 308:1181-1184(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH DAF-16.
• defense response to Gram-positive bacterium Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus."
    Irazoqui J.E., Troemel E.R., Feinbaum R.L., Luhachack L.G., Cezairliyan B.O., Ausubel F.M.
    PLoS Pathog. 6:E1000982-E1000982(2010) [PubMed] [Europe PMC] [Abstract]
• determination of adult lifespan Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • Ref.11

    "Functional interaction between beta-catenin and FOXO in oxidative stress signaling."
    Essers M.A.G., de Vries-Smits L.M.M., Barker N., Polderman P.E., Burgering B.M.T., Korswagen H.C.
    Science 308:1181-1184(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH DAF-16.
• establishment of mitotic spindle orientation Source: UniProtKBInferred from genetic interactionⁱ
  • "The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac."
    Cabello J., Neukomm L.J., Guenesdogan U., Burkart K., Charette S.J., Lochnit G., Hengartner M.O., Schnabel R.
    PLoS Biol. 8:E1000297-E1000297(2010) [PubMed] [Europe PMC] [Abstract]
• hermaphrodite genitalia development Source: WormBaseInferred from mutant phenotypeⁱ
  • Ref.6

    "The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo."
    Natarajan L., Witwer N.E., Eisenmann D.M.
    Genetics 159:159-172(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH APR-1 AND POP-1.
• left/right axis specification Source: UniProtKBInferred from genetic interactionⁱ
  • "The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac."
    Cabello J., Neukomm L.J., Guenesdogan U., Burkart K., Charette S.J., Lochnit G., Hengartner M.O., Schnabel R.
    PLoS Biol. 8:E1000297-E1000297(2010) [PubMed] [Europe PMC] [Abstract]
• mating behavior Source: WormBaseInferred from mutant phenotypeⁱ
  • Ref.4

    "Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development."
    Eisenmann D.M., Kim S.K.
    Genetics 156:1097-1116(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• morphogenesis of an epithelium Source: WormBaseInferred from mutant phenotypeⁱ
  • Ref.6

    "The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo."
    Natarajan L., Witwer N.E., Eisenmann D.M.
    Genetics 159:159-172(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH APR-1 AND POP-1.
  • "A beta-catenin identified by functional rather than sequence criteria and its role in Wnt/MAPK signaling."
    Kidd A.R., Miskowski J.A., Siegfried K.R., Sawa H., Kimble J.
    Cell 121:761-772(2005) [PubMed] [Europe PMC] [Abstract]
• oviposition Source: WormBaseInferred from mutant phenotypeⁱ
  • Ref.4

    "Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development."
    Eisenmann D.M., Kim S.K.
    Genetics 156:1097-1116(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
  • Ref.6

    "The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo."
    Natarajan L., Witwer N.E., Eisenmann D.M.
    Genetics 159:159-172(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH APR-1 AND POP-1.
• positive regulation of distal tip cell migration Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac."
    Cabello J., Neukomm L.J., Guenesdogan U., Burkart K., Charette S.J., Lochnit G., Hengartner M.O., Schnabel R.
    PLoS Biol. 8:E1000297-E1000297(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: WormBaseInferred from direct assayⁱ
  • Ref.5

    "Distinct beta-catenins mediate adhesion and signalling functions in C. elegans."
    Korswagen H.C., Herman M.A., Clevers H.C.
    Nature 406:527-532(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH POP-1.
  • Ref.6

    "The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo."
    Natarajan L., Witwer N.E., Eisenmann D.M.
    Genetics 159:159-172(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH APR-1 AND POP-1.
• positive regulation of vulval development Source: WormBaseInferred from mutant phenotypeⁱ
  • "Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction."
    Gleason J.E., Korswagen H.C., Eisenmann D.M.
    Genes Dev. 16:1281-1290(2002) [PubMed] [Europe PMC] [Abstract]
• Ras protein signal transduction Source: WormBaseInferred from genetic interactionⁱ
  • Ref.4

    "Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development."
    Eisenmann D.M., Kim S.K.
    Genetics 156:1097-1116(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• regulation of backward locomotion Source: WormBaseInferred from mutant phenotypeⁱ
  • Ref.4

    "Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development."
    Eisenmann D.M., Kim S.K.
    Genetics 156:1097-1116(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• regulation of cell fate specification Source: WormBaseInferred from mutant phenotypeⁱ
  • Ref.4

    "Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development."
    Eisenmann D.M., Kim S.K.
    Genetics 156:1097-1116(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
  • Ref.6

    "The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo."
    Natarajan L., Witwer N.E., Eisenmann D.M.
    Genetics 159:159-172(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH APR-1 AND POP-1.
• regulation of cell migration Source: WormBaseInferred from mutant phenotypeⁱ
  • Ref.4

    "Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development."
    Eisenmann D.M., Kim S.K.
    Genetics 156:1097-1116(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• regulation of vulval development Source: WormBaseInferred from mutant phenotypeⁱ
  • Ref.4

    "Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development."
    Eisenmann D.M., Kim S.K.
    Genetics 156:1097-1116(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
  • Ref.6

    "The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo."
    Natarajan L., Witwer N.E., Eisenmann D.M.
    Genetics 159:159-172(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH APR-1 AND POP-1.
  • "A beta-catenin identified by functional rather than sequence criteria and its role in Wnt/MAPK signaling."
    Kidd A.R., Miskowski J.A., Siegfried K.R., Sawa H., Kimble J.
    Cell 121:761-772(2005) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• alpha-catenin binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cadherin binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• nuclear hormone receptor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein phosphatase binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II-specific DNA-binding transcription factor binding Source: WormBaseInferred from physical interactionⁱ
  • Ref.5

    "Distinct beta-catenins mediate adhesion and signalling functions in C. elegans."
    Korswagen H.C., Herman M.A., Clevers H.C.
    Nature 406:527-532(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH POP-1.
• transcription factor binding Source: WormBaseInferred from physical interactionⁱ
  • Ref.6

    "The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo."
    Natarajan L., Witwer N.E., Eisenmann D.M.
    Genetics 159:159-172(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH APR-1 AND POP-1.
  • "A beta-catenin identified by functional rather than sequence criteria and its role in Wnt/MAPK signaling."
    Kidd A.R., Miskowski J.A., Siegfried K.R., Sawa H., Kimble J.
    Cell 121:761-772(2005) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDLDPNLVIN HDDTNLSEAS FTMEQHTSSY SDIHMGSTPC TGHRKVDMWR 
        60         70         80         90        100
NHNFDSGFQT MNHSEAPSII SSLHPSSHLS GMSSMADYEP IPTLSDQQKQ 
       110        120        130        140        150
KFDGITQNQA DGQYNTVRAI PELTMLMKDQ DNEVVHKAVI LMQNIAKMEC 
       160        170        180        190        200
DPMRRQNEAR IVDPRVIFTL RDLLRDKVEF PNIIRCTLGT FFHICNRQEG 
       210        220        230        240        250
IDLVTRAIAE QPDIIPNLIR HIGTYPSSIY KYAILTMHSI LSDKQRGGQS 
       260        270        280        290        300
VIIARQQDAI THVTPWLEAE KSEKLLPVIV DLIRVLCEKN TEQKIKFVKM 
       310        320        330        340        350
GGPQKLLMLL QHRVYENLLW RTTQLLKTFS NFDAPNLVAF GGRQILANLL 
       360        370        380        390        400
SHGSPRLVQS TLETLRNISD VPSKIKEDLL LKSLLELVNS RNTTIRLYSA 
       410        420        430        440        450
QIMSNLVANN RHNKEFMCGN NGVVILVRAL TIATKEMGDL RDKEAQQMED 
       460        470        480        490        500
YIESLICTLR HLCVGHPMSD KVQAFVFRDP ALFLHKLLTM RPVLLKHTLS 
       510        520        530        540        550
LLLKVVSQHA LLAPFRSCRI GDKGFVEQLI HILRVACTQL NVQESIEGVR 
       560        570        580        590        600
VKDIIHLCIQ ILRWITRDQD ILNEVVFFLQ TPENSRMGDG HTLPIFVLQK 
       610        620        630        640        650
ANVEENTKSS ALALIYNLMH HEQMANVLDR DDVLVKMLQN VQMQSQTHPE 
       660        670        680        690        700
LASLANNILK MMYEKREKTR NTLPRYNSYL ESQFGHMSMT TPRSEALNSS 
       710        720        730        740        750
GEVCEGAGEQ WSTPLTDDTM MDSYCNSSGR DSSKPYNSPM YHSPPAMYPE 
       760        770        780        790        800
YSIGPPETYL DPHATASCYP RPTPPQYNSY DRSPPVYNDL PSNPGPSSHS 
       810 
SDYYPSRNSR F                                           

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Caenorhabditis elegans
   Caenorhabditis elegans: entries, gene names and cross-references to WormBase
2. SIMILARITY comments
   Index of protein domains and families