UniProtKB - Q18825 (BAR1_CAEEL)
Beta-catenin/armadillo-related protein 1
bar-1
Functioni
Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectodermal cell P12 specification, movement, body length, male tail development and dauer induction. Functionally redundant to wrm-1 and hmp-2.
8 PublicationsMiscellaneous
Caution
GO - Molecular functioni
- alpha-catenin binding Source: GO_Central
- cadherin binding Source: GO_Central
- DNA-binding transcription factor binding Source: WormBase
- protein phosphatase binding Source: GO_Central
- RNA polymerase II-specific DNA-binding transcription factor binding Source: WormBase
- transcription coactivator activity Source: WormBase
GO - Biological processi
- canonical Wnt signaling pathway Source: WormBase
- cell adhesion Source: UniProtKB
- cell fate specification Source: UniProtKB
- cellular response to oxidative stress Source: ParkinsonsUK-UCL
- dauer larval development Source: ParkinsonsUK-UCL
- defense response to Gram-positive bacterium Source: UniProtKB
- determination of adult lifespan Source: ParkinsonsUK-UCL
- establishment of mitotic spindle orientation Source: UniProtKB
- hermaphrodite genitalia development Source: WormBase
- left/right axis specification Source: UniProtKB
- mating behavior Source: WormBase
- morphogenesis of an epithelium Source: WormBase
- oviposition Source: WormBase
- positive regulation of distal tip cell migration Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: WormBase
- positive regulation of vulval development Source: WormBase
- programmed cell death involved in cell development Source: UniProtKB
- Ras protein signal transduction Source: WormBase
- regulation of backward locomotion Source: WormBase
- regulation of cell fate specification Source: WormBase
- regulation of cell migration Source: WormBase
- regulation of vulval development Source: WormBase
Keywordsi
Molecular function | Activator, Developmental protein |
Biological process | Transcription, Transcription regulation, Wnt signaling pathway |
Enzyme and pathway databases
Reactomei | R-CEL-5218920, VEGFR2 mediated vascular permeability R-CEL-6798695, Neutrophil degranulation R-CEL-6809371, Formation of the cornified envelope R-CEL-8980692, RHOA GTPase cycle R-CEL-9013026, RHOB GTPase cycle R-CEL-9013106, RHOC GTPase cycle R-CEL-9013407, RHOH GTPase cycle |
SignaLinki | Q18825 |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-catenin/armadillo-related protein 1Alternative name(s): Protruding vulva protein 1 Suppressor of polyray 1 |
Gene namesi | ORF Names:C54D1.6 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | C54D1.6 ; CE08973 ; WBGene00000238 ; bar-1 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 2 Publications
Nucleus
- Nucleus 2 Publications
Other locations
- Membrane 2 Publications
- Cell junction 2 Publications
Note: Mostly cytoplasmic.2 Publications
Cytosol
- cytosol Source: WormBase
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- catenin complex Source: GO_Central
Other locations
- adherens junction Source: WormBase
- cell junction Source: UniProtKB
- cytoplasm Source: UniProtKB
- membrane Source: WormBase
Keywords - Cellular componenti
Cell junction, Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 239 | S → L in ep451; interferes with neuroblast Q migration. 1 Publication | 1 | |
Mutagenesisi | 278 | V → G in ep484; interferes with neuroblast Q migration; in association with Asn-281. 1 Publication | 1 | |
Mutagenesisi | 281 | D → N in ep484; interferes with neuroblast Q migration; in association with Gly-278. 1 Publication | 1 | |
Mutagenesisi | 369 | S → K in ep466; interferes with neuroblast Q migration. 1 Publication | 1 | |
Mutagenesisi | 449 | E → K in ep487/ep478; variable interference with neuroblast Q migration. 1 Publication | 1 | |
Mutagenesisi | 460 | R → W in ep461; interferes with neuroblast Q migration. 1 Publication | 1 | |
Mutagenesisi | 482 | L → I in mu349; suppresses ectopic expression of mab-5 and interferes with neuroblast Q migration. 2 Publications | 1 | |
Mutagenesisi | 498 | T → I in ep485; interferes with neuroblast Q migration. 1 Publication | 1 | |
Mutagenesisi | 524 | G → D in ep460/mu63; suppresses ectopic expression of mab-5. 2 Publications | 1 | |
Mutagenesisi | 524 | G → S in ep486; interferes with neuroblast Q migration. 2 Publications | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000372805 | 1 – 811 | Beta-catenin/armadillo-related protein 1Add BLAST | 811 |
Proteomic databases
PaxDbi | Q18825 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | WBGene00000238, Expressed in material anatomical entity and 4 other tissues |
Interactioni
Subunit structurei
Interacts with apr-1, axl-1, daf-16, lin-23, and pop-1 (via acidic region in N-terminus 1-44).
Interacts (via ARM repeats) with pry-1.
6 PublicationsBinary interactionsi
GO - Molecular functioni
- alpha-catenin binding Source: GO_Central
- cadherin binding Source: GO_Central
- DNA-binding transcription factor binding Source: WormBase
- protein phosphatase binding Source: GO_Central
- RNA polymerase II-specific DNA-binding transcription factor binding Source: WormBase
Protein-protein interaction databases
BioGRIDi | 45907, 203 interactors |
IntActi | Q18825, 20 interactors |
STRINGi | 6239.C54D1.6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 108 – 147 | ARM 1Sequence analysisAdd BLAST | 40 | |
Repeati | 331 – 369 | ARM 2Sequence analysisAdd BLAST | 39 | |
Repeati | 370 – 408 | ARM 3Sequence analysisAdd BLAST | 39 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 85 | Involved in transcriptional activation1 PublicationAdd BLAST | 85 | |
Regioni | 541 – 811 | Involved in transcriptional activation1 PublicationAdd BLAST | 271 | |
Regioni | 763 – 811 | DisorderedSequence analysisAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 771 – 811 | Polar residuesSequence analysisAdd BLAST | 41 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4203, Eukaryota |
HOGENOMi | CLU_347902_0_0_1 |
InParanoidi | Q18825 |
OMAi | EAQQMED |
OrthoDBi | 303939at2759 |
PhylomeDBi | Q18825 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR013284, Beta-catenin |
PANTHERi | PTHR45976, PTHR45976, 1 hit |
PRINTSi | PR01869, BCATNINFAMLY |
SMARTi | View protein in SMART SM00185, ARM, 3 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MDLDPNLVIN HDDTNLSEAS FTMEQHTSSY SDIHMGSTPC TGHRKVDMWR
60 70 80 90 100
NHNFDSGFQT MNHSEAPSII SSLHPSSHLS GMSSMADYEP IPTLSDQQKQ
110 120 130 140 150
KFDGITQNQA DGQYNTVRAI PELTMLMKDQ DNEVVHKAVI LMQNIAKMEC
160 170 180 190 200
DPMRRQNEAR IVDPRVIFTL RDLLRDKVEF PNIIRCTLGT FFHICNRQEG
210 220 230 240 250
IDLVTRAIAE QPDIIPNLIR HIGTYPSSIY KYAILTMHSI LSDKQRGGQS
260 270 280 290 300
VIIARQQDAI THVTPWLEAE KSEKLLPVIV DLIRVLCEKN TEQKIKFVKM
310 320 330 340 350
GGPQKLLMLL QHRVYENLLW RTTQLLKTFS NFDAPNLVAF GGRQILANLL
360 370 380 390 400
SHGSPRLVQS TLETLRNISD VPSKIKEDLL LKSLLELVNS RNTTIRLYSA
410 420 430 440 450
QIMSNLVANN RHNKEFMCGN NGVVILVRAL TIATKEMGDL RDKEAQQMED
460 470 480 490 500
YIESLICTLR HLCVGHPMSD KVQAFVFRDP ALFLHKLLTM RPVLLKHTLS
510 520 530 540 550
LLLKVVSQHA LLAPFRSCRI GDKGFVEQLI HILRVACTQL NVQESIEGVR
560 570 580 590 600
VKDIIHLCIQ ILRWITRDQD ILNEVVFFLQ TPENSRMGDG HTLPIFVLQK
610 620 630 640 650
ANVEENTKSS ALALIYNLMH HEQMANVLDR DDVLVKMLQN VQMQSQTHPE
660 670 680 690 700
LASLANNILK MMYEKREKTR NTLPRYNSYL ESQFGHMSMT TPRSEALNSS
710 720 730 740 750
GEVCEGAGEQ WSTPLTDDTM MDSYCNSSGR DSSKPYNSPM YHSPPAMYPE
760 770 780 790 800
YSIGPPETYL DPHATASCYP RPTPPQYNSY DRSPPVYNDL PSNPGPSSHS
810
SDYYPSRNSR F
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF063646 mRNA Translation: AAC17424.1 FO080795 Genomic DNA Translation: CCD66852.1 |
PIRi | T43175 |
RefSeqi | NP_509206.1, NM_076805.5 |
Genome annotation databases
EnsemblMetazoai | C54D1.6.1; C54D1.6.1; WBGene00000238 |
GeneIDi | 180982 |
KEGGi | cel:CELE_C54D1.6 |
UCSCi | C54D1.6.1, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF063646 mRNA Translation: AAC17424.1 FO080795 Genomic DNA Translation: CCD66852.1 |
PIRi | T43175 |
RefSeqi | NP_509206.1, NM_076805.5 |
3D structure databases
SMRi | Q18825 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 45907, 203 interactors |
IntActi | Q18825, 20 interactors |
STRINGi | 6239.C54D1.6 |
Proteomic databases
PaxDbi | Q18825 |
Genome annotation databases
EnsemblMetazoai | C54D1.6.1; C54D1.6.1; WBGene00000238 |
GeneIDi | 180982 |
KEGGi | cel:CELE_C54D1.6 |
UCSCi | C54D1.6.1, c. elegans |
Organism-specific databases
CTDi | 180982 |
WormBasei | C54D1.6 ; CE08973 ; WBGene00000238 ; bar-1 |
Phylogenomic databases
eggNOGi | KOG4203, Eukaryota |
HOGENOMi | CLU_347902_0_0_1 |
InParanoidi | Q18825 |
OMAi | EAQQMED |
OrthoDBi | 303939at2759 |
PhylomeDBi | Q18825 |
Enzyme and pathway databases
Reactomei | R-CEL-5218920, VEGFR2 mediated vascular permeability R-CEL-6798695, Neutrophil degranulation R-CEL-6809371, Formation of the cornified envelope R-CEL-8980692, RHOA GTPase cycle R-CEL-9013026, RHOB GTPase cycle R-CEL-9013106, RHOC GTPase cycle R-CEL-9013407, RHOH GTPase cycle |
SignaLinki | Q18825 |
Miscellaneous databases
PROi | PR:Q18825 |
Gene expression databases
Bgeei | WBGene00000238, Expressed in material anatomical entity and 4 other tissues |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR013284, Beta-catenin |
PANTHERi | PTHR45976, PTHR45976, 1 hit |
PRINTSi | PR01869, BCATNINFAMLY |
SMARTi | View protein in SMART SM00185, ARM, 3 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BAR1_CAEEL | |
Accessioni | Q18825Primary (citable) accession number: Q18825 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | June 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families