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Entry version 98 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

G-protein coupled receptor-associated protein LMBRD2

Gene

C47G2.4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May associate with G-protein coupled receptors and regulate downstream signaling pathways.

By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G-protein coupled receptor-associated protein LMBRD2By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:C47G2.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
C47G2.4 ; CE02167 ; WBGene00008165

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 3ExtracellularSequence analysis3
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4 – 26HelicalSequence analysisAdd BLAST23
Topological domaini27 – 31CytoplasmicSequence analysis5
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 103ExtracellularSequence analysisAdd BLAST51
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 141CytoplasmicSequence analysisAdd BLAST17
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 173ExtracellularSequence analysisAdd BLAST11
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 367CytoplasmicSequence analysisAdd BLAST173
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Topological domaini389 – 412ExtracellularSequence analysisAdd BLAST24
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 453CytoplasmicSequence analysisAdd BLAST20
Transmembranei454 – 474HelicalSequence analysisAdd BLAST21
Topological domaini475 – 502ExtracellularSequence analysisAdd BLAST28
Transmembranei503 – 523HelicalSequence analysisAdd BLAST21
Topological domaini524 – 644CytoplasmicSequence analysisAdd BLAST121

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002991671 – 644G-protein coupled receptor-associated protein LMBRD2Add BLAST644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q18695

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q18695

PeptideAtlas

More...
PeptideAtlasi
Q18695

PRoteomics IDEntifications database

More...
PRIDEi
Q18695

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00008165, Expressed in adult organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C47G2.4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q18695

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni567 – 644DisorderedSequence analysisAdd BLAST78

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili219 – 242Sequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi573 – 599Polar residuesSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LIMR family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2296, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018651

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018886_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q18695

Identification of Orthologs from Complete Genome Data

More...
OMAi
LPLMQSY

Database of Orthologous Groups

More...
OrthoDBi
778022at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q18695

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006876, LMBR1-like_membr_prot

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04791, LMBR1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q18695-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTISLAVQL FIVFLLTSYL LNKYSTIRKQ NPIVTISTFI GWYFSLIIVF
60 70 80 90 100
VLPLDVAITF FHKCENDRQR ILNTTTSTPA PVVPECELPG GYVPDDVLFN
110 120 130 140 150
LWRVVYWSAQ LLTWLILPLL QSYVTAGNFT ILGKIRAAVI NNALYYAIYS
160 170 180 190 200
LCFLAILIYA MFKGVSINIE NLKVIVVSAS NTWGLFLLVV LLGHGLVELP
210 220 230 240 250
RSLWHHGNRH YRLRKTYFDI EKLASEKSEA EENVKDIYKK VRVLFNSMKN
260 270 280 290 300
DSNGQRRKVR TILSKFSDDV IDNLFPSRQV IDNAHLDESG PCSEAKLISL
310 320 330 340 350
HKKTIYAVQT LNNATAQWKV LVDRALFLEN LAFSESNGYN LELSRNTCVP
360 370 380 390 400
IGVRRFWYTR LQTPFCRILG IVTVFMTFFV LFSECTFFVV SYTLSPAAFV
410 420 430 440 450
TEYASTRFHY KYTQFVAFGI IVYLITSAYF TIFRLQIYKY YHLDPNGHTD
460 470 480 490 500
ENSILFSAIL LCRLTPPICL NFLGMIHMDS HISMAKSFGI ETQFTKLMGH
510 520 530 540 550
LDVIPILAKG INIYLPICII LLCAIHYYRV GAYVLHNIGF DQFVEADEMT
560 570 580 590 600
NDMINSGRSL VQIERNSIKR SNDRSQRTQN WTNSFGSSNA GNGSTTSKFK
610 620 630 640
RSNKNDEERP MLEDDDEEVE ESSTRISMMS PTEHPSSSGF FDDM
Length:644
Mass (Da):73,646
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i056776A638B2667E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z49125 Genomic DNA Translation: CAA88936.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T20034

NCBI Reference Sequences

More...
RefSeqi
NP_496413.1, NM_064012.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C47G2.4.1; C47G2.4.1; WBGene00008165

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174724

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C47G2.4

UCSC genome browser

More...
UCSCi
C47G2.4, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49125 Genomic DNA Translation: CAA88936.1
PIRiT20034
RefSeqiNP_496413.1, NM_064012.6

3D structure databases

SMRiQ18695
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.C47G2.4

Proteomic databases

EPDiQ18695
PaxDbiQ18695
PeptideAtlasiQ18695
PRIDEiQ18695

Genome annotation databases

EnsemblMetazoaiC47G2.4.1; C47G2.4.1; WBGene00008165
GeneIDi174724
KEGGicel:CELE_C47G2.4
UCSCiC47G2.4, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174724
WormBaseiC47G2.4 ; CE02167 ; WBGene00008165

Phylogenomic databases

eggNOGiKOG2296, Eukaryota
GeneTreeiENSGT00390000018651
HOGENOMiCLU_018886_0_0_1
InParanoidiQ18695
OMAiLPLMQSY
OrthoDBi778022at2759
PhylomeDBiQ18695

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q18695

Gene expression databases

BgeeiWBGene00008165, Expressed in adult organism and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR006876, LMBR1-like_membr_prot
PfamiView protein in Pfam
PF04791, LMBR1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLMBD2_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q18695
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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