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Protein

Protein unc-112

Gene

unc-112

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of an integrin containing attachment complex, which is required for muscle development and maintenance (PubMed:22253611). Probable regulator of cell-extracellular matrix adhesion (PubMed:10893272). Required during initial muscle assembly to form dense bodies and M-lines (PubMed:10893272).2 Publications

GO - Molecular functioni

  • cell adhesion molecule binding Source: UniProtKB
  • integrin binding Source: UniProtKB
  • protein self-association Source: UniProtKB
  • structural molecule activity Source: WormBase

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-CEL-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-112
Alternative name(s):
Mitogen-inducible mig-2 protein-like
Uncoordinated protein 112
Gene namesi
Name:unc-112Imported
ORF Names:C47E8.7Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC47E8.7 ; CE05443 ; WBGene00006836 ; unc-112

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown results in impaired mobility, mitochondrial fragmentation and disrupted integrin attachment complexes in muscle. This leads to degradation of muscle proteins in the cytosol, myofibrillar defects and disruption of sarcomere organization.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi85T → I in R367; temperature sensitive. Adults are paralyzed. Induces disorganized body wall muscle. Disrupted integrin attachment complexes in muscle, which results in degradation of muscle proteins in the cytosol, myofibrillar defects and disruption of sarcomere organization. Mitochondrial fragmentation. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194581 – 720Protein unc-112Add BLAST720

Proteomic databases

EPDiQ18685
PaxDbiQ18685
PeptideAtlasiQ18685
PRIDEiQ18685

PTM databases

iPTMnetiQ18685

Expressioni

Tissue specificityi

Mainly expressed in muscle cells in both embryos and adults.4 Publications

Gene expression databases

BgeeiWBGene00006836 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Interactioni

Subunit structurei

Interacts with pat-4/ILK (PubMed:12015115, PubMed:12781130). Probably forms a complex with pat-4 and pat-6 (PubMed:12781130). Component of an integrin containing attachment complex, composed of at least pat-2, pat-3, pat-4, pat-6, unc-52, unc-97 and unc-112 (PubMed:22253611).1 Publication2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
pat-4Q9TZC45EBI-1564809,EBI-1564527

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ18685, 2 interactors
STRINGi6239.C47E8.7.2

Structurei

3D structure databases

ProteinModelPortaliQ18685
SMRiQ18685
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini288 – 614FERMAdd BLAST327
Domaini402 – 507PHPROSITE-ProRule annotationAdd BLAST106

Domaini

The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.

Sequence similaritiesi

Belongs to the kindlin family.Curated

Phylogenomic databases

eggNOGiKOG3727 Eukaryota
ENOG410XS1B LUCA
GeneTreeiENSGT00390000013444
HOGENOMiHOG000231715
InParanoidiQ18685
KOiK17083
OMAiVNWEVKH
OrthoDBiEOG091G03SD
PhylomeDBiQ18685

Family and domain databases

CDDicd14473 FERM_B-lobe, 2 hits
cd01237 PH_fermitin, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR037843 Kindlin/fermitin
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037837 PH_Kindlin/fermitin
PANTHERiPTHR16160 PTHR16160, 1 hit
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q18685-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHLVEGTSI IDGKWQLPIL VTDLNIQRSI SVLGNLNVGG LMLELVSECD
60 70 80 90 100
VERDWSDHAL WWPEKRRWLQ HTRSTLDQNG ITAETQLEFT PMHKEARIQL
110 120 130 140 150
PDMQMIDARV DFSVNSFKAT KKLCRDLGIR YSEELSLKRY IPPEDLRRGT
160 170 180 190 200
SDADNMNGPL SMRPGEESVG PMTLRKAAPI FASQSNLDMR RRGQSPALSQ
210 220 230 240 250
SGHIFNAHEM GTLPRHGTLP RGVSPSPGAY NDTMRRTPIM PSISFSEGLE
260 270 280 290 300
NEQFDDALIH SPRLAPSRDT PVFRPQNYVE KAAINRGWLD SSRSLMEQGI
310 320 330 340 350
FEGDIILLRF KFMNFFDLNP KYDPVRINQL YEQAKWSILL DEFDHTEEEA
360 370 380 390 400
TLFAALQLQA TLQRDSPEPE ENNKDDVDIL LDELEQNLDA AALNRRSDLT
410 420 430 440 450
QVPELADYLK YMKPKKLAAF KGFKRAFFSF RDLYLSYHQS SSDVNSAPLG
460 470 480 490 500
HFSLKGCEVS QDVSVGQQKY HIKLLLPTAE GMIDFILKCD SEHQYARWMA
510 520 530 540 550
ACRLASRGKS MADSSYQQEV ESIKNLLKMQ SGNGNENGNS NTASRKAAAV
560 570 580 590 600
KLPNDFNVDE YISSKYVRRA RSKQQIQQRV SDAHGNVRQL TATEAKLQYI
610 620 630 640 650
RAWQALPEHG IHYFIVRFRN ARKAELVAVA VNRLAKLNMD NGESLKTWRF
660 670 680 690 700
ANMKKWHVNW EIRHLKIQFE DEDIEFKPLS ADCKVVHEFI GGYIFLSMRS
710 720
KEHSQNLDEE LFHKLTGGWA
Length:720
Mass (Da):82,355
Last modified:November 1, 1996 - v1
Checksum:i663CB0E9891C1A12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217185 mRNA Translation: AAF20162.1
BX284605 Genomic DNA Translation: CAA99790.1
PIRiT20016
RefSeqiNP_506628.1, NM_074227.6
UniGeneiCel.5462

Genome annotation databases

EnsemblMetazoaiC47E8.7.1; C47E8.7.1; WBGene00006836
C47E8.7.2; C47E8.7.2; WBGene00006836
GeneIDi179972
KEGGicel:CELE_C47E8.7
UCSCiC47E8.7.1 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217185 mRNA Translation: AAF20162.1
BX284605 Genomic DNA Translation: CAA99790.1
PIRiT20016
RefSeqiNP_506628.1, NM_074227.6
UniGeneiCel.5462

3D structure databases

ProteinModelPortaliQ18685
SMRiQ18685
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ18685, 2 interactors
STRINGi6239.C47E8.7.2

PTM databases

iPTMnetiQ18685

Proteomic databases

EPDiQ18685
PaxDbiQ18685
PeptideAtlasiQ18685
PRIDEiQ18685

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC47E8.7.1; C47E8.7.1; WBGene00006836
C47E8.7.2; C47E8.7.2; WBGene00006836
GeneIDi179972
KEGGicel:CELE_C47E8.7
UCSCiC47E8.7.1 c. elegans

Organism-specific databases

CTDi179972
WormBaseiC47E8.7 ; CE05443 ; WBGene00006836 ; unc-112

Phylogenomic databases

eggNOGiKOG3727 Eukaryota
ENOG410XS1B LUCA
GeneTreeiENSGT00390000013444
HOGENOMiHOG000231715
InParanoidiQ18685
KOiK17083
OMAiVNWEVKH
OrthoDBiEOG091G03SD
PhylomeDBiQ18685

Enzyme and pathway databases

ReactomeiR-CEL-114608 Platelet degranulation

Miscellaneous databases

PROiPR:Q18685

Gene expression databases

BgeeiWBGene00006836 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

CDDicd14473 FERM_B-lobe, 2 hits
cd01237 PH_fermitin, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR037843 Kindlin/fermitin
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037837 PH_Kindlin/fermitin
PANTHERiPTHR16160 PTHR16160, 1 hit
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUN112_CAEEL
AccessioniPrimary (citable) accession number: Q18685
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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