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Protein

Probable transaldolase

Gene

tal

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.UniRule annotation

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable transaldolase (tal), Transaldolase (CD630_31060), Transaldolase (CD630_21100)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei83Schiff-base intermediate with substrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPentose shunt
LigandSchiff base

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-2481-MONOMER
UniPathwayi
UPA00115;UER00414

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transaldolaseUniRule annotation (EC:2.2.1.2UniRule annotation)
Gene namesi
Name:talUniRule annotation
Ordered Locus Names:CD630_23290
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000604631 – 216Probable transaldolaseAdd BLAST216

Interactioni

Protein-protein interaction databases

STRINGi272563.CD2329

Structurei

3D structure databases

ProteinModelPortaliQ185K3
SMRiQ185K3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 3B subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CW3 Bacteria
COG0176 LUCA
HOGENOMiHOG000226073
KOiK00616
OMAiVRHPMHV

Family and domain databases

CDDicd00956 Transaldolase_FSA, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00494 Transaldolase_3b, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001585 TAL/FSA
IPR022999 Transaldolase_3B
IPR004731 Transaldolase_3B/F6P_aldolase
IPR018225 Transaldolase_AS
IPR033919 TSA/FSA_arc/bac
PANTHERiPTHR10683 PTHR10683, 1 hit
PfamiView protein in Pfam
PF00923 TAL_FSA, 1 hit
TIGRFAMsiTIGR00875 fsa_talC_mipB, 1 hit
PROSITEiView protein in PROSITE
PS01054 TRANSALDOLASE_1, 1 hit
PS00958 TRANSALDOLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q185K3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFFIDTANI EEIKEANDLG VICGVTTNPS LIAKEGRDFI EVVKEISEIV
60 70 80 90 100
DGPISAEVIS LEHKGMIEEA EKLSKIHKNI VIKIPMTAEG LKAVKVLSSK
110 120 130 140 150
GIKTNVTLIF SAGQALLAAR AGATYVSPFV GRLDDISQNG LDLIEEIVDI
160 170 180 190 200
FSVNSIEAQI IVASVRNPIH VLQAARMGAD IATVPLKVIN QMIKHPLTDK
210
GIDSFMKDWE GASLKL
Length:216
Mass (Da):23,401
Last modified:July 25, 2006 - v1
Checksum:i79CDDE3831B2CFA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ69216.1
RefSeqiWP_003423115.1, NZ_CP010905.2
YP_001088844.1, NC_009089.1

Genome annotation databases

EnsemblBacteriaiCAJ69216; CAJ69216; CD630_23290
GeneIDi31353922
4914171
KEGGicdf:CD630_23290
pdc:CDIF630_02567
PATRICifig|272563.120.peg.2460

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ69216.1
RefSeqiWP_003423115.1, NZ_CP010905.2
YP_001088844.1, NC_009089.1

3D structure databases

ProteinModelPortaliQ185K3
SMRiQ185K3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD2329

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ69216; CAJ69216; CD630_23290
GeneIDi31353922
4914171
KEGGicdf:CD630_23290
pdc:CDIF630_02567
PATRICifig|272563.120.peg.2460

Phylogenomic databases

eggNOGiENOG4105CW3 Bacteria
COG0176 LUCA
HOGENOMiHOG000226073
KOiK00616
OMAiVRHPMHV

Enzyme and pathway databases

UniPathwayi
UPA00115;UER00414

BioCyciPDIF272563:G12WB-2481-MONOMER

Family and domain databases

CDDicd00956 Transaldolase_FSA, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00494 Transaldolase_3b, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001585 TAL/FSA
IPR022999 Transaldolase_3B
IPR004731 Transaldolase_3B/F6P_aldolase
IPR018225 Transaldolase_AS
IPR033919 TSA/FSA_arc/bac
PANTHERiPTHR10683 PTHR10683, 1 hit
PfamiView protein in Pfam
PF00923 TAL_FSA, 1 hit
TIGRFAMsiTIGR00875 fsa_talC_mipB, 1 hit
PROSITEiView protein in PROSITE
PS01054 TRANSALDOLASE_1, 1 hit
PS00958 TRANSALDOLASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAL_PEPD6
AccessioniPrimary (citable) accession number: Q185K3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 25, 2006
Last modified: October 10, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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