Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 127 (13 Nov 2019)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Sphingosine kinase 1

Gene

sphk-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on sphinganine (By similarity). Required for neurotransmitter release from neuromuscular junctions. Acts by recruiting the synaptic vesicle priming protein unc-13 to synapses (PubMed:22588719, PubMed:23223309) (Probable).By similarity1 Publication2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei153Proton donor/acceptorBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei158ATPPROSITE-ProRule annotation1
Binding sitei251SubstrateBy similarity1
Binding sitei258ATPPROSITE-ProRule annotation1
Binding sitei265ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi93 – 95ATPPROSITE-ProRule annotation3
Nucleotide bindingi125 – 129ATPPROSITE-ProRule annotation5
Nucleotide bindingi184 – 186ATPPROSITE-ProRule annotation3
Nucleotide bindingi448 – 450ATPPROSITE-ProRule annotation3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • lipid phosphorylation Source: WormBase
  • positive regulation of acetylcholine secretion, neurotransmission Source: WormBase
  • protein acetylation Source: UniProtKB
  • regulation of locomotion Source: WormBase
  • regulation of phagocytosis Source: UniProtKB
  • sphingolipid metabolic process Source: UniProtKB-UniPathway

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processLipid metabolism, Sphingolipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1660661 Sphingolipid de novo biosynthesis
R-CEL-390471 Association of TriC/CCT with target proteins during biosynthesis
R-CEL-5218921 VEGFR2 mediated cell proliferation
R-CEL-9009391 Extra-nuclear estrogen signaling

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00222

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sphingosine kinase 1 (EC:2.7.1.91Curated)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sphk-1
Synonyms:tag-274
ORF Names:C34C6.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
C34C6.5a ; CE03053 ; WBGene00007918 ; sphk-1
C34C6.5b ; CE35833 ; WBGene00007918 ; sphk-1
C34C6.5c ; CE44377 ; WBGene00007918 ; sphk-1
C34C6.5d ; CE47276 ; WBGene00007918 ; sphk-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Mitochondrion, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi151 – 155SGDGL → AAAAA: Impairs responsiveness to aldicarb, probably due to loss of kinase function. 1 Publication5
Mutagenesisi184 – 187GSGN → DDDD: Impairs responsiveness to aldicarb, probably due to loss of kinase function. 1 Publication4
Mutagenesisi268V → Q: Disrupts location in axons. Loss of neurotransmission. 1 Publication1
Mutagenesisi271 – 272FI → AQ: Impairs translocation to the presynaptic membrane. 1 Publication2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004214521 – 473Sphingosine kinase 1Add BLAST473

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q18425

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q18425

PeptideAtlas

More...
PeptideAtlasi
Q18425

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the majority of cholinergic and GABAergic neurons, body wall muscle, excretory canal cells, intestine, and hypodermis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00007918 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C34C6.5a

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini83 – 233DAGKcPROSITE-ProRule annotationAdd BLAST151

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni151 – 154Substrate bindingBy similarity4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1116 Eukaryota
COG1597 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167991

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000122773

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q18425

KEGG Orthology (KO)

More...
KOi
K04718

Identification of Orthologs from Complete Genome Data

More...
OMAi
HYISIDG

Database of Orthologous Groups

More...
OrthoDBi
681139at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q18425

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00781 DAGK_cat, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00046 DAGKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111331 SSF111331, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50146 DAGK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: Q18425-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFIVVVTIFE NYTQWYSSLL TIFSLTIKRK LKTIRSMQDS TSKCTCTEHH
60 70 80 90 100
MGGTICCCCR SDAEENEQLT SVILSRKPPP QEQCRGNLLV FINPNSGTGK
110 120 130 140 150
SLETFANTVG PKLDKSLIRY EVVVTTGPNH ARNVLMTKAD LGKFNGVLIL
160 170 180 190 200
SGDGLVFEAL NGILCREDAF RIFPTLPIGI VPSGSGNGLL CSVLSKYGTK
210 220 230 240 250
MNEKSVMERA LEIATSPTAK AESVALYSVK TDNQSYASFL SIGWGLMADI
260 270 280 290 300
DIDSEKWRKS LGHHRFTVMG FIRSCNLRSY KGRLTYRPYK PKGFHPSSNV
310 320 330 340 350
FSVYEKTTQQ RIDDSKVKTN GSVSDSEEET METKFQNWTL PDSDETLAVG
360 370 380 390 400
SSDLEETVVI EDNFVNIYAV TLSHIAADGP FAPSAKLEDN RIHLSYILWK
410 420 430 440 450
DIGTRVNIAK YLLAIEHETH LDLPFVKHVE VSSMKLEVIS EGSHVVLDGE
460 470
VVDTKTIEVA STKNHISVFS STA
Length:473
Mass (Da):52,453
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC9296EAD915103E
GO
Isoform b (identifier: Q18425-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Show »
Length:423
Mass (Da):46,540
Checksum:iBFDAA526AF9E2626
GO
Isoform c (identifier: Q18425-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     80-81: PQ → ME

Show »
Length:394
Mass (Da):43,451
Checksum:i7BD2B6F35484E656
GO
Isoform d (identifier: Q18425-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.

Show »
Length:338
Mass (Da):37,339
Checksum:iEFE68AC31900177C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0457201 – 135Missing in isoform d. CuratedAdd BLAST135
Alternative sequenceiVSP_0457211 – 79Missing in isoform c. CuratedAdd BLAST79
Alternative sequenceiVSP_0457221 – 50Missing in isoform b. CuratedAdd BLAST50
Alternative sequenceiVSP_04572380 – 81PQ → ME in isoform c. Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z66494 Genomic DNA Translation: CAA91259.1
Z66494 Genomic DNA Translation: CAE48497.1
Z66494 Genomic DNA Translation: CBI83226.1
Z66494 Genomic DNA Translation: CCG28273.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T19707

NCBI Reference Sequences

More...
RefSeqi
NP_001022017.1, NM_001026846.1 [Q18425-1]
NP_001022018.1, NM_001026847.4 [Q18425-2]
NP_001254179.1, NM_001267250.1 [Q18425-3]
NP_001254180.1, NM_001267251.1 [Q18425-4]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C34C6.5a.1; C34C6.5a.1; WBGene00007918 [Q18425-1]
C34C6.5b.1; C34C6.5b.1; WBGene00007918 [Q18425-2]
C34C6.5b.2; C34C6.5b.2; WBGene00007918 [Q18425-2]
C34C6.5b.3; C34C6.5b.3; WBGene00007918 [Q18425-2]
C34C6.5b.4; C34C6.5b.4; WBGene00007918 [Q18425-2]
C34C6.5c.1; C34C6.5c.1; WBGene00007918 [Q18425-3]
C34C6.5d.1; C34C6.5d.1; WBGene00007918 [Q18425-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
183197

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C34C6.5

UCSC genome browser

More...
UCSCi
C34C6.5b.1 c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z66494 Genomic DNA Translation: CAA91259.1
Z66494 Genomic DNA Translation: CAE48497.1
Z66494 Genomic DNA Translation: CBI83226.1
Z66494 Genomic DNA Translation: CCG28273.1
PIRiT19707
RefSeqiNP_001022017.1, NM_001026846.1 [Q18425-1]
NP_001022018.1, NM_001026847.4 [Q18425-2]
NP_001254179.1, NM_001267250.1 [Q18425-3]
NP_001254180.1, NM_001267251.1 [Q18425-4]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.C34C6.5a

Proteomic databases

EPDiQ18425
PaxDbiQ18425
PeptideAtlasiQ18425

Genome annotation databases

EnsemblMetazoaiC34C6.5a.1; C34C6.5a.1; WBGene00007918 [Q18425-1]
C34C6.5b.1; C34C6.5b.1; WBGene00007918 [Q18425-2]
C34C6.5b.2; C34C6.5b.2; WBGene00007918 [Q18425-2]
C34C6.5b.3; C34C6.5b.3; WBGene00007918 [Q18425-2]
C34C6.5b.4; C34C6.5b.4; WBGene00007918 [Q18425-2]
C34C6.5c.1; C34C6.5c.1; WBGene00007918 [Q18425-3]
C34C6.5d.1; C34C6.5d.1; WBGene00007918 [Q18425-4]
GeneIDi183197
KEGGicel:CELE_C34C6.5
UCSCiC34C6.5b.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
183197
WormBaseiC34C6.5a ; CE03053 ; WBGene00007918 ; sphk-1
C34C6.5b ; CE35833 ; WBGene00007918 ; sphk-1
C34C6.5c ; CE44377 ; WBGene00007918 ; sphk-1
C34C6.5d ; CE47276 ; WBGene00007918 ; sphk-1

Phylogenomic databases

eggNOGiKOG1116 Eukaryota
COG1597 LUCA
GeneTreeiENSGT00940000167991
HOGENOMiHOG000122773
InParanoidiQ18425
KOiK04718
OMAiHYISIDG
OrthoDBi681139at2759
PhylomeDBiQ18425

Enzyme and pathway databases

UniPathwayiUPA00222
ReactomeiR-CEL-1660661 Sphingolipid de novo biosynthesis
R-CEL-390471 Association of TriC/CCT with target proteins during biosynthesis
R-CEL-5218921 VEGFR2 mediated cell proliferation
R-CEL-9009391 Extra-nuclear estrogen signaling

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q18425

Gene expression databases

BgeeiWBGene00007918 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Family and domain databases

Gene3Di3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
PfamiView protein in Pfam
PF00781 DAGK_cat, 1 hit
SMARTiView protein in SMART
SM00046 DAGKc, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit
PROSITEiView protein in PROSITE
PS50146 DAGK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPHK1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q18425
Secondary accession number(s): D2Y8W1, H9G2Q9, Q7JM91
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: November 1, 1996
Last modified: November 13, 2019
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again