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Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.UniRule annotation
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, RNA-binding, Transferase
Biological processTranscription, Transcription regulation, Transcription termination

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-2752-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrRUniRule annotation
Including the following 2 domains:
Pyrimidine operon regulatory proteinUniRule annotation
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Short name:
UPRTaseUniRule annotation
Gene namesi
Name:pyrRUniRule annotation
Ordered Locus Names:CD630_25950
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000538271 – 177Bifunctional protein PyrRAdd BLAST177

Proteomic databases

PRIDEiQ182T5

Interactioni

Subunit structurei

Homodimer and homohexamer; in equilibrium.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD2595

Structurei

3D structure databases

ProteinModelPortaliQ182T5
SMRiQ182T5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi99 – 111PRPP-bindingUniRule annotationAdd BLAST13

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UK1 Bacteria
COG2065 LUCA
HOGENOMiHOG000245770
KOiK02825
OMAiRISHEIL

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01219 PyrR, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR023050 PyrR
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit

Sequencei

Sequence statusi: Complete.

Q182T5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVEKAQLMDE KAIARAITRI SHEIIERNKG VENLVLVGIK TRGVPIANRI
60 70 80 90 100
SKKIEQIEGT KVDTGDIDIT LYRDDLEKIH VEPVVKGTYL DFNVNDKTVV
110 120 130 140 150
LVDDVLYTGR TVRASLDAII DIGRPKSIQL AVLVDRGHRE LPIRADYVGK
160 170
NVPTSRHEII SVSLLEIDGE DSVTIKE
Length:177
Mass (Da):19,761
Last modified:July 25, 2006 - v1
Checksum:iA0588FE71A668507
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ69485.1
RefSeqiWP_003431186.1, NZ_CP010905.2
YP_001089112.1, NC_009089.1

Genome annotation databases

EnsemblBacteriaiCAJ69485; CAJ69485; CD630_25950
GeneIDi31354193
4915118
KEGGicdf:CD630_25950
pdc:CDIF630_02849
PATRICifig|272563.120.peg.2737

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ69485.1
RefSeqiWP_003431186.1, NZ_CP010905.2
YP_001089112.1, NC_009089.1

3D structure databases

ProteinModelPortaliQ182T5
SMRiQ182T5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD2595

Proteomic databases

PRIDEiQ182T5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ69485; CAJ69485; CD630_25950
GeneIDi31354193
4915118
KEGGicdf:CD630_25950
pdc:CDIF630_02849
PATRICifig|272563.120.peg.2737

Phylogenomic databases

eggNOGiENOG4108UK1 Bacteria
COG2065 LUCA
HOGENOMiHOG000245770
KOiK02825
OMAiRISHEIL

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-2752-MONOMER

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01219 PyrR, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR023050 PyrR
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPYRR_PEPD6
AccessioniPrimary (citable) accession number: Q182T5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: November 7, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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