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Protein

Guanylate kinase

Gene

gmk

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-2745-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:CD630_25880
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002663071 – 205Guanylate kinaseAdd BLAST205

Proteomic databases

PRIDEiQ182S8

Interactioni

Protein-protein interaction databases

STRINGi272563.CD2588

Structurei

3D structure databases

ProteinModelPortaliQ182S8
SMRiQ182S8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 184Guanylate kinase-likeUniRule annotationAdd BLAST179

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UHA Bacteria
COG0194 LUCA
HOGENOMiHOG000037639
KOiK00942
OMAiAGNYYGT

Family and domain databases

HAMAPiMF_00328 Guanylate_kinase, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q182S8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFVKKGLLLV VSGPSGAGKG TICKELLKEN DTIKLSVSAT TRKPRTGEVD
60 70 80 90 100
GVNYFFISKE KFEEMIEKGE FLEYAQIYDN FYGTPKAAIM ECLEKGQDVL
110 120 130 140 150
LEIEMQGAKQ IKEVCPEGVF IFVLPPSLEE LKNRIVGRGT ETEAEIEKRF
160 170 180 190 200
SCAYEEIKMI KDYDYFIFNE DVKTSAKEIE GIISSEKNKV SRYKNIIIEK

FKEEL
Length:205
Mass (Da):23,372
Last modified:July 25, 2006 - v1
Checksum:i0B780DB7446291B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ69478.1
RefSeqiWP_003431170.1, NZ_CP010905.2
YP_001089105.1, NC_009089.1

Genome annotation databases

EnsemblBacteriaiCAJ69478; CAJ69478; CD630_25880
GeneIDi31354188
4914710
KEGGicdf:CD630_25880
pdc:CDIF630_02842
PATRICifig|272563.120.peg.2730

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ69478.1
RefSeqiWP_003431170.1, NZ_CP010905.2
YP_001089105.1, NC_009089.1

3D structure databases

ProteinModelPortaliQ182S8
SMRiQ182S8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD2588

Proteomic databases

PRIDEiQ182S8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ69478; CAJ69478; CD630_25880
GeneIDi31354188
4914710
KEGGicdf:CD630_25880
pdc:CDIF630_02842
PATRICifig|272563.120.peg.2730

Phylogenomic databases

eggNOGiENOG4108UHA Bacteria
COG0194 LUCA
HOGENOMiHOG000037639
KOiK00942
OMAiAGNYYGT

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-2745-MONOMER

Family and domain databases

HAMAPiMF_00328 Guanylate_kinase, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKGUA_PEPD6
AccessioniPrimary (citable) accession number: Q182S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 25, 2006
Last modified: October 10, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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