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Entry version 151 (17 Jun 2020)
Sequence version 2 (01 Aug 1998)
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Protein
Submitted name:

Uncharacterized protein

Gene

rad-26

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rad-26Imported
ORF Names:C27B7.4Imported, CELE_C27B7.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
C27B7.4a ; CE17477 ; WBGene00007761 ; rad-26

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q18241

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q18241

PeptideAtlas

More...
PeptideAtlasi
Q18241

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00007761 Expressed in multi-cellular organism and 4 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q18241 differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-26472N

Protein interaction database and analysis system

More...
IntActi
Q18241, 37 interactors

STRING: functional protein association networks

More...
STRINGi
6239.C27B7.4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q18241

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini277 – 512Helicase ATP-bindingInterPro annotationAdd BLAST236
Domaini778 – 945Helicase C-terminalInterPro annotationAdd BLAST168

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 52DisorderedSequence analysisAdd BLAST52
Regioni399 – 420DisorderedSequence analysisAdd BLAST22
Regioni680 – 753DisorderedSequence analysisAdd BLAST74
Regioni1152 – 1172DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili629 – 649Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 24AcidicSequence analysisAdd BLAST24
Compositional biasi687 – 727PolarSequence analysisAdd BLAST41
Compositional biasi738 – 753PolyampholyteSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1015 Eukaryota
COG0553 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155763

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000315_11_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q18241

KEGG Orthology (KO)

More...
KOi
K10876

Identification of Orthologs from Complete Genome Data

More...
OMAi
TIQNWYS

Database of Orthologous Groups

More...
OrthoDBi
815681at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q18241

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10810, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q18241-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEEIDENTM KEEQEEEERD EIEEKEEKPD AQQQELLNIR IPTQTKKSLK
60 70 80 90 100
RKHIKTDFGA EDLDENVLEA QRLEKQRLER LEKIKPENDH IQQMESLFLA
110 120 130 140 150
GASEGQLPQL DLQDDDFEEM FGFSVENDNK KYRYGDEEKP EPMFHLQEPS
160 170 180 190 200
TSRGHVDVVD LTLDDSDDDC LITDVKSVMP QVVPGRRMRW AQAEKDRIDA
210 220 230 240 250
DQMDIQHNIE ARRLKKMRSA KDLESTEKKE GRLLVNAGHP EEDPDIFVIS
260 270 280 290 300
HLTHVLQPHQ LGGIRFMYDN TIESLGEYKK SDGFGCILAH SMGLGKTIQV
310 320 330 340 350
ITFSEIFLRA TKAKKVLVIV PINTIQNWYS EYDKWIPKFS DTGDRIRSFE
360 370 380 390 400
VFLLGDGVKT FDQRVNLIEQ WDQTGGVMLV GYDMFRLLIK MTLPKKQKKG
410 420 430 440 450
RPKLNLSGIS SGFSKDSSED QKLRDEELEF ETGFTSGGRV RQEAYSLIRS
460 470 480 490 500
ALLEPGPDLV VCDEGHKIKN ITAEISMTLG AINTKRRIVL TGYPLQNNLL
510 520 530 540 550
EYFCMIDFVR PKYLGTRKSF IDRFEKPIKN GQCVDSSPDD VKIALQRTHV
560 570 580 590 600
LVELVKGFVQ RRTHHLLKKI LPESKEYVLL LRKSQIQRQL YRNFVLWAKN
610 620 630 640 650
EIAANNDAVF NPLMAFSACS KIWNHPDILY RLVEQKKRAE EDKKRVEQMK
660 670 680 690 700
FAQLQQQQQQ QQQQLQGMMM MGNNGMMPGF GAQFHPQQNG MMMQNGSWHP
710 720 730 740 750
NNYQMPSPFN SIPSNPSTPT SSSTSKSAKK TKKPRGSKKA PKSDEEDEEV
760 770 780 790 800
EKESRMKYDW TFELFEKYQE GVLENGYKIV ISLEILDEST QIGEKILIFS
810 820 830 840 850
QNLTALDMLE EILKKRQIRG KDGPGQRWEK NRNYLRLDGT TSGADREKLI
860 870 880 890 900
NRFNSEPGLS LFLISTRAGS LGINLVSANR CIIIDACWNP CHDAQAVCRV
910 920 930 940 950
YRYGQQKKTF VYRLIMDNSM ERSIFNRQIS KHGLQQRVVD DAQVDANISQ
960 970 980 990 1000
KELETLLMYD EAQDVNHDKW NTDDWDFGDP VLDSITKRMS QMFAGKPFLH
1010 1020 1030 1040 1050
ETLIMESEQS LSEQEKREAQ LLFDRERRME NYDPLSGLSS SNFYNNAPGS
1060 1070 1080 1090 1100
SMGMMGPPPV PMFNNNMQNS FNNHWQQSPN QLAPNFGSYP PQQFPQPMPN
1110 1120 1130 1140 1150
MSQFPPHGPS PQIPSIRPSP MPHTLRMNVS QFHHQGGGHT MTSFNNGYPN
1160 1170 1180 1190 1200
NNNGGAIGNP QQMLPPRDPS AFPGAVMSKI PSFSPAGAVQ QLITDRQLVF
1210 1220 1230 1240 1250
PIVGHRDQLH QVQANTPIQL VVPKNGYYVK LRDGTILDAV GSVFENHARQ
1260 1270
LRDMYLSKNF NHDPQQVQEV IDLD
Length:1,274
Mass (Da):146,155
Last modified:August 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BED49329F7BC790
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B1E4Z6A0A3B1E4Z6_CAEEL
Uncharacterized protein
rad-26 C27B7.4, CELE_C27B7.4
935Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA90984.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T19508

NCBI Reference Sequences

More...
RefSeqi
NP_501545.1, NM_069144.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C27B7.4a.1; C27B7.4a.1; WBGene00007761

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
177706

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C27B7.4

UCSC genome browser

More...
UCSCi
C27B7.4 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA90984.1
PIRiT19508
RefSeqiNP_501545.1, NM_069144.4

3D structure databases

SMRiQ18241
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-26472N
IntActiQ18241, 37 interactors
STRINGi6239.C27B7.4

Proteomic databases

EPDiQ18241
PaxDbiQ18241
PeptideAtlasiQ18241

Genome annotation databases

EnsemblMetazoaiC27B7.4a.1; C27B7.4a.1; WBGene00007761
GeneIDi177706
KEGGicel:CELE_C27B7.4
UCSCiC27B7.4 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
177706
WormBaseiC27B7.4a ; CE17477 ; WBGene00007761 ; rad-26

Phylogenomic databases

eggNOGiKOG1015 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00940000155763
HOGENOMiCLU_000315_11_1_1
InParanoidiQ18241
KOiK10876
OMAiTIQNWYS
OrthoDBi815681at2759
PhylomeDBiQ18241

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q18241

Gene expression databases

BgeeiWBGene00007761 Expressed in multi-cellular organism and 4 other tissues
ExpressionAtlasiQ18241 differential

Family and domain databases

Gene3Di3.40.50.10810, 2 hits
InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ18241_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q18241
Secondary accession number(s): Q18243
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: August 1, 1998
Last modified: June 17, 2020
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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