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Protein

tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG

Gene

mnmG

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 20FADUniRule annotation6
Nucleotide bindingi274 – 288NADUniRule annotationAdd BLAST15

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processtRNA processing
LigandFAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-3867-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGUniRule annotation
Alternative name(s):
Glucose-inhibited division protein AUniRule annotation
Gene namesi
Name:mnmGUniRule annotation
Synonyms:gidAUniRule annotation
Ordered Locus Names:CD630_36750
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003452601 – 631tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGAdd BLAST631

Proteomic databases

PRIDEiQ181S8

Interactioni

Subunit structurei

Homodimer. Heterotetramer of two MnmE and two MnmG subunits.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD3675

Structurei

3D structure databases

ProteinModelPortaliQ181S8
SMRiQ181S8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RE5 Bacteria
COG0445 LUCA
HOGENOMiHOG000201060
KOiK03495
OMAiFRPGYAI

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_00129 MnmG_GidA, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR026904 GidA-assoc_3
IPR004416 MnmG
IPR002218 MnmG-rel
IPR020595 MnmG-rel_CS
PANTHERiPTHR11806 PTHR11806, 1 hit
PTHR11806:SF0 PTHR11806:SF0, 1 hit
PfamiView protein in Pfam
PF01134 GIDA, 1 hit
PF13932 GIDA_assoc, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR00136 gidA, 1 hit
PROSITEiView protein in PROSITE
PS01280 GIDA_1, 1 hit
PS01281 GIDA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q181S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKFEAGKYD VIVVGAGHAG CEAALATARM GYKTLIITMS LDSIALMPCN
60 70 80 90 100
PSIGGTGKGQ LVKEIDALGG QMGLNIDKTY IQSRMLNTAK GPAVHSLRAQ
110 120 130 140 150
ADKFKYHEEM KKTLEDEPNL DIAMDEVVEI LHEGNVVIGV GTKLGCSFKS
160 170 180 190 200
KAVILATGVY LNSKIYMGEV AFYEGPNALG YAKYLTDSLV ELGLRMRRFK
210 220 230 240 250
TGTPARVHRD SIDFSVMSLQ EGDEKVTPFS FMNENIEKKQ EPCYLTRTTE
260 270 280 290 300
ETQKVILDNL KRSAMYSGVI ESTGPRYCPS IEDKVVRFSD KTSHQLFIEP
310 320 330 340 350
EGLNTKEMYI QGISTSLPFE VQLDMYKTIK GLENCKIMRP AYAIEYDCVD
360 370 380 390 400
PTQLKISLEI KGVENLFSAG QFNGTSGYEE AAAQGLMAGI NAVRKIEGKE
410 420 430 440 450
PFVLDRSEAY IGVLLDDLVT KGTNEPYRMM TSRAEYRLYL RQDNADMRLT
460 470 480 490 500
QKGYDIGLVK KDRYERFLNK KAAVEKEFER LKNERVTPKE VNSLLEEKGA
510 520 530 540 550
TPIKVGISLY EFLKRPEVTY ELLEELGKGA GDDVSREVKE QCVIITKYEG
560 570 580 590 600
YIEKQLKQID QFKKLENKKL DEKINYSSIE GLRLEARQKL DDIKPISIGQ
610 620 630
ASRISGVSPA DISVLLIYLE QIRRTRGGKG E
Length:631
Mass (Da):70,731
Last modified:July 25, 2006 - v1
Checksum:i2F61AC5BF5D37E94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ70584.1
RefSeqiWP_009898858.1, NZ_CP010905.2
YP_001090199.1, NC_009089.1

Genome annotation databases

EnsemblBacteriaiCAJ70584; CAJ70584; CD630_36750
GeneIDi31355363
4912993
KEGGicdf:CD630_36750
pdc:CDIF630_04005
PATRICifig|272563.120.peg.3887

Entry informationi

Entry nameiMNMG_PEPD6
AccessioniPrimary (citable) accession number: Q181S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 25, 2006
Last modified: February 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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