Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 159 (29 Sep 2021)
Sequence version 3 (01 Oct 2001)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Uncharacterized protein

Gene

let-716

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processrRNA processingARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:let-716Imported
ORF Names:C16A3.3Imported, CELE_C16A3.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
C16A3.3 ; CE27690 ; WBGene00002850 ; let-716

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q18038

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q18038

PeptideAtlas

More...
PeptideAtlasi
Q18038

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00002850, Expressed in adult organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C16A3.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q18038

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini72 – 150S1 motifInterPro annotationAdd BLAST79
Domaini244 – 316S1 motifInterPro annotationAdd BLAST73
Domaini429 – 500S1 motifInterPro annotationAdd BLAST72
Domaini713 – 781S1 motifInterPro annotationAdd BLAST69
Domaini1194 – 1268S1 motifInterPro annotationAdd BLAST75
Domaini1290 – 1352S1 motifInterPro annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 58DisorderedSequence analysisAdd BLAST58
Regioni1366 – 1404DisorderedSequence analysisAdd BLAST39
Regioni1419 – 1463DisorderedSequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi42 – 58Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi1366 – 1402Basic and acidic residuesSequence analysisAdd BLAST37
Compositional biasi1422 – 1463Acidic residuesSequence analysisAdd BLAST42

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1070, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012228

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000845_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q18038

Identification of Orthologs from Complete Genome Data

More...
OMAi
LWVNLSP

Database of Orthologous Groups

More...
OrthoDBi
23482at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q18038

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003107, HAT
IPR012340, NA-bd_OB-fold
IPR022967, S1_dom
IPR003029, S1_domain
IPR011990, TPR-like_helical_dom_sf

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00386, HAT, 7 hits
SM00316, S1, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 2 hits
SSF50249, SSF50249, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50126, S1, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q18038-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKLDEVTNE KCFPRGGGSD KPKPLNKSNS DFVGTKGGLK RKSAAPEQHE
60 70 80 90 100
AKKAKEESSW IPKVEENCFI EGLTGFGVVS EVFDDGVLLH TAGTHTVKIH
110 120 130 140 150
ASEVSKKFTE LFNEEKIEIK NAFQLGQMVP FRVISKKQGN DKGKVKGTCN
160 170 180 190 200
PARLNKHLSP NMLAAGLVLH TAVVSIEEKG AILDVGLDQI TGFIEKSQFP
210 220 230 240 250
AAGLKEGMPL IVRVLSSTSR VVKVTSFVEQ DNLNMTSCEK LQLNHLMPGT
260 270 280 290 300
ILECEPTGDA VTAGVIVNIG NGLKGILPRR NLPPRLRENP EKLGKAIRAI
310 320 330 340 350
VMFCQQNSKI LVLNAHPDIV AASRIEKRTS FEGISIGDKV KCTVIDVLPT
360 370 380 390 400
KSMVYFALPA IDGKKSLVTA VSSRGLLEKP DQVSTEYEVG TEKLCRVTGF
410 420 430 440 450
RYADRSITIS TRKDILNQKI TKYQDAKCGD VLDARVHHVA KSGVYFMVCN
460 470 480 490 500
FVKAFAPLSM LSDKPLPAQK MKNIYKVGTE VKCRVWQICD ERKNLIVTCR
510 520 530 540 550
ESILGLKSPS VNSVQELEIG VTVPCVIRKV FPTGVLLLGT FNNICGVLRK
560 570 580 590 600
ESAVHLPGTP KNNDFVVANV EKIEDNRVVF VLRDVNPSAA VANGQNSEKK
610 620 630 640 650
LVQRPNPADG GISIGKIYKG SLCAKAGEKA NVTFTGEGKK EVYASVDDHL
660 670 680 690 700
LSDLLDAPIG LTKRLLIENK EDISTIVPMG KMAAINRACV KRSVASFVKG
710 720 730 740 750
MKLPKKIDEL KVGKVIVGIV GQVITNVGVF VELVGGSGLV GKVLERKNAK
760 770 780 790 800
NTSELLEVGQ VIVGTIESID TTKKSFLIDP CTDLETGELM LKKYALPLLE
810 820 830 840 850
SIVEEVKWLA EQSNYPIPGS KVNGKVTKEL DDLTLVEFEH NGKKIAGILP
860 870 880 890 900
KMVDDKKTTE KTKKKKATKS FIVVDINHST NEVVLATPST EQSRIVAIRR
910 920 930 940 950
DYLCAVSPDG LIYLPTRLHP NHLPTSDSKV KLHTVIDLND QKSVGEGVFV
960 970 980 990 1000
ATRGGGDVDD VARTTLINKE FVGDEKKKKQ TAEGSDGAVS TSTKSVKNFG
1010 1020 1030 1040 1050
VYSGVVIGTA NLEENRKRNS LFADIRLPGD NIGRLHVSEL PPSLLKAENP
1060 1070 1080 1090 1100
LDEFVKRNVR KAVIVRIIGF IKSSKGPRIA ELTMIPSKIQ AGKVRASNLS
1110 1120 1130 1140 1150
YKSNYKIGDV VKCFGANTMT EKQELKVEVN PVWTGTISRE NLSDDLKVTA
1160 1170 1180 1190 1200
ADGGIVDLAL KKGEMREAKI TAVDRKNMSL KLTLDTAEEA FEIGASVTGR
1210 1220 1230 1240 1250
VFFVSKTYIR LKLSSGQQAV LTPTAITDKY ETIEKITENQ LTDGKLVDVV
1260 1270 1280 1290 1300
CAKLQEKPRR YFVVLKNRFN SKSTDAKRQL LLDSKLMKEG DQYDGIVENA
1310 1320 1330 1340 1350
SKGSLFIELG PGVSGRIPVN EENQDLLEIG TNSVIRVTVV KVAKNEITLK
1360 1370 1380 1390 1400
LDDILIRKWT VKPDRKRTSS KSEGVPSKVA LLEEERSKET VEAEDPGFDW
1410 1420 1430 1440 1450
SNKGFRNEDL AAVGKLTLKD AEEESEEEEE EDEEEVEDEE VDEDASDEEE
1460 1470 1480 1490 1500
EVDGEEDESD DEENIELIEK SEEDHSRLVR SDPNSAINWI EYMSHFIEKS
1510 1520 1530 1540 1550
DLAAARKTAE EALGAINPTE SDELLKIWTA YLNMEVAYGD AATVQKVFER
1560 1570 1580 1590 1600
ACKNANAYTV HKTLSKIYQK FEKNAEATQI LEQMVKKFRA NQLEVWTLLA
1610 1620 1630 1640 1650
EHLMTQNDQK AARELLPRAL KSAPKAQQHV QLISKFAQLE FKHGDAERGR
1660 1670 1680 1690 1700
TLLEGLVTAH PKKTDLWLVY AEAVLKHLGI EHARKVLERA CNLGFSIHKM
1710 1720 1730 1740
RPLYKKWLEM ESKHGDAAAV ELVKAKAEKF LQAVADNVLE EDN
Length:1,743
Mass (Da):192,261
Last modified:October 1, 2001 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i864A497614AF4D21
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CCD63223.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E88481

NCBI Reference Sequences

More...
RefSeqi
NP_498398.1, NM_065997.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C16A3.3.1; C16A3.3.1; WBGene00002850

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175906

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C16A3.3

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CCD63223.1
PIRiE88481
RefSeqiNP_498398.1, NM_065997.3

3D structure databases

SMRiQ18038
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.C16A3.3

Proteomic databases

EPDiQ18038
PaxDbiQ18038
PeptideAtlasiQ18038

Genome annotation databases

EnsemblMetazoaiC16A3.3.1; C16A3.3.1; WBGene00002850
GeneIDi175906
KEGGicel:CELE_C16A3.3

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175906
WormBaseiC16A3.3 ; CE27690 ; WBGene00002850 ; let-716

Phylogenomic databases

eggNOGiKOG1070, Eukaryota
GeneTreeiENSGT00390000012228
HOGENOMiCLU_000845_0_0_1
InParanoidiQ18038
OMAiLWVNLSP
OrthoDBi23482at2759
PhylomeDBiQ18038

Enzyme and pathway databases

ReactomeiR-CEL-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

Gene expression databases

BgeeiWBGene00002850, Expressed in adult organism and 5 other tissues

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR003107, HAT
IPR012340, NA-bd_OB-fold
IPR022967, S1_dom
IPR003029, S1_domain
IPR011990, TPR-like_helical_dom_sf
SMARTiView protein in SMART
SM00386, HAT, 7 hits
SM00316, S1, 9 hits
SUPFAMiSSF48452, SSF48452, 2 hits
SSF50249, SSF50249, 2 hits
PROSITEiView protein in PROSITE
PS50126, S1, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ18038_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q18038
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2001
Last modified: September 29, 2021
This is version 159 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again