Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Heme Responsive protein

Gene

hrg-7

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei90PROSITE-ProRule annotation1
Active sitei318PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl proteasePROSITE-ProRule annotation, Hydrolase, Protease

Enzyme and pathway databases

ReactomeiR-CEL-2132295 MHC class II antigen presentation

Protein family/group databases

MEROPSiA01.A76

Names & Taxonomyi

Protein namesi
Submitted name:
Heme Responsive proteinImported
Gene namesi
Name:hrg-7Imported
ORF Names:C15C8.3Imported, CELE_C15C8.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC15C8.3a ; CE05287 ; WBGene00007605 ; hrg-7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_500418673817 – 428Sequence analysisAdd BLAST412

Proteomic databases

EPDiQ18020
PaxDbiQ18020
PeptideAtlasiQ18020

Expressioni

Gene expression databases

BgeeiWBGene00007605 Expressed in 4 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasiQ18020 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ18020, 1 interactor
STRINGi6239.C15C8.3a.2

Structurei

3D structure databases

ProteinModelPortaliQ18020
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 425Peptidase A1InterPro annotationAdd BLAST354

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 52Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the peptidase A1 family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
GeneTreeiENSGT00760000118929
HOGENOMiHOG000197681
InParanoidiQ18020
OMAiFYPAWML
OrthoDBiEOG091G07VO
PhylomeDBiQ18020

Family and domain databases

CDDicd05471 pepsin_like, 1 hit
Gene3Di2.40.70.10, 3 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR034164 Pepsin-like_dom
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 2 hits
PROSITEiView protein in PROSITE
PS51767 PEPTIDASE_A1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q18020-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTFIALLAL LTVVSAEVHQ FNIGYRPNMR QRMNAKGKLA EYEKERNELL
60 70 80 90 100
SKKSLQLASS SSPVIDYEDM AYMVQISLGS PAQNFVLFID SGSSNLWVPD
110 120 130 140 150
ITCAGGKDAT CGSYCKSTPY DACLTFCQEE CCTKTVEGVK VLSTTDACQS
160 170 180 190 200
KHRFNSSLSS SYVTNGQKFD MTYNTGEVKG FFGVDTFCFT NTSVCATGQV
210 220 230 240 250
FGQATTIGEA FAKQPEDGII GLGWPALAVN QQTPPLFNLM NQGKLDQPYF
260 270 280 290 300
VVYLANIGPT SQINGGAFTV GGLDTTHCSS NVDWVPLSTQ TFWQFKLGGV
310 320 330 340 350
SSGSYSQAPN SGWQAAADTA ASFIGAPKSV VTSLAKAVGA TYVPLTGAFF
360 370 380 390 400
MDCDAVVPDI VFTINGKTYN MPSTSFVVSA GPGPCMFAFY ELTAGGFYPA
410 420
WMLGPPFMRA YCHVHDMKSG RLGLAKVL
Length:428
Mass (Da):45,993
Last modified:November 1, 1996 - v1
Checksum:i2E1378E9F59CD14E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0AHB8E0AHB8_CAEEL
Heme Responsive protein
hrg-7 C15C8.3, CELE_C15C8.3
189Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAA99777.1
PIRiT19309
RefSeqiNP_001256448.1, NM_001269519.1
UniGeneiCel.36122

Genome annotation databases

EnsemblMetazoaiC15C8.3a; C15C8.3a; WBGene00007605
GeneIDi182635
KEGGicel:CELE_C15C8.3
UCSCiC15C8.3 c. elegans

Similar proteinsi

Entry informationi

Entry nameiQ18020_CAEEL
AccessioniPrimary (citable) accession number: Q18020
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again