UniProtKB - Q17ST2 (KCNA7_MOUSE)
Protein
Potassium voltage-gated channel subfamily A member 7
Gene
Kcna7
Organism
Mus musculus (Mouse)
Status
Functioni
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channels formed by isoform 1 inactivate faster than channels formed by isoform 2.3 Publications
GO - Molecular functioni
- delayed rectifier potassium channel activity Source: GO_Central
- voltage-gated potassium channel activity Source: GO_Central
GO - Biological processi
- potassium ion transmembrane transport Source: GO_Central
- protein homooligomerization Source: InterPro
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
Reactomei | R-MMU-1296072, Voltage gated Potassium channels |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium voltage-gated channel subfamily A member 7Alternative name(s): Voltage-gated potassium channel subunit Kv1.7 |
Gene namesi | Name:Kcna7 Synonyms:Kcnc7 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96664, Kcna7 |
Subcellular locationi
Other locations
- Membrane 3 Publications; Multi-pass membrane protein 3 Publications
Plasma Membrane
- voltage-gated potassium channel complex Source: GO_Central
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 176 – 196 | Helical; Name=Segment S1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 242 – 262 | Helical; Name=Segment S2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 274 – 294 | Helical; Name=Segment S3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 309 – 328 | Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST | 20 | |
Transmembranei | 345 – 365 | Helical; Name=Segment S5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 406 – 426 | Helical; Name=Segment S6Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000308274 | 1 – 489 | Potassium voltage-gated channel subfamily A member 7Add BLAST | 489 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 224 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 264 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, Lipoprotein, PalmitateProteomic databases
jPOSTi | Q17ST2 |
PaxDbi | Q17ST2 |
PRIDEi | Q17ST2 |
PTM databases
GlyGeni | Q17ST2, 1 site |
iPTMneti | Q17ST2 |
PhosphoSitePlusi | Q17ST2 |
Expressioni
Tissue specificityi
Detected in heart, skeletal muscle, brain, and pancreatic islet cells.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000038201, Expressed in cardiac ventricle and 174 other tissues |
Genevisiblei | Q17ST2, MM |
Interactioni
Subunit structurei
Heterotetramer of potassium channel proteins.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000103403 |
Miscellaneous databases
RNActi | Q17ST2, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 391 – 396 | Selectivity filterBy similarity | 6 |
Domaini
The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similaritiesi
Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1545, Eukaryota |
GeneTreei | ENSGT00940000162339 |
HOGENOMi | CLU_011722_4_0_1 |
InParanoidi | Q17ST2 |
OMAi | RAMEPRC |
OrthoDBi | 818306at2759 |
PhylomeDBi | Q17ST2 |
TreeFami | TF313103 |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003972, K_chnl_volt-dep_Kv1 IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF00520, Ion_trans, 1 hit |
PRINTSi | PR01491, KVCHANNEL PR01496, SHAKERCHANEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing and alternative initiation. AlignAdd to basketIsoform 1 (identifier: Q17ST2-1) [UniParc]FASTAAdd to basket
Also known as: Kv1.7L
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLFLPADTGH PTGVAAASGP HVRSPVARAV RAMEPRCPPP CGCCERLVLN
60 70 80 90 100
VAGLRFETRA RTLGRFPDTL LGDPVRRSRF YDGARREYFF DRHRPSFDAV
110 120 130 140 150
LYYYQSGGRL RRPAHVPLDV FLEEVSFYGL GAAALARLRE DEGCAVPPER
160 170 180 190 200
PLPRRAFARQ LWLLFEFPES SQAARVLAVV SVLVILVSIV VFCLETLPDF
210 220 230 240 250
RDDRDDPGLA PVAAATGPFL ARLNGSSPMP GAPPRQPFND PFFVVETLCI
260 270 280 290 300
CWFSFELLVR LVACPSKAVF FKNVMNLIDF VAILPYFVAL GTELARQRGV
310 320 330 340 350
GQPAMSLAIL RVIRLVRVFR IFKLSRHSKG LQILGQTLRA SMRELGLLIF
360 370 380 390 400
FLFIGVVLFS SAVYFAEVDR VDTHFTSIPE SFWWAVVTMT TVGYGDMAPV
410 420 430 440 450
TVGGKIVGSL CAIAGVLTIS LPVPVIVSNF SYFYHRETEG EEAGMYSHVD
460 470 480
TQPCGTLEGK ANGGLVDSEV PELLPPLWPP AGKHMVTEV
Sequence cautioni
The sequence AAC12271 differs from that shown. Reason: Frameshift.Curated
The sequence AAC23664 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 86 | R → A in AAC12271 (PubMed:9488722).Curated | 1 | |
Sequence conflicti | 116 | V → L in AAX11185 (PubMed:16801386).Curated | 1 | |
Sequence conflicti | 218 | P → S in AAC12271 (PubMed:9488722).Curated | 1 | |
Sequence conflicti | 260 | R → H in AAC12271 (PubMed:9488722).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028953 | 1 – 32 | Missing in isoform 2. 1 PublicationAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF032099 mRNA Translation: AAC12271.1 Frameshift. AF032101, AF032100 Genomic DNA Translation: AAC23664.1 Frameshift. AY779767 mRNA Translation: AAX11185.1 |
CCDSi | CCDS39951.1 [Q17ST2-1] |
PIRi | S09047 |
RefSeqi | NP_034726.2, NM_010596.2 [Q17ST2-1] |
Genome annotation databases
Ensembli | ENSMUST00000107774; ENSMUSP00000103403; ENSMUSG00000038201 [Q17ST2-1] |
GeneIDi | 16495 |
KEGGi | mmu:16495 |
UCSCi | uc009guz.1, mouse [Q17ST2-1] |
Keywords - Coding sequence diversityi
Alternative initiation, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF032099 mRNA Translation: AAC12271.1 Frameshift. AF032101, AF032100 Genomic DNA Translation: AAC23664.1 Frameshift. AY779767 mRNA Translation: AAX11185.1 |
CCDSi | CCDS39951.1 [Q17ST2-1] |
PIRi | S09047 |
RefSeqi | NP_034726.2, NM_010596.2 [Q17ST2-1] |
3D structure databases
SMRi | Q17ST2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000103403 |
Chemistry databases
DrugCentrali | Q17ST2 |
GuidetoPHARMACOLOGYi | 544 |
PTM databases
GlyGeni | Q17ST2, 1 site |
iPTMneti | Q17ST2 |
PhosphoSitePlusi | Q17ST2 |
Proteomic databases
jPOSTi | Q17ST2 |
PaxDbi | Q17ST2 |
PRIDEi | Q17ST2 |
Protocols and materials databases
ABCDi | Q17ST2, 1 sequenced antibody |
Antibodypediai | 18500, 71 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000107774; ENSMUSP00000103403; ENSMUSG00000038201 [Q17ST2-1] |
GeneIDi | 16495 |
KEGGi | mmu:16495 |
UCSCi | uc009guz.1, mouse [Q17ST2-1] |
Organism-specific databases
CTDi | 3743 |
MGIi | MGI:96664, Kcna7 |
Phylogenomic databases
eggNOGi | KOG1545, Eukaryota |
GeneTreei | ENSGT00940000162339 |
HOGENOMi | CLU_011722_4_0_1 |
InParanoidi | Q17ST2 |
OMAi | RAMEPRC |
OrthoDBi | 818306at2759 |
PhylomeDBi | Q17ST2 |
TreeFami | TF313103 |
Enzyme and pathway databases
Reactomei | R-MMU-1296072, Voltage gated Potassium channels |
Miscellaneous databases
BioGRID-ORCSi | 16495, 1 hit in 17 CRISPR screens |
PROi | PR:Q17ST2 |
RNActi | Q17ST2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038201, Expressed in cardiac ventricle and 174 other tissues |
Genevisiblei | Q17ST2, MM |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003972, K_chnl_volt-dep_Kv1 IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF00520, Ion_trans, 1 hit |
PRINTSi | PR01491, KVCHANNEL PR01496, SHAKERCHANEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNA7_MOUSE | |
Accessioni | Q17ST2Primary (citable) accession number: Q17ST2 Secondary accession number(s): O70259 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | October 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 101 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families