Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Collagen alpha-1(XXIV) chain

Gene

COL24A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8948216 Collagen chain trimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXIV) chain
Gene namesi
Name:COL24A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000171502.14
HGNCiHGNC:20821 COL24A1
MIMi610025 gene
neXtProtiNX_Q17RW2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi255631
OpenTargetsiENSG00000171502
PharmGKBiPA134932695

Chemistry databases

ChEMBLiCHEMBL2364188

Polymorphism and mutation databases

BioMutaiCOL24A1
DMDMi290457636

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000031761636 – 1714Collagen alpha-1(XXIV) chainAdd BLAST1679

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi376N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ17RW2
PaxDbiQ17RW2
PeptideAtlasiQ17RW2
PRIDEiQ17RW2
ProteomicsDBi61168
61169 [Q17RW2-2]

PTM databases

iPTMnetiQ17RW2
PhosphoSitePlusiQ17RW2

Expressioni

Gene expression databases

BgeeiENSG00000171502 Expressed in 105 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_COL24A1
ExpressionAtlasiQ17RW2 baseline and differential
GenevisibleiQ17RW2 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926245EBI-2529266,EBI-743771

Protein-protein interaction databases

BioGridi129112, 1 interactor
ComplexPortaliCPX-1765 Collagen type XXIV trimer
IntActiQ17RW2, 1 interactor
STRINGi9606.ENSP00000359603

Structurei

3D structure databases

ProteinModelPortaliQ17RW2
SMRiQ17RW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 217Laminin G-likeAdd BLAST77
Domaini487 – 542Collagen-like 1Add BLAST56
Domaini552 – 611Collagen-like 2Add BLAST60
Domaini660 – 719Collagen-like 3Add BLAST60
Domaini741 – 797Collagen-like 4Add BLAST57
Domaini798 – 857Collagen-like 5Add BLAST60
Domaini858 – 887Collagen-like 6Add BLAST30
Domaini888 – 947Collagen-like 7Add BLAST60
Domaini948 – 1007Collagen-like 8Add BLAST60
Domaini1011 – 1052Collagen-like 9Add BLAST42
Domaini1053 – 1112Collagen-like 10Add BLAST60
Domaini1116 – 1170Collagen-like 11Add BLAST55
Domaini1172 – 1196Collagen-like 12Add BLAST25
Domaini1201 – 1249Collagen-like 13Add BLAST49
Domaini1252 – 1306Collagen-like 14Add BLAST55
Domaini1309 – 1353Collagen-like 15Add BLAST45
Domaini1354 – 1413Collagen-like 16Add BLAST60
Domaini1420 – 1479Collagen-like 17Add BLAST60
Domaini1515 – 1714Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi470 – 475Poly-Tyr6

Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00900000140789
HOGENOMiHOG000085654
HOVERGENiHBG098141
InParanoidiQ17RW2
KOiK19721
OMAiIPGPHGN
OrthoDBiEOG091G00WS
PhylomeDBiQ17RW2
TreeFamiTF344135

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01410 COLFI, 2 hits
PF01391 Collagen, 13 hits
PF02210 Laminin_G_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q17RW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHLRAHRTRR GKVSPTAKTK SLLHFIVLCV AGVVVHAQEQ GIDILHQLGL
60 70 80 90 100
GGKDVRHSSP ATAVPSASTP LPQGVHLTES GVIFKNDAYI ETPFVKILPV
110 120 130 140 150
NLGQPFTILT GLQSHRVNNA FLFSIRNKNR LQLGVQLLPK KLVVHIRGKQ
160 170 180 190 200
PAVFNYSVHD EQWHSFAITI RNQSVSMFVE CGKKYFSTET IPEVQTFDSN
210 220 230 240 250
SVFTLGSMNN NSIHFEGIVC QLDIIPSAEA SADYCRYVKQ QCRQADKYQP
260 270 280 290 300
ETSIPCTTLI PTKIPEHSPP PKLFAEKVLS EDTFTEGKSI PNIIKNDSET
310 320 330 340 350
VYKRQEHQIS RSQLSSLQSG NVSAVDLTNH GIQAKEMITE EDTQTNFSLS
360 370 380 390 400
VTTHRISEAK MNTKEKFSSL LNMSDNITQH DDRVTGLSLF KKMPSILPQI
410 420 430 440 450
KQDTITNLKK AITANLHTNE LMEMQPILNT SLHRVTNEPS VDNHLDLRKE
460 470 480 490 500
GEFYPDATYP IENSYETELY DYYYYEDLNT MLEMEYLRGP KGDTGPPGPP
510 520 530 540 550
GPAGIPGPSG KRGPRGIPGP HGNPGLPGLP GPKGPKGDPG FSPGQPVPGE
560 570 580 590 600
KGDQGLSGLM GPPGMQGDKG LKGHPGLPGL PGEQGIPGFA GNIGSPGYPG
610 620 630 640 650
RQGLAGPEGN PGPKGAQGFI GSPGEAGQLG PEGERGIPGI RGKKGFKGRQ
660 670 680 690 700
GFPGDFGDRG PAGLDGSPGL VGGTGPPGFP GLRGSVGPVG PIGPAGIPGP
710 720 730 740 750
MGLSGNKGLP GIKGDKGEQG TAGELGEPGY PGDKGAVGLP GPPGMRGKSG
760 770 780 790 800
PSGQTGDPGL QGPSGPPGPE GFPGDIGIPG QNGPEGPKGL LGNRGPPGPP
810 820 830 840 850
GLKGTQGEEG PIGAFGELGP RGKPGQKGYA GEPGPEGLKG EVGDQGNIGK
860 870 880 890 900
IGETGPVGLP GEVGMTGSIG EKGERGSPGP LGPQGEKGVM GYPGPPGVPG
910 920 930 940 950
PIGPLGLPGH VGARGPPGSQ GPKGQRGSRG PDGLLGEQGI QGAKGEKGDQ
960 970 980 990 1000
GKRGPHGLIG KTGNPGERGF QGKPGLQGLP GSTGDRGLPG EPGLRGLQGD
1010 1020 1030 1040 1050
VGPPGEMGME GPPGTEGESG LQGEPGAKGD VGTAGSVGGT GEPGLRGEPG
1060 1070 1080 1090 1100
APGEEGLQGK DGLKGVPGGR GLPGEDGEKG EMGLPGIIGP LGRSGQTGLP
1110 1120 1130 1140 1150
GPEGIVGIPG QRGRPGKKGD KGQIGPTGEV GSRGPPGKIG KSGPKGARGT
1160 1170 1180 1190 1200
RGAVGHLGLM GPDGEPGIPG YRGHQGQPGP SGLPGPKGEK GYPGEDSTVL
1210 1220 1230 1240 1250
GPPGPRGEPG PVGDQGERGE PGAEGYKGHV GVPGLRGATG QQGPPGEPGD
1260 1270 1280 1290 1300
QGEQGLKGER GSEGNKGKKG APGPSGKPGI PGLQGLLGPK GIQGYHGADG
1310 1320 1330 1340 1350
ISGNPGKIGP PGKQGLPGIR GGPGRTGLAG APGPPGVKGS SGLPGSPGIQ
1360 1370 1380 1390 1400
GPKGEQGLPG QPGIQGKRGH RGAQGDQGPC GDPGLKGQPG EYGVQGLTGF
1410 1420 1430 1440 1450
QGFPGPKGPE GDAGIVGISG PKGPIGHRGN TGPLGREGII GPTGRTGPRG
1460 1470 1480 1490 1500
EKGFRGETGP QGPRGQPGPP GPPGAPGPRK QMDINAAIQA LIESNTALQM
1510 1520 1530 1540 1550
ESYQNTEVTL IDHSEEIFKT LNYLSNLLHS IKNPLGTRDN PARICKDLLN
1560 1570 1580 1590 1600
CEQKVSDGKY WIDPNLGCPS DAIEVFCNFS AGGQTCLPPV SVTKLEFGVG
1610 1620 1630 1640 1650
KVQMNFLHLL SSEATHIITI HCLNTPRWTS TQTSGPGLPI GFKGWNGQIF
1660 1670 1680 1690 1700
KVNTLLEPKV LSDDCKIQDG SWHKATFLFH TQEPNQLPVI EVQKLPHLKT
1710
ERKYYIDSSS VCFL
Length:1,714
Mass (Da):175,496
Last modified:March 2, 2010 - v2
Checksum:i2AC82E13DB5BBD3D
GO
Isoform 2 (identifier: Q17RW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1459-1479: Missing.

Note: No experimental confirmation available.
Show »
Length:1,693
Mass (Da):173,583
Checksum:iA8BEDD096C17C47F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WDM8F8WDM8_HUMAN
Collagen alpha-1(XXIV) chain
COL24A1
890Annotation score:
E9PNK8E9PNK8_HUMAN
Collagen alpha-1(XXIV) chain
COL24A1
81Annotation score:
H0YCZ7H0YCZ7_HUMAN
Collagen alpha-1(XXIV) chain
COL24A1
166Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti828 – 849GYAGE…QGNIG → ITVFATLYSFLTGRSRRSRK YW in BAD92923 (Ref. 5) CuratedAdd BLAST22

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06286561A → V2 PublicationsCorresponds to variant dbSNP:rs11161747Ensembl.1
Natural variantiVAR_055672151P → L. Corresponds to variant dbSNP:rs1027819Ensembl.1
Natural variantiVAR_055673293I → T. Corresponds to variant dbSNP:rs17128866Ensembl.1
Natural variantiVAR_055674481M → L. Corresponds to variant dbSNP:rs10493784Ensembl.1
Natural variantiVAR_055675546P → S1 PublicationCorresponds to variant dbSNP:rs11161732Ensembl.1
Natural variantiVAR_061116641R → H. Corresponds to variant dbSNP:rs60891279Ensembl.1
Natural variantiVAR_055676731P → S1 PublicationCorresponds to variant dbSNP:rs641712Ensembl.1
Natural variantiVAR_0385651423G → R. Corresponds to variant dbSNP:rs7520146Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0310901459 – 1479Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY244357 mRNA Translation: AAP80185.1
AC099561 Genomic DNA No translation available.
AC104455 Genomic DNA No translation available.
AL356059 Genomic DNA No translation available.
AL359971 Genomic DNA No translation available.
AL445427 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73193.1
BC113654 mRNA Translation: AAI13655.1
BC117170 mRNA Translation: AAI17171.1
AB209686 mRNA Translation: BAD92923.1
CCDSiCCDS41353.1 [Q17RW2-1]
RefSeqiNP_690850.2, NM_152890.5 [Q17RW2-1]
UniGeneiHs.659516

Genome annotation databases

EnsembliENST00000370571; ENSP00000359603; ENSG00000171502 [Q17RW2-1]
GeneIDi255631
KEGGihsa:255631
UCSCiuc001dlj.4 human [Q17RW2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY244357 mRNA Translation: AAP80185.1
AC099561 Genomic DNA No translation available.
AC104455 Genomic DNA No translation available.
AL356059 Genomic DNA No translation available.
AL359971 Genomic DNA No translation available.
AL445427 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73193.1
BC113654 mRNA Translation: AAI13655.1
BC117170 mRNA Translation: AAI17171.1
AB209686 mRNA Translation: BAD92923.1
CCDSiCCDS41353.1 [Q17RW2-1]
RefSeqiNP_690850.2, NM_152890.5 [Q17RW2-1]
UniGeneiHs.659516

3D structure databases

ProteinModelPortaliQ17RW2
SMRiQ17RW2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129112, 1 interactor
ComplexPortaliCPX-1765 Collagen type XXIV trimer
IntActiQ17RW2, 1 interactor
STRINGi9606.ENSP00000359603

Chemistry databases

ChEMBLiCHEMBL2364188

PTM databases

iPTMnetiQ17RW2
PhosphoSitePlusiQ17RW2

Polymorphism and mutation databases

BioMutaiCOL24A1
DMDMi290457636

Proteomic databases

EPDiQ17RW2
PaxDbiQ17RW2
PeptideAtlasiQ17RW2
PRIDEiQ17RW2
ProteomicsDBi61168
61169 [Q17RW2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370571; ENSP00000359603; ENSG00000171502 [Q17RW2-1]
GeneIDi255631
KEGGihsa:255631
UCSCiuc001dlj.4 human [Q17RW2-1]

Organism-specific databases

CTDi255631
DisGeNETi255631
EuPathDBiHostDB:ENSG00000171502.14
GeneCardsiCOL24A1
H-InvDBiHIX0018170
HGNCiHGNC:20821 COL24A1
MIMi610025 gene
neXtProtiNX_Q17RW2
OpenTargetsiENSG00000171502
PharmGKBiPA134932695
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00900000140789
HOGENOMiHOG000085654
HOVERGENiHBG098141
InParanoidiQ17RW2
KOiK19721
OMAiIPGPHGN
OrthoDBiEOG091G00WS
PhylomeDBiQ17RW2
TreeFamiTF344135

Enzyme and pathway databases

ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8948216 Collagen chain trimerization

Miscellaneous databases

ChiTaRSiCOL24A1 human
GenomeRNAii255631
PROiPR:Q17RW2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171502 Expressed in 105 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_COL24A1
ExpressionAtlasiQ17RW2 baseline and differential
GenevisibleiQ17RW2 HS

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01410 COLFI, 2 hits
PF01391 Collagen, 13 hits
PF02210 Laminin_G_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOOA1_HUMAN
AccessioniPrimary (citable) accession number: Q17RW2
Secondary accession number(s): C9J1X6
, Q14BD7, Q59EX5, Q5VY50, Q7Z5L5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 2, 2010
Last modified: November 7, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again