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Protein

Collagen alpha-1(XXIV) chain

Gene

COL24A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(XXIV) chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL24A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000171502.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20821 COL24A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610025 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q17RW2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
255631

Open Targets

More...
OpenTargetsi
ENSG00000171502

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134932695

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2364188

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COL24A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
290457636

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031761636 – 1714Collagen alpha-1(XXIV) chainAdd BLAST1679

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi376N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q17RW2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q17RW2

PeptideAtlas

More...
PeptideAtlasi
Q17RW2

PRoteomics IDEntifications database

More...
PRIDEi
Q17RW2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61168
61169 [Q17RW2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q17RW2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q17RW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171502 Expressed in 105 organ(s), highest expression level in Brodmann (1909) area 23

CleanEx database of gene expression profiles

More...
CleanExi
HS_COL24A1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q17RW2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q17RW2 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926245EBI-2529266,EBI-743771

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129112, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1765 Collagen type XXIV trimer

Protein interaction database and analysis system

More...
IntActi
Q17RW2, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359603

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q17RW2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q17RW2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini141 – 217Laminin G-likeAdd BLAST77
Domaini487 – 542Collagen-like 1Add BLAST56
Domaini552 – 611Collagen-like 2Add BLAST60
Domaini660 – 719Collagen-like 3Add BLAST60
Domaini741 – 797Collagen-like 4Add BLAST57
Domaini798 – 857Collagen-like 5Add BLAST60
Domaini858 – 887Collagen-like 6Add BLAST30
Domaini888 – 947Collagen-like 7Add BLAST60
Domaini948 – 1007Collagen-like 8Add BLAST60
Domaini1011 – 1052Collagen-like 9Add BLAST42
Domaini1053 – 1112Collagen-like 10Add BLAST60
Domaini1116 – 1170Collagen-like 11Add BLAST55
Domaini1172 – 1196Collagen-like 12Add BLAST25
Domaini1201 – 1249Collagen-like 13Add BLAST49
Domaini1252 – 1306Collagen-like 14Add BLAST55
Domaini1309 – 1353Collagen-like 15Add BLAST45
Domaini1354 – 1413Collagen-like 16Add BLAST60
Domaini1420 – 1479Collagen-like 17Add BLAST60
Domaini1515 – 1714Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi470 – 475Poly-Tyr6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410XNMM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162448

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000085654

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG098141

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q17RW2

KEGG Orthology (KO)

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KOi
K19721

Identification of Orthologs from Complete Genome Data

More...
OMAi
IPGPHGN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00WS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q17RW2

TreeFam database of animal gene trees

More...
TreeFami
TF344135

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410 COLFI, 2 hits
PF01391 Collagen, 13 hits
PF02210 Laminin_G_2, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038 COLFI, 1 hit
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461 NC1_FIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q17RW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHLRAHRTRR GKVSPTAKTK SLLHFIVLCV AGVVVHAQEQ GIDILHQLGL
60 70 80 90 100
GGKDVRHSSP ATAVPSASTP LPQGVHLTES GVIFKNDAYI ETPFVKILPV
110 120 130 140 150
NLGQPFTILT GLQSHRVNNA FLFSIRNKNR LQLGVQLLPK KLVVHIRGKQ
160 170 180 190 200
PAVFNYSVHD EQWHSFAITI RNQSVSMFVE CGKKYFSTET IPEVQTFDSN
210 220 230 240 250
SVFTLGSMNN NSIHFEGIVC QLDIIPSAEA SADYCRYVKQ QCRQADKYQP
260 270 280 290 300
ETSIPCTTLI PTKIPEHSPP PKLFAEKVLS EDTFTEGKSI PNIIKNDSET
310 320 330 340 350
VYKRQEHQIS RSQLSSLQSG NVSAVDLTNH GIQAKEMITE EDTQTNFSLS
360 370 380 390 400
VTTHRISEAK MNTKEKFSSL LNMSDNITQH DDRVTGLSLF KKMPSILPQI
410 420 430 440 450
KQDTITNLKK AITANLHTNE LMEMQPILNT SLHRVTNEPS VDNHLDLRKE
460 470 480 490 500
GEFYPDATYP IENSYETELY DYYYYEDLNT MLEMEYLRGP KGDTGPPGPP
510 520 530 540 550
GPAGIPGPSG KRGPRGIPGP HGNPGLPGLP GPKGPKGDPG FSPGQPVPGE
560 570 580 590 600
KGDQGLSGLM GPPGMQGDKG LKGHPGLPGL PGEQGIPGFA GNIGSPGYPG
610 620 630 640 650
RQGLAGPEGN PGPKGAQGFI GSPGEAGQLG PEGERGIPGI RGKKGFKGRQ
660 670 680 690 700
GFPGDFGDRG PAGLDGSPGL VGGTGPPGFP GLRGSVGPVG PIGPAGIPGP
710 720 730 740 750
MGLSGNKGLP GIKGDKGEQG TAGELGEPGY PGDKGAVGLP GPPGMRGKSG
760 770 780 790 800
PSGQTGDPGL QGPSGPPGPE GFPGDIGIPG QNGPEGPKGL LGNRGPPGPP
810 820 830 840 850
GLKGTQGEEG PIGAFGELGP RGKPGQKGYA GEPGPEGLKG EVGDQGNIGK
860 870 880 890 900
IGETGPVGLP GEVGMTGSIG EKGERGSPGP LGPQGEKGVM GYPGPPGVPG
910 920 930 940 950
PIGPLGLPGH VGARGPPGSQ GPKGQRGSRG PDGLLGEQGI QGAKGEKGDQ
960 970 980 990 1000
GKRGPHGLIG KTGNPGERGF QGKPGLQGLP GSTGDRGLPG EPGLRGLQGD
1010 1020 1030 1040 1050
VGPPGEMGME GPPGTEGESG LQGEPGAKGD VGTAGSVGGT GEPGLRGEPG
1060 1070 1080 1090 1100
APGEEGLQGK DGLKGVPGGR GLPGEDGEKG EMGLPGIIGP LGRSGQTGLP
1110 1120 1130 1140 1150
GPEGIVGIPG QRGRPGKKGD KGQIGPTGEV GSRGPPGKIG KSGPKGARGT
1160 1170 1180 1190 1200
RGAVGHLGLM GPDGEPGIPG YRGHQGQPGP SGLPGPKGEK GYPGEDSTVL
1210 1220 1230 1240 1250
GPPGPRGEPG PVGDQGERGE PGAEGYKGHV GVPGLRGATG QQGPPGEPGD
1260 1270 1280 1290 1300
QGEQGLKGER GSEGNKGKKG APGPSGKPGI PGLQGLLGPK GIQGYHGADG
1310 1320 1330 1340 1350
ISGNPGKIGP PGKQGLPGIR GGPGRTGLAG APGPPGVKGS SGLPGSPGIQ
1360 1370 1380 1390 1400
GPKGEQGLPG QPGIQGKRGH RGAQGDQGPC GDPGLKGQPG EYGVQGLTGF
1410 1420 1430 1440 1450
QGFPGPKGPE GDAGIVGISG PKGPIGHRGN TGPLGREGII GPTGRTGPRG
1460 1470 1480 1490 1500
EKGFRGETGP QGPRGQPGPP GPPGAPGPRK QMDINAAIQA LIESNTALQM
1510 1520 1530 1540 1550
ESYQNTEVTL IDHSEEIFKT LNYLSNLLHS IKNPLGTRDN PARICKDLLN
1560 1570 1580 1590 1600
CEQKVSDGKY WIDPNLGCPS DAIEVFCNFS AGGQTCLPPV SVTKLEFGVG
1610 1620 1630 1640 1650
KVQMNFLHLL SSEATHIITI HCLNTPRWTS TQTSGPGLPI GFKGWNGQIF
1660 1670 1680 1690 1700
KVNTLLEPKV LSDDCKIQDG SWHKATFLFH TQEPNQLPVI EVQKLPHLKT
1710
ERKYYIDSSS VCFL
Length:1,714
Mass (Da):175,496
Last modified:March 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2AC82E13DB5BBD3D
GO
Isoform 2 (identifier: Q17RW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1459-1479: Missing.

Note: No experimental confirmation available.
Show »
Length:1,693
Mass (Da):173,583
Checksum:iA8BEDD096C17C47F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WDM8F8WDM8_HUMAN
Collagen alpha-1(XXIV) chain
COL24A1
890Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNK8E9PNK8_HUMAN
Collagen alpha-1(XXIV) chain
COL24A1
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCZ7H0YCZ7_HUMAN
Collagen alpha-1(XXIV) chain
COL24A1
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti828 – 849GYAGE…QGNIG → ITVFATLYSFLTGRSRRSRK YW in BAD92923 (Ref. 5) CuratedAdd BLAST22

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06286561A → V2 PublicationsCorresponds to variant dbSNP:rs11161747Ensembl.1
Natural variantiVAR_055672151P → L. Corresponds to variant dbSNP:rs1027819Ensembl.1
Natural variantiVAR_055673293I → T. Corresponds to variant dbSNP:rs17128866Ensembl.1
Natural variantiVAR_055674481M → L. Corresponds to variant dbSNP:rs10493784Ensembl.1
Natural variantiVAR_055675546P → S1 PublicationCorresponds to variant dbSNP:rs11161732Ensembl.1
Natural variantiVAR_061116641R → H. Corresponds to variant dbSNP:rs60891279Ensembl.1
Natural variantiVAR_055676731P → S1 PublicationCorresponds to variant dbSNP:rs641712Ensembl.1
Natural variantiVAR_0385651423G → R. Corresponds to variant dbSNP:rs7520146Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0310901459 – 1479Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY244357 mRNA Translation: AAP80185.1
AC099561 Genomic DNA No translation available.
AC104455 Genomic DNA No translation available.
AL356059 Genomic DNA No translation available.
AL359971 Genomic DNA No translation available.
AL445427 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73193.1
BC113654 mRNA Translation: AAI13655.1
BC117170 mRNA Translation: AAI17171.1
AB209686 mRNA Translation: BAD92923.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41353.1 [Q17RW2-1]

NCBI Reference Sequences

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RefSeqi
NP_690850.2, NM_152890.5 [Q17RW2-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.659516

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000370571; ENSP00000359603; ENSG00000171502 [Q17RW2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
255631

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:255631

UCSC genome browser

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UCSCi
uc001dlj.4 human [Q17RW2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY244357 mRNA Translation: AAP80185.1
AC099561 Genomic DNA No translation available.
AC104455 Genomic DNA No translation available.
AL356059 Genomic DNA No translation available.
AL359971 Genomic DNA No translation available.
AL445427 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73193.1
BC113654 mRNA Translation: AAI13655.1
BC117170 mRNA Translation: AAI17171.1
AB209686 mRNA Translation: BAD92923.1
CCDSiCCDS41353.1 [Q17RW2-1]
RefSeqiNP_690850.2, NM_152890.5 [Q17RW2-1]
UniGeneiHs.659516

3D structure databases

ProteinModelPortaliQ17RW2
SMRiQ17RW2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129112, 1 interactor
ComplexPortaliCPX-1765 Collagen type XXIV trimer
IntActiQ17RW2, 1 interactor
STRINGi9606.ENSP00000359603

Chemistry databases

ChEMBLiCHEMBL2364188

PTM databases

iPTMnetiQ17RW2
PhosphoSitePlusiQ17RW2

Polymorphism and mutation databases

BioMutaiCOL24A1
DMDMi290457636

Proteomic databases

EPDiQ17RW2
PaxDbiQ17RW2
PeptideAtlasiQ17RW2
PRIDEiQ17RW2
ProteomicsDBi61168
61169 [Q17RW2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370571; ENSP00000359603; ENSG00000171502 [Q17RW2-1]
GeneIDi255631
KEGGihsa:255631
UCSCiuc001dlj.4 human [Q17RW2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
255631
DisGeNETi255631
EuPathDBiHostDB:ENSG00000171502.14

GeneCards: human genes, protein and diseases

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GeneCardsi
COL24A1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0018170
HGNCiHGNC:20821 COL24A1
MIMi610025 gene
neXtProtiNX_Q17RW2
OpenTargetsiENSG00000171502
PharmGKBiPA134932695

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00940000162448
HOGENOMiHOG000085654
HOVERGENiHBG098141
InParanoidiQ17RW2
KOiK19721
OMAiIPGPHGN
OrthoDBiEOG091G00WS
PhylomeDBiQ17RW2
TreeFamiTF344135

Enzyme and pathway databases

ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8948216 Collagen chain trimerization

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
COL24A1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
255631

Protein Ontology

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PROi
PR:Q17RW2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171502 Expressed in 105 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_COL24A1
ExpressionAtlasiQ17RW2 baseline and differential
GenevisibleiQ17RW2 HS

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01410 COLFI, 2 hits
PF01391 Collagen, 13 hits
PF02210 Laminin_G_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOOA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17RW2
Secondary accession number(s): C9J1X6
, Q14BD7, Q59EX5, Q5VY50, Q7Z5L5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 2, 2010
Last modified: December 5, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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