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Protein

Pancreatic lipase-related protein 3

Gene

PNLIPRP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168NucleophileBy similarity1
Active sitei191Charge relay systemPROSITE-ProRule annotation1
Active sitei279Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-192456 Digestion of dietary lipid

Protein family/group databases

ESTHERihuman-PNLIPRP3 Pancreatic_lipase

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic lipase-related protein 3 (EC:3.1.1.3)
Short name:
PL-RP3
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000203837.4
HGNCiHGNC:23492 PNLIPRP3
neXtProtiNX_Q17RR3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000203837
PharmGKBiPA134954941

Polymorphism and mutation databases

BioMutaiPNLIPRP3
DMDMi269849614

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000028660218 – 467Pancreatic lipase-related protein 3Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi21 ↔ 27By similarity
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi107 ↔ 118By similarity
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi252 ↔ 277By similarity
Disulfide bondi301 ↔ 312By similarity
Disulfide bondi315 ↔ 320By similarity
Disulfide bondi451 ↔ 467By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ17RR3
PeptideAtlasiQ17RR3
PRIDEiQ17RR3
ProteomicsDBi61163

PTM databases

iPTMnetiQ17RR3
PhosphoSitePlusiQ17RR3

Expressioni

Tissue specificityi

Overexpressed in hepatocellular carcinoma.1 Publication

Gene expression databases

BgeeiENSG00000203837
CleanExiHS_PNLIPRP3
GenevisibleiQ17RR3 HS

Organism-specific databases

HPAiHPA046202
HPA052009

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000358232

Structurei

3D structure databases

ProteinModelPortaliQ17RR3
SMRiQ17RR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini355 – 467PLATAdd BLAST113

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IK4Z Eukaryota
ENOG41118P1 LUCA
GeneTreeiENSGT00760000119069
HOGENOMiHOG000038552
HOVERGENiHBG003243
InParanoidiQ17RR3
KOiK14076
OMAiPTMGHFA
OrthoDBiEOG091G0DJ5
PhylomeDBiQ17RR3
TreeFamiTF324997

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR002331 Lipase_panc
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00823 PANCLIPASE
PR00821 TAGLIPASE
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17RR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGIWIVAFL FFGTSRGKEV CYERLGCFKD GLPWTRTFST ELVGLPWSPE
60 70 80 90 100
KINTRFLLYT IHNPNAYQEI SAVNSSTIQA SYFGTDKITR INIAGWKTDG
110 120 130 140 150
KWQRDMCNVL LQLEDINCIN LDWINGSREY IHAVNNLRVV GAEVAYFIDV
160 170 180 190 200
LMKKFEYSPS KVHLIGHSLG AHLAGEAGSR IPGLGRITGL DPAGPFFHNT
210 220 230 240 250
PKEVRLDPSD ANFVDVIHTN AARILFELGV GTIDACGHLD FYPNGGKHMP
260 270 280 290 300
GCEDLITPLL KFNFNAYKKE MASFFDCNHA RSYQFYAESI LNPDAFIAYP
310 320 330 340 350
CRSYTSFKAG NCFFCSKEGC PTMGHFADRF HFKNMKTNGS HYFLNTGSLS
360 370 380 390 400
PFARWRHKLS VKLSGSEVTQ GTVFLRVGGA VRKTGEFAIV SGKLEPGMTY
410 420 430 440 450
TKLIDADVNV GNITSVQFIW KKHLFEDSQN KLGAEMVINT SGKYGYKSTF
460
CSQDIMGPNI LQNLKPC
Length:467
Mass (Da):52,254
Last modified:November 24, 2009 - v2
Checksum:iF383E516278D1FC2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0321412L → F. Corresponds to variant dbSNP:rs10885929Ensembl.1
Natural variantiVAR_032142332F → L. Corresponds to variant dbSNP:rs7077408Ensembl.1
Natural variantiVAR_060285381V → I1 PublicationCorresponds to variant dbSNP:rs10736251Ensembl.1
Natural variantiVAR_060286382R → G1 PublicationCorresponds to variant dbSNP:rs1897519Ensembl.1
Natural variantiVAR_032143450F → Y. Corresponds to variant dbSNP:rs2116286Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011328 Genomic DNA No translation available.
BC117224 mRNA Translation: AAI17225.1
CCDSiCCDS31292.1
RefSeqiNP_001011709.2, NM_001011709.2
UniGeneiHs.276724

Genome annotation databases

EnsembliENST00000369230; ENSP00000358232; ENSG00000203837
GeneIDi119548
KEGGihsa:119548
UCSCiuc001lcl.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLIPR3_HUMAN
AccessioniPrimary (citable) accession number: Q17RR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 24, 2009
Last modified: June 20, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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