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UniProtKB - Q17RR3 (LIPR3_HUMAN)
Protein
Pancreatic lipase-related protein 3
Gene
PNLIPRP3
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.1.1.3
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 168 | NucleophileBy similarity | 1 | |
Active sitei | 191 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 279 | Charge relay systemPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- lipase activity Source: GO_Central
- triglyceride lipase activity Source: GO_Central
GO - Biological processi
- lipid catabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism |
Enzyme and pathway databases
PathwayCommonsi | Q17RR3 |
Reactomei | R-HSA-192456, Digestion of dietary lipid |
SignaLinki | Q17RR3 |
Protein family/group databases
ESTHERi | human-PNLIPRP3, Pancreatic_lipase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PNLIPRP3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23492, PNLIPRP3 |
neXtProti | NX_Q17RR3 |
VEuPathDBi | HostDB:ENSG00000203837 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 119548 |
OpenTargetsi | ENSG00000203837 |
PharmGKBi | PA134954941 |
Miscellaneous databases
Pharosi | Q17RR3, Tdark |
Genetic variation databases
BioMutai | PNLIPRP3 |
DMDMi | 269849614 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000286602 | 18 – 467 | Pancreatic lipase-related protein 3Add BLAST | 450 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 21 ↔ 27 | By similarity | ||
Glycosylationi | 74 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 107 ↔ 118 | By similarity | ||
Glycosylationi | 125 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 252 ↔ 277 | By similarity | ||
Disulfide bondi | 301 ↔ 312 | By similarity | ||
Disulfide bondi | 315 ↔ 320 | By similarity | ||
Disulfide bondi | 451 ↔ 467 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q17RR3 |
jPOSTi | Q17RR3 |
MassIVEi | Q17RR3 |
PaxDbi | Q17RR3 |
PeptideAtlasi | Q17RR3 |
PRIDEi | Q17RR3 |
PTM databases
GlyGeni | Q17RR3, 3 sites |
iPTMneti | Q17RR3 |
PhosphoSitePlusi | Q17RR3 |
Expressioni
Tissue specificityi
Overexpressed in hepatocellular carcinoma.1 Publication
Gene expression databases
Bgeei | ENSG00000203837, Expressed in zone of skin and 59 other tissues |
Genevisiblei | Q17RR3, HS |
Organism-specific databases
HPAi | ENSG00000203837, Tissue enhanced (breast, skin) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000358232 |
Miscellaneous databases
RNActi | Q17RR3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 355 – 467 | PLATAdd BLAST | 113 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SHK7, Eukaryota |
GeneTreei | ENSGT00940000163197 |
HOGENOMi | CLU_027171_0_2_1 |
InParanoidi | Q17RR3 |
OMAi | NRSYYFL |
OrthoDBi | 534956at2759 |
PhylomeDBi | Q17RR3 |
TreeFami | TF324997 |
Family and domain databases
CDDi | cd00707, Pancreat_lipase_like, 1 hit |
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR013818, Lipase IPR016272, Lipase_LIPH IPR033906, Lipase_N IPR002331, Lipase_panc IPR001024, PLAT/LH2_dom IPR036392, PLAT/LH2_dom_sf IPR000734, TAG_lipase |
PANTHERi | PTHR11610, PTHR11610, 1 hit |
Pfami | View protein in Pfam PF00151, Lipase, 1 hit PF01477, PLAT, 1 hit |
PIRSFi | PIRSF000865, Lipoprotein_lipase_LIPH, 1 hit |
PRINTSi | PR00823, PANCLIPASE PR00821, TAGLIPASE |
SUPFAMi | SSF49723, SSF49723, 1 hit SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00120, LIPASE_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q17RR3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGIWIVAFL FFGTSRGKEV CYERLGCFKD GLPWTRTFST ELVGLPWSPE
60 70 80 90 100
KINTRFLLYT IHNPNAYQEI SAVNSSTIQA SYFGTDKITR INIAGWKTDG
110 120 130 140 150
KWQRDMCNVL LQLEDINCIN LDWINGSREY IHAVNNLRVV GAEVAYFIDV
160 170 180 190 200
LMKKFEYSPS KVHLIGHSLG AHLAGEAGSR IPGLGRITGL DPAGPFFHNT
210 220 230 240 250
PKEVRLDPSD ANFVDVIHTN AARILFELGV GTIDACGHLD FYPNGGKHMP
260 270 280 290 300
GCEDLITPLL KFNFNAYKKE MASFFDCNHA RSYQFYAESI LNPDAFIAYP
310 320 330 340 350
CRSYTSFKAG NCFFCSKEGC PTMGHFADRF HFKNMKTNGS HYFLNTGSLS
360 370 380 390 400
PFARWRHKLS VKLSGSEVTQ GTVFLRVGGA VRKTGEFAIV SGKLEPGMTY
410 420 430 440 450
TKLIDADVNV GNITSVQFIW KKHLFEDSQN KLGAEMVINT SGKYGYKSTF
460
CSQDIMGPNI LQNLKPC
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032141 | 2 | L → F. Corresponds to variant dbSNP:rs10885929Ensembl. | 1 | |
Natural variantiVAR_032142 | 332 | F → L. Corresponds to variant dbSNP:rs7077408Ensembl. | 1 | |
Natural variantiVAR_060285 | 381 | V → I1 PublicationCorresponds to variant dbSNP:rs10736251Ensembl. | 1 | |
Natural variantiVAR_060286 | 382 | R → G1 PublicationCorresponds to variant dbSNP:rs1897519Ensembl. | 1 | |
Natural variantiVAR_032143 | 450 | F → Y. Corresponds to variant dbSNP:rs2116286Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011328 Genomic DNA No translation available. BC117224 mRNA Translation: AAI17225.1 |
CCDSi | CCDS31292.1 |
RefSeqi | NP_001011709.2, NM_001011709.2 |
Genome annotation databases
Ensembli | ENST00000369230.4; ENSP00000358232.3; ENSG00000203837.5 |
GeneIDi | 119548 |
KEGGi | hsa:119548 |
MANE-Selecti | ENST00000369230.4; ENSP00000358232.3; NM_001011709.3; NP_001011709.2 |
UCSCi | uc001lcl.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011328 Genomic DNA No translation available. BC117224 mRNA Translation: AAI17225.1 |
CCDSi | CCDS31292.1 |
RefSeqi | NP_001011709.2, NM_001011709.2 |
3D structure databases
AlphaFoldDBi | Q17RR3 |
SMRi | Q17RR3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000358232 |
Protein family/group databases
ESTHERi | human-PNLIPRP3, Pancreatic_lipase |
PTM databases
GlyGeni | Q17RR3, 3 sites |
iPTMneti | Q17RR3 |
PhosphoSitePlusi | Q17RR3 |
Genetic variation databases
BioMutai | PNLIPRP3 |
DMDMi | 269849614 |
Proteomic databases
EPDi | Q17RR3 |
jPOSTi | Q17RR3 |
MassIVEi | Q17RR3 |
PaxDbi | Q17RR3 |
PeptideAtlasi | Q17RR3 |
PRIDEi | Q17RR3 |
Protocols and materials databases
Antibodypediai | 52438, 113 antibodies from 15 providers |
DNASUi | 119548 |
Genome annotation databases
Ensembli | ENST00000369230.4; ENSP00000358232.3; ENSG00000203837.5 |
GeneIDi | 119548 |
KEGGi | hsa:119548 |
MANE-Selecti | ENST00000369230.4; ENSP00000358232.3; NM_001011709.3; NP_001011709.2 |
UCSCi | uc001lcl.5, human |
Organism-specific databases
CTDi | 119548 |
DisGeNETi | 119548 |
GeneCardsi | PNLIPRP3 |
HGNCi | HGNC:23492, PNLIPRP3 |
HPAi | ENSG00000203837, Tissue enhanced (breast, skin) |
neXtProti | NX_Q17RR3 |
OpenTargetsi | ENSG00000203837 |
PharmGKBi | PA134954941 |
VEuPathDBi | HostDB:ENSG00000203837 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SHK7, Eukaryota |
GeneTreei | ENSGT00940000163197 |
HOGENOMi | CLU_027171_0_2_1 |
InParanoidi | Q17RR3 |
OMAi | NRSYYFL |
OrthoDBi | 534956at2759 |
PhylomeDBi | Q17RR3 |
TreeFami | TF324997 |
Enzyme and pathway databases
PathwayCommonsi | Q17RR3 |
Reactomei | R-HSA-192456, Digestion of dietary lipid |
SignaLinki | Q17RR3 |
Miscellaneous databases
BioGRID-ORCSi | 119548, 6 hits in 1064 CRISPR screens |
ChiTaRSi | PNLIPRP3, human |
GenomeRNAii | 119548 |
Pharosi | Q17RR3, Tdark |
PROi | PR:Q17RR3 |
RNActi | Q17RR3, protein |
Gene expression databases
Bgeei | ENSG00000203837, Expressed in zone of skin and 59 other tissues |
Genevisiblei | Q17RR3, HS |
Family and domain databases
CDDi | cd00707, Pancreat_lipase_like, 1 hit |
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR013818, Lipase IPR016272, Lipase_LIPH IPR033906, Lipase_N IPR002331, Lipase_panc IPR001024, PLAT/LH2_dom IPR036392, PLAT/LH2_dom_sf IPR000734, TAG_lipase |
PANTHERi | PTHR11610, PTHR11610, 1 hit |
Pfami | View protein in Pfam PF00151, Lipase, 1 hit PF01477, PLAT, 1 hit |
PIRSFi | PIRSF000865, Lipoprotein_lipase_LIPH, 1 hit |
PRINTSi | PR00823, PANCLIPASE PR00821, TAGLIPASE |
SUPFAMi | SSF49723, SSF49723, 1 hit SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00120, LIPASE_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LIPR3_HUMAN | |
Accessioni | Q17RR3Primary (citable) accession number: Q17RR3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | November 24, 2009 | |
Last modified: | May 25, 2022 | |
This is version 124 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families