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Entry version 109 (05 Jun 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Tigger transposable element-derived protein 6

Gene

TIGD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi30 – 50H-T-H motifBy similarityAdd BLAST21
DNA bindingi99 – 130H-T-H motifBy similarityAdd BLAST32

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tigger transposable element-derived protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TIGD6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18332 TIGD6

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q17RP2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000164296

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38525

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TIGD6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124053415

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002726191 – 521Tigger transposable element-derived protein 6Add BLAST521

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q17RP2

PeptideAtlas

More...
PeptideAtlasi
Q17RP2

PRoteomics IDEntifications database

More...
PRIDEi
Q17RP2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61161

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2085

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q17RP2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q17RP2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164296 Expressed in 136 organ(s), highest expression level in prostate gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q17RP2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044599

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123582, 20 interactors

Protein interaction database and analysis system

More...
IntActi
Q17RP2, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000296736

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q17RP2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 54HTH psq-typePROSITE-ProRule annotationAdd BLAST52
Domaini66 – 137HTH CENPB-typePROSITE-ProRule annotationAdd BLAST72
Domaini170 – 372DDE-1Sequence analysisAdd BLAST203

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3105 Eukaryota
ENOG4110CDI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163700

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000136548

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q17RP2

Identification of Orthologs from Complete Genome Data

More...
OMAi
KAVCRED

Database of Orthologous Groups

More...
OrthoDBi
1343623at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q17RP2

TreeFam database of animal gene trees

More...
TreeFami
TF101131

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR007889 HTH_Psq

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04218 CENP-B_N, 1 hit
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00674 CENPB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS50960 HTH_PSQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q17RP2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANKGNKKRR QFSLEEKMKV VGAVDSGKRK GDVAKEFGIT PSTLSTFLKD
60 70 80 90 100
RTKFEEKVRE ASVGPQRKRM RSALYDDIDK AVFAWFQEIH AKNILVTGSV
110 120 130 140 150
IRKKALNLAN MLGYDNFQAS VGWLNRFRDR HGIALKAVCR EDSDRLMNGL
160 170 180 190 200
GIDKINEWHA GEIIKLIADY SPDDIFNADE TGVFFQLLPQ HTLAAKGDHC
210 220 230 240 250
RGGKKAKQRL TALFCCNASG TEKMRPLIVG RSASPHCLKN IHSLPCDYRA
260 270 280 290 300
NQWAWMTRDL FNEWLMQVDA RMKRAERRIL LLIDNCSAHN MLPHLERIQV
310 320 330 340 350
GYLPSNCTAV LQPLNLGIIH TMKVLYQSHL LKQILLKLNS SEDQEEVDIK
360 370 380 390 400
QAIDMIAAAW WSVKPSTVVK CWQKAGIVPM EFAECDTESA ASEPDIAIEK
410 420 430 440 450
LWHTVAIATC VPNEVNFQDF VTADDDLIIS QDTDIIQDMV AGENTSEAGS
460 470 480 490 500
EDEGEVSLPE QPKVTITEAI SSVQKLRQFL STCVDIPDAI FGQLNGIDEY
510 520
LMKRVTQTLI DSKITDFLQT K
Length:521
Mass (Da):58,656
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C0526E08036324A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6N → K in BAB71230 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03004459R → W. Corresponds to variant dbSNP:rs9324636Ensembl.1
Natural variantiVAR_030045327Q → R1 PublicationCorresponds to variant dbSNP:rs10875553Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136539 mRNA Translation: CAB66474.1
AK056604 mRNA Translation: BAB71230.1
AK096325 mRNA Translation: BAG53260.1
CR533559 mRNA Translation: CAG38590.1
BC117249 mRNA Translation: AAI17250.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4301.1

NCBI Reference Sequences

More...
RefSeqi
NP_001230182.1, NM_001243253.1
NP_112215.1, NM_030953.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296736; ENSP00000296736; ENSG00000164296
ENST00000515406; ENSP00000425318; ENSG00000164296

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
81789

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:81789

UCSC genome browser

More...
UCSCi
uc003lri.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136539 mRNA Translation: CAB66474.1
AK056604 mRNA Translation: BAB71230.1
AK096325 mRNA Translation: BAG53260.1
CR533559 mRNA Translation: CAG38590.1
BC117249 mRNA Translation: AAI17250.1
CCDSiCCDS4301.1
RefSeqiNP_001230182.1, NM_001243253.1
NP_112215.1, NM_030953.3

3D structure databases

SMRiQ17RP2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123582, 20 interactors
IntActiQ17RP2, 17 interactors
STRINGi9606.ENSP00000296736

PTM databases

GlyConnecti2085
iPTMnetiQ17RP2
PhosphoSitePlusiQ17RP2

Polymorphism and mutation databases

BioMutaiTIGD6
DMDMi124053415

Proteomic databases

PaxDbiQ17RP2
PeptideAtlasiQ17RP2
PRIDEiQ17RP2
ProteomicsDBi61161

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
81789
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296736; ENSP00000296736; ENSG00000164296
ENST00000515406; ENSP00000425318; ENSG00000164296
GeneIDi81789
KEGGihsa:81789
UCSCiuc003lri.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
81789

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TIGD6
HGNCiHGNC:18332 TIGD6
HPAiHPA044599
neXtProtiNX_Q17RP2
OpenTargetsiENSG00000164296
PharmGKBiPA38525

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3105 Eukaryota
ENOG4110CDI LUCA
GeneTreeiENSGT00940000163700
HOGENOMiHOG000136548
InParanoidiQ17RP2
OMAiKAVCRED
OrthoDBi1343623at2759
PhylomeDBiQ17RP2
TreeFamiTF101131

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
81789

Protein Ontology

More...
PROi
PR:Q17RP2

Gene expression databases

BgeeiENSG00000164296 Expressed in 136 organ(s), highest expression level in prostate gland
GenevisibleiQ17RP2 HS

Family and domain databases

InterProiView protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR007889 HTH_Psq
PfamiView protein in Pfam
PF04218 CENP-B_N, 1 hit
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit
SMARTiView protein in SMART
SM00674 CENPB, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS50960 HTH_PSQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTIGD6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17RP2
Secondary accession number(s): B3KTZ8, Q96MQ4, Q9H0X7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: June 5, 2019
This is version 109 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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