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Entry version 91 (08 May 2019)
Sequence version 1 (25 Jul 2006)
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Protein

Protein FAM98C

Gene

FAM98C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM98C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM98C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:27119 FAM98C

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q17RN3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
147965

Open Targets

More...
OpenTargetsi
ENSG00000130244

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671779

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM98C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121940586

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002824281 – 349Protein FAM98CAdd BLAST349

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q17RN3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q17RN3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q17RN3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q17RN3

PeptideAtlas

More...
PeptideAtlasi
Q17RN3

PRoteomics IDEntifications database

More...
PRIDEi
Q17RN3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61159
61160 [Q17RN3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q17RN3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q17RN3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130244 Expressed in 186 organ(s), highest expression level in cerebellar vermis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q17RN3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q17RN3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040930
HPA041730

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
127106, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q17RN3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000252530

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM98 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3973 Eukaryota
ENOG4111GTB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000037341

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231951

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q17RN3

Identification of Orthologs from Complete Genome Data

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OMAi
QGTCCAI

Database of Orthologous Groups

More...
OrthoDBi
800008at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q17RN3

TreeFam database of animal gene trees

More...
TreeFami
TF320308

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018797 FAM98

The PANTHER Classification System

More...
PANTHERi
PTHR31353 PTHR31353, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10239 DUF2465, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q17RN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAVKAEAWE GAAVAQDLLA LGYGGVPGAA SRGASCPDFR GLCVRLAAEL
60 70 80 90 100
ATLGALEQQR EAGAEVLSAG DGPGAEEDFL RQLGSLLREL HCPDRALCGG
110 120 130 140 150
DGAAALREPG AGLRLLRFLC SELQATRLLC LRSLLDPSPR PPLGEGVVEG
160 170 180 190 200
AGMVQELDLT LQALGLPRPA PGTPASQLLQ ELHAKISELQ PSLPPGSLQP
210 220 230 240 250
LLSCSLDAPR WEALESLSQS LRDQYRCRRC LLLKRLDLTT SAFHWSDRAE
260 270 280 290 300
AQGEAMRAVL IPIREVLTPE SDISIAHVLA ARADLSCLVP ATSVAVRRGT
310 320 330 340
CCAINKVLMG NVPDRGGRPN ELEPPMPTWR SRREDGGPQC WGRKKKKKK
Length:349
Mass (Da):37,329
Last modified:July 25, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB53925695FC7F358
GO
Isoform 2 (identifier: Q17RN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-211: Missing.
     251-306: Missing.

Note: No experimental confirmation available.
Show »
Length:267
Mass (Da):28,701
Checksum:iBA5A2ABB626A8DE1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQL1K7EQL1_HUMAN
Protein FAM98C
FAM98C
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQT7K7EQT7_HUMAN
Protein FAM98C
FAM98C
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ES49K7ES49_HUMAN
Protein FAM98C
FAM98C
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049030240T → K. Corresponds to variant dbSNP:rs3745962Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024142186 – 211Missing in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_024143251 – 306Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC005789 Genomic DNA No translation available.
BC080606 mRNA Translation: AAH80606.1
BC117258 mRNA Translation: AAI17259.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42562.1 [Q17RN3-1]
CCDS86763.1 [Q17RN3-2]

NCBI Reference Sequences

More...
RefSeqi
NP_777565.3, NM_174905.3 [Q17RN3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000252530; ENSP00000252530; ENSG00000130244 [Q17RN3-1]
ENST00000343358; ENSP00000340348; ENSG00000130244 [Q17RN3-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
147965

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:147965

UCSC genome browser

More...
UCSCi
uc002oin.2 human [Q17RN3-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005789 Genomic DNA No translation available.
BC080606 mRNA Translation: AAH80606.1
BC117258 mRNA Translation: AAI17259.1
CCDSiCCDS42562.1 [Q17RN3-1]
CCDS86763.1 [Q17RN3-2]
RefSeqiNP_777565.3, NM_174905.3 [Q17RN3-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi127106, 1 interactor
IntActiQ17RN3, 1 interactor
STRINGi9606.ENSP00000252530

PTM databases

iPTMnetiQ17RN3
PhosphoSitePlusiQ17RN3

Polymorphism and mutation databases

BioMutaiFAM98C
DMDMi121940586

Proteomic databases

EPDiQ17RN3
jPOSTiQ17RN3
MaxQBiQ17RN3
PaxDbiQ17RN3
PeptideAtlasiQ17RN3
PRIDEiQ17RN3
ProteomicsDBi61159
61160 [Q17RN3-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
147965
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252530; ENSP00000252530; ENSG00000130244 [Q17RN3-1]
ENST00000343358; ENSP00000340348; ENSG00000130244 [Q17RN3-2]
GeneIDi147965
KEGGihsa:147965
UCSCiuc002oin.2 human [Q17RN3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
147965
DisGeNETi147965

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM98C
HGNCiHGNC:27119 FAM98C
HPAiHPA040930
HPA041730
neXtProtiNX_Q17RN3
OpenTargetsiENSG00000130244
PharmGKBiPA142671779

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3973 Eukaryota
ENOG4111GTB LUCA
GeneTreeiENSGT00440000037341
HOGENOMiHOG000231951
InParanoidiQ17RN3
OMAiQGTCCAI
OrthoDBi800008at2759
PhylomeDBiQ17RN3
TreeFamiTF320308

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM98C human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
147965

Protein Ontology

More...
PROi
PR:Q17RN3

Gene expression databases

BgeeiENSG00000130244 Expressed in 186 organ(s), highest expression level in cerebellar vermis
ExpressionAtlasiQ17RN3 baseline and differential
GenevisibleiQ17RN3 HS

Family and domain databases

InterProiView protein in InterPro
IPR018797 FAM98
PANTHERiPTHR31353 PTHR31353, 1 hit
PfamiView protein in Pfam
PF10239 DUF2465, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA98C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17RN3
Secondary accession number(s): A6NMW3, Q66K45
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 25, 2006
Last modified: May 8, 2019
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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