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Protein

Coiled-coil domain-containing protein 142

Gene

CCDC142

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 142
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC142
ORF Names:PSEC0243
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000135637.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25889 CCDC142

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q17RM4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000135637

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162381450

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC142

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121940584

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003112601 – 750Coiled-coil domain-containing protein 142Add BLAST750

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q17RM4

PeptideAtlas

More...
PeptideAtlasi
Q17RM4

PRoteomics IDEntifications database

More...
PRIDEi
Q17RM4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61154
61155 [Q17RM4-2]
61156 [Q17RM4-3]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q17RM4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135637 Expressed in 154 organ(s), highest expression level in buccal mucosa cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_CCDC142

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q17RM4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q17RM4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA056946

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124310, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000290418

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q17RM4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili87 – 110Sequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEKX Eukaryota
ENOG4111G4R LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009871

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082479

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG095606

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q17RM4

Identification of Orthologs from Complete Genome Data

More...
OMAi
PPCCCAC

Database of Orthologous Groups

More...
OrthoDBi
489914at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q17RM4

TreeFam database of animal gene trees

More...
TreeFami
TF328445

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026700 CCDC142

The PANTHER Classification System

More...
PANTHERi
PTHR21436 PTHR21436, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14923 CCDC142, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q17RM4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQASRSGSL PPLVIVPPLR AQPGGTGEEQ WERSRTGGLR WEVHCWPSGT
60 70 80 90 100
SGGTPWWPTP ADVSEDYEAD AAAWRRGPAG GGPIPPALQR LRAVLLRLHR
110 120 130 140 150
EREQLLQARD CAYHLQSAVR LMKTLSPGSP SGGPSPLPQW CRDLQLHPSQ
160 170 180 190 200
GAVLRIGPGE TLEPLLLARP IGLAAQCLEA VIEMQLRALG REPASPGLSS
210 220 230 240 250
QLAELLFALP AYHTLQRKAL SHVPGAARPF PTSRVLRLLT GERGCQVASR
260 270 280 290 300
LDEALQGSAL RDQLRRRCQE EGDLLPGLLG LVGGVAGSAS CGLGLGGAGA
310 320 330 340 350
LWSQYWTLLW AACAQSLDLN LGPWRDPRAT AQQLSQALGQ ASLPQECEKE
360 370 380 390 400
LASLCHRLLH QSLIWSWDQG FCQALGSALG GQSSLPTSSG TAELLQQLFP
410 420 430 440 450
PLLDALREPR LRRIFCQPAD PAPVALGLCT LQTTLLWFLG RAQQYLAAWD
460 470 480 490 500
PASFLLLIQK DLPPLLHEAE ALYSLASEES LALEVEQQLG LEIQKLTAQI
510 520 530 540 550
QLLPEESLSV FSQECHKQAM QGFKLYMPRG RYWRLRLCPE PPSAPSEYAG
560 570 580 590 600
LVVRTVLEPV LQGLQGLPPQ AQAPALGQAL TAIVGAWLDH ILTHGIRFSL
610 620 630 640 650
QGALQLKQDF GVVRELLEEE QWSLSPDLRQ TLLMLSIFQQ LDGALLCLLQ
660 670 680 690 700
QPLPKSQVHR RPPCCCACQE VQTTKLPSSC LNSLESLEPP LQPGTSPAQT
710 720 730 740 750
GQLQSTLGGR GPSPEGYLVG NQQAWLALRQ HQRPRWHLPF FSCLGTSPES
Length:750
Mass (Da):81,643
Last modified:July 25, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7A7C54ABB819936B
GO
Isoform 2 (identifier: Q17RM4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-426: Missing.

Note: No experimental confirmation available.
Show »
Length:743
Mass (Da):80,979
Checksum:iD7324A185FAFA39C
GO
Isoform 3 (identifier: Q17RM4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     666-750: Missing.

Note: No experimental confirmation available.
Show »
Length:665
Mass (Da):72,473
Checksum:iBF97BCB15D13513E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C450H7C450_HUMAN
Coiled-coil domain-containing prote...
CCDC142
567Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11474 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037210534R → Q. Corresponds to variant dbSNP:rs13385919Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029497420 – 426Missing in isoform 2. 1 Publication7
Alternative sequenceiVSP_029498666 – 750Missing in isoform 3. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK075543 mRNA Translation: BAC11686.1
BC117269 mRNA Translation: AAI17270.1
BC143398 mRNA Translation: AAI43399.1
AK075209 mRNA Translation: BAC11474.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1945.1 [Q17RM4-2]

NCBI Reference Sequences

More...
RefSeqi
NP_116168.3, NM_032779.3 [Q17RM4-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.430199

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000290418; ENSP00000290418; ENSG00000135637 [Q17RM4-2]
ENST00000393965; ENSP00000377537; ENSG00000135637 [Q17RM4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84865

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84865

UCSC genome browser

More...
UCSCi
uc002slq.4 human [Q17RM4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075543 mRNA Translation: BAC11686.1
BC117269 mRNA Translation: AAI17270.1
BC143398 mRNA Translation: AAI43399.1
AK075209 mRNA Translation: BAC11474.1 Different initiation.
CCDSiCCDS1945.1 [Q17RM4-2]
RefSeqiNP_116168.3, NM_032779.3 [Q17RM4-2]
UniGeneiHs.430199

3D structure databases

ProteinModelPortaliQ17RM4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124310, 6 interactors
STRINGi9606.ENSP00000290418

PTM databases

PhosphoSitePlusiQ17RM4

Polymorphism and mutation databases

BioMutaiCCDC142
DMDMi121940584

Proteomic databases

PaxDbiQ17RM4
PeptideAtlasiQ17RM4
PRIDEiQ17RM4
ProteomicsDBi61154
61155 [Q17RM4-2]
61156 [Q17RM4-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84865
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290418; ENSP00000290418; ENSG00000135637 [Q17RM4-2]
ENST00000393965; ENSP00000377537; ENSG00000135637 [Q17RM4-1]
GeneIDi84865
KEGGihsa:84865
UCSCiuc002slq.4 human [Q17RM4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84865
EuPathDBiHostDB:ENSG00000135637.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC142

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0002186
HGNCiHGNC:25889 CCDC142
HPAiHPA056946
neXtProtiNX_Q17RM4
OpenTargetsiENSG00000135637
PharmGKBiPA162381450

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEKX Eukaryota
ENOG4111G4R LUCA
GeneTreeiENSGT00390000009871
HOGENOMiHOG000082479
HOVERGENiHBG095606
InParanoidiQ17RM4
OMAiPPCCCAC
OrthoDBi489914at2759
PhylomeDBiQ17RM4
TreeFamiTF328445

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCDC142 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84865

Protein Ontology

More...
PROi
PR:Q17RM4

Gene expression databases

BgeeiENSG00000135637 Expressed in 154 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_CCDC142
ExpressionAtlasiQ17RM4 baseline and differential
GenevisibleiQ17RM4 HS

Family and domain databases

InterProiView protein in InterPro
IPR026700 CCDC142
PANTHERiPTHR21436 PTHR21436, 1 hit
PfamiView protein in Pfam
PF14923 CCDC142, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC142_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17RM4
Secondary accession number(s): B7ZKV5
, Q8NBJ3, Q8NBV2, Q96KA7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 25, 2006
Last modified: January 16, 2019
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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