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Protein

Synaptotagmin-16

Gene

SYT16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca2+-independent.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-16
Alternative name(s):
Chr14Syt
Synaptotagmin 14-like protein
Synaptotagmin XIV-related protein
Gene namesi
Name:SYT16
Synonyms:STREP14, SYT14L, SYT14R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000139973.15
HGNCiHGNC:23142 SYT16
MIMi610950 gene
neXtProtiNX_Q17RD7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi83851
OpenTargetsiENSG00000139973
PharmGKBiPA134964250

Polymorphism and mutation databases

BioMutaiSYT16
DMDMi313104017

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002585841 – 645Synaptotagmin-16Add BLAST645

Proteomic databases

PaxDbiQ17RD7
PeptideAtlasiQ17RD7
PRIDEiQ17RD7
ProteomicsDBi61148
61149 [Q17RD7-2]
61150 [Q17RD7-3]

PTM databases

iPTMnetiQ17RD7
PhosphoSitePlusiQ17RD7

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Gene expression databases

BgeeiENSG00000139973 Expressed in 82 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_SYT14L
HS_SYT16
ExpressionAtlasiQ17RD7 baseline and differential
GenevisibleiQ17RD7 HS

Organism-specific databases

HPAiHPA004199
HPA076871

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123767, 18 interactors
IntActiQ17RD7, 27 interactors
MINTiQ17RD7
STRINGi9606.ENSP00000394700

Structurei

3D structure databases

ProteinModelPortaliQ17RD7
SMRiQ17RD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini352 – 453C2 1PROSITE-ProRule annotationAdd BLAST102
Domaini507 – 611C2 2PROSITE-ProRule annotationAdd BLAST105

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XT5D LUCA
GeneTreeiENSGT00920000148994
HOGENOMiHOG000070178
HOVERGENiHBG062897
InParanoidiQ17RD7
KOiK19328
OMAiYAARKMT
OrthoDBiEOG091G099X
PhylomeDBiQ17RD7
TreeFamiTF351132

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR028690 SYT16
PANTHERiPTHR10024:SF113 PTHR10024:SF113, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q17RD7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLAMASQDV QNFFQPFSSW ISRVYEALQQ AGDMLSASLV NISKQDSKLS
60 70 80 90 100
DKLDQDLDNI QIQETYFEDE EQDNDWSQED ANSLFLEVDH FSCCNSDLQD
110 120 130 140 150
SAQNSSPSLS QHAKDSCSTM SQWPNWASDD RKLPHVLSSI AEEEHHLEKQ
160 170 180 190 200
RSGLQHGFDS QLPGTLETVN GKKQVNSFGD DEELSTSSDS DEEVIKQFEI
210 220 230 240 250
SVSRSQSFRS VTSEKGKQTG LEQKPKFSRS LLTHGEDGTE VSACEDLDGA
260 270 280 290 300
SQRRYSENLS YGEDDHIPAH SQSPCERGDA KHHGTSHQES SVVQSLRRQS
310 320 330 340 350
TEGSLEMETA FNSRGFEDSY ATDSSSMWSP EEQDRTNLQV PSGVSEPISK
360 370 380 390 400
CGDLDVIFEY RAASQKLTVT IVRAQGLPDK DRSGVNSWQV HVVLLPGKKH
410 420 430 440 450
RGRTNIQRGP NPVFREKVTF AKLEPRDVAA CAVRFRLYAA RKMTRERMMG
460 470 480 490 500
EKLFYLSHLH PEGEMKVTLV LEPRSNISSG GSPLSPSAVS HSDSTSSTQS
510 520 530 540 550
LSHGGAPELL VGLSYNATTG RLSVEMIKGS HFRNLAVNRA PDTYGKLFLL
560 570 580 590 600
NSVGQEMSRC KTSIRRGQPN PVYKETFVFQ VALFQLSDVT LMISVYNRRT
610 620 630 640
MKRKEMIGWI ALGQNSSGEE EQDHWEEMKE TKGQQICRWH TLLES
Length:645
Mass (Da):72,274
Last modified:November 30, 2010 - v2
Checksum:iA9E11164542AAAAE
GO
Isoform 2 (identifier: Q17RD7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-331: Missing.

Show »
Length:625
Mass (Da):70,039
Checksum:iA0C5FF2E7231293B
GO
Isoform 3 (identifier: Q17RD7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-442: Missing.

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):22,824
Checksum:iAC3B6BEE011868ED
GO
Isoform 4 (identifier: Q17RD7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-383: EQDRTNLQVP...AQGLPDKDRS → ANLNLKRKGY...SQSPSQSVVT
     384-645: Missing.

Note: No experimental confirmation available.
Show »
Length:383
Mass (Da):42,800
Checksum:iD2DC06B06EE32A84
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GUW0A0A1B0GUW0_HUMAN
Synaptotagmin-16
SYT16
221Annotation score:

Sequence cautioni

The sequence CAE85114 differs from that shown. Reason: Erroneous termination at position 72. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175V → I in BAC76810 (PubMed:12801916).Curated1
Sequence conflicti517A → V in CAE85114 (PubMed:15238157).Curated1
Sequence conflicti614Q → L in CAE85114 (PubMed:15238157).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02893010V → A1 PublicationCorresponds to variant dbSNP:rs8019076Ensembl.1
Natural variantiVAR_028931131R → L1 PublicationCorresponds to variant dbSNP:rs17099370Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0213781 – 442Missing in isoform 3. 1 PublicationAdd BLAST442
Alternative sequenceiVSP_021379312 – 331Missing in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_057225332 – 383EQDRT…DKDRS → ANLNLKRKGYLLDVYCLSSP LLFTTSLHRRNRTGPICRCH PGSQSPSQSVVT in isoform 4. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_057226384 – 645Missing in isoform 4. 1 PublicationAdd BLAST262

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB102949 mRNA Translation: BAC76810.1
AJ617628 mRNA Translation: CAE85114.1 Sequence problems.
AK302919 mRNA Translation: BAG64084.1
AL356018 Genomic DNA No translation available.
AL390816 Genomic DNA No translation available.
BC040924 mRNA Translation: AAH40924.1
BC117363 mRNA Translation: AAI17364.1
BC143598 mRNA Translation: AAI43599.1
AJ303367 mRNA Translation: CAC33889.1
CCDSiCCDS45121.1 [Q17RD7-1]
RefSeqiNP_114120.2, NM_031914.2 [Q17RD7-1]
XP_006720335.1, XM_006720272.3 [Q17RD7-1]
XP_011535521.1, XM_011537219.1 [Q17RD7-1]
XP_016877182.1, XM_017021693.1 [Q17RD7-1]
XP_016877183.1, XM_017021694.1 [Q17RD7-1]
XP_016877184.1, XM_017021695.1 [Q17RD7-1]
UniGeneiHs.404139
Hs.713240

Genome annotation databases

EnsembliENST00000430451; ENSP00000394700; ENSG00000139973 [Q17RD7-3]
ENST00000555409; ENSP00000451035; ENSG00000139973 [Q17RD7-4]
ENST00000568344; ENSP00000478637; ENSG00000139973 [Q17RD7-1]
GeneIDi83851
KEGGihsa:83851
UCSCiuc001xfu.2 human [Q17RD7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSYT16_HUMAN
AccessioniPrimary (citable) accession number: Q17RD7
Secondary accession number(s): B4DZH2
, B7ZL60, C9J8I3, Q707N2, Q7Z441, Q8IUU0, Q9BQR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 30, 2010
Last modified: September 12, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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