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Protein

Retrotransposon Gag-like protein 8B

Gene

RTL8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

RTL8B is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retrotransposon Gag-like protein 8BImported
Alternative name(s):
Mammalian retrotransposon derived protein 8B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RTL8B
Synonyms:CXX1C, FAM127C, MAR8B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000212747.4

Human Gene Nomenclature Database

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HGNCi
HGNC:33156 RTL8B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q17RB0

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000212747

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162385922

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
RTL8B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003116941 – 113Retrotransposon Gag-like protein 8BAdd BLAST113

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q17RB0

MaxQB - The MaxQuant DataBase

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MaxQBi
Q17RB0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q17RB0

PeptideAtlas

More...
PeptideAtlasi
Q17RB0

PRoteomics IDEntifications database

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PRIDEi
Q17RB0

ProteomicsDB human proteome resource

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ProteomicsDBi
61142

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q17RB0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q17RB0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000212747 Expressed in 90 organ(s), highest expression level in popliteal artery

CleanEx database of gene expression profiles

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CleanExi
HS_FAM127C

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
137545, 8 interactors

Protein interaction database and analysis system

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IntActi
Q17RB0, 11 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000375268

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q17RB0

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM127 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IXM4 Eukaryota
ENOG41113F5 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154665

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000049195

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052318

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q17RB0

Identification of Orthologs from Complete Genome Data

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OMAi
VFGWVEE

Database of Orthologous Groups

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OrthoDBi
1526235at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q17RB0

TreeFam database of animal gene trees

More...
TreeFami
TF337843

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel

The PANTHER Classification System

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PANTHERi
PTHR15503 PTHR15503, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16297 DUF4939, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q17RB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGRVQLMKA LLARPLRPAA RRWRNPIPFP ETFDGDTDRL PEFIVQTSSY
60 70 80 90 100
MFVDENTFSN DALKVTFLIT RLTGPALQWV IPYIKKESPL LSDYRGFLAE
110
MKRVFGWEED EDF
Length:113
Mass (Da):13,246
Last modified:July 25, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i422EDCABF6CA9205
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL136169 Genomic DNA No translation available.
BC113720 mRNA Translation: AAI13721.1
BC117393 mRNA Translation: AAI17394.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS43996.1

NCBI Reference Sequences

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RefSeqi
NP_001071641.1, NM_001078173.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.378813

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000391440; ENSP00000375268; ENSG00000212747

Database of genes from NCBI RefSeq genomes

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GeneIDi
441518

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:441518

UCSC genome browser

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UCSCi
uc004eyc.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136169 Genomic DNA No translation available.
BC113720 mRNA Translation: AAI13721.1
BC117393 mRNA Translation: AAI17394.1
CCDSiCCDS43996.1
RefSeqiNP_001071641.1, NM_001078173.1
UniGeneiHs.378813

3D structure databases

ProteinModelPortaliQ17RB0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137545, 8 interactors
IntActiQ17RB0, 11 interactors
STRINGi9606.ENSP00000375268

PTM databases

iPTMnetiQ17RB0
PhosphoSitePlusiQ17RB0

Polymorphism and mutation databases

BioMutaiRTL8B

Proteomic databases

jPOSTiQ17RB0
MaxQBiQ17RB0
PaxDbiQ17RB0
PeptideAtlasiQ17RB0
PRIDEiQ17RB0
ProteomicsDBi61142

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
441518
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391440; ENSP00000375268; ENSG00000212747
GeneIDi441518
KEGGihsa:441518
UCSCiuc004eyc.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
441518
EuPathDBiHostDB:ENSG00000212747.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RTL8B
HGNCiHGNC:33156 RTL8B
neXtProtiNX_Q17RB0
OpenTargetsiENSG00000212747
PharmGKBiPA162385922

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IXM4 Eukaryota
ENOG41113F5 LUCA
GeneTreeiENSGT00940000154665
HOGENOMiHOG000049195
HOVERGENiHBG052318
InParanoidiQ17RB0
OMAiVFGWVEE
OrthoDBi1526235at2759
PhylomeDBiQ17RB0
TreeFamiTF337843

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
441518

Protein Ontology

More...
PROi
PR:Q17RB0

Gene expression databases

BgeeiENSG00000212747 Expressed in 90 organ(s), highest expression level in popliteal artery
CleanExiHS_FAM127C

Family and domain databases

InterProiView protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel
PANTHERiPTHR15503 PTHR15503, 1 hit
PfamiView protein in Pfam
PF16297 DUF4939, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRTL8B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17RB0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 25, 2006
Last modified: January 16, 2019
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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