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Protein

Retrotransposon Gag-like protein 8B

Gene

RTL8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

RTL8B is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Retrotransposon Gag-like protein 8BImported
Alternative name(s):
Mammalian retrotransposon derived protein 8B
Gene namesi
Name:RTL8B
Synonyms:CXX1C, FAM127C, MAR8B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000212747.4
HGNCiHGNC:33156 RTL8B
neXtProtiNX_Q17RB0

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000212747
PharmGKBiPA162385922

Polymorphism and mutation databases

BioMutaiFAM127C

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003116941 – 113Retrotransposon Gag-like protein 8BAdd BLAST113

Proteomic databases

MaxQBiQ17RB0
PaxDbiQ17RB0
PeptideAtlasiQ17RB0
PRIDEiQ17RB0
ProteomicsDBi61142

PTM databases

iPTMnetiQ17RB0
PhosphoSitePlusiQ17RB0

Expressioni

Gene expression databases

BgeeiENSG00000212747 Expressed in 90 organ(s), highest expression level in popliteal artery
CleanExiHS_FAM127C

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi137545, 8 interactors
IntActiQ17RB0, 11 interactors
STRINGi9606.ENSP00000375268

Structurei

3D structure databases

ProteinModelPortaliQ17RB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM127 family.Curated

Phylogenomic databases

eggNOGiENOG410IXM4 Eukaryota
ENOG41113F5 LUCA
GeneTreeiENSGT00510000047956
HOGENOMiHOG000049195
HOVERGENiHBG052318
InParanoidiQ17RB0
OMAiWGFLAEM
OrthoDBiEOG091G02TH
PhylomeDBiQ17RB0
TreeFamiTF337843

Family and domain databases

InterProiView protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel
PANTHERiPTHR15503 PTHR15503, 1 hit
PfamiView protein in Pfam
PF16297 DUF4939, 1 hit

Sequencei

Sequence statusi: Complete.

Q17RB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGRVQLMKA LLARPLRPAA RRWRNPIPFP ETFDGDTDRL PEFIVQTSSY
60 70 80 90 100
MFVDENTFSN DALKVTFLIT RLTGPALQWV IPYIKKESPL LSDYRGFLAE
110
MKRVFGWEED EDF
Length:113
Mass (Da):13,246
Last modified:July 25, 2006 - v1
Checksum:i422EDCABF6CA9205
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136169 Genomic DNA No translation available.
BC113720 mRNA Translation: AAI13721.1
BC117393 mRNA Translation: AAI17394.1
CCDSiCCDS43996.1
RefSeqiNP_001071641.1, NM_001078173.1
UniGeneiHs.378813

Genome annotation databases

EnsembliENST00000391440; ENSP00000375268; ENSG00000212747
GeneIDi441518
KEGGihsa:441518
UCSCiuc004eyc.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136169 Genomic DNA No translation available.
BC113720 mRNA Translation: AAI13721.1
BC117393 mRNA Translation: AAI17394.1
CCDSiCCDS43996.1
RefSeqiNP_001071641.1, NM_001078173.1
UniGeneiHs.378813

3D structure databases

ProteinModelPortaliQ17RB0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137545, 8 interactors
IntActiQ17RB0, 11 interactors
STRINGi9606.ENSP00000375268

PTM databases

iPTMnetiQ17RB0
PhosphoSitePlusiQ17RB0

Polymorphism and mutation databases

BioMutaiFAM127C

Proteomic databases

MaxQBiQ17RB0
PaxDbiQ17RB0
PeptideAtlasiQ17RB0
PRIDEiQ17RB0
ProteomicsDBi61142

Protocols and materials databases

DNASUi441518
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391440; ENSP00000375268; ENSG00000212747
GeneIDi441518
KEGGihsa:441518
UCSCiuc004eyc.2 human

Organism-specific databases

CTDi441518
EuPathDBiHostDB:ENSG00000212747.4
GeneCardsiRTL8B
HGNCiHGNC:33156 RTL8B
neXtProtiNX_Q17RB0
OpenTargetsiENSG00000212747
PharmGKBiPA162385922
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXM4 Eukaryota
ENOG41113F5 LUCA
GeneTreeiENSGT00510000047956
HOGENOMiHOG000049195
HOVERGENiHBG052318
InParanoidiQ17RB0
OMAiWGFLAEM
OrthoDBiEOG091G02TH
PhylomeDBiQ17RB0
TreeFamiTF337843

Miscellaneous databases

GenomeRNAii441518
PROiPR:Q17RB0

Gene expression databases

BgeeiENSG00000212747 Expressed in 90 organ(s), highest expression level in popliteal artery
CleanExiHS_FAM127C

Family and domain databases

InterProiView protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel
PANTHERiPTHR15503 PTHR15503, 1 hit
PfamiView protein in Pfam
PF16297 DUF4939, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRTL8B_HUMAN
AccessioniPrimary (citable) accession number: Q17RB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 25, 2006
Last modified: September 12, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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