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Entry version 118 (13 Nov 2019)
Sequence version 1 (25 Jul 2006)
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Protein

Zinc finger protein 827

Gene

ZNF827

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri374 – 396C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri817 – 839C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri845 – 867C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri897 – 919C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri929 – 952C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1019 – 1041C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1047 – 1069C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 827
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF827
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27193 ZNF827

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617962 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q17R98

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
152485

Open Targets

More...
OpenTargetsi
ENSG00000151612

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162410714

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q17R98

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF827

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121945543

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003258891 – 1081Zinc finger protein 827Add BLAST1081

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki216Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki360Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki372Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki466Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki475Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki523Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki549Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki580Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki587Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki597Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki634Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki639Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki658Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki673Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki673Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki704Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki710Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki742Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki778Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki798Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki870Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki891Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki958Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1014Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q17R98

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q17R98

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q17R98

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q17R98

PeptideAtlas

More...
PeptideAtlasi
Q17R98

PRoteomics IDEntifications database

More...
PRIDEi
Q17R98

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61138 [Q17R98-1]
61139 [Q17R98-2]
61140 [Q17R98-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q17R98

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q17R98

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q17R98

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000151612 Expressed in 208 organ(s), highest expression level in buccal mucosa cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q17R98 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q17R98 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021166

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127447, 22 interactors

Database of interacting proteins

More...
DIPi
DIP-61048N

Protein interaction database and analysis system

More...
IntActi
Q17R98, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000368761

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q17R98

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi311 – 354Pro-richAdd BLAST44
Compositional biasi961 – 972Poly-SerAdd BLAST12

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri374 – 396C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri817 – 839C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri845 – 867C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri897 – 919C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri929 – 952C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1019 – 1041C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1047 – 1069C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156063

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082483

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q17R98

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q17R98

TreeFam database of animal gene trees

More...
TreeFami
TF333046

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q17R98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRRKQEQPK RLPSHVSRQE EAEGELSEGE HWYGNSSETP SEASYGEVQE
60 70 80 90 100
NYKLSLEDRI QEQSTSPDTS LGSTTPSSHT LELVALDSEV LRDSLQCQDH
110 120 130 140 150
LSPGVSSLCD DDPGSNKPLS SNLRRLLEAG SLKLDAAATA NGRVESPVNV
160 170 180 190 200
GSNLSFSPPS HHAQQLSVLA RKLAEKQEQN DQYTPSNRFI WNQGKWLPNS
210 220 230 240 250
TTTCSLSPDS AILKLKAAAN AVLQDKSLTR TEETMRFESF SSPFSSQSAS
260 270 280 290 300
STLAALSKKV SERSLTPGQE HPPPASSFLS LASMTSSAAL LKEVAARAAG
310 320 330 340 350
SLLAEKSSLL PEDPLPPPPS EKKPEKVTPP PPPPPPPPPP PPPQSLELLL
360 370 380 390 400
LPVPKGRVSK PSNSASEEES GKPFQCPICG LVIKRKSYWK RHMVIHTGLK
410 420 430 440 450
SHQCPLCPFR CARKDNLKSH MKVHQHQDRG ETFQCQLCPF TSSRHFSLKL
460 470 480 490 500
HMRCHQHFLR TEAKVKEEIP DPDVKGSPHL SDSACLGQQR EGGGTELVGT
510 520 530 540 550
MMTSNTPERT SQGGAGVSPL LVKEEPKEDN GLPTSFTLNA ADRPANHTKL
560 570 580 590 600
KDPSEYVANS ASALFSQDIS VKMASDFLMK LSAANQKEPM NLNFKVKEEP
610 620 630 640 650
KEGESLSTTL PRSSYVFSPE SEVSAPGVSE DALKPQEGKG SVLRRDVSVK
660 670 680 690 700
AASELLMKLS AESYKETQMV KIKEEPMEVD IQDSHVSISP SRNVGYSTLI
710 720 730 740 750
GREKTEPLQK MPEGRVPPER NLFSQDISVK MASELLFQLS EKVSKEHNHT
760 770 780 790 800
KENTIRTTTS PFFSEDTFRQ SPFTSNSKEL LPSDSVLHGR ISAPETEKIV
810 820 830 840 850
LEAGNGLPSW KFNDQLFPCD VCGKVFGRQQ TLSRHLSLHT EERKYKCHLC
860 870 880 890 900
PYAAKCRANL NQHLTVHSVK LVSTDTEDIV SAVTSEGSDG KKHPYYYSCH
910 920 930 940 950
VCGFETELNV QFVSHMSLHV DKEQWMFSIC CTACDFVTME EAEIKTHIGT
960 970 980 990 1000
KHTGEDRKTP SESNSPSSSS LSALSDSANS KDDSDGSQKN KGGNNLLVIS
1010 1020 1030 1040 1050
VMPGSQPSLN SEEKPEKGFE CVFCNFVCKT KNMFERHLQI HLITRMFECD
1060 1070 1080
VCHKFMKTPE QLLEHKKCHT VPTGGLNSGQ W
Length:1,081
Mass (Da):119,165
Last modified:July 25, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA32DF19FE700EFA
GO
Isoform 2 (identifier: Q17R98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1077-1077: N → K
     1078-1081: Missing.

Note: No experimental confirmation available.
Show »
Length:1,077
Mass (Da):118,721
Checksum:i09000EFA9DDC74CE
GO
Isoform 3 (identifier: Q17R98-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-365: Missing.

Note: No experimental confirmation available.
Show »
Length:731
Mass (Da):81,863
Checksum:iB3958BAE22BADCE3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9Z1G5E9Z1_HUMAN
Zinc finger protein 827
ZNF827 LOC152485, hCG_38981
731Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9K9H0Y9K9_HUMAN
Zinc finger protein 827
ZNF827
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0H4A0A494C0H4_HUMAN
Zinc finger protein 827
ZNF827
1,085Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9M2H0Y9M2_HUMAN
Zinc finger protein 827
ZNF827
1,349Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJE4A0A590UJE4_HUMAN
Zinc finger protein 827
ZNF827
1,084Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15H → P in AAP97679 (Ref. 1) Curated1
Sequence conflicti39T → A in BAC03591 (PubMed:14702039).Curated1
Sequence conflicti164Q → R in BAC03591 (PubMed:14702039).Curated1
Sequence conflicti240F → L in BAC03591 (PubMed:14702039).Curated1
Sequence conflicti859N → D in AAP97679 (Ref. 1) Curated1
Sequence conflicti905E → G in BAC03591 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03246316 – 365Missing in isoform 3. 1 PublicationAdd BLAST350
Alternative sequenceiVSP_0324641077N → K in isoform 2. 1 Publication1
Alternative sequenceiVSP_0324651078 – 1081Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF450485 mRNA Translation: AAP97679.1
AK091130 mRNA Translation: BAC03591.1
BC117407 mRNA Translation: AAI17408.1
BC143577 mRNA Translation: AAI43578.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34072.1 [Q17R98-2]
CCDS77968.1 [Q17R98-1]

NCBI Reference Sequences

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RefSeqi
NP_001293144.1, NM_001306215.1 [Q17R98-1]
NP_849157.2, NM_178835.4 [Q17R98-2]
XP_016863261.1, XM_017007772.1 [Q17R98-2]
XP_016863262.1, XM_017007773.1 [Q17R98-2]
XP_016863263.1, XM_017007774.1 [Q17R98-2]
XP_016863264.1, XM_017007775.1 [Q17R98-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000379448; ENSP00000368761; ENSG00000151612 [Q17R98-2]
ENST00000508784; ENSP00000421863; ENSG00000151612 [Q17R98-1]
ENST00000656985; ENSP00000499364; ENSG00000151612 [Q17R98-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
152485

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:152485

UCSC genome browser

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UCSCi
uc003ikm.4 human [Q17R98-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450485 mRNA Translation: AAP97679.1
AK091130 mRNA Translation: BAC03591.1
BC117407 mRNA Translation: AAI17408.1
BC143577 mRNA Translation: AAI43578.1
CCDSiCCDS34072.1 [Q17R98-2]
CCDS77968.1 [Q17R98-1]
RefSeqiNP_001293144.1, NM_001306215.1 [Q17R98-1]
NP_849157.2, NM_178835.4 [Q17R98-2]
XP_016863261.1, XM_017007772.1 [Q17R98-2]
XP_016863262.1, XM_017007773.1 [Q17R98-2]
XP_016863263.1, XM_017007774.1 [Q17R98-2]
XP_016863264.1, XM_017007775.1 [Q17R98-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XXQX-ray1.90C/D1-14[»]
SMRiQ17R98
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi127447, 22 interactors
DIPiDIP-61048N
IntActiQ17R98, 15 interactors
STRINGi9606.ENSP00000368761

PTM databases

iPTMnetiQ17R98
PhosphoSitePlusiQ17R98
SwissPalmiQ17R98

Polymorphism and mutation databases

BioMutaiZNF827
DMDMi121945543

Proteomic databases

jPOSTiQ17R98
MassIVEiQ17R98
MaxQBiQ17R98
PaxDbiQ17R98
PeptideAtlasiQ17R98
PRIDEiQ17R98
ProteomicsDBi61138 [Q17R98-1]
61139 [Q17R98-2]
61140 [Q17R98-3]

Genome annotation databases

EnsembliENST00000379448; ENSP00000368761; ENSG00000151612 [Q17R98-2]
ENST00000508784; ENSP00000421863; ENSG00000151612 [Q17R98-1]
ENST00000656985; ENSP00000499364; ENSG00000151612 [Q17R98-2]
GeneIDi152485
KEGGihsa:152485
UCSCiuc003ikm.4 human [Q17R98-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
152485
DisGeNETi152485

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF827
HGNCiHGNC:27193 ZNF827
HPAiHPA021166
MIMi617962 gene
neXtProtiNX_Q17R98
OpenTargetsiENSG00000151612
PharmGKBiPA162410714

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000156063
HOGENOMiHOG000082483
InParanoidiQ17R98
OrthoDBi1318335at2759
PhylomeDBiQ17R98
TreeFamiTF333046

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF827 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
152485
PharosiQ17R98

Protein Ontology

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PROi
PR:Q17R98

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000151612 Expressed in 208 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasiQ17R98 baseline and differential
GenevisibleiQ17R98 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN827_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17R98
Secondary accession number(s): B7ZL52, Q7Z4S7, Q8N279
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 25, 2006
Last modified: November 13, 2019
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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